{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T06:16:32Z","timestamp":1776579392084,"version":"3.51.2"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["valuehealthregionalissues.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Value in Health Regional Issues"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.vhri.2021.10.005","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T17:59:05Z","timestamp":1642096745000},"page":"9-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Evaluating the Incidence and Risk Factors Associated With Mild and Severe Hypoglycemia in Insulin-Treated Type 2 Diabetes"],"prefix":"10.1016","volume":"30","author":[{"given":"Athanasios","family":"Chantzaras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Yfantopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.vhri.2021.10.005_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/dom.12129","article-title":"Treat-to-target trials: uses, interpretation and review of concepts","volume":"16","author":"Garber","year":"2014","journal-title":"Diabetes Obes Metab"},{"issue":"5","key":"10.1016\/j.vhri.2021.10.005_bib3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/07315724.2003.10719316","article-title":"Importance of weight management in type 2 diabetes: review with meta-analysis of clinical studies","volume":"22","author":"Anderson","year":"2003","journal-title":"J\u00a0Am Coll Nutr"},{"issue":"4","key":"10.1016\/j.vhri.2021.10.005_bib4","doi-asserted-by":"crossref","first-page":"458","DOI":"10.14310\/horm.2002.1378","article-title":"Type 2 diabetes mellitus is associated with obesity, smoking and low socioeconomic status in large and representative samples of rural, urban, and suburban adult Greek populations","volume":"11","author":"Tentolouris","year":"2012","journal-title":"Hormones (Athens)"},{"issue":"6","key":"10.1016\/j.vhri.2021.10.005_bib6","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10198-013-0513-0","article-title":"Costs of diabetes and its complications in Poland","volume":"15","author":"Le\u015bniowska","year":"2014","journal-title":"Eur J Health Econ"},{"issue":"suppl 2","key":"10.1016\/j.vhri.2021.10.005_bib7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1177\/1474651408100520","article-title":"Defining and characterising progression of type 2 diabetes","volume":"8","author":"Fonseca","year":"2008","journal-title":"Br J Diab Vasc Dis"},{"issue":"1","key":"10.1016\/j.vhri.2021.10.005_bib8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2337\/dc08-9025","article-title":"Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes","volume":"32","author":"Nathan","year":"2009","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.vhri.2021.10.005_bib10","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00125-002-0822-9","article-title":"Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes","volume":"45","author":"Cryer","year":"2002","journal-title":"Diabetologia"},{"issue":"13","key":"10.1016\/j.vhri.2021.10.005_bib11","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/archinte.161.13.1653","article-title":"Hypoglycemia in patients with type 2 diabetes mellitus","volume":"161","author":"Miller","year":"2001","journal-title":"Arch Intern Med"},{"issue":"7","key":"10.1016\/j.vhri.2021.10.005_bib12","doi-asserted-by":"crossref","first-page":"A435","DOI":"10.1016\/j.jval.2013.08.644","article-title":"PDB23 - anti-diabetic medications related severe hypoglycaemia risk in diabetes type 1 and type 2 \u2013 a systematic review of observational studies","volume":"16","author":"Paweska","year":"2013","journal-title":"Value Health"},{"issue":"3","key":"10.1016\/j.vhri.2021.10.005_bib13","doi-asserted-by":"crossref","first-page":"A159","DOI":"10.1016\/j.jval.2013.03.795","article-title":"PDB23 - treatment related severe hypoglycaemia risk in diabetes type-1 and type-2\u2013a systematic review of observational studies","volume":"16","author":"Paweska","year":"2013","journal-title":"Value Health"},{"issue":"9","key":"10.1016\/j.vhri.2021.10.005_bib14","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1185\/030079905X61929","article-title":"Impact of hypoglycaemia on quality of life and productivity in type 1 and type 2 diabetes","volume":"21","author":"Davis","year":"2005","journal-title":"Curr Med Res Opin"},{"issue":"5","key":"10.1016\/j.vhri.2021.10.005_bib15","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10198-020-01167-y","article-title":"Health-related quality of life and health utilities in insulin-treated type 2 diabetes: the impact of related comorbidities\/complications","volume":"21","author":"Yfantopoulos","year":"2020","journal-title":"Eur J Health Econ"},{"issue":"7","key":"10.1016\/j.vhri.2021.10.005_bib16","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.numecd.2019.04.009","article-title":"Impact of severe and symptomatic hypoglycemia on quality of life and fear of hypoglycemia in type 1 and type 2 diabetes. Results of the HYPOS-1 observational study","volume":"29","author":"Rossi","year":"2019","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"1-2","key":"10.1016\/j.vhri.2021.10.005_bib17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/jocn.15538","article-title":"Fear of hypoglycaemia in patients with type 1 and 2 diabetes: a systematic review","volume":"30","author":"Zhang","year":"2020","journal-title":"J\u00a0Clin Nurs"},{"issue":"1","key":"10.1016\/j.vhri.2021.10.005_bib18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.pec.2007.05.003","article-title":"A\u00a0critical review of the literature on fear of hypoglycemia in diabetes: implications for diabetes management and patient education","volume":"68","author":"Wild","year":"2007","journal-title":"Patient Educ Couns"},{"issue":"5","key":"10.1016\/j.vhri.2021.10.005_bib19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s40271-016-0163-2","article-title":"Development and psychometric evaluation of the Hypoglycemia Perspectives Questionnaire in patients with type 2 diabetes mellitus","volume":"9","author":"Kawata","year":"2016","journal-title":"Patient"},{"issue":"5","key":"10.1016\/j.vhri.2021.10.005_bib20","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1210\/jc.2009-2828","article-title":"Determinants of severe hypoglycemia complicating type 2 diabetes: the Fremantle diabetes study","volume":"95","author":"Davis","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.vhri.2021.10.005_bib21","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/j.1464-5491.2004.01250.x","article-title":"Evaluating risk factors associated with severe hypoglycaemia in epidiomology studies - what method should we use?","volume":"21","author":"Bulsara","year":"2004","journal-title":"Diabet Med"},{"key":"10.1016\/j.vhri.2021.10.005_bib22","series-title":"Regression Analysis of Count Data","author":"Cameron","year":"2013"},{"issue":"6","key":"10.1016\/j.vhri.2021.10.005_bib23","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1464-5491.2005.01501.x","article-title":"Frequency and predictors of hypoglycaemia in type 1 and insulin-treated type 2 diabetes: a population-based study","volume":"22","author":"Donnelly","year":"2005","journal-title":"Diabet Med"},{"issue":"1","key":"10.1016\/j.vhri.2021.10.005_bib24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/01.CCM.0000194536.89694.06","article-title":"Predisposing factors for hypoglycemia in the intensive care unit","volume":"34","author":"Vriesendorp","year":"2006","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.vhri.2021.10.005_bib25","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1007\/s00125-007-0599-y","article-title":"Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration","volume":"50","year":"2007","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.vhri.2021.10.005_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jdiacomp.2005.08.005","article-title":"Frequency and risk factors of severe hypoglycemia in insulin-treated type 2 diabetes: a literature survey","volume":"20","author":"Akram","year":"2006","journal-title":"J\u00a0Diabetes Complications"},{"issue":"1","key":"10.1016\/j.vhri.2021.10.005_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/dmrr.2470","article-title":"The incidence of mild and severe hypoglycaemia in patients with type 2 diabetes mellitus treated with sulfonylureas: a systematic review and meta-analysis","volume":"30","author":"Schopman","year":"2014","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.vhri.2021.10.005_bib28","author":"Bloomfield"},{"issue":"4","key":"10.1016\/j.vhri.2021.10.005_bib29","doi-asserted-by":"crossref","first-page":"550","DOI":"10.14310\/horm.2002.1443","article-title":"The prevalence of hypoglycemia and its impact on the quality of life (QoL) of type 2 diabetes mellitus patients (The HYPO Study)","volume":"12","author":"Rombopoulos","year":"2013","journal-title":"Hormones (Athens)"},{"issue":"9131","key":"10.1016\/j.vhri.2021.10.005_bib30","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0140-6736(98)07019-6","volume":"352","year":"1998","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.vhri.2021.10.005_bib31","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.2337\/diacare.26.4.1176","article-title":"Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes: a population-based study of health service resource use","volume":"26","author":"Leese","year":"2003","journal-title":"Diabetes Care"},{"issue":"12","key":"10.1016\/j.vhri.2021.10.005_bib32","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1046\/j.1464-5491.2003.01072.x","article-title":"Hypoglycaemia in insulin-treated Type 2 diabetes: frequency, symptoms and impaired awareness","volume":"20","author":"Henderson","year":"2003","journal-title":"Diabet Med"},{"issue":"10","key":"10.1016\/j.vhri.2021.10.005_bib33","first-page":"455","article-title":"Incidence and cost of hypoglycemia among patients with type 2 diabetes in the United States: analysis of a health insurance database","volume":"18","author":"Curkendall","year":"2011","journal-title":"J\u00a0Clin Outcomes Manag"},{"issue":"1","key":"10.1016\/j.vhri.2021.10.005_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1472-6823-12-23","article-title":"Incidence and predictors of hypoglycaemia in type 2 diabetes - an analysis of the prospective DiaRegis registry","volume":"12","author":"Tsch\u00f6pe","year":"2012","journal-title":"BMC Endocr Disord"},{"issue":"3","key":"10.1016\/j.vhri.2021.10.005_bib35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1557-0843(07)80041-8","article-title":"Insulin therapy and hypoglycemia in type 2 diabetes mellitus","volume":"2","author":"Cryer","year":"2007","journal-title":"Insulin"},{"issue":"1","key":"10.1016\/j.vhri.2021.10.005_bib36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/dme.12261","article-title":"Self-reported non-severe hypoglycaemic events in Europe","volume":"31","author":"Ostenson","year":"2014","journal-title":"Diabet Med"},{"issue":"3","key":"10.1016\/j.vhri.2021.10.005_bib37","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1464-5491.2007.02341.x","article-title":"Hypoglycaemia in type 2 diabetes","volume":"25","author":"Amiel","year":"2008","journal-title":"Diabet Med"},{"issue":"5","key":"10.1016\/j.vhri.2021.10.005_bib38","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.2337\/diacare.28.5.1245","article-title":"Defining and reporting hypoglycemia in diabetes: a report from the American Diabetes Association Workgroup on Hypoglycemia","volume":"28","year":"2005","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.vhri.2021.10.005_bib39","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.clinthera.2011.09.020","article-title":"Risk factors for hypoglycemia-related hospitalization in patients with type 2 diabetes: a nested case - control study","volume":"33","author":"Quilliam","year":"2011","journal-title":"Clin Ther"},{"issue":"7","key":"10.1016\/j.vhri.2021.10.005_bib40","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1464-5491.2006.01880.x","article-title":"Frequency and risk factors of severe hypoglycaemia in insulin-treated type 2 diabetes: a cross-sectional survey","volume":"23","author":"Akram","year":"2006","journal-title":"Diabet Med"},{"issue":"7","key":"10.1016\/j.vhri.2021.10.005_bib41","doi-asserted-by":"crossref","first-page":"912","DOI":"10.4239\/wjd.v6.i7.912","article-title":"Mechanisms of hypoglycemia unawareness and implications in diabetic patients","volume":"6","author":"Mart\u00edn-Tim\u00f3n","year":"2015","journal-title":"World J Diabetes"},{"issue":"12","key":"10.1016\/j.vhri.2021.10.005_bib42","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.2337\/db08-1084","article-title":"The barrier of hypoglycemia in diabetes","volume":"57","author":"Cryer","year":"2008","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.vhri.2021.10.005_bib43","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1111\/jdi.13290","article-title":"Hypoglycemia unawareness and autonomic dysfunction in diabetes: lessons learned and roles of diabetes technologies","volume":"11","author":"Lin","year":"2020","journal-title":"J\u00a0Diabetes Investig"},{"key":"10.1016\/j.vhri.2021.10.005_bib44","doi-asserted-by":"crossref","first-page":"b5444","DOI":"10.1136\/bmj.b5444","article-title":"The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study","volume":"340","author":"Miller","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.vhri.2021.10.005_bib45","series-title":"Regression Models for Categorical Dependent Variables Using Stata","author":"Long","year":"2015"}],"container-title":["Value in Health Regional Issues"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212109921001564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212109921001564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T20:13:37Z","timestamp":1761941617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212109921001564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":42,"alternative-id":["S2212109921001564"],"URL":"https:\/\/doi.org\/10.1016\/j.vhri.2021.10.005","relation":{},"ISSN":["2212-1099"],"issn-type":[{"value":"2212-1099","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating the Incidence and Risk Factors Associated With Mild and Severe Hypoglycemia in Insulin-Treated Type 2 Diabetes","name":"articletitle","label":"Article Title"},{"value":"Value in Health Regional Issues","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vhri.2021.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 ISPOR--The professional society for health economics and outcomes research. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}