{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:05:43Z","timestamp":1791533143377,"version":"4.3.4"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3060,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.virol.2004.12.025","type":"journal-article","created":{"date-parts":[[2005,1,29]],"date-time":"2005-01-29T03:48:09Z","timestamp":1106970489000},"page":"66-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Development of a mouse model for the study of Toscana virus pathogenesis"],"prefix":"10.1016","volume":"333","author":[{"given":"Maria","family":"Grazia Cusi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Gori Savellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Terrosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppa","family":"Di Genova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Valassina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Valentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Bartolommei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clelia","family":"Miracco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2004.12.025_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0168-1702(93)90076-Y","article-title":"Toscana virus genomic L segment: molecular cloning, strategy and amino acid sequence in comparison with other negative strand RNA viruses","volume":"27","author":"Accardi","year":"1993","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2004.12.025_bib2","series-title":"American Society of Tropical Medicine and Hygiene for The Subcommittee on Information Exchange of the American Committee on Arthropod-borne Viruses","article-title":"International catalogue of arboviruses","year":"1985"},{"key":"10.1016\/j.virol.2004.12.025_bib3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1086\/381201","article-title":"Unusual presentation of life-threatening Toscana virus meningoencephalitis","volume":"38","author":"Baldelli","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.virol.2004.12.025_bib4","series-title":"Virology","first-page":"1155","article-title":"Bunyaviridae and their replication: I. Bunyaviridae","author":"Bishop","year":"1990"},{"key":"10.1016\/j.virol.2004.12.025_bib5","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1023\/A:1007422103992","article-title":"Evidence of Toscana virus infections without central nervous system involvement: a serological study","volume":"13","author":"Braito","year":"1997","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.virol.2004.12.025_bib6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/00365549850161539","article-title":"Phlebotomus-transmitted Toscana virus infections of the central nervous system: a seven-year experience in Tuscany","volume":"30","author":"Braito","year":"1998","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.virol.2004.12.025_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0140-6736(87)92005-8","article-title":"Toscana virus infection in United States citizen returning from Italy","volume":"8525","author":"Calisher","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.virol.2004.12.025_bib8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1128\/JVI.72.1.823-829.1998","article-title":"Apoptosis in the mouse central nervous system in response to infection with mouse-neurovirulent Dengue virus","volume":"72","author":"Despr\u00e8s","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2004.12.025_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1099\/0022-1317-78-1-77","article-title":"Organization of the genomic segment of Toscana phlebovirus","volume":"78","author":"Di Bonito","year":"1997","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2004.12.025_bib10","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1086\/319759","article-title":"Encephalitis without meningitis due to sandfly fever virus serotype Toscana","volume":"32","author":"Dionisio","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.virol.2004.12.025_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4269\/ajtmh.1990.43.207","article-title":"Incidence of sandfly fever among Swedish United Nations soldiers on Cyprus during 1985","volume":"43","author":"Eitrem","year":"1990","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2004.12.025_bib12","doi-asserted-by":"crossref","first-page":"862","DOI":"10.4269\/ajtmh.1983.32.862","article-title":"Transovarial transmission of Rio Grande virus (Bunyaviridae: Phlebovirus) by the sandfly, Luztomyia anthophora","volume":"32","author":"Endris","year":"1983","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2004.12.025_bib13","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1111\/j.1471-4159.1993.tb09843.x","article-title":"Regional variability in DNA fragmentation after global ischemia evidenced by combined histological and gel electrophoresis observations in the rat brain","volume":"61","author":"Heron","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.virol.2004.12.025_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.virol.2004.12.025_bib15","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1128\/jvi.70.3.1828-1835.1996","article-title":"Alpha-virus-induced apoptosis in mouse brains correlates with neurovirulence","volume":"70","author":"Lewis","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2004.12.025_bib16","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1086\/514684","article-title":"Infections due to sandfly fever virus serotype Toscana in Spain","volume":"27","author":"Mendoza-Montero","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.virol.2004.12.025_bib17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/1523-1747.ep12472355","article-title":"Apoptotic index: discriminant feature for the differentiation of cutaneous diffuse malignant follicular center cell lymphomas from lymphoid hyperplasia","volume":"100","author":"Miracco","year":"1993","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.virol.2004.12.025_bib18","doi-asserted-by":"crossref","first-page":"429","DOI":"10.4269\/ajtmh.1991.45.429","article-title":"Central nervous system involvement during infection by Phlebovirus Toscana of residents in natural foci in central Italy (1977\u20131988)","volume":"45","author":"Nicoletti","year":"1991","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2004.12.025_bib19","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/jvi.65.2.880-886.1991","article-title":"Japanese encephalitis virus neurotropism is dependent on the degree of neuronal maturity","volume":"65","author":"Ogata","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2004.12.025_bib20","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.1128\/jvi.70.8.5329-5335.1996","article-title":"Induction of apoptosis by La Crosse virus infection and role of neuronal differentiation and Human bcl-2 expression in its prevention","volume":"70","author":"Pekosz","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2004.12.025_bib21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S0950268800052213","article-title":"Serosurvey and laboratory diagnosis of imported sandfly fever virus, serotype Toscana, infection in Germany","volume":"114","author":"Schwarz","year":"1995","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.virol.2004.12.025_bib22","series-title":"The Arboviruses: Epidemiology and Ecology","first-page":"15","article-title":"Phlebotomus fevers","author":"Tesh","year":"1988"},{"key":"10.1016\/j.virol.2004.12.025_bib23","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.4269\/ajtmh.1984.33.1007","article-title":"Studies on the biology of Phleboviruses in sandflies (Diptera: Psychodidae): I. Experimental infection of the vector","volume":"33","author":"Tesh","year":"1984","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2004.12.025_bib24","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1128\/JCM.36.7.2103-2104.1998","article-title":"Evidence of Toscana virus variants circulating in Tuscany, Italy, during the summers of 1995\u20131997","volume":"36","author":"Valassina","year":"1998","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2004.12.025_bib25","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1128\/JCM.36.11.3170-3172.1998","article-title":"Diagnostic potential of Toscana virus N protein expressed in E. coli","volume":"36","author":"Valassina","year":"1998","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2004.12.025_bib26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/(SICI)1096-9071(200001)60:1<86::AID-JMV14>3.0.CO;2-N","article-title":"Detection of neurotropic viruses circulating in Tuscany: the incisive role of Toscana virus","volume":"60","author":"Valassina","year":"2000","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virol.2004.12.025_bib27","series-title":"Arboviruses in the Mediterranean Countries","first-page":"195","article-title":"Studies on phlebotomus-transmitted viruses in Italy: I. Isolation and characterization of a sandfly fever Naples-like virus","author":"Verani","year":"1980"},{"key":"10.1016\/j.virol.2004.12.025_bib28","first-page":"397","article-title":"Ecological and epidemiological studies of Toscana virus, an arbovirus isolated from Phlebotomus","volume":"18","author":"Verani","year":"1982","journal-title":"Ann. Ist. Super. Sanita"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682204008396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682204008396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:34:42Z","timestamp":1758584082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682204008396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0042682204008396"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2004.12.025","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a mouse model for the study of Toscana virus pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2004.12.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}