{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:42:34Z","timestamp":1791286954839,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2335,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.virol.2006.11.012","type":"journal-article","created":{"date-parts":[[2006,12,19]],"date-time":"2006-12-19T09:32:05Z","timestamp":1166520725000},"page":"229-241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis"],"prefix":"10.1016","volume":"361","author":[{"given":"Francesc","family":"Puig-Basagoiti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Tilgner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey J.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangsheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Mu\u00f1oz-Jord\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Garc\u00eda-Sastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen A.","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2006.11.012_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.virol.2005.06.009","article-title":"Role of RNA structures present at the 3\u2032UTR of dengue virus on translation, RNA synthesis, and viral replication","volume":"339","author":"Alvarez","year":"2005","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.virol.2006.11.012_bib2","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1128\/JVI.73.4.2803-2813.1999","article-title":"The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells","volume":"73","author":"Aubert","year":"1999","journal-title":"J. Virol."},{"issue":"5498","key":"10.1016\/j.virol.2006.11.012_bib3","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1126\/science.290.5498.1972","article-title":"Efficient initiation of HCV RNA replication in cell culture","volume":"290","author":"Blight","year":"2000","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.virol.2006.11.012_bib4","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1128\/JVI.77.5.3181-3190.2003","article-title":"Efficient replication of hepatitis C virus genotype 1a RNAs in cell culture","volume":"77","author":"Blight","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2006.11.012_bib5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev.micro.56.012302.160654","article-title":"The molecular biology of West Nile virus: a new invader of the Western Hemisphere","volume":"56","author":"Brinton","year":"2002","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.virol.2006.11.012_bib6","first-page":"1043","article-title":"Flaviviruses","volume":"vol. 1","author":"Burke","year":"2001"},{"issue":"2","key":"10.1016\/j.virol.2006.11.012_bib7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/viro.2001.1302","article-title":"Differences in interferon sensitivity and biological properties of two related isolates of simian virus 5: a model for virus persistence","volume":"293","author":"Chatziandreou","year":"2002","journal-title":"Virology"},{"issue":"3","key":"10.1016\/j.virol.2006.11.012_bib8","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1128\/JVI.77.3.2265-2270.2003","article-title":"Fine mapping of a cis-acting sequence element in yellow fever virus RNA that is required for RNA replication and cyclization","volume":"77","author":"Corver","year":"2003","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2006.11.012_bib9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/infdis\/129.3.248","article-title":"Genetically determined resistance to infection with group B arboviruses: II. Increased production of interfering particles in cell cultures from resistant mice","volume":"129","author":"Darnell","year":"1974","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.virol.2006.11.012_bib10","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.virol.2004.09.016","article-title":"Emergence of attenuated West Nile virus variants in Texas, 2003","volume":"330","author":"Davis","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.virol.2006.11.012_bib11","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1128\/JVI.79.8.4599-4609.2005","article-title":"Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication","author":"Deas","year":"2005","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2006.11.012_bib12","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/viro.2000.0457","article-title":"Determinants in the envelope E protein and viral RNA helicase NS3 that influence the induction of apoptosis in response to infection with dengue type 1 virus","volume":"274","author":"Duarte dos Santos","year":"2000","journal-title":"Virology"},{"issue":"5","key":"10.1016\/j.virol.2006.11.012_bib13","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1128\/JVI.73.5.3854-3865.1999","article-title":"Selection of RNA replicons capable of persistent noncytopathic replication in mammalian cells","volume":"73","author":"Frolov","year":"1999","journal-title":"J. Virol."},{"issue":"16","key":"10.1016\/j.virol.2006.11.012_bib14","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.1128\/JVI.77.16.8924-8933.2003","article-title":"Incorporation of tick-borne encephalitis virus replicons into virus-like particles by a packaging cell line","volume":"77","author":"Gehrke","year":"2003","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2006.11.012_bib15","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1128\/JVI.79.3.1343-1350.2005","article-title":"West Nile virus inhibits the signal transduction pathway of alpha interferon","volume":"79","author":"Guo","year":"2005","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2006.11.012_bib16","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0042-6822(03)00197-1","article-title":"A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4","volume":"312","author":"Hanley","year":"2003","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.virol.2006.11.012_bib17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.virol.2005.08.034","article-title":"Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3\u2032 stem-loop structure","volume":"344","author":"Holden","year":"2006","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.virol.2006.11.012_bib18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.virol.2004.10.034","article-title":"Construction and applications of yellow fever virus replicons","volume":"331","author":"Jones","year":"2005","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.virol.2006.11.012_bib19","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1128\/jvi.71.2.1497-1505.1997","article-title":"Subgenomic replicons of the flavivirus Kunjin: construction and applications","volume":"71","author":"Khromykh","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2006.11.012_bib20","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1128\/JVI.72.7.5967-5977.1998","article-title":"Encapsidation of the flavivirus Kunjin replicon RNA by using a complementation system providing Kunjin virus structural proteins in trans","volume":"72","author":"Khromykh","year":"1998","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.virol.2006.11.012_bib21","doi-asserted-by":"crossref","first-page":"9247","DOI":"10.1128\/JVI.73.11.9247-9255.1999","article-title":"Trans-Complementation analysis of the flavivirus Kunjin ns5 gene reveals an essential role for translation of its N-terminal half in RNA replication","volume":"73","author":"Khromykh","year":"1999","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.virol.2006.11.012_bib22","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1128\/JVI.76.10.4773-4784.2002","article-title":"Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles","volume":"76","author":"Kummerer","year":"2002","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.virol.2006.11.012_bib23","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1128\/jvi.67.4.2327-2335.1993","article-title":"Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A\/4B signalase site","volume":"67","author":"Lin","year":"1993","journal-title":"J. Virol."},{"issue":"14","key":"10.1016\/j.virol.2006.11.012_bib24","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.1128\/JVI.77.14.7804-7813.2003","article-title":"Molecular and functional analyses of Kunjin virus infectious cDNA clones demonstrate the essential roles for NS2A in virus assembly and for a nonconservative residue in NS3 in RNA replication","volume":"77","author":"Liu","year":"2003","journal-title":"J. Virol."},{"issue":"22","key":"10.1016\/j.virol.2006.11.012_bib25","doi-asserted-by":"crossref","first-page":"12225","DOI":"10.1128\/JVI.78.22.12225-12235.2004","article-title":"Analysis of adaptive mutations in Kunjin virus replicon RNA reveals a novel role for the flavivirus nonstructural protein NS2A in inhibition of beta interferon promoter-driven transcription","volume":"78","author":"Liu","year":"2004","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2006.11.012_bib26","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1128\/JVI.79.3.1934-1942.2005","article-title":"Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins","volume":"79","author":"Liu","year":"2005","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.virol.2006.11.012_bib27","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1128\/JVI.80.5.2396-2404.2006","article-title":"A single amino acid substitution in the West Nile virus nonstructural protein NS2A disables its ability to inhibit alpha\/beta interferon induction and attenuates virus virulence in mice","volume":"80","author":"Liu","year":"2006","journal-title":"J. Virol."},{"issue":"18","key":"10.1016\/j.virol.2006.11.012_bib28","doi-asserted-by":"crossref","first-page":"10004","DOI":"10.1128\/JVI.77.18.10004-10014.2003","article-title":"Functional analysis of mosquito-borne flavivirus conserved sequence elements within 3\u2032 untranslated region of West Nile virus using a reporting replicon that differentiates between viral translation and RNA replication","volume":"77","author":"Lo","year":"2003","journal-title":"J. Virol."},{"issue":"23","key":"10.1016\/j.virol.2006.11.012_bib29","doi-asserted-by":"crossref","first-page":"12901","DOI":"10.1128\/JVI.77.23.12901-12906.2003","article-title":"A potential high-throughput assay for screening inhibitors of West Nile virus replication","volume":"77","author":"Lo","year":"2003","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2006.11.012_bib30","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1128\/JVI.75.3.1437-1449.2001","article-title":"Mutations in hepatitis C virus RNAs conferring cell culture adaptation","volume":"75","author":"Lohmann","year":"2001","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.virol.2006.11.012_bib31","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1128\/JVI.77.5.3007-3019.2003","article-title":"Viral and cellular determinants of hepatitis C virus RNA replication in cell culture","volume":"77","author":"Lohmann","year":"2003","journal-title":"J. Virol."},{"issue":"13","key":"10.1016\/j.virol.2006.11.012_bib32","doi-asserted-by":"crossref","first-page":"8854","DOI":"10.1074\/jbc.M512697200","article-title":"Subcellular localization and membrane topology of the dengue virus type 2 non-structural protein 4B","volume":"281","author":"Miller","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.virol.2006.11.012_bib33","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1128\/JVI.77.2.1644-1648.2003","article-title":"Yellow fever virus replicons as an expression system for hepatitis C virus structural proteins","volume":"77","author":"Molenkamp","year":"2003","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.virol.2006.11.012_bib34","first-page":"2279","article-title":"Transcriptional and posttranscriptional regulation of exogenous human beta interferon gene in simian cells defective in interferon synthesis","volume":"6","author":"Mosca","year":"1986","journal-title":"Mol. Cell. Biol."},{"issue":"24","key":"10.1016\/j.virol.2006.11.012_bib35","doi-asserted-by":"crossref","first-page":"14333","DOI":"10.1073\/pnas.2335168100","article-title":"Inhibition of interferon signaling by dengue virus","volume":"100","author":"Munoz-Jordan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"13","key":"10.1016\/j.virol.2006.11.012_bib36","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.1128\/JVI.79.13.8004-8013.2005","article-title":"Inhibition of alpha\/beta interferon signaling by the NS4B protein of flaviviruses","volume":"79","author":"Munoz-Jordan","year":"2005","journal-title":"J. Virol."},{"issue":"3\u20134","key":"10.1016\/j.virol.2006.11.012_bib37","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF01317496","article-title":"Studies on avian infectious bronchitis virus (IBV): III. Interferon induction by and sensitivity to interferon of IBV","volume":"60","author":"Otsuki","year":"1979","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2006.11.012_bib38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2180-1-18","article-title":"Development of dengue virus type 2 replicons capable of prolonged expression in host cells","volume":"1","author":"Pang","year":"2001","journal-title":"BMC Microbiol."},{"issue":"7","key":"10.1016\/j.virol.2006.11.012_bib39","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1073\/pnas.062055699","article-title":"Regulation of PKR and IRF-1 during hepatitis C virus RNA replication","volume":"99","author":"Pflugheber","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.virol.2006.11.012_bib40","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1073\/pnas.022652799","article-title":"West Nile virus\/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacy","volume":"99","author":"Pletnev","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.virol.2006.11.012_bib41","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0042-6822(91)90540-R","article-title":"Processing of nonstructural proteins NS4A and NS4B of dengue 2 virus in vitro and in vivo","volume":"185","author":"Preugschat","year":"1991","journal-title":"Virology"},{"issue":"9","key":"10.1016\/j.virol.2006.11.012_bib42","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1128\/jvi.64.9.4364-4374.1990","article-title":"In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3","volume":"64","author":"Preugschat","year":"1990","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2006.11.012_bib43","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1128\/JVI.78.2.1032-1038.2004","article-title":"High fidelity of yellow fever virus RNA polymerase","volume":"78","author":"Pugachev","year":"2004","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.virol.2006.11.012_bib44","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1128\/AAC.49.12.4980-4988.2005","article-title":"High-throughput assays using luciferase-expressing replicon, virus-like particle, and full-length virus for West Nile virus drug discovery","volume":"49","author":"Puig-Basagoiti","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.virol.2006.11.012_bib45","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1128\/AAC.50.4.1320-1329.2006","article-title":"Triaryl pyrazoline compound inhibits flavivirus RNA replication","volume":"50","author":"Puig-Basagoiti","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.virol.2006.11.012_bib46","doi-asserted-by":"crossref","first-page":"10651","DOI":"10.1128\/JVI.75.22.10651-10662.2001","article-title":"Isolation and characterization of noncytopathic pestivirus mutants reveals a role for nonstructural protein NS4B in viral cytopathogenicity","volume":"75","author":"Qu","year":"2001","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2006.11.012_bib47","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.virol.2004.10.046","article-title":"Adaptation of West Nile virus replicons to cells in culture and use of replicon-bearing cells to probe antiviral action","volume":"331","author":"Rossi","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.virol.2006.11.012_bib48","first-page":"53","article-title":"PHD\u2014an automatic mail server for protein secondary structure prediction","volume":"10","author":"Rost","year":"1994","journal-title":"Comput. Appl. Biosci."},{"key":"10.1016\/j.virol.2006.11.012_bib49","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1146\/annurev.micro.53.1.577","article-title":"Viruses and apoptosis","volume":"53","author":"Roulston","year":"1999","journal-title":"Annu. Rev. Microbiol."},{"issue":"21","key":"10.1016\/j.virol.2006.11.012_bib50","doi-asserted-by":"crossref","first-page":"11605","DOI":"10.1128\/JVI.78.21.11605-11614.2004","article-title":"trans-Packaged West Nile virus-like particles: infectious properties in vitro and in infected mosquito vectors","volume":"78","author":"Scholle","year":"2004","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.virol.2006.11.012_bib51","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1128\/JCM.39.4.1264-1271.2001","article-title":"High-throughput detection of West Nile virus RNA","volume":"39","author":"Shi","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2006.11.012_bib52","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/viro.2002.1453","article-title":"Construction and characterization of subgenomic replicons of New York strain of West Nile virus","volume":"296","author":"Shi","year":"2002","journal-title":"Virology"},{"issue":"12","key":"10.1016\/j.virol.2006.11.012_bib53","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1128\/JVI.76.12.5847-5856.2002","article-title":"Infectious cDNA clone of the epidemic West Nile virus from New York City","volume":"76","author":"Shi","year":"2002","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.virol.2006.11.012_bib54","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3201\/eid0812.020224","article-title":"Induction of inflammation by West Nile virus capsid through the caspase-9 apoptotic pathway","volume":"8","author":"Yang","year":"2002","journal-title":"Emerging Infect. Dis."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682206008415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682206008415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:46:11Z","timestamp":1758584771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682206008415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0042682206008415"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2006.11.012","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2006.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}