{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:08:47Z","timestamp":1772690927430,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"CONICET-CICPBA"},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y T\u00e9cnica","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.vetpar.2019.109010","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T21:04:09Z","timestamp":1575925449000},"page":"109010","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Pharmacokinetic-pharmacodynamic assessment of the ivermectin and abamectin nematodicidal interaction in cattle"],"prefix":"10.1016","volume":"279","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-9744","authenticated-orcid":false,"given":"M.","family":"Ballent","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Canton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bernat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lanusse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Virkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lifschitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2019.109010_bib0005","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.vetpar.2004.03.007","article-title":"Efficacy of abamectin against ivermectin-resistant strain of Trichostrongylus colubriformis in sheep","volume":"121","author":"Alka","year":"2004","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0010","first-page":"417","article-title":"Ivermectin in goat milk after subcutaneous injection","volume":"24","author":"Alvinerie","year":"1993","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetpar.2019.109010_bib0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.vetpar.2008.06.017","article-title":"Ketoconazole increases the plasma levels of ivermectin in sheep","volume":"157","author":"Alvinerie","year":"2008","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0020","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1751-0813.1988.tb07355.x","article-title":"Mixtures of anthelmintics: a strategy against resistance","volume":"65","author":"Anderson","year":"1988","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetpar.2019.109010_bib0025","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1124\/dmd.105.007757","article-title":"Modulation of the P-glycoprotein-mediated intestinal secretion of ivermectin: in vitro and in vivo assessments","volume":"34","author":"Ballent","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2019.109010_bib0030","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1365-2885.2007.00848.x","article-title":"Involvement of P-glycoprotein on ivermectin kinetic behaviour in sheep: itraconazole-mediated changes on gastrointestinal disposition","volume":"30","author":"Ballent","year":"2007","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2019.109010_bib0035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/jvp.12739","article-title":"Assessment of the long-acting ivermectin formulation in sheep: further insight into potential pharmacokinetic interactions","volume":"42","author":"Ballent","year":"2019","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2019.109010_bib0040","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.vetpar.2012.02.011","article-title":"Influence of Pluronic 85 and ketoconazole on disposition and efficacy of ivermectin in sheep infected with a multiple resistant Haemonchus contortus isolate","volume":"187","author":"Bartley","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.vetpar.2011.11.030","article-title":"The role of combination anthelmintic formulations in the sustainable control of sheep nematodes","volume":"186","author":"Bartram","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1365-2885.2007.00816.x","article-title":"Pharmacokinetics of a new long acting endectocide formulation containing 2.25% ivermectin and 1.25% abamectin in cattle","volume":"30","author":"Borges","year":"2007","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2019.109010_bib0055","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.vetpar.2008.04.019","article-title":"Endectocide activity of a new long-action formulation containing 2.25% ivermectin + 1.25% abamectin in cattle","volume":"155","author":"Borges","year":"2008","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0060","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/jvp.12438","article-title":"Pharmaco-parasitological evaluation of the ricobendazole plus levamisole nematodicidal combination in cattle","volume":"41","author":"Canton","year":"2018","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2019.109010_bib0065","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.vetpar.2016.12.021","article-title":"Resistant nematodes in cattle: pharmacotherapeutic assessment of the ivermectin- ricobendazole combination","volume":"234","author":"Canton","year":"2017","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0304-4017(92)90141-U","article-title":"World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance","volume":"44","author":"Coles","year":"1992","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0075","first-page":"25","article-title":"Anthelmintic resistance in grazing beef cattle in central and northeastern areas of Argentina - An update","volume":"9","author":"Cristel","year":"2017","journal-title":"Vet. Parasitol. Reg. Stud. Reports."},{"key":"10.1016\/j.vetpar.2019.109010_bib0080","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0731-7085(90)80060-3","article-title":"Liquid chromatographic determination of ivermectin in animal plasma with trifluoroacetic anhydride and N-methylimidazole as the derivatization reagent","volume":"8","author":"De Montigny","year":"1990","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.vetpar.2019.109010_bib0085","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.molbiopara.2013.01.004","article-title":"Potential contribution of P-glycoproteins to macrocyclic lactone resistance in the cattle parasitic nematode Cooperia oncophora","volume":"188","author":"Demeler","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0090","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0304-4017(03)00008-6","article-title":"Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: Quercetin","volume":"112","author":"Dupuy","year":"2003","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0095","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.vetpar.2008.04.015","article-title":"Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes","volume":"155","author":"Entrocasso","year":"2008","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0100","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.149","article-title":"Analysis of drug combinations: current methodological landscape","volume":"3","author":"Foucquier","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.vetpar.2019.109010_bib0105","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.vetpar.2012.09.004","article-title":"World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Guideline: anthelmintic combination products targeting nematode infections of ruminants and horses","volume":"190","author":"Geary","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0110","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijpddr.2015.08.001","article-title":"Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe","volume":"5","author":"Geurden","year":"2015","journal-title":"J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.vetpar.2019.109010_bib0115","series-title":"Revised and Expanded","article-title":"Pharmacokinetics","author":"Gibaldi","year":"1982"},{"key":"10.1016\/j.vetpar.2019.109010_bib0120","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.vetpar.2011.11.048","article-title":"An inconvenient truth: global warming and anthelmintic resistance","volume":"186","author":"Kaplan","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0125","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.vetpar.2014.04.005","article-title":"Relative potency of macrocyclic lactones in in vitro assays with larvae of susceptible and drug-resistant Australian isolates of Haemonchus contortus and H. Placei","volume":"203","author":"Kotze","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0130","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1124\/dmd.30.6.626","article-title":"Intestinal secretion is a major route for parent ivermectin elimination in the rat","volume":"30","author":"Laffont","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2019.109010_bib0135","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.pt.2018.05.005","article-title":"Strategies to optimize the efficacy of anthelmintic drugs in ruminants","volume":"34","author":"Lanusse","year":"2018","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vetpar.2015.07.015","article-title":"Basic and clinical pharmacology contribution to extend anthelmintic molecules lifespan","volume":"212","author":"Lanusse","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0145","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/00480169.2000.36183","article-title":"Ivermectin-resistant Ostertagia circumcincta from sheep in the lower North Island and their susceptibility to other macrocyclic lactone anthelmintics","volume":"48","author":"Leathwick","year":"2000","journal-title":"N. Z. Vet. J."},{"key":"10.1016\/j.vetpar.2019.109010_bib0150","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.vetpar.2013.12.022","article-title":"The management of anthelmintic resistance in grazing ruminants in Australasia--strategies and experiences","volume":"204","author":"Leathwick","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0155","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejps.2006.10.004","article-title":"Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship","volume":"30","author":"Lespine","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.vetpar.2019.109010_bib0160","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ijpddr.2011.10.001","article-title":"P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: prospects for reversing transport-dependent anthelmintic resistance","volume":"2","author":"Lespine","year":"2011","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.vetpar.2019.109010_bib0165","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.exppara.2010.01.009","article-title":"Cattle nematodes resistant to macrocyclic lactones: comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin","volume":"125","author":"Lifschitz","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0170","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.vetpar.2010.04.039","article-title":"Interference with P-glycoprotein improves ivermectin activity against adult resistant nematodes in sheep","volume":"172","author":"Lifschitz","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0175","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0304-4017(99)00142-9","article-title":"Ivermectin disposition kinetics after subcutaneous and intramuscular administration of an oil-based formulation to cattle","volume":"86","author":"Lifschitz","year":"1999","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0180","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijpddr.2012.11.001","article-title":"Comparative tissue pharmacokinetics and efficacy of moxidectin, abamectin and ivermectin in lambs infected with resistant nematodes: impact of drug treatments on parasite Pglycoprotein expression","volume":"3","author":"Lloberas","year":"2013","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.vetpar.2019.109010_bib0185","series-title":"Manual of Veterinary Parasitological Laboratory Techniques","author":"MAFF (Ministry of Agriculture, Fisheries and Food)","year":"1986"},{"key":"10.1016\/j.vetpar.2019.109010_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2018.10.011","article-title":"Assessment of P-glycoprotein gene expression in adult stage of Haemonchus contortus in vivo exposed to ivermectin","volume":"264","author":"Mate","year":"2018","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0195","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/00480169.1990.35640","article-title":"The detection of anthelmintic resistance by the faecal egg count reduction test: an examination of some of the factors affecting performance and interpretation","volume":"38","author":"McKenna","year":"1990","journal-title":"N. Z. Vet. J."},{"key":"10.1016\/j.vetpar.2019.109010_bib0200","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00436-003-1022-3","article-title":"Influence of verapamil on the pharmacokinetics of the parasitic drugs ivermectin and moxidectin in sheep","volume":"92","author":"Molento","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2019.109010_bib0205","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1017\/S0031182007000091","article-title":"ABC transporters and -tubulin in macrocyclic lactones resistance: prospects for marker development","volume":"134","author":"Prichard","year":"2007","journal-title":"Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0210","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1071\/AR9500099","article-title":"Methods for egg counts and larval cultures for strongyles infesting the gastrointestinal tract of cattle","volume":"1","author":"Roberts","year":"1950","journal-title":"Crop. Pasture Sci."},{"key":"10.1016\/j.vetpar.2019.109010_bib0215","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1006\/expr.1998.4373","article-title":"Haemonchus contortus: sequence heterogeneity of internucleotide binding domains from p-glycoproteinsand an association with avermectin\/milbemycin resistance","volume":"91","author":"Sangster","year":"1999","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0220","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.vetpar.2013.12.015","article-title":"Evaluation of pharmacological interactions after administration of a levamisole, albendazole and ivermectin triple combination in lambs","volume":"201","author":"Suarez","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.109010_bib0225","series-title":"Macrocyclic Lactones in Antiparasitic Therapy","first-page":"185","article-title":"General efficacy of the macrocyclic lactones to control parasites of cattle","author":"Vercruysse","year":"2002"},{"key":"10.1016\/j.vetpar.2019.109010_bib0230","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.2174\/0929867325666180201094730","article-title":"Role of ABC transporters in veterinary medicine: pharmaco- toxicological implications","volume":"26","author":"Virkel","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.vetpar.2019.109010_bib0235","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/ng1755","article-title":"Functional classification of drugs by properties of their pairwise interactions","volume":"38","author":"Yeh","year":"2006","journal-title":"Nat. Genet."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401719302912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401719302912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T01:32:18Z","timestamp":1759627938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401719302912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":47,"alternative-id":["S0304401719302912"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2019.109010","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetic-pharmacodynamic assessment of the ivermectin and abamectin nematodicidal interaction in cattle","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2019.109010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109010"}}