{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:51:26Z","timestamp":1783086686624,"version":"3.54.6"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2146,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.virol.2007.04.016","type":"journal-article","created":{"date-parts":[[2007,5,24]],"date-time":"2007-05-24T03:39:32Z","timestamp":1179977972000},"page":"51-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["JE Nakayama\/JE SA14-14-2 virus structural region intertypic viruses: Biological properties in the mouse model of neuroinvasive disease"],"prefix":"10.1016","volume":"366","author":[{"given":"Thomas J.","family":"Chambers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Droll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.M.","family":"Wold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice A.","family":"Nickells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2007.04.016_bib1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00571925","article-title":"Identification of mutations that occurred on the genome of Japanese encephalitis virus during the attenuation process","volume":"5","author":"Aihara","year":"1991","journal-title":"Virus Genes"},{"key":"10.1016\/j.virol.2007.04.016_bib2","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1128\/JVI.75.2.934-942.2001","article-title":"Molecular basis for attenuation of neurovirulence of a yellow fever Virus\/Japanese encephalitis virus chimera vaccine (ChimeriVax-JE)","volume":"75","author":"Arroyo","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0042-6822(88)90468-0","article-title":"Sequence and secondary structure analysis of the 5\u2032-terminal region of flavivirus genome RNA","volume":"162","author":"Brinton","year":"1988","journal-title":"Virology"},{"key":"10.1016\/j.virol.2007.04.016_bib4","series-title":"The Arboviruses: Epidemiology and Ecology","first-page":"63","article-title":"Japanese encephalitis","author":"Burke","year":"1988"},{"key":"10.1016\/j.virol.2007.04.016_bib5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1006\/viro.1995.1052","article-title":"Growth-restricted dengue virus mutants containing deletions in the 5\u2032 noncoding region of the RNA genome","volume":"207","author":"Cahour","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.virol.2007.04.016_bib6","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1099\/0022-1317-76-11-2757","article-title":"Passage of Japanese encephalitis virus in HeLa cells results in attenuation of virulence in mice","volume":"76","author":"Cao","year":"1995","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0042-6822(91)90471-M","article-title":"Nucleotide changes responsible for loss of neuroinvasiveness in Japanese encephalitis virus neutralization-resistant mutants","volume":"181","author":"Cecilia","year":"1991","journal-title":"Virology"},{"key":"10.1016\/j.virol.2007.04.016_bib8","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1128\/JVI.73.4.3095-3101.1999","article-title":"Yellow fever\/Japanese encephalitis chimeric viruses: construction and biological properties","volume":"73","author":"Chambers","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib9","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1099\/vir.0.81909-0","article-title":"Chimeric Japanese encephalitis virus\/dengue-2 virus infectious clone : biological properties, immunogenicity and protection against dengue encephalitis in mice","volume":"87","author":"Chambers","year":"2006","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib10","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/0264-410X(88)90103-X","article-title":"Japanese encephalitis virus live attenuated vaccine, Chinese strain SA14-14-2: adaptation to primary canine kidney cell cultures and preparation of a vaccine for human use","volume":"6","author":"Eckels","year":"1988","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2007.04.016_bib11","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","article-title":"SWISS-MODEL and the Swiss-Pdb viewer: an environment for comparative protein modelling","volume":"18","author":"Guex","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.virol.2007.04.016_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0065-3527(03)61003-1","article-title":"Japanese encephalitis","volume":"61","author":"Halstead","year":"2003","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.virol.2007.04.016_bib13","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0042-6822(92)90177-Q","article-title":"Mutations in the envelope protein of Japanese encephalitis virus affect entry into cultured cells and virulence in mice","volume":"191","author":"Hasegawa","year":"1992","journal-title":"Virology"},{"key":"10.1016\/j.virol.2007.04.016_bib14","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1128\/JVI.76.7.3534-3543.2002","article-title":"Capsid protein C of tick-borne encephalitis virus tolerates large internal deletions and is a favorable target for attenuation of virulence","volume":"76","author":"Kofler","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1128\/JVI.77.1.443-451.2003","article-title":"Spontaneous mutations restore the viability of tick-borne encephalitis virus mutants with large deletions in protein C","volume":"77","author":"Kofler","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib16","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.1128\/JVI.73.7.5527-5534.1999","article-title":"Anamnestic neutralizing antibody response is critical for protection of mice from challenge following vaccination with a plasmid encoding Japanese encephalitis virus premembrane and envelope genes","volume":"73","author":"Konishi","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib17","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1128\/JVI.76.10.4901-4911.2002","article-title":"Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus","volume":"76","author":"Lee","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib18","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1073\/pnas.0305892101","article-title":"Solution structure of dengue virus capsid protein reveals another fold","volume":"101","author":"Ma","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"12 Suppl","key":"10.1016\/j.virol.2007.04.016_bib19","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1038\/nm1144","article-title":"Emerging flaviviruses: the spread and resurgence of Japanese encephalitis, West Nile and dengue viruses","volume":"10","author":"Mackenzie","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.virol.2007.04.016_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.idc.2004.11.004","article-title":"Yellow fever and Japanese encephalitis vaccines: indications and complications","volume":"19","author":"Marfin","year":"2005","journal-title":"Infect. Dis. Clin. North Am."},{"key":"10.1016\/j.virol.2007.04.016_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0065-3527(03)59006-6","article-title":"5\u2032- and 3\u2032-noncoding regions in flavivirus RNA","volume":"59","author":"Markoff","year":"2003","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.virol.2007.04.016_bib22","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1099\/vir.0.80120-0","article-title":"Fusion PCR generated Japanese encephalitis virus\/dengue 4 virus chimera exhibits lack of neuroinvasiveness, attenuated neurovirulence, and a dual-flavi immune response in mice","volume":"85","author":"Mathenge","year":"2004","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib23","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1006\/jmbi.1999.2700","article-title":"Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure","volume":"288","author":"Mathews","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.virol.2007.04.016_bib24","series-title":"Fields Virology","first-page":"961","article-title":"Flaviviruses","author":"Monath","year":"1996"},{"key":"10.1016\/j.virol.2007.04.016_bib25","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1099\/0022-1317-77-7-1449","article-title":"Molecular differences between wild-type Japanese encephalitis virus strains of high and low mouse neuroinvasiveness","volume":"77","author":"Ni","year":"1996","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/viro.1997.8956","article-title":"Attenuation of Japanese encephalitis virus by selection of its mouse brain membrane receptor preparation escape variants","volume":"241","author":"Ni","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.virol.2007.04.016_bib27","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1099\/0022-1317-75-6-1505","article-title":"Comparison nucleotide and deduced amino acid sequence of the 5\u2032 non-coding region and structural protein genes of the wild-type Japanese encephalitis virus strain SA14 and its attenuated vaccine derivatives","volume":"75","author":"Ni","year":"1994","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib28","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1099\/0022-1317-76-2-409","article-title":"Molecular basis of attenuation of neurovirulence of wild-type Japanese encephalitis virus strain SA14","volume":"76","author":"Ni","year":"1995","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib29","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0042-6822(90)90519-W","article-title":"Nucleotide sequence of the virulent SA-14 strain of Japanese encephalitis virus and its attenuated vaccine derivative, SA14-14-2","volume":"177","author":"Nitayaphan","year":"1990","journal-title":"Virology"},{"key":"10.1016\/j.virol.2007.04.016_bib30","first-page":"658","article-title":"Protein modeling by E-mail","volume":"13","author":"Peitsch","year":"1995","journal-title":"Bio\/Technology"},{"key":"10.1016\/j.virol.2007.04.016_bib31","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Hyg."},{"key":"10.1016\/j.virol.2007.04.016_bib32","first-page":"285","article-title":"Transcription of infectious yellow fever virus RNA from full-length cDNA templates produced by in vitro ligation","volume":"1","author":"Rice","year":"1989","journal-title":"New Biol."},{"key":"10.1016\/j.virol.2007.04.016_bib33","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1099\/0022-1317-77-6-1277","article-title":"Replication of yellow fever virus in the mouse central nervous system; comparison of neuroadapted and nonneuroadapted virus and partial sequence analysis of the neuroadapted strain","volume":"77","author":"Schlesinger","year":"1996","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib34","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1093\/nar\/gkg520","article-title":"SWISS-MODEL an automated protein homology-modeling server","volume":"31","author":"Schwede","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.virol.2007.04.016_bib35","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.68.4.405","article-title":"Japanese encephalitis","volume":"68","author":"Solomon","year":"2000","journal-title":"J. Neurol., Neurosurg. Psychiatry"},{"key":"10.1016\/j.virol.2007.04.016_bib37","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/infdis\/171.5.1144","article-title":"Characterization of a highly attenuated Japanese encephalitis virus generated from molecularly cloned cDNA","volume":"171","author":"Sumiyoshi","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2007.04.016_bib38","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1016\/S0264-410X(00)00111-0","article-title":"Adverse events after Japanese encephalitis vaccination: review of post-marketing surveillance data from Japan and the United States","volume":"18","author":"Takahashi","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2007.04.016_bib39","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1099\/vir.0.19462-0","article-title":"Conserved RNA secondary structures in Flaviviridae genomes","volume":"85","author":"Thurner","year":"2004","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib40","series-title":"Vaccines","first-page":"671","article-title":"Japanese encephalitis vaccines","author":"Tsai","year":"1994"},{"key":"10.1016\/j.virol.2007.04.016_bib41","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1099\/vir.0.80638-0","article-title":"Characterization of the E-138 (Glu\/Lys) mutation in Japanese encephalitis virus by using a stable, full-length, infectious cDNA clone","volume":"86","author":"Zhao","year":"2005","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2007.04.016_bib42","series-title":"RNA Biochemistry, NATO ASI Series","first-page":"11","article-title":"Algorithms and thermodynamics for RNA secondary structure predictions: a practical guide","author":"Zuker","year":"1999"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682207002619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682207002619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:48:34Z","timestamp":1758584914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682207002619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0042682207002619"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2007.04.016","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"JE Nakayama\/JE SA14-14-2 virus structural region intertypic viruses: Biological properties in the mouse model of neuroinvasive disease","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2007.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}