{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T21:11:49Z","timestamp":1762290709524,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013061","name":"Jilin Provincial Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20230101346JC","YDZJ202102CXJD029","YDZJ202301ZYTS326","20220202057NC","20230202080NC"],"award-info":[{"award-number":["20230101346JC","YDZJ202102CXJD029","YDZJ202301ZYTS326","20220202057NC","20230202080NC"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20240469KJ"],"award-info":[{"award-number":["JJKH20240469KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1800302"],"award-info":[{"award-number":["2023YFD1800302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072888","32202819","32302901","U21A20261"],"award-info":[{"award-number":["32072888","32202819","32302901","U21A20261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007710","name":"Jilin Agricultural University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.vetpar.2025.110396","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T19:15:36Z","timestamp":1736795736000},"page":"110396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The role of 5-hydroxytryptamine on expulsion of Trichinella spiralis during the intestinal stage"],"prefix":"10.1016","volume":"334","author":[{"given":"Tongxuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanrui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanlong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunwei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2025.110396_bib1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ijpara.2012.01.007","article-title":"Trichostrongylus colubriformis larvae induce necrosis and release of IL33 from intestinal epithelial cells in vitro: implications for gastrointestinal nematode vaccine design","volume":"42","author":"Andronicos","year":"2012","journal-title":"Int J. Parasitol."},{"key":"10.1016\/j.vetpar.2025.110396_bib2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.fsi.2006.05.006","article-title":"Immunohistochemical study on the neuroendocrine system of the digestive tract of turbot, Scophthalmus maximus (L.), infected by Enteromyxum scophthalmi (Myxozoa)","volume":"22","author":"Berm\u00fadez","year":"2007","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.vetpar.2025.110396_bib3","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1186\/s13071-015-0970-7","article-title":"Enteric neuromodulators and mucus discharge in a fish infected with the intestinal helminth Pomphorhynchus laevis","volume":"8","author":"Bosi","year":"2015","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.vetpar.2025.110396_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120985","article-title":"Moderate intestinal immunopathology after acute oral infection with Toxoplasma gondii oocysts is associated with expressive levels of serotonin","volume":"309","author":"Casagrande","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.vetpar.2025.110396_bib5","first-page":"G540","article-title":"Mediators of anaphylaxis-induced ion transport changes in small intestine","volume":"253","author":"Castro","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.vetpar.2025.110396_bib6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/imr.12619","article-title":"Interleukin-33 (IL-33): a nuclear cytokine from the IL-1 family","volume":"281","author":"Cayrol","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.vetpar.2025.110396_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155891","article-title":"Interleukin-33 (IL-33): a critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine","volume":"156","author":"Cayrol","year":"2022","journal-title":"Cytokine"},{"key":"10.1016\/j.vetpar.2025.110396_bib8","doi-asserted-by":"crossref","first-page":"S258","DOI":"10.1016\/j.bj.2020.11.008","article-title":"3-Hydroxybenzaldehyde and 4-Hydroxybenzaldehyde enhance survival of mouse astrocytes treated with Angiostrongylus cantonensis young adults excretory\/secretory products","volume":"44","author":"Chen","year":"2021","journal-title":"Biomed. J."},{"key":"10.1016\/j.vetpar.2025.110396_bib9","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/apha.12470","article-title":"T lymphocytes possess the machinery for 5-HT synthesis, storage, degradation and release","volume":"213","author":"Chen","year":"2015","journal-title":"Acta Physiol."},{"key":"10.1016\/j.vetpar.2025.110396_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.immuni.2020.10.014","article-title":"Interleukin-33 promotes serotonin release from enterochromaffin cells for intestinal homeostasis","volume":"54","author":"Chen","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.vetpar.2025.110396_bib11","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1182\/blood.2021013474","article-title":"Intestinal IL-33 promotes platelet activity for neutrophil recruitment during acute inflammation","volume":"139","author":"Chen","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.vetpar.2025.110396_bib12","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.celrep.2017.05.001","article-title":"Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity","volume":"19","author":"Coakley","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.vetpar.2025.110396_bib13","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1476-5381.1984.tb16486.x","article-title":"Effects of p-chlorophenylalanine on the sensitivity of rat intestine to agonists and on intestinal 5-hydroxytryptamine levels during Nippostrongylus brasiliensis infection","volume":"82","author":"Farmer","year":"1984","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.vetpar.2025.110396_bib14","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1053\/j.gastro.2022.02.016","article-title":"Mucosal serotonin reuptake transporter expression in irritable bowel syndrome is modulated by gut microbiota via mast cell-prostaglandin E2","volume":"162","author":"Gao","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.vetpar.2025.110396_bib15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/j.gastro.2006.11.002","article-title":"The serotonin signaling system: from basic understanding to drug development for functional GI disorders","volume":"132","author":"Gershon","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.vetpar.2025.110396_bib16","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1096\/fj.15-277822","article-title":"The helminth T2 RNase \u03c91 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism","volume":"30","author":"Hams","year":"2016","journal-title":"Faseb J."},{"key":"10.1016\/j.vetpar.2025.110396_bib17","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1128\/IAI.69.2.838-844.2001","article-title":"Critical role for signal transducer and activator of transcription factor 6 in mediating intestinal muscle hypercontractility and worm expulsion in Trichinella spiralis-infected mice","volume":"69","author":"Khan","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetpar.2025.110396_bib18","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1017\/S0031182008004319","article-title":"Innate immune response mechanisms in the intestinal epithelium: potential roles for mast cells and goblet cells in the expulsion of adult Trichinella spiralis","volume":"135","author":"Knight","year":"2008","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2025.110396_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2024.110322","article-title":"Eimeria tenella rhoptry neck protein 2 plays a key role in the process of invading the host intestinal epithelium","volume":"332","author":"Li","year":"2024","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2025.110396_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.711907","article-title":"Group 2 innate lymphoid cells exhibit tissue-specific dynamic behaviour during type 2 immune responses","volume":"12","author":"Lok","year":"2021","journal-title":"Front Immunol."},{"issue":"Pt 1","key":"10.1016\/j.vetpar.2025.110396_bib21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1017\/S0031182000079816","article-title":"Hymenolepis diminuta: changes in intestinal morphology and the enterochromaffin cell population associated with infection in male C57 mice","volume":"101","author":"McKay","year":"1990","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2025.110396_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031714","article-title":"COVID-19 and lung mast cells: the kallikrein-kinin activation pathway","volume":"23","author":"Nagashima","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.vetpar.2025.110396_bib23","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1084\/jem.20120408","article-title":"Tryptophan hydroxylase-1 regulates immune tolerance and inflammation","volume":"209","author":"Nowak","year":"2012","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.vetpar.2025.110396_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00382-22","article-title":"NLRP3 Plays a key role in antihelminth immunity in the enteral and parenteral stages of Trichinella spiralis-infected mice","volume":"91","author":"Pan","year":"2023","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetpar.2025.110396_bib25","first-page":"565","article-title":"Effect of a Trichinella spiralis infection on the distribution of mast cell precursors in tissues of thymus-bearing and non-thymus-bearing (nude) mice determined by an in vitro assay","volume":"60","author":"Parmentier","year":"1987","journal-title":"Immunology"},{"key":"10.1016\/j.vetpar.2025.110396_bib26","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99208","article-title":"From proteomics to discovery of first-in-class ST2 inhibitors active in vivo","volume":"3","author":"Ramadan","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.vetpar.2025.110396_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000231108","article-title":"Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. I. In vivo and in vitro effects of the amines","volume":"46","author":"Rothwell","year":"1974","journal-title":"Int Arch. Allergy Appl. Immunol."},{"key":"10.1016\/j.vetpar.2025.110396_bib28","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3389\/fimmu.2019.00702","article-title":"Blockade of IL-33R\/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression","volume":"10","author":"Ryffel","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.vetpar.2025.110396_bib29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/apha.12430","article-title":"The role of serotonin and its receptors in activation of immune responses and inflammation","volume":"213","author":"Shajib","year":"2015","journal-title":"Acta Physiol."},{"key":"10.1016\/j.vetpar.2025.110396_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2024.107208","article-title":"Differential protective impact of peptide vaccine formulae targeting the lung- and liver-stage of challenge Schistosoma mansoni infection in mice","volume":"254","author":"Tallima","year":"2024","journal-title":"Acta Trop."},{"key":"10.1016\/j.vetpar.2025.110396_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003698","article-title":"IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection","volume":"9","author":"Turner","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetpar.2025.110396_bib32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13567-020-0741-0","article-title":"Primary characterization of the immune response in pigs infected with Trichinella spiralis","volume":"51","author":"Wang","year":"2020","journal-title":"Vet. Res"},{"key":"10.1016\/j.vetpar.2025.110396_bib33","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.4049\/jimmunol.1801034","article-title":"TLR2 plays a pivotal role in mediating mucosal serotonin production in the gut","volume":"202","author":"Wang","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetpar.2025.110396_bib34","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1136\/gut.2006.103226","article-title":"CD4+\u2009T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection","volume":"56","author":"Wang","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.vetpar.2025.110396_bib35","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1073\/pnas.1201042109","article-title":"Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice","volume":"109","author":"Yasuda","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.vetpar.2025.110396_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-67788-y","article-title":"Immune response, oxidative stress, and histological changes of Wistar rats after being administered with Parascaris equorum antigen","volume":"14","author":"Yehia","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetpar.2025.110396_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2022.106388","article-title":"Epidemiology of trichinellosis in the People's Republic of China during 2009-2020","volume":"229","author":"Zhang","year":"2022","journal-title":"Acta Trop."},{"key":"10.1016\/j.vetpar.2025.110396_bib38","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1053\/j.gastro.2006.05.013","article-title":"Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hypercontractility","volume":"131","author":"Zhao","year":"2006","journal-title":"Gastroenterology"}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030440172500007X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030440172500007X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T21:03:14Z","timestamp":1762290194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030440172500007X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":38,"alternative-id":["S030440172500007X"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2025.110396","relation":{},"ISSN":["0304-4017"],"issn-type":[{"type":"print","value":"0304-4017"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of 5-hydroxytryptamine on expulsion of Trichinella spiralis during the intestinal stage","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2025.110396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110396"}}