{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:01:38Z","timestamp":1785546098553,"version":"3.56.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":3035,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.virol.2005.02.014","type":"journal-article","created":{"date-parts":[[2005,3,22]],"date-time":"2005-03-22T07:34:10Z","timestamp":1111476850000},"page":"242-251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Host range, growth property, and virulence of the smallpox vaccine: Vaccinia virus Tian Tan strain"],"prefix":"10.1016","volume":"335","author":[{"given":"Qing","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genfu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po","family":"Tien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.virol.2005.02.014_bib1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1128\/JVI.75.2.850-856.2001","article-title":"Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse model","volume":"75","author":"Brandt","year":"2001","journal-title":"J. Virol."},{"issue":"22","key":"10.1016\/j.virol.2005.02.014_bib2","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1056\/NEJM198011273032204","article-title":"The confirmation and maintenance of smallpox eradication","volume":"303","author":"Breman","year":"1980","journal-title":"N. Engl. J. Med."},{"issue":"6040","key":"10.1016\/j.virol.2005.02.014_bib3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/317813a0","article-title":"Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype","volume":"317","author":"Buller","year":"1985","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.virol.2005.02.014_bib4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/viro.1997.8845","article-title":"Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell line","volume":"238","author":"Carroll","year":"1997","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.virol.2005.02.014_bib5","first-page":"30","article-title":"Time frame and reasons of Kangxi Emperor adopted variolation","volume":"26","author":"Chang","year":"1996","journal-title":"Zhonghua Yishi Zazhi"},{"issue":"5","key":"10.1016\/j.virol.2005.02.014_bib6","first-page":"312","article-title":"The clinic reaction and evaluation of Chinese purifying Vero cell rabies vaccine","volume":"5","author":"Dong","year":"2002","journal-title":"Chin. J. Biol."},{"issue":"5","key":"10.1016\/j.virol.2005.02.014_bib7","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/clinids\/4.5.916","article-title":"A successful eradication campaign. Global eradication of smallpox","volume":"4","author":"Fenner","year":"1982","journal-title":"Rev. Infect Dis."},{"issue":"1","key":"10.1016\/j.virol.2005.02.014_bib8","first-page":"24","article-title":"Construction of expression vectors of non-replication recombinant vaccinia virus Tiantan strain with CK region deletion and studying of biological properties of the recombinant viruses","volume":"17","author":"Guo","year":"2001","journal-title":"Chin. J. Virol."},{"key":"10.1016\/j.virol.2005.02.014_bib9","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1099\/0022-1317-66-8-1819","article-title":"Variation in the HindIII restriction fragments of DNA from the Chinese Tian Tan strain of vaccinia virus","volume":"66","author":"Hou","year":"1985","journal-title":"J. Gen. Virol."},{"issue":"6","key":"10.1016\/j.virol.2005.02.014_bib10","first-page":"562","article-title":"Characterization of the complete genomic sequence of the vaccinia virus Tian Tan strain","volume":"27","author":"Jin","year":"1997","journal-title":"Sci. China"},{"issue":"1","key":"10.1016\/j.virol.2005.02.014_bib11","first-page":"1","article-title":"Analysis of open reading frames located in HindIII-C and -B fragments of vaccinia virus strain TianTan","volume":"13","author":"Jin","year":"1997","journal-title":"Chin. J. Virol."},{"key":"10.1016\/j.virol.2005.02.014_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0042-6822(62)90172-1","article-title":"The purification of four strains of poxvirus","volume":"18","author":"Joklik","year":"1962","journal-title":"Virology"},{"issue":"17","key":"10.1016\/j.virol.2005.02.014_bib13","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1089\/aid.1997.13.1497","article-title":"Immunogenicity of recombinant vaccinia viruses that display the HIV type 1 envelope glycoprotein on the surface of infectious virions","volume":"13","author":"Katz","year":"1997","journal-title":"AIDS Res. Hum. Retroviruses"},{"issue":"5","key":"10.1016\/j.virol.2005.02.014_bib14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0264-410X(94)00019-J","article-title":"Search for optimal parent for recombinant vaccinia virus vaccines. Study of three vaccinia virus vaccine strains and several virus lines derived from them","volume":"13","author":"Kutinova","year":"1995","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.virol.2005.02.014_bib15","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1128\/jvi.66.5.2617-2630.1992","article-title":"Molecular attenuation of vaccinia virus: mutant generation and animal characterization","volume":"66","author":"Lee","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2005.02.014_bib16","first-page":"170","article-title":"Construction and characterization of non-replicating recombinant vaccinia virus expressing rabies glycoprotein","volume":"13","author":"Li","year":"1999","journal-title":"Chin. J. Exp. Clin. Virol."},{"issue":"3","key":"10.1016\/j.virol.2005.02.014_bib17","first-page":"139","article-title":"Variolation, pioneer of modern immunology","volume":"25","author":"Ma","year":"1995","journal-title":"Zhonghua YiShi ZaZhi"},{"issue":"4685","key":"10.1016\/j.virol.2005.02.014_bib18","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1126\/science.2981435","article-title":"Vaccinia virus recombinants: expression of VSV genes and protective immunization of mice and cattle","volume":"227","author":"Mackett","year":"1985","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.virol.2005.02.014_bib19","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.it.2004.10.002","article-title":"25 years since the eradication of smallpox: why poxvirus research is still relevant","volume":"25","author":"Mahalingam","year":"2004","journal-title":"Trends Immunol."},{"issue":"9","key":"10.1016\/j.virol.2005.02.014_bib20","first-page":"322","article-title":"Historical review of smallpox, the eradication of smallpox and the attenuated smallpox MVA vaccine","volume":"112","author":"Mayr","year":"1999","journal-title":"Berl. Muench. Tieraerztl. Wochenschr."},{"key":"10.1016\/j.virol.2005.02.014_bib21","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF01641272","article-title":"Abstammung,eigenschaften und verwendung des attenuierten vaccinia-stammes MVA","volume":"3","author":"Mayr","year":"1975","journal-title":"Infection"},{"key":"10.1016\/j.virol.2005.02.014_bib22","first-page":"375","article-title":"Der pockenimptamm MVA: marker, genetische struktur, erfahrungen mit der parenteralen schutzimpfung und verhalten im abwehrgesch wa \u00a8chten organismus","volume":"167","author":"Mayr","year":"1978","journal-title":"Zentralbl. Bakteriol. Hyg."},{"issue":"4","key":"10.1016\/j.virol.2005.02.014_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nri779","article-title":"The quest for an AIDS vaccine: is the CD8+ T-cell approach feasible?","volume":"2","author":"McMichael","year":"2002","journal-title":"Nat. Rev., Immunol."},{"issue":"Pt. 5","key":"10.1016\/j.virol.2005.02.014_bib24","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1099\/0022-1317-72-5-1031","article-title":"Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence","volume":"72","author":"Meyer","year":"1991","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2005.02.014_bib25","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.ijid.2004.09.002","article-title":"ACAM2000 clonal Vero cell culture vaccinia virus (New York City Board of Health strain)\u2014a second-generation smallpox vaccine for biological defense","volume":"Suppl. 2","author":"Monath","year":"2004","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.virol.2005.02.014_bib26","series-title":"Fundamental Virology","first-page":"953","article-title":"Poxviridae and their replication","author":"Moss","year":"1991"},{"issue":"21","key":"10.1016\/j.virol.2005.02.014_bib27","doi-asserted-by":"crossref","first-page":"11341","DOI":"10.1073\/pnas.93.21.11341","article-title":"Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety","volume":"93","author":"Moss","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"21","key":"10.1016\/j.virol.2005.02.014_bib28","doi-asserted-by":"crossref","first-page":"11349","DOI":"10.1073\/pnas.93.21.11349","article-title":"Applications of pox virus vectors to vaccination: an update","volume":"93","author":"Paoletti","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.virol.2005.02.014_bib29","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1006\/viro.1995.1021","article-title":"Restriction of vaccinia virus replication in CHO cells occurs at the stage of viral intermediate protein synthesis","volume":"206","author":"Ramsey-Ewing","year":"1995","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.virol.2005.02.014_bib30","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/viro.1997.8985","article-title":"Apoptosis induced by a postbinding step of vaccinia virus entry into Chinese hamster ovary cells","volume":"242","author":"Ramsey-Ewing","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.virol.2005.02.014_bib31","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Hyg."},{"issue":"3","key":"10.1016\/j.virol.2005.02.014_bib32","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1128\/jvi.71.3.1821-1833.1997","article-title":"Characterization of early stages in vaccinia virus membrane biogenesis: implications of the 21-kilodalton protein and a newly identified 15-kilodalton envelope protein","volume":"71","author":"Rodriguez","year":"1997","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.virol.2005.02.014_bib33","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.vaccine.2004.08.001","article-title":"An immunogenicity study of a newly introduced purified Vero cell rabies vaccine (Abhayrab) manufactured in India","volume":"23","author":"Sampath","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2005.02.014_bib34","article-title":"History and characterization of the Vero cell line","author":"Sheets","year":"2000"},{"issue":"Pt. 12","key":"10.1016\/j.virol.2005.02.014_bib35","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1099\/0022-1317-83-12-2915","article-title":"The formation and function of extracellular enveloped vaccinia virus","volume":"83","author":"Smith","year":"2002","journal-title":"J. Gen. Virol."},{"issue":"1","key":"10.1016\/j.virol.2005.02.014_bib36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/viro.2000.0411","article-title":"Enveloped virus is the major virus form produced during productive infection with the modified vaccinia virus Ankara strain","volume":"273","author":"Spehner","year":"2000","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.virol.2005.02.014_bib37","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1128\/jvi.62.4.1297-1304.1988","article-title":"A cowpox virus gene required for multiplication in Chinese hamster ovary cells","volume":"62","author":"Spehner","year":"1988","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2005.02.014_bib38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0196-6553(82)90003-7","article-title":"The global eradication of smallpox","volume":"10","author":"Strassburg","year":"1982","journal-title":"Am. J. Infect. Control"},{"issue":"17","key":"10.1016\/j.virol.2005.02.014_bib39","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.3748\/wjg.v10.i17.2571","article-title":"A novel process for production of hepatitis A virus in Vero cells grown on microcarriers in bioreactor","volume":"10","author":"Sun","year":"2004","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.virol.2005.02.014_bib40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0042-6822(92)90752-B","article-title":"NYVAC: a highly attenuated strain of vaccinia virus","volume":"188","author":"Tartaglia","year":"1992","journal-title":"Virology"},{"key":"10.1016\/j.virol.2005.02.014_bib41","series-title":"Requirements for the Manufacture of Biological Products in China","year":"1979"},{"issue":"2","key":"10.1016\/j.virol.2005.02.014_bib42","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1128\/jvi.57.2.693-696.1986","article-title":"Gene coding for the late 11,000-dalton polypeptide of the Tian Tan strain of vaccinia virus and its 5\u2032-flanking region: nucleotide sequence","volume":"57","author":"Tsao","year":"1986","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2005.02.014_bib43","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nm916","article-title":"Clonal vaccinia virus grown in cell culture as a new smallpox vaccine","volume":"9","author":"Weltzin","year":"2003","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.virol.2005.02.014_bib44","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1128\/jvi.70.5.2797-2808.1996","article-title":"Vaccinia virus A17L open reading frame encodes an essential component of nascent viral membranes that is required to initiate morphogenesis","volume":"70","author":"Wolffe","year":"1996","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2005.02.014_bib45","first-page":"39","article-title":"Observation of inoculation reaction and immune efficacy of edulcorate-lyophilized Vero cell prepared Japanese B encephalitis (JBE) vaccine in children","volume":"8","author":"Yan","year":"2002","journal-title":"Chin. J. Vaccines Immun."},{"key":"10.1016\/j.virol.2005.02.014_bib46","series-title":"The Corpus for the 30th Anniversary of P.R. China","first-page":"54","article-title":"Screening and study the attenuated strains form Vaccinia TT stocks","author":"Yang","year":"1979"},{"issue":"1","key":"10.1016\/j.virol.2005.02.014_bib47","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/oxfordjournals.aje.a114956","article-title":"Outbreaks of smallpox due to variolation in China, 1962\u20131965","volume":"128","author":"Yutu","year":"1988","journal-title":"Am. J. Epidemiol."},{"issue":"24","key":"10.1016\/j.virol.2005.02.014_bib48","doi-asserted-by":"crossref","first-page":"11654","DOI":"10.1128\/JVI.74.24.11654-11662.2000","article-title":"Vaccinia virus F12L protein is required for actin tail formation, normal plaque size, and virulence","volume":"74","author":"Zhang","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2005.02.014_bib49","first-page":"421","article-title":"Studies on attenuation of vaccinia virus","volume":"1","author":"Zhao","year":"1981","journal-title":"Chin. J. Microbiol. Immunol."},{"issue":"6","key":"10.1016\/j.virol.2005.02.014_bib50","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/BF01718609","article-title":"Immunogenicity and relative attenuation of different vaccinia-rabies virus recombinants","volume":"141","author":"Zhu","year":"1996","journal-title":"Arch. Virol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682205001194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682205001194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:34:15Z","timestamp":1758584055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682205001194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0042682205001194"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2005.02.014","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2005,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Host range, growth property, and virulence of the smallpox vaccine: Vaccinia virus Tian Tan strain","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2005.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}