{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:50:12Z","timestamp":1763765412901,"version":"3.44.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3425,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.virol.2003.12.008","type":"journal-article","created":{"date-parts":[[2004,2,28]],"date-time":"2004-02-28T06:37:41Z","timestamp":1077950261000},"page":"87-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["A poliomyelitis model through mucosal infection in transgenic mice bearing human poliovirus receptor, TgPVR21"],"prefix":"10.1016","volume":"321","author":[{"given":"Noriyo","family":"Nagata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Ami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuyoshi","family":"Hatano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Harashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriko","family":"Suzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Yoshii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Hashikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsutaro","family":"Sata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinobu","family":"Horiuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kurata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Nomoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2003.12.008_BIB1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1006\/viro.1995.1030","article-title":"Neurovirulence test for oral live poliovaccines using poliovirus-sensitive transgenic mice","volume":"206","author":"Abe","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.virol.2003.12.008_BIB2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1006\/viro.1995.1327","article-title":"Studies on neurovirulence in poliovirus-sensitive transgenic mice and cynomolgus monkeys for the different temperature-sensitive viruses derived from the Sabin type 3 virus","volume":"210","author":"Abe","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.virol.2003.12.008_BIB3","doi-asserted-by":"crossref","first-page":"8431","DOI":"10.1016\/S0021-9258(17)37212-5","article-title":"Amino acid residues on human poliovirus receptor involved in interaction with poliovirus","volume":"269","author":"Aoki","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2003.12.008_BIB4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1001\/archneurpsyc.1948.02300380097008","article-title":"Distribution of lesions of the brain stem in poliomyelitis","volume":"59","author":"Barnhart","year":"1948","journal-title":"Arch. Neurol. Psychiatry"},{"key":"10.1016\/j.virol.2003.12.008_BIB5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/viro.1994.1102","article-title":"Molecular characterization of the cellular receptor for poliovirus","volume":"199","author":"Bernhardt","year":"1994","journal-title":"Virology"},{"key":"10.1016\/j.virol.2003.12.008_BIB6","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1006\/viro.1994.1493","article-title":"The poliovirus receptor: identification of domains and amino acid residues critical for virus binding","volume":"203","author":"Bernhardt","year":"1994","journal-title":"Virology"},{"key":"10.1016\/j.virol.2003.12.008_BIB7","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0002-9343(49)90130-8","article-title":"Histopathologic basis of clinical findings in poliomyelitis","volume":"6","author":"Bodian","year":"1949","journal-title":"Am. J. Med."},{"key":"10.1016\/j.virol.2003.12.008_BIB8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/brain\/63.2.135","article-title":"An experimental study of the role of neurons in the dissemination of poliomyelitis virus in the nervous system","volume":"63","author":"Bodian","year":"1940","journal-title":"Brain"},{"key":"10.1016\/j.virol.2003.12.008_BIB37","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1099\/0022-1317-83-7-1707","article-title":"Poliovirus pathogenesis in a new poliovirus receptor transgenic mouse model: age-dependent paralysis and a mucosal route of infection","volume":"83","author":"Crotty","year":"2002","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2003.12.008_BIB9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/biol.1996.0010","article-title":"A poliovirus-susceptible transgenic mouse model as a possible replacement for the monkey neurovirulence test of oral poliovirus vaccine","volume":"24","author":"Dragunsky","year":"1996","journal-title":"Biologicals"},{"key":"10.1016\/j.virol.2003.12.008_BIB10","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1007\/BF01323236","article-title":"Low levels of poliovirus replication in primary human monocytes: possible interactions with lymphocytes","volume":"140","author":"Eberle","year":"1995","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2003.12.008_BIB11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.109.2822.85","article-title":"Cultivation of the Lansing strain of poliomyelitis in cultures of various human embryonic tissues","volume":"109","author":"Enders","year":"1949","journal-title":"Science"},{"year":"1964","series-title":"Probit Analysis: A Statistical Treatment of the Sigmoid Response Curve","author":"Finney","key":"10.1016\/j.virol.2003.12.008_BIB12"},{"key":"10.1016\/j.virol.2003.12.008_BIB13","doi-asserted-by":"crossref","first-page":"6486","DOI":"10.1128\/jvi.70.9.6486-6492.1996","article-title":"Correlation between poliovirus type 1 Mahoney replication in blood cells and neurovirulence","volume":"70","author":"Freistadt","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.12.008_BIB14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/mpat.2000.0386","article-title":"Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo","volume":"29","author":"Freistadt","year":"2000","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.virol.2003.12.008_BIB15","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1128\/jvi.65.7.3873-3876.1991","article-title":"Mutational analysis of the cellular receptor for poliovirus","volume":"65","author":"Freistadt","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.12.008_BIB16","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1128\/jvi.68.2.681-688.1994","article-title":"Transgenic mice carrying the human poliovirus receptor; new animal model for study of poliovirus neurovirulence","volume":"68","author":"Horie","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.12.008_BIB17","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s007050050535","article-title":"Exacerbation of influenzavirus pneumonia by intranasal administration of surfactant in a mouse model","volume":"144","author":"Iwasaki","year":"1999","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2003.12.008_BIB38","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1126\/science.1068284","article-title":"Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus","volume":"296","author":"Kew","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.virol.2003.12.008_BIB18","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1002\/j.1460-2075.1990.tb07520.x","article-title":"The poliovirus receptor protein is produced both as membrane-bound and secreted forms","volume":"9","author":"Koike","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.virol.2003.12.008_BIB19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1073\/pnas.88.3.951","article-title":"Transgenic mice susceptible to poliovirus","volume":"88","author":"Koike","year":"1991","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.virol.2003.12.008_BIB20","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1073\/pnas.88.10.4104","article-title":"Functional domains of the poliovirus receptor","volume":"88","author":"Koike","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.virol.2003.12.008_BIB21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF01310797","article-title":"Characterization of three transgenic mouse lines that carry human poliovirus receptor gene-influence of the transgene expression on pathogenesis","volume":"130","author":"Koike","year":"1994","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2003.12.008_BIB22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0264-410X(00)00190-0","article-title":"Development of a transgenic mouse neurovirulence test for oral poliovirus vaccine: international collaborative study 1993\u20131999","volume":"19","author":"Levenbrook","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2003.12.008_BIB23","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(89)90690-9","article-title":"Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily","volume":"56","author":"Mendelsohn","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.virol.2003.12.008_BIB24","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1016\/S0264-410X(01)00016-0","article-title":"Comparison of neuropathogenicity of poliovirus type 3 in transgenic mice bearing the poliovirus receptor gene and cynomolgus monkeys","volume":"19","author":"Nagata","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2003.12.008_BIB25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/viro.1998.9360","article-title":"Retrograde transport of intact poliovirus through the axon via the fast transport system","volume":"250","author":"Ohka","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.virol.2003.12.008_BIB29","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1128\/jvi.66.1.296-304.1992","article-title":"Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice","volume":"66","author":"Ren","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.12.008_BIB30","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/infdis\/166.4.747","article-title":"Poliovirus spreads from muscle to the central nervous system by neural pathways","volume":"166","author":"Ren","year":"1992","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2003.12.008_BIB28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0092-8674(90)90168-E","article-title":"Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis","volume":"63","author":"Ren","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.virol.2003.12.008_BIB31","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/infdis\/151.3.420","article-title":"Oral poliovirus vaccine: history of its development and use and current challenge to eliminate poliomyelitis from the world","volume":"151","author":"Sabin","year":"1985","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2003.12.008_BIB32","doi-asserted-by":"crossref","first-page":"6825","DOI":"10.1128\/jvi.69.11.6825-6832.1995","article-title":"A new cis-acting element for RNA replication within the 5\u2032 noncoding region of poliovirus type 1 RNA","volume":"69","author":"Shiroki","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2003.12.008_BIB39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1099\/0022-1317-79-2-291","article-title":"Antibody-forming cells in the nasal-associated lymphoid tissue during primary influenza virus infection","volume":"79","author":"Tamura","year":"1998","journal-title":"J. Gen. Virol."},{"year":"1997","series-title":"Manual for the Virological Investigation of Polio","author":"WHO","key":"10.1016\/j.virol.2003.12.008_BIB33"},{"key":"10.1016\/j.virol.2003.12.008_BIB34","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0264-410X(96)00190-9","article-title":"New approaches to oral poliovirus vaccine neurovirulence tests: transgenic mice susceptible to poliovirus and molecular analysis of poliovirus","volume":"15","author":"Wood","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2003.12.008_BIB35","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1006\/viro.1997.8450","article-title":"Efficient delivery of circulating poliovirus to the central nervous system independently of poliovirus receptor","volume":"229","author":"Yang","year":"1997","journal-title":"Virology"},{"key":"10.1016\/j.virol.2003.12.008_BIB36","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1128\/jvi.71.7.4915-4920.1997","article-title":"Expression of the poliovirus receptor in intestinal epithelial cells is not sufficient to permit poliovirus replication in the mouse gut","volume":"71","author":"Zhang","year":"1997","journal-title":"J. Virol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268220300919X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268220300919X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:27:42Z","timestamp":1758583662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004268220300919X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S004268220300919X"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2003.12.008","relation":{},"ISSN":["0042-6822"],"issn-type":[{"type":"print","value":"0042-6822"}],"subject":[],"published":{"date-parts":[[2004,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A poliomyelitis model through mucosal infection in transgenic mice bearing human poliovirus receptor, TgPVR21","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2003.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}