{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:25:04Z","timestamp":1793863504523,"version":"4.6.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012970","name":"Canadian Mennonite University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","award":["FF66\/021"],"award-info":[{"award-number":["FF66\/021"]}],"id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","award":["904\/2566"],"award-info":[{"award-number":["904\/2566"]}],"id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","award":["R000029530"],"award-info":[{"award-number":["R000029530"]}],"id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.vetpar.2023.110055","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T04:30:22Z","timestamp":1697776222000},"page":"110055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Inhibitory effects on bovine babesial infection by iron chelator, 1-(N-acetyl-6-aminohexyl)\u2212\u00a03-hydroxy-2-methylpyridin-4-one (CM1), and antimalarial drugs"],"prefix":"10.1016","volume":"324","author":[{"given":"Pongpisid","family":"Koonyosying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somdet","family":"Srichairatanakool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saruda","family":"Tiwananthagorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattawooti","family":"Sthitmatee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.vetpar.2023.110055_bib1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ijpddr.2018.10.002","article-title":"Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity","volume":"8","author":"Aguiar","year":"2018","journal-title":"Int J. Parasitol. Drugs Drug Resist"},{"issue":"4","key":"10.1016\/j.vetpar.2023.110055_bib2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1128\/AAC.42.4.818","article-title":"In vitro evaluation of drug susceptibilities of Babesia divergens isolates","volume":"42","author":"Brasseur","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"issue":"10","key":"10.1016\/j.vetpar.2023.110055_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0030148","article-title":"Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa","volume":"3","author":"Brayton","year":"2007","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.vetpar.2023.110055_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-020-04235-7","article-title":"Activities of artesunate-based combinations and tafenoquine against Babesia bovis in vitro and Babesia microti in vivo","volume":"13","author":"Carvalho","year":"2020","journal-title":"Parasites Vectors"},{"issue":"3","key":"10.1016\/j.vetpar.2023.110055_bib5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.vetpar.2023.110055_bib6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/bjh.12234","article-title":"Parasite maturation and host serum iron influence the labile iron pool of erythrocyte stage Plasmodium falciparum","volume":"161","author":"Clark","year":"2013","journal-title":"Br. J. Haematol."},{"issue":"2","key":"10.1016\/j.vetpar.2023.110055_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.molbiopara.2003.08.013","article-title":"An amino acid substitution in the Babesia bovis dihydrofolate reductase-thymidylate synthase gene is correlated to cross-resistance against pyrimethamine and WR99210","volume":"133","author":"Gaffar","year":"2004","journal-title":"Mol. Biochem Parasitol."},{"issue":"10","key":"10.1016\/j.vetpar.2023.110055_bib8","article-title":"Primaquine for preventing relapse in people with Plasmodium vivax malaria treated with chloroquine","author":"Galappaththy","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"issue":"7","key":"10.1016\/j.vetpar.2023.110055_bib9","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.pt.2019.05.002","article-title":"Ozonide antimalarial activity in the context of artemisinin-resistant malaria","volume":"35","author":"Giannangelo","year":"2019","journal-title":"Trends Parasitol."},{"issue":"3","key":"10.1016\/j.vetpar.2023.110055_bib10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.parint.2010.06.004","article-title":"Artesunate, a potential drug for treatment of Babesia infection","volume":"59","author":"Goo","year":"2010","journal-title":"Parasitol. Int."},{"issue":"1","key":"10.1016\/j.vetpar.2023.110055_bib11","first-page":"104","article-title":"17-DMAG inhibits the multiplication of several Babesia species and Theileria equi on in vitro cultures, and Babesia microti in mice","volume":"8","author":"Guswanto","year":"2018","journal-title":"Int. J. Parasitol.: Drugs Drug Resist."},{"issue":"5","key":"10.1016\/j.vetpar.2023.110055_bib12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/jac\/11.5.427","article-title":"The fractional inhibitory concentration (FIC) index as a measure of synergy","volume":"11","author":"Hall","year":"1983","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.vetpar.2023.110055_bib13","first-page":"91","article-title":"Toxic effect of babesiosis in cattle and chemotherapiotic treatment in Egypt","volume":"2","author":"Hamoda","year":"2014","journal-title":"Am. J. Infect. Dis. Microbiol."},{"issue":"6","key":"10.1016\/j.vetpar.2023.110055_bib14","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1292\/jvms.09-0535","article-title":"Development and characterization of a strain of Babesia gibsoni resistant to diminazene aceturate in vitro","volume":"72","author":"Hwang","year":"2010","journal-title":"J. Vet. Med Sci."},{"issue":"2","key":"10.1016\/j.vetpar.2023.110055_bib15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.parint.2014.12.006","article-title":"The efficacy of artemisinin, artemether, and lumefantrine against Babesia gibsoni in vitro","volume":"64","author":"Iguchi","year":"2015","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.vetpar.2023.110055_bib16","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.13835","article-title":"Incidence of hemoparasitic infections in cattle from central and northern Thailand","volume":"10","author":"Koonyosying","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.vetpar.2023.110055_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.mimet.2022.106641","article-title":"Measurement of Babesia bovis infected red blood cells using flow cytometry","volume":"204","author":"Koonyosying","year":"2023","journal-title":"J. Microbiol Methods"},{"key":"10.1016\/j.vetpar.2023.110055_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2020.107831","article-title":"Drug screening of food and drug administration-approved compounds against Babesia bovis in vitro","volume":"210","author":"Li","year":"2020","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/j.vetpar.2023.110055_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1128\/AAC.41.1.91","article-title":"2nd. Evaluation of selected antiprotozoal drugs in the Babesia microti-hamster model","volume":"41","author":"Marley","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1\u20132","key":"10.1016\/j.vetpar.2023.110055_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2008.07.023","article-title":"In vitro evaluation of the growth inhibitory activities of 15 drugs against Babesia gibsoni (Aomori strain)","volume":"157","author":"Matsuu","year":"2008","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2023.110055_bib21","doi-asserted-by":"crossref","DOI":"10.2174\/092986712799828355","article-title":"Current advances in detection and treatment of babesiosis","volume":"19","author":"Mosqueda","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"5","key":"10.1016\/j.vetpar.2023.110055_bib22","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/jphp.12373","article-title":"Characterisation of a novel oral iron chelator: 1-(N-Acetyl-6-Aminohexyl)-3-Hydroxy-2-Methylpyridin-4-one","volume":"67","author":"Pangjit","year":"2015","journal-title":"J. Pharm. Pharm."},{"issue":"8","key":"10.1016\/j.vetpar.2023.110055_bib23","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1128\/AAC.00928-16","article-title":"Extensive shared chemosensitivity between malaria and babesiosis blood-stage parasites","volume":"60","author":"Paul","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"issue":"9","key":"10.1016\/j.vetpar.2023.110055_bib24","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.3390\/pathogens10091120","article-title":"Treatment of Human Babesiosis: Then and Now","volume":"10","author":"Renard","year":"2021","journal-title":"Pathogens"},{"issue":"4","key":"10.1016\/j.vetpar.2023.110055_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125276","article-title":"Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites","volume":"10","author":"Rizk","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.vetpar.2023.110055_bib26","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2147\/IDR.S159519","article-title":"Inhibitory effects of fluoroquinolone antibiotics on Babesia divergens and Babesia microti, blood parasites of veterinary and zoonotic importance","volume":"11","author":"Rizk","year":"2018","journal-title":"Infect. Drug Resist"},{"key":"10.1016\/j.vetpar.2023.110055_bib27","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1146\/annurev-micro-012220-064343","article-title":"Genomic approaches to drug resistance in malaria","volume":"74","author":"Rocamora","year":"2020","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.vetpar.2023.110055_bib28","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.exppara.2016.10.002","article-title":"In vitro culture of Babesia bovis in a bovine serum-free culture medium supplemented with insulin, transferrin, and selenite","volume":"170","author":"Rojas Mart\u00ednez","year":"2016","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/j.vetpar.2023.110055_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-023-05783-4","article-title":"Why is Babesia not killed by artemisinin like Plasmodium?","volume":"16","author":"Si","year":"2023","journal-title":"Parasit. Vectors"},{"issue":"2","key":"10.1016\/j.vetpar.2023.110055_bib30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ijpddr.2018.04.004","article-title":"Assessment of Draxxin\u00ae (tulathromycin) as an inhibitor of in vitro growth of Babesia bovis, Babesia bigemina and Theileria equi","volume":"8","author":"Silva","year":"2018","journal-title":"Int J. Parasitol. Drugs Drug Resist"},{"issue":"8","key":"10.1016\/j.vetpar.2023.110055_bib31","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.3390\/microorganisms10081651","article-title":"Babesia, Theileria, Plasmodium and Hemoglobin","volume":"10","author":"Sojka","year":"2022","journal-title":"Microorganisms"},{"issue":"1\u20132","key":"10.1016\/j.vetpar.2023.110055_bib32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.vetpar.2011.05.032","article-title":"Emerging perspectives in the research of bovine babesiosis and anaplasmosis","volume":"180","author":"Suarez","year":"2011","journal-title":"Vet. Parasitol."},{"issue":"3","key":"10.1016\/j.vetpar.2023.110055_bib33","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1647\/20178-373","article-title":"Empirical Primaquine Treatment of Avian Babesiosis in Seabirds","volume":"33","author":"Thijl Vanstreels","year":"2019","journal-title":"J. Avian Med Surg."},{"issue":"1","key":"10.1016\/j.vetpar.2023.110055_bib34","doi-asserted-by":"crossref","DOI":"10.1186\/s12936-015-0910-1","article-title":"Inhibitory effect of novel iron chelator, 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) and green tea extract on growth of Plasmodium falciparum","volume":"14","author":"Thipubon","year":"2015","journal-title":"Malar. J."},{"key":"10.1016\/j.vetpar.2023.110055_bib35","first-page":"28","article-title":"Improvement of SYBR Green I\u2212based fluorescence assay reading procedure for anti\u2212babesial drugs screening in vitro","author":"Tserendorj","year":"2019","journal-title":"J. Protozool. Res."},{"key":"10.1016\/j.vetpar.2023.110055_bib36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.vetpar.2006.01.048","article-title":"Chemotherapy against babesiosis","volume":"138","author":"Vial","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2023.110055_bib37","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.exppara.2017.10.016","article-title":"Intracellular diminazene aceturate content and adenosine incorporation in diminazene aceturate-resistant Babesia gibsoni isolate in vitro","volume":"183","author":"Yamasaki","year":"2017","journal-title":"Exp. Parasitol."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401723001863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401723001863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:54:48Z","timestamp":1777553688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401723001863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":37,"alternative-id":["S0304401723001863"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2023.110055","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibitory effects on bovine babesial infection by iron chelator, 1-(N-acetyl-6-aminohexyl)\u2212\u00a03-hydroxy-2-methylpyridin-4-one (CM1), and antimalarial drugs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2023.110055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110055"}}