{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:11:27Z","timestamp":1791047487290,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":3613,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI30048"],"award-info":[{"award-number":["AI30048"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2003,10]]},"DOI":"10.1016\/j.virol.2003.07.001","type":"journal-article","created":{"date-parts":[[2003,11,2]],"date-time":"2003-11-02T08:38:53Z","timestamp":1067762333000},"page":"93-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation"],"prefix":"10.1016","volume":"315","author":[{"given":"Robbert G","family":"van der Most","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaja","family":"Murali-Krishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.Gibson","family":"Lanier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.John","family":"Wherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryann T","family":"Puglielli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph N","family":"Blattman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2003.07.001_BIB1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.274.5284.94","article-title":"Direct visualization and phenotypic analysis of virus-specific T lymphocytes in HIV-infected individuals","volume":"274","author":"Altman","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.virol.2003.07.001_BIB2","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.4049\/jimmunol.163.6.3379","article-title":"Inverted immunodominance and impaired cytolytic function of CD8(+) T cells during viral persistence in the CNS","volume":"163","author":"Bergmann","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2003.07.001_BIB3","doi-asserted-by":"crossref","first-page":"9144","DOI":"10.1128\/JVI.74.19.9144-9151.2000","article-title":"Putative immunodominant human immunodeficiency virus-specific CD8(+) T-cell responses cannot be predicted by major histocompatibility complex class I haplotype","volume":"74","author":"Betts","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.07.001_BIB4","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1084\/jem.189.10.1591","article-title":"The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones","volume":"189","author":"Bousso","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2003.07.001_BIB5","series-title":"Persistent Viral Infections","first-page":"575","article-title":"Lymphocytic choriomeningitis virus","author":"Buchmeier","year":"1999"},{"key":"10.1016\/j.virol.2003.07.001_BIB6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1074-7613(00)80161-2","article-title":"Dissecting the multifactorial causes of immunodominance in class I-restricted T cell responses to viruses","volume":"12","author":"Chen","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.virol.2003.07.001_BIB7","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1128\/JVI.75.22.10663-10669.2001","article-title":"Recruitment times, proliferation, and apoptotic rates during the CD8+ T-cell response to lymphocytic choriomeningitis virus","volume":"75","author":"De Boer","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.07.001_BIB8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4049\/jimmunol.170.1.477","article-title":"Ablation of CD4 and CD8 T cell responses by high viral loads","volume":"170","author":"Fuller","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2003.07.001_BIB9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0042-6822(88)90419-9","article-title":"Temporal analysis of transcription and replication during acute infection with lymphocytic choriomeningitis virus","volume":"162","author":"Fuller-Pace","year":"1988","journal-title":"Virology"},{"key":"10.1016\/j.virol.2003.07.001_BIB10","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1084\/jem.187.10.1647-b","article-title":"Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides","volume":"187","author":"Gallimore","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2003.07.001_BIB11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1600-065X.1998.tb01205.x","article-title":"Hierarchies of antigen-specific T-cell responses","volume":"164","author":"Gallimore","year":"1998","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.virol.2003.07.001_BIB12","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3301::AID-IMMU3301>3.0.CO;2-Q","article-title":"A protective cytotoxic T cell response to a subdominant epitope is influenced by the stability of the MHC class I peptide complex and the overall spectrum of viral peptides generated within infected cells","volume":"28","author":"Gallimore","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.virol.2003.07.001_BIB13","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.4049\/jimmunol.168.6.2667","article-title":"Efficient and qualitatively distinct MHC class I-restricted presentation of antigen targeted to the endoplasmic reticulum","volume":"168","author":"Golovina","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2003.07.001_BIB14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1084\/jem.193.2.181","article-title":"Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection","volume":"193","author":"Goulder","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2003.07.001_BIB15","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1084\/jem.185.8.1423","article-title":"Patterns of immunodominance in HIV-1-specific cytotoxic T cell responses in two HLA-identical siblings with HLA-A*0201 are influenced by epitope mutation","volume":"185","author":"Goulder","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2003.07.001_BIB16","doi-asserted-by":"crossref","first-page":"5550","DOI":"10.1128\/JVI.75.12.5550-5558.2001","article-title":"Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus","volume":"75","author":"Gruener","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.07.001_BIB17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/viro.1997.8627","article-title":"The signal sequence of lymphocytic choriomeningitis virus contains an immunodominant cytotoxic T cell epitope that is restricted by both H-2D(b) and H-2K(b) molecules","volume":"234","author":"Hudrisier","year":"1997","journal-title":"Virology"},{"key":"10.1016\/j.virol.2003.07.001_BIB18","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1128\/JVI.76.12.6104-6113.2002","article-title":"Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities","volume":"76","author":"Lauer","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.07.001_BIB19","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1128\/JVI.74.8.3470-3477.2000","article-title":"NP and L proteins of lymphocytic choriomeningitis virus (LCMV) are sufficient for efficient transcription and replication of LCMV genomic RNA analogs","volume":"74","author":"Lee","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.07.001_BIB20","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1128\/JVI.76.2.875-884.2002","article-title":"Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of the infection","volume":"76","author":"Mothe","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.07.001_BIB21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1074-7613(00)80470-7","article-title":"Counting antigen-specific CD8 T cells","volume":"8","author":"Murali-Krishna","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.virol.2003.07.001_BIB22","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/375606a0","article-title":"Antigenic oscillations and shifting immunodominance in HIV-1 infections","volume":"375","author":"Nowak","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.virol.2003.07.001_BIB23","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.1128\/jvi.69.12.7423-7429.1995","article-title":"Discriminated selection among viral peptides with the appropriate anchor residues","volume":"69","author":"Oldstone","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.07.001_BIB24","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/300360a0","article-title":"Restricted expression of viral glycoprotein in cells of persistently infected mice","volume":"300","author":"Oldstone","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.virol.2003.07.001_BIB25","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/(SICI)1521-4141(199904)29:04<1243::AID-IMMU1243>3.0.CO;2-A","article-title":"Single H2Kb, H2Db and double H2KbDbb knockout mice","volume":"29","author":"P\u00e9rarnau","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.virol.2003.07.001_BIB26","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1128\/JVI.77.6.3882-3887.2003","article-title":"Role of the virus nucleoprotein in the regulation of lymphocytic choriomeningitis virus transcription and RNA replication","volume":"77","author":"Pinschewer","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.07.001_BIB27","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1128\/JVI.75.11.5099-5107.2001","article-title":"In vivo selection of an LCMV variant that affects recognition of the GP 33\u201343 epitope by H-2Db but not H-2Kb","volume":"75","author":"Puglielli","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.07.001_BIB28","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1128\/JVI.76.9.4251-4259.2002","article-title":"Immunodominance in virus-induced CD8+ T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon","volume":"76","author":"Rodrigues","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.07.001_BIB29","series-title":"Virology","first-page":"1505","article-title":"Arenaviridae","author":"Southern","year":"1996"},{"key":"10.1016\/j.virol.2003.07.001_BIB30","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/(SICI)1521-4141(199904)29:04<1059::AID-IMMU1059>3.0.CO;2-L","article-title":"Changing patterns of dominance in the CD8 T cell response during acute and persistent murine \u03b3-herpesvirus infection","volume":"29","author":"Stevenson","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.virol.2003.07.001_BIB32","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/viro.1997.8934","article-title":"Identification of Db- and Kb-restricted subdominant cytotoxic T-cell responses in lymphocytic choriomeningitis virus-infected mice","volume":"240","author":"Van der Most","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.virol.2003.07.001_BIB33","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.4049\/jimmunol.157.12.5543","article-title":"Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection","volume":"157","author":"Van der Most","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2003.07.001_BIB34","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1128\/JVI.77.8.4911-4927.2003","article-title":"Viral persistence alters CD8 T cell immunodominance, tissue distribution, and results in distinct stages of functional impairment","volume":"77","author":"Wherry","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.07.001_BIB35","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.4049\/jimmunol.168.9.4455","article-title":"Generation of CD8+ T cell memory to low, high, and excessive levels of epitope","volume":"168","author":"Wherry","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2003.07.001_BIB36","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0161-5890(02)00097-4","article-title":"To DriP or not to DriP","volume":"39","author":"Yewdell","year":"2002","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.virol.2003.07.001_BIB37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.immunol.17.1.51","article-title":"Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses","volume":"17","author":"Yewdell","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.virol.2003.07.001_BIB38","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1084\/jem.188.12.2205","article-title":"Viral immune evasion due to persistence of activated T cells without effector function","volume":"188","author":"Zajac","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2003.07.001_BIB39","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1128\/JVI.76.2.829-840.2002","article-title":"Critical role for perforein-, Fas\/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection","volume":"76","author":"Zhou","year":"2002","journal-title":"J. Virol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682203005944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682203005944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:26:58Z","timestamp":1758583618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682203005944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["S0042682203005944"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2003.07.001","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2003.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}