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Sci."},{"key":"10.1016\/j.vetpar.2025.110679_bib71","doi-asserted-by":"crossref","first-page":"8683","DOI":"10.1016\/S0021-9258(18)52929-X","article-title":"Nucleotide binding to actin. Cation dependence of nucleotide dissociation and exchange rates","volume":"268","author":"Kinosian","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetpar.2025.110679_bib72","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.immuni.2012.09.016","article-title":"Recognition of profilin by toll-like receptor 12 is critical for host resistance to Toxoplasma gondii","volume":"38","author":"Koblansky","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.vetpar.2025.110679_bib73","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ejop.2018.08.006","article-title":"Effect of jasplakinolide and cytochalasin D on cortical elements involved in the gliding motility of the eugregarine Gregarina garnhami (Apicomplexa)","volume":"66","author":"Kov\u00e1\u010dikov\u00e1","year":"2018","journal-title":"Eur. J. 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Sci."},{"key":"10.1016\/j.vetpar.2025.110679_bib77","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1107\/S2053230X1500391X","article-title":"Towards a molecular understanding of the apicomplexan actin motor: on a road to novel targets for malaria remedies?","volume":"71","author":"Kumpula","year":"2015","journal-title":"Acta Crystallogr F. Struct. Biol. Commun."},{"key":"10.1016\/j.vetpar.2025.110679_bib78","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11330-w","article-title":"Apicomplexan actin polymerization depends on nucleation","volume":"7","author":"Kumpula","year":"2017","journal-title":"Sci. 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Sci."},{"key":"10.1016\/j.vetpar.2025.110679_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2011.03.003","article-title":"Immune response and protective efficacy against homologous challenge in BALB\/c mice vaccinated with DNA vaccine encoding Toxoplasma gondii actin depolymerizing factor gene","volume":"179","author":"Li","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2025.110679_bib83","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/sj.cr.7310014","article-title":"The identification of a new actin-binding region in p57","volume":"16","author":"Liu","year":"2006","journal-title":"Cell Res."},{"key":"10.1016\/j.vetpar.2025.110679_bib84","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12865-016-0173-9","article-title":"Intranasal immunization with recombinant Toxoplasma gondii actin depolymerizing factor confers protective efficacy against toxoplasmosis in mice","volume":"17","author":"Liu","year":"2016","journal-title":"BMC Immunol."},{"key":"10.1016\/j.vetpar.2025.110679_bib85","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1462-5822.2009.01378.x","article-title":"A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin during Toxoplasma gondii infection","volume":"12","author":"Lodoen","year":"2010","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.vetpar.2025.110679_bib86","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007872","article-title":"TLR11-independent inflammasome activation is critical for CD4+ T cell-derived IFN-\u03b3 production and host resistance to Toxoplasma gondii","volume":"15","author":"L\u00f3pez-Yglesias","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetpar.2025.110679_bib87","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/cm.21077","article-title":"Targeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments using MORN1","volume":"69","author":"Lorestani","year":"2012","journal-title":"Cytoskeleton"},{"key":"10.1016\/j.vetpar.2025.110679_bib88","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1021\/np400196w","article-title":"Synthetic chondramide A analogues stabilize filamentous actin and block invasion by Toxoplasma gondii","volume":"76","author":"Ma","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.vetpar.2025.110679_bib89","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.exppara.2009.01.011","article-title":"Toxoplasma gondii: proteomic analysis of antigenicity of soluble tachyzoite antigen","volume":"122","author":"Ma","year":"2009","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2025.110679_bib90","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1021\/acs.molpharmaceut.9b01262","article-title":"Vitamin E Scaffolds of pH-responsive lipid nanoparticles as DNA vaccines in cancer and Protozoan Infection","volume":"17","author":"Maeta","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.vetpar.2025.110679_bib91","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1074\/jbc.M109.068155","article-title":"Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin","volume":"285","author":"Mehta","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetpar.2025.110679_bib92","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1091\/mbc.e10-12-0939","article-title":"Actin depolymerizing factor controls actin turnover and gliding motility in Toxoplasma gondii","volume":"22","author":"Mehta","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.vetpar.2025.110679_bib93","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1007\/s00436-002-0666-8","article-title":"Effect of jasplakinolide on the growth, invasion, and actin cytoskeleton of Plasmodium falciparum","volume":"88","author":"Mizuno","year":"2002","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2025.110679_bib94","article-title":"Toxoplasma effector Tg WIP hijacks dendritic cell actin and motility via Nck1\/Grb2 and the WAVE complex","author":"Morales","year":"2025","journal-title":"bioRxiv"},{"issue":"Pt 6","key":"10.1016\/j.vetpar.2025.110679_bib95","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1242\/jcs.108.6.2457","article-title":"Invasion of Toxoplasma gondii occurs by active penetration of the host cell","volume":"108","author":"Morisaki","year":"1995","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.vetpar.2025.110679_bib96","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.chom.2009.11.007","article-title":"Plasmodium sporozoite motility is modulated by the turnover of discrete adhesion sites","volume":"6","author":"M\u00fcnter","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vetpar.2025.110679_bib97","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/emboj.2011.48","article-title":"Structural basis for the slow dynamics of the actin filament pointed end","volume":"30","author":"Narita","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.vetpar.2025.110679_bib98","doi-asserted-by":"crossref","first-page":"15828","DOI":"10.1074\/jbc.M112195200","article-title":"A cross-linked profilin-actin heterodimer interferes with elongation at the fast-growing end of F-actin","volume":"277","author":"Nyman","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetpar.2025.110679_bib99","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nature07685","article-title":"The nature of the globular- to fibrous-actin transition","volume":"457","author":"Oda","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.vetpar.2025.110679_bib100","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.str.2010.05.009","article-title":"Multiple conformations of F-actin","volume":"18","author":"Oda","year":"2010","journal-title":"Structure"},{"key":"10.1016\/j.vetpar.2025.110679_bib101","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/PL00008580","article-title":"Improved methods for examination of Toxoplasma gondii cytoskeleton at ultrastructural level","volume":"87","author":"Oliveira-Lima","year":"2001","journal-title":"Parasitol. 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Microbiol."},{"key":"10.1016\/j.vetpar.2025.110679_bib105","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0022-2836(92)90520-T","article-title":"Structural basis for the destabilization of F-actin by phosphate release following ATP hydrolysis","volume":"227","author":"Orlova","year":"1992","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetpar.2025.110679_bib106","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1126\/science.1059700","article-title":"The crystal structure of uncomplexed actin in the ADP state","volume":"293","author":"Otterbein","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.vetpar.2025.110679_bib107","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jmb.2009.11.001","article-title":"F-actin structure destabilization and DNase I binding loop: fluctuations mutational cross-linking and electron microscopy analysis of loop states and effects on F-actin","volume":"395","author":"Oztug Durer","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetpar.2025.110679_bib108","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1006\/jmbi.1998.1879","article-title":"Domain motions in actin","volume":"280","author":"Page","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetpar.2025.110679_bib109","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.ijpara.2005.03.016","article-title":"Identification and purification of actin from the subpellicular network of Toxoplasma gondii tachyzoites","volume":"35","author":"Patr\u00f3n S","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2025.110679_bib110","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.1021\/acsnano.0c01893","article-title":"Coupling polar adhesion with traction, spring, and torque forces allows high-speed helical migration of the protozoan parasite toxoplasma","volume":"14","author":"Pavlou","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.vetpar.2025.110679_bib111","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00508-21","article-title":"Novel Murine pancreatic tumor model demonstrates immunotherapeutic control of tumor progression by a Toxoplasma gondii protein","volume":"89","author":"Payne","year":"2021","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetpar.2025.110679_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106120","article-title":"Toxoplasma gondii profilin induces NLRP3 activation and IL-1\u03b2 production\/secretion in THP-1 cells","volume":"180","author":"Pazoki","year":"2023","journal-title":"Micro Pathog."},{"key":"10.1016\/j.vetpar.2025.110679_bib113","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/002215540104900404","article-title":"Calmodulin distribution and the actomyosin cytoskeleton in Toxoplasma gondii","volume":"49","author":"Pezzella-D\u2019Alessandro","year":"2001","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.vetpar.2025.110679_bib114","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.chom.2008.01.001","article-title":"Toxoplasma Profilin Is Essential for Host Cell Invasion and TLR11-Dependent Induction of an Interleukin-12 Response","volume":"3","author":"Plattner","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vetpar.2025.110679_bib115","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/jcb.240310202","article-title":"Assembly and dynamics of the actin filament system in nonmuscle cells","volume":"31","author":"Pollard","year":"1986","journal-title":"J. Cell Biochem"},{"key":"10.1016\/j.vetpar.2025.110679_bib116","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1175862","article-title":"Actin, a central player in cell shape and movement","volume":"326","author":"Pollard","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.vetpar.2025.110679_bib117","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0014-5793(84)81376-9","article-title":"The rate constant for ATP hydrolysis by polymerized actin","volume":"170","author":"Pollard","year":"1984","journal-title":"FEBS Lett."},{"key":"10.1016\/j.vetpar.2025.110679_bib118","doi-asserted-by":"crossref","first-page":"10636","DOI":"10.1073\/pnas.1707506114","article-title":"Near-atomic structure of jasplakinolide-stabilized malaria parasite F-actin reveals the structural basis of filament instability","volume":"114","author":"Pospich","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.vetpar.2025.110679_bib119","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1091\/mbc.11.1.355","article-title":"Toxofilin, a Novel Actin-binding Protein from Toxoplasma gondii, sequesters actin monomers and caps actin filaments","volume":"11","author":"Poupel","year":"2000","journal-title":"MBoC"},{"key":"10.1016\/j.vetpar.2025.110679_bib120","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1286-4579(99)80066-5","article-title":"Toxoplasma gondii motility and host cell invasiveness are drastically impaired by jasplakinolide, a cyclic peptide stabilizing F-actin","volume":"1","author":"Poupel","year":"1999","journal-title":"Microbes Infect."},{"key":"10.1016\/j.vetpar.2025.110679_bib121","doi-asserted-by":"crossref","first-page":"74107","DOI":"10.18632\/oncotarget.12316","article-title":"Immune adjuvant effect of a Toxoplasma gondii profilin-like protein in autologous whole-tumor-cell vaccination in mice","volume":"7","author":"Pyo","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.vetpar.2025.110679_bib122","doi-asserted-by":"crossref","first-page":"31909","DOI":"10.1016\/S0021-9258(19)84105-4","article-title":"Crystal structures of expressed non-polymerizable monomeric actin in the ADP and ATP states","volume":"281","author":"Rould","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetpar.2025.110679_bib123","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1128\/iai.20.3.739-743.1978","article-title":"Effect of cytochalasin D on Toxoplasma gondii cell entry","volume":"20","author":"Ryning","year":"1978","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetpar.2025.110679_bib124","doi-asserted-by":"crossref","first-page":"10945","DOI":"10.1073\/pnas.152329899","article-title":"How does ATP hydrolysis control actin\u2019s associations?","volume":"99","author":"Sablin","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.vetpar.2025.110679_bib125","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1091\/mbc.e05-06-0512","article-title":"Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii","volume":"17","author":"Sahoo","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.vetpar.2025.110679_bib126","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1096\/fj.14-252569","article-title":"Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress","volume":"28","author":"Salamun","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.vetpar.2025.110679_bib127","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.chom.2019.09.008","article-title":"In Vivo CRISPR screen identifies TgWIP as a toxoplasma modulator of dendritic cell migration","volume":"26","author":"Sangar\u00e9","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vetpar.2025.110679_bib128","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jmb.2005.03.056","article-title":"Malaria parasite actin filaments are very short","volume":"349","author":"Schmitz","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetpar.2025.110679_bib129","doi-asserted-by":"crossref","first-page":"36577","DOI":"10.1074\/jbc.M110.142638","article-title":"Malaria parasite actin polymerization and filament structure","volume":"285","author":"Schmitz","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetpar.2025.110679_bib130","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/j.1600-0854.2006.00484.x","article-title":"Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins","volume":"7","author":"Sch\u00fcler","year":"2006","journal-title":"Traffic"},{"key":"10.1016\/j.vetpar.2025.110679_bib131","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.pt.2006.02.005","article-title":"Plasmodium motility: actin not actin\u2019 like actin","volume":"22","author":"Sch\u00fcler","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.vetpar.2025.110679_bib132","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.febslet.2004.12.037","article-title":"Unusual properties of Plasmodium falciparum actin: new insights into microfilament dynamics of apicomplexan parasites","volume":"579","author":"Sch\u00fcler","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.vetpar.2025.110679_bib133","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1021\/bi981543c","article-title":"Impact of profilin on actin-bound nucleotide exchange and actin polymerization dynamics","volume":"38","author":"Selden","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.vetpar.2025.110679_bib134","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.molbiopara.2006.09.003","article-title":"Involvement of actin and myosins in Plasmodium berghei ookinete motility","volume":"150","author":"Siden-Kiamos","year":"2006","journal-title":"Mol. 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