{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:45:32Z","timestamp":1759063532316,"version":"3.44.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2055,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.virol.2007.06.048","type":"journal-article","created":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T08:05:32Z","timestamp":1187942732000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["The degradation pathway for the HBV envelope proteins involves proteolysis prior to degradation via the cytosolic proteasome"],"prefix":"10.1016","volume":"369","author":[{"given":"Yuanjie","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianlun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ender","family":"Simsek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Block","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.virol.2007.06.048_bib1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1084\/jem.186.4.479","volume":"186","author":"Bacik","year":"1997","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.virol.2007.06.048_bib2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.111.3.857","article-title":"Quality control in the endoplasmic reticulum: folding and misfolding of vesicular stomatitis virus G protein in cells and in vitro","volume":"111","author":"de Silva","year":"1990","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.virol.2007.06.048_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev.bi.62.070193.000433","article-title":"Analysis of glycoprotein-associated oligosaccharides","volume":"62","author":"Dwek","year":"1993","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.virol.2007.06.048_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrd708","article-title":"Targeting glycosylation as a therapeutic approach","volume":"1","author":"Dwek","year":"2002","journal-title":"Nat. Rev., Drug Discov."},{"key":"10.1016\/j.virol.2007.06.048_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-3-7091-5633-9_28","article-title":"Functions of hepatitis B surface proteins","volume":"4","author":"Gerlich","year":"1992","journal-title":"Arch. Virol., Suppl."},{"key":"10.1016\/j.virol.2007.06.048_bib6","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1146\/annurev.biochem.73.011303.073752","article-title":"Roles of N-linked glycans in the endoplasmic reticulum","volume":"73","author":"Helenius","year":"2004","journal-title":"Annu. Rev. Biochem."},{"issue":"5","key":"10.1016\/j.virol.2007.06.048_bib7","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/emboj\/cdg107","article-title":"A role for N-glycanase in the cytosolic turnover of glycoproteins","volume":"22","author":"Hirsch","year":"2003","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.virol.2007.06.048_bib8","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1093\/carcin\/bgh207","article-title":"Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage","volume":"25","author":"Hsieh","year":"2004","journal-title":"Carcinogenesis"},{"issue":"17","key":"10.1016\/j.virol.2007.06.048_bib9","doi-asserted-by":"crossref","first-page":"7522","DOI":"10.1128\/MCB.25.17.7522-7533.2005","article-title":"Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress","volume":"25","author":"Huang","year":"2005","journal-title":"Mol. Cell. Biol."},{"issue":"45","key":"10.1016\/j.virol.2007.06.048_bib10","doi-asserted-by":"crossref","first-page":"46384","DOI":"10.1074\/jbc.M403568200","article-title":"Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase","volume":"279","author":"Hung","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.virol.2007.06.048_bib11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1006\/viro.1995.1435","article-title":"Secretion and antigenicity of hepatitis B virus small envelope proteins lacking cysteines in the major antigenic region","volume":"211","author":"Mangold","year":"1995","journal-title":"Virology"},{"issue":"11","key":"10.1016\/j.virol.2007.06.048_bib12","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1007\/s007050050240","article-title":"Analysis of intermolecular disulfide bonds and free sulfhydryl groups in hepatitis B surface antigen particles","volume":"142","author":"Mangold","year":"1997","journal-title":"Arch. Virol."},{"issue":"3","key":"10.1016\/j.virol.2007.06.048_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1083\/jcb.132.3.291","article-title":"Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP","volume":"132","author":"McCracken","year":"1996","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.virol.2007.06.048_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/gb-2000-1-2-reviews1013","article-title":"A molecular portrait of the response to unfolded proteins","volume":"1","author":"McCracken","year":"2000","journal-title":"Genome Biol."},{"issue":"9","key":"10.1016\/j.virol.2007.06.048_bib15","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/bies.10320","article-title":"Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD)","volume":"25","author":"McCracken","year":"2003","journal-title":"BioEssays"},{"issue":"6","key":"10.1016\/j.virol.2007.06.048_bib16","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1128\/AAC.48.6.2085-2090.2004","article-title":"Alpha-galactosylceramide and novel synthetic glycolipids directly induce the innate host defense pathway and have direct activity against hepatitis B and C viruses","volume":"48","author":"Mehta","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"issue":"8","key":"10.1016\/j.virol.2007.06.048_bib17","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/ncb0805-766","article-title":"ERAD: the long road to destruction","volume":"7","author":"Meusser","year":"2005","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.virol.2007.06.048_bib18","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1172\/JCI0216787","article-title":"Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury","volume":"110","author":"Perlmutter","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.virol.2007.06.048_bib19","doi-asserted-by":"crossref","first-page":"6147","DOI":"10.4049\/jimmunol.164.12.6147","article-title":"The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses","volume":"164","author":"Schwarz","year":"2000","journal-title":"J. Immunol."},{"issue":"Pt 11","key":"10.1016\/j.virol.2007.06.048_bib20","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1099\/0022-1317-75-11-3031","article-title":"Biogenesis of the hepatitis B viral middle (M) surface protein in a human hepatoma cell line: demonstration of an alternative secretion pathway","volume":"75","author":"Sheu","year":"1994","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2007.06.048_bib21","first-page":"165","article-title":"Detection of hypermodified middle-envelope (M) proteins secreted from naturally occurring HBV variants containing a preS2 internal deletion","volume":"95","author":"Shih","year":"2004","journal-title":"Methods Mol. Med."},{"issue":"20","key":"10.1016\/j.virol.2007.06.048_bib22","doi-asserted-by":"crossref","first-page":"12914","DOI":"10.1128\/JVI.79.20.12914-12920.2005","article-title":"Hepatitis B virus large and middle glycoproteins are degraded by a proteasome pathway in glucosidase-inhibited cells but not in cells with functional glucosidase enzyme","volume":"79","author":"Simsek","year":"2005","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2007.06.048_bib23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1006\/viro.2001.1239","article-title":"Hypermodification and immune escape of an internally deleted middle-envelope (M) protein of frequent and predominant hepatitis B virus variants","volume":"292","author":"Tai","year":"2002","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.virol.2007.06.048_bib24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/hep.20615","article-title":"Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes","volume":"41","author":"Wang","year":"2005","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.virol.2007.06.048_bib25","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1349-7006.2006.00235.x","article-title":"Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis","volume":"97","author":"Wang","year":"2006","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.virol.2007.06.048_bib26","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/JVI.72.1.778-782.1998","article-title":"Role for calnexin and N-linked glycosylation in the assembly and secretion of hepatitis B virus middle envelope protein particles","volume":"72","author":"Werr","year":"1998","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.virol.2007.06.048_bib27","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1128\/jvi.71.7.5487-5494.1997","article-title":"Formation of intracellular particles by hepatitis B virus large surface protein","volume":"71","author":"Xu","year":"1997","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.virol.2007.06.048_bib28","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.1128\/jvi.71.10.7387-7392.1997","article-title":"Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum","volume":"71","author":"Xu","year":"1997","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.virol.2007.06.048_bib29","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.4049\/jimmunol.157.5.1823","article-title":"Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?","volume":"157","author":"Yewdell","year":"1996","journal-title":"J. Immunol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682207004680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682207004680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:49:46Z","timestamp":1758584986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682207004680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0042682207004680"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2007.06.048","relation":{},"ISSN":["0042-6822"],"issn-type":[{"type":"print","value":"0042-6822"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The degradation pathway for the HBV envelope proteins involves proteolysis prior to degradation via the cytosolic proteasome","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2007.06.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}