{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:40:34Z","timestamp":1789558834055,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3088,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.virol.2004.11.009","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T11:51:31Z","timestamp":1103197891000},"page":"130-144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":133,"title":["Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection"],"prefix":"10.1016","volume":"332","author":[{"given":"Ivan","family":"Bi\u00e8che","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Asselah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Laurendeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Vidaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Degot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Paradis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bedossa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique-Charles","family":"Valla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Marcellin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Vidaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2004.11.009_bib1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group","volume":"24","author":"Bedossa","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.virol.2004.11.009_bib2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/clinchem\/45.8.1148","article-title":"Real-time reverse transcription-PCR assay for future management of ERBB2-based clinical applications","volume":"45","author":"Bieche","year":"1999","journal-title":"Clin. Chem."},{"key":"10.1016\/j.virol.2004.11.009_bib3","first-page":"1652","article-title":"Identification of CGA as a novel estrogen receptor-responsive gene in breast cancer: an outstanding candidate marker to predict the response to endocrine therapy","volume":"61","author":"Bieche","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.virol.2004.11.009_bib4","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1128\/JVI.75.15.7059-7066.2001","article-title":"DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection","volume":"75","author":"Bigger","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2004.11.009_bib5","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/path.1451","article-title":"Quantitative RT-PCR in cirrhotic nodules reveals gene expression changes associated with liver carcinogenesis","volume":"201","author":"Colombat","year":"2003","journal-title":"J. Pathol."},{"key":"10.1016\/j.virol.2004.11.009_bib6","doi-asserted-by":"crossref","first-page":"15623","DOI":"10.1073\/pnas.95.26.15623","article-title":"Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays","volume":"95","author":"Der","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.virol.2004.11.009_bib7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng1296-457","article-title":"Use of a cDNA microarray to analyse gene expression patterns in human cancer","volume":"14","author":"DeRisi","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.virol.2004.11.009_bib8","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2004.11.009_bib9","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1053\/jhep.2003.50201","article-title":"Effector genes of interferon action against hepatitis C virus","volume":"37","author":"Gale","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.virol.2004.11.009_bib10","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/0006-2952(94)00515-N","article-title":"Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis","volume":"49","author":"George","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.virol.2004.11.009_bib11","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1006\/viro.2002.1373","article-title":"An altered cellular response to interferon and up-regulation of interleukin-8 induced by the hepatitis C viral protein NS5A uncovered by microarray analysis","volume":"295","author":"Girard","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.virol.2004.11.009_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"Hanley","year":"1982","journal-title":"Radiology"},{"key":"10.1016\/j.virol.2004.11.009_bib13","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1189\/jlb.0303093","article-title":"Expression of the chemokine IP-10 (CXCL10) by hepatocytes in chronic hepatitis C virus infection correlates with histological severity and lobular inflammation","volume":"74","author":"Harvey","year":"2003","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/j.virol.2004.11.009_bib14","first-page":"5477","article-title":"A four gene expression model predicts recurrence in patients with clinically localized prostate cancer","volume":"9","author":"Latil","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.virol.2004.11.009_bib15","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1210\/endo.142.6.8101","article-title":"Identification and implantation stage-specific expression of an interferon-alpha-regulated gene in human and rat endometrium","volume":"142","author":"Li","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.virol.2004.11.009_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1214\/aoms\/1177730491","article-title":"On a test of whether one of two random variables is stochastically larger than the other","volume":"18","author":"Mann","year":"1947","journal-title":"Ann. Math. Stat."},{"key":"10.1016\/j.virol.2004.11.009_bib17","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1002\/hep.1840360707","article-title":"Fibrosis and disease progression in hepatitis C","volume":"36","author":"Marcellin","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.virol.2004.11.009_bib18","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/hep.1840220406","article-title":"Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alpha therapy in chronic hepatitis C","volume":"22","author":"Martinot-Peignoux","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.virol.2004.11.009_bib19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0168-8278(03)00161-2","article-title":"Initial signaling of the fibronectin receptor (alpha5beta1 integrin) in hepatic stellate cells is independent of tyrosine phosphorylation","volume":"39","author":"Milliano","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.virol.2004.11.009_bib20","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0002-9440(10)63700-5","article-title":"Molecular profiling of hepatocellular carcinomas (HCC) using a large-scale real-time RT-PCR approach: determination of a molecular diagnostic index","volume":"163","author":"Paradis","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.virol.2004.11.009_bib21","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/S0140-6736(98)07124-4","article-title":"Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (IHIT)","volume":"352","author":"Poynard","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.virol.2004.11.009_bib22","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(03)15109-4","article-title":"Viral hepatitis C","volume":"362","author":"Poynard","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.virol.2004.11.009_bib23","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.4049\/jimmunol.163.11.6236","article-title":"Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver","volume":"163","author":"Shields","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2004.11.009_bib24","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.hep.2003.09.024","article-title":"Hepatitis C virus and liver disease: global transcriptional profiling and identification of potential markers","volume":"38","author":"Smith","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.virol.2004.11.009_bib25","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/hep.1840220142","article-title":"Kupffer cell-derived 95-kd type IV collagenase\/gelatinase B: characterization and expression in cultured cells","volume":"22","author":"Winwood","year":"1995","journal-title":"Hepatology"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268220400769X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268220400769X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:32:16Z","timestamp":1758583936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004268220400769X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S004268220400769X"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2004.11.009","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular profiling of early stage liver fibrosis in patients with chronic hepatitis C virus infection","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2004.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}