{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:02:43Z","timestamp":1758672163536,"version":"3.44.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2968,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1016\/j.virol.2005.03.033","type":"journal-article","created":{"date-parts":[[2005,4,27]],"date-time":"2005-04-27T07:41:22Z","timestamp":1114587682000},"page":"136-148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neutralization sensitivity of HIV-1 Env-pseudotyped virus clones is determined by co-operativity between mutations which modulate the CD4-binding site and those that affect gp120\u2013gp41 stability"],"prefix":"10.1016","volume":"337","author":[{"given":"Simon","family":"Beddows","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie N.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod S.","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan N.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.virol.2005.03.033_bib1","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1128\/JVI.73.2.1740-1745.1999","volume":"73","author":"Beddows","year":"1999","journal-title":"J. Virol."},{"issue":"23","key":"10.1016\/j.virol.2005.03.033_bib2","doi-asserted-by":"crossref","first-page":"13232","DOI":"10.1128\/JVI.78.23.13232-13252.2004","article-title":"Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies","volume":"78","author":"Binley","year":"2004","journal-title":"J. Virol."},{"issue":"5187","key":"10.1016\/j.virol.2005.03.033_bib3","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1126\/science.7973652","article-title":"Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody","volume":"266","author":"Burton","year":"1994","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.virol.2005.03.033_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ni0304-233","article-title":"HIV vaccine design and the neutralizing antibody problem","volume":"5","author":"Burton","year":"2004","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.virol.2005.03.033_bib5","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1128\/jvi.67.5.2747-2755.1993","article-title":"Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein","volume":"67","author":"Cao","year":"1993","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2005.03.033_bib6","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1128\/JVI.73.2.976-984.1999","article-title":"Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2)","volume":"73","author":"Cayabyab","year":"1999","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.virol.2005.03.033_bib7","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1128\/jvi.67.6.3615-3619.1993","article-title":"Mutational analysis of the leucine zipper-like motif of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein","volume":"67","author":"Chen","year":"1993","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.virol.2005.03.033_bib8","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1128\/JVI.73.7.5294-5300.1999","article-title":"Selection for neutralization resistance of the simian\/human immunodeficiency virus SHIVSF33A variant in vivo by virtue of sequence changes in the extracellular envelope glycoprotein that modify N-linked glycosylation","volume":"73","author":"Cheng-Mayer","year":"1999","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.virol.2005.03.033_bib9","doi-asserted-by":"crossref","first-page":"6994","DOI":"10.1128\/jvi.68.11.6994-7000.1994","article-title":"Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D","volume":"68","author":"Conley","year":"1994","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.virol.2005.03.033_bib10","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.1128\/jvi.70.10.6751-6758.1996","article-title":"The consequence of passive administration of an anti-human immunodeficiency virus type 1 neutralizing monoclonal antibody before challenge of chimpanzees with a primary virus isolate","volume":"70","author":"Conley","year":"1996","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.virol.2005.03.033_bib11","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.1128\/jvi.70.8.5306-5311.1996","article-title":"Characterization of the functional properties of env genes from long-term survivors of human immunodeficiency virus type 1 infection","volume":"70","author":"Connor","year":"1996","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2005.03.033_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/jmbi.1997.1277","article-title":"HIV\/SIV glycoproteins: structure\u2013function relationships","volume":"273","author":"Douglas","year":"1997","journal-title":"J. Mol. Biol."},{"issue":"5","key":"10.1016\/j.virol.2005.03.033_bib13","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1086\/516443","article-title":"Evaluation of monoclonal antibodies to human immunodeficiency virus type 1 primary isolates by neutralization assays: performance criteria for selecting candidate antibodies for clinical trials. AIDS Clinical Trials Group Antibody Selection Working Group","volume":"175","author":"D'Souza","year":"1997","journal-title":"J. Infect. Dis."},{"issue":"8","key":"10.1016\/j.virol.2005.03.033_bib14","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1128\/jvi.66.8.4748-4756.1992","article-title":"Mutations in the leucine zipper of the human immunodeficiency virus type 1 transmembrane glycoprotein affect fusion and infectivity","volume":"66","author":"Dubay","year":"1992","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2005.03.033_bib15","doi-asserted-by":"crossref","first-page":"7603","DOI":"10.1128\/JVI.72.9.7603-7608.1998","article-title":"Continued utilization of CCR5 coreceptor by a newly derived T-cell line-adapted isolate of human immunodeficiency virus type 1","volume":"72","author":"Follis","year":"1998","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.virol.2005.03.033_bib16","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1128\/jvi.71.4.2779-2785.1997","article-title":"Neutralization of the human immunodeficiency virus type 1 primary isolate JR-FL by human monoclonal antibodies correlates with antibody binding to the oligomeric form of the envelope glycoprotein complex","volume":"71","author":"Fouts","year":"1997","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.virol.2005.03.033_bib17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1473-3099(04)01056-4","article-title":"Prospects for an AIDS vaccine: three big questions, no easy answers","volume":"4","author":"Garber","year":"2004","journal-title":"Lancet Infect. Dis."},{"issue":"1","key":"10.1016\/j.virol.2005.03.033_bib18","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1128\/JVI.73.1.684-694.1999","article-title":"Enhancement of human immunodeficiency virus type 1 infection by the CC-chemokine RANTES is independent of the mechanism of virus-cell fusion","volume":"73","author":"Gordon","year":"1999","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.virol.2005.03.033_bib19","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.1128\/jvi.66.12.7538-7542.1992","article-title":"Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody","volume":"66","author":"Gorny","year":"1992","journal-title":"J. Virol."},{"issue":"5628","key":"10.1016\/j.virol.2005.03.033_bib20","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1126\/science.1086916","article-title":"Medicine. The need for a global HIV vaccine enterprise","volume":"300","author":"Klausner","year":"2003","journal-title":"Science"},{"issue":"6686","key":"10.1016\/j.virol.2005.03.033_bib21","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/31405","article-title":"Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody","volume":"393","author":"Kwong","year":"1998","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.virol.2005.03.033_bib22","doi-asserted-by":"crossref","first-page":"10310","DOI":"10.1128\/JVI.73.12.10310-10319.1999","article-title":"Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity","volume":"73","author":"LaBranche","year":"1999","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2005.03.033_bib23","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1128\/JVI.72.3.2491-2495.1998","article-title":"Coreceptor utilization by human immunodeficiency virus type 1 is not a primary determinant of neutralization sensitivity","volume":"72","author":"LaCasse","year":"1998","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2005.03.033_bib24","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1128\/JVI.77.1.560-570.2003","article-title":"Concordant modulation of neutralization resistance and high infectivity of the primary human immunodeficiency virus type 1 MN strain and definition of a potential gp41 binding site in gp120","volume":"77","author":"Leavitt","year":"2003","journal-title":"J. Virol."},{"issue":"19","key":"10.1016\/j.virol.2005.03.033_bib25","doi-asserted-by":"crossref","first-page":"11013","DOI":"10.1073\/pnas.1832214100","article-title":"A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding","volume":"100","author":"Lin","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.virol.2005.03.033_bib26","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1128\/JVI.73.5.4009-4018.1999","article-title":"Protection of macaques against pathogenic simian\/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies","volume":"73","author":"Mascola","year":"1999","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2005.03.033_bib27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/72318","article-title":"Protection of macaques against vaginal transmission of a pathogenic HIV-1\/SIV chimeric virus by passive infusion of neutralizing antibodies","volume":"6","author":"Mascola","year":"2000","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.virol.2005.03.033_bib28","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.1128\/jvi.71.9.6869-6874.1997","article-title":"Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody IgG1b12","volume":"71","author":"Mo","year":"1997","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2005.03.033_bib29","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1128\/JVI.72.3.1886-1893.1998","article-title":"Evidence that antibody-mediated neutralization of human immunodeficiency virus type 1 by sera from infected individuals is independent of coreceptor usage","volume":"72","author":"Montefiori","year":"1998","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2005.03.033_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1128\/jvi.69.1.101-109.1995","article-title":"Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120","volume":"69","author":"Moore","year":"1995","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2005.03.033_bib31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1128\/jvi.70.1.427-444.1996","article-title":"Inter- and intraclade neutralization of human immunodeficiency virus type: 1. genetic clades do not correspond to neutralization serotypes but partially correspond to gp120 antigenic serotypes","volume":"70","author":"Moore","year":"1996","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.virol.2005.03.033_bib32","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1128\/jvi.67.11.6642-6647.1993","article-title":"A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1","volume":"67","author":"Muster","year":"1993","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.virol.2005.03.033_bib33","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1128\/jvi.68.6.4031-4034.1994","article-title":"Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS","volume":"68","author":"Muster","year":"1994","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2005.03.033_bib34","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1128\/jvi.70.9.6235-6243.1996","article-title":"Multivariate analysis of human immunodeficiency virus type 1 neutralization data","volume":"70","author":"Nyambi","year":"1996","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.virol.2005.03.033_bib35","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1128\/jvi.68.8.5264-5269.1994","article-title":"Macrophage-tropic and T-cell line-adapted chimeric strains of human immunodeficiency virus type 1 differ in their susceptibilities to neutralization by soluble CD4 at different temperatures","volume":"68","author":"O'Brien","year":"1994","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2005.03.033_bib36","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1128\/JVI.77.1.642-658.2003","article-title":"Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120","volume":"77","author":"Pantophlet","year":"2003","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.virol.2005.03.033_bib37","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1128\/JVI.73.7.5707-5713.1999","article-title":"Both neutralization resistance and high infectivity phenotypes are caused by mutations of interacting residues in the human immunodeficiency virus type 1 gp41 leucine zipper and the gp120 receptor- and coreceptor-binding domains","volume":"73","author":"Park","year":"1999","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2005.03.033_bib38","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1128\/JVI.72.9.7099-7107.1998","article-title":"Mutations in both gp120 and gp41 are responsible for the broad neutralization resistance of variant human immunodeficiency virus type 1 MN to antibodies directed at V3 and non-V3 epitopes","volume":"72","author":"Park","year":"1998","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2005.03.033_bib39","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1128\/JVI.74.9.4183-4191.2000","article-title":"A global neutralization resistance phenotype of human immunodeficiency virus type 1 is determined by distinct mechanisms mediating enhanced infectivity and conformational change of the envelope complex","volume":"74","author":"Park","year":"2000","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2005.03.033_bib40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.virol.2003.12.012","article-title":"The prolonged culture of human immunodeficiency virus type 1 in primary lymphocytes increases its sensitivity to neutralization by soluble CD4","volume":"321","author":"Pugach","year":"2004","journal-title":"Virology"},{"issue":"10","key":"10.1016\/j.virol.2005.03.033_bib41","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1128\/JVI.78.10.5476-5485.2004","article-title":"Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity","volume":"78","author":"Reeves","year":"2004","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2005.03.033_bib42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0092-8674(88)90179-1","article-title":"Generation of a neutralization-resistant variant of HIV-1 is due to selection for a point mutation in the envelope gene","volume":"54","author":"Reitz","year":"1988","journal-title":"Cell"},{"issue":"5371","key":"10.1016\/j.virol.2005.03.033_bib43","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1126\/science.280.5371.1949","article-title":"A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding","volume":"280","author":"Rizzuto","year":"1998","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.virol.2005.03.033_bib44","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1128\/jvi.68.8.4821-4828.1994","article-title":"Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1","volume":"68","author":"Roben","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2005.03.033_bib45","series-title":"HIV Sequence Compendium 2002","first-page":"43","article-title":"Mutational analyses and natural variability of the gp41 ectodomain","author":"Sanders","year":"2002"},{"issue":"3","key":"10.1016\/j.virol.2005.03.033_bib46","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1128\/jvi.68.3.1342-1349.1994","article-title":"Neutralization sensitivity of human immunodeficiency virus type 1 is determined in part by the cell in which the virus is propagated","volume":"68","author":"Sawyer","year":"1994","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2005.03.033_bib47","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/5568","article-title":"Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1\/SIV chimeric virus infections of macaque monkeys","volume":"5","author":"Shibata","year":"1999","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.virol.2005.03.033_bib48","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1128\/JVI.75.9.4208-4218.2001","article-title":"Envelope glycoprotein determinants of neutralization resistance in a simian-human immunodeficiency virus (SHIV-HXBc2P 3.2) derived by passage in monkeys","volume":"75","author":"Si","year":"2001","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2005.03.033_bib49","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1128\/jvi.65.9.5007-5012.1991","article-title":"Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity","volume":"65","author":"Thali","year":"1991","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.virol.2005.03.033_bib50","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.1128\/jvi.65.11.6188-6193.1991","article-title":"Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody","volume":"65","author":"Thali","year":"1991","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.virol.2005.03.033_bib51","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1128\/jvi.67.7.3978-3988.1993","article-title":"Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding","volume":"67","author":"Thali","year":"1993","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.virol.2005.03.033_bib52","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1128\/jvi.69.11.6609-6617.1995","article-title":"Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG","volume":"69","author":"Trkola","year":"1995","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2005.03.033_bib53","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1128\/jvi.70.2.1100-1108.1996","article-title":"Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1","volume":"70","author":"Trkola","year":"1996","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2005.03.033_bib54","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1128\/JVI.72.3.1876-1885.1998","article-title":"Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage","volume":"72","author":"Trkola","year":"1998","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2005.03.033_bib55","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nm833","article-title":"Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120","volume":"9","author":"Veazey","year":"2003","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.virol.2005.03.033_bib56","doi-asserted-by":"crossref","first-page":"8431","DOI":"10.1128\/jvi.70.12.8431-8437.1996","article-title":"Resistance of human immunodeficiency virus type 1 to neutralization by natural antisera occurs through single amino acid substitutions that cause changes in antibody binding at multiple sites","volume":"70","author":"Watkins","year":"1996","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.virol.2005.03.033_bib57","doi-asserted-by":"crossref","first-page":"7827","DOI":"10.1128\/jvi.70.11.7827-7832.1996","article-title":"Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype","volume":"70","author":"Weber","year":"1996","journal-title":"J. Virol."},{"issue":"26","key":"10.1016\/j.virol.2005.03.033_bib58","doi-asserted-by":"crossref","first-page":"12676","DOI":"10.1073\/pnas.91.26.12676","article-title":"Propensity for a leucine zipper-like domain of human immunodeficiency virus type 1 gp41 to form oligomers correlates with a role in virus-induced fusion rather than assembly of the glycoprotein complex","volume":"91","author":"Wild","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.virol.2005.03.033_bib59","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1128\/jvi.69.1.39-48.1995","article-title":"Adaptation to persistent growth in the H9 cell line renders a primary isolate of human immunodeficiency virus type 1 sensitive to neutralization by vaccine sera","volume":"69","author":"Wrin","year":"1995","journal-title":"J. Virol."},{"issue":"22","key":"10.1016\/j.virol.2005.03.033_bib60","doi-asserted-by":"crossref","first-page":"10892","DOI":"10.1128\/JVI.75.22.10892-10905.2001","article-title":"Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41","volume":"75","author":"Zwick","year":"2001","journal-title":"J. Virol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682205001893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682205001893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:35:42Z","timestamp":1758584142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682205001893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0042682205001893"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2005.03.033","relation":{},"ISSN":["0042-6822"],"issn-type":[{"type":"print","value":"0042-6822"}],"subject":[],"published":{"date-parts":[[2005,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutralization sensitivity of HIV-1 Env-pseudotyped virus clones is determined by co-operativity between mutations which modulate the CD4-binding site and those that affect gp120\u2013gp41 stability","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2005.03.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}