{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:37:18Z","timestamp":1776451038390,"version":"3.51.2"},"reference-count":69,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1993,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.virol.2007.10.009","type":"journal-article","created":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T17:17:07Z","timestamp":1196788627000},"page":"257-266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["An auto-regulatory loop for EBV LMP2A involves activation of Notch"],"prefix":"10.1016","volume":"371","author":[{"given":"Leah J.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Longnecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Pt 10","key":"10.1016\/j.virol.2007.10.009_bib1","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1099\/vir.0.81906-0","article-title":"Analysis of Epstein\u2013Barr virus latent gene expression in endemic Burkitt's lymphoma and nasopharyngeal carcinoma tumour cells by using quantitative real-time PCR assays","volume":"87","author":"Bell","year":"2006","journal-title":"J. Gen. Virol."},{"issue":"8","key":"10.1016\/j.virol.2007.10.009_bib2","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1128\/jvi.66.8.5161-5167.1992","article-title":"An Epstein\u2013Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases","volume":"66","author":"Burkhardt","year":"1992","journal-title":"J. Virol."},{"issue":"19","key":"10.1016\/j.virol.2007.10.009_bib3","doi-asserted-by":"crossref","first-page":"9697","DOI":"10.1128\/JVI.00746-06","article-title":"Kaposi's sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk\/CSL to activate the Notch pathway","volume":"80","author":"Carroll","year":"2006","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.virol.2007.10.009_bib4","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1128\/JVI.77.7.4139-4148.2003","article-title":"A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein\u2013Barr virus","volume":"77","author":"Chen","year":"2003","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2007.10.009_bib5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1182\/blood.V94.2.411","article-title":"Reed-Sternberg cell genome expression supports a B-cell lineage","volume":"94","author":"Cossman","year":"1999","journal-title":"Blood"},{"issue":"Pt 11","key":"10.1016\/j.virol.2007.10.009_bib6","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1099\/0022-1317-70-11-2989","article-title":"The role of methylation in the phenotype-dependent modulation of Epstein\u2013Barr nuclear antigen 2 and latent membrane protein genes in cells latently infected with Epstein\u2013Barr virus","volume":"70","author":"Ernberg","year":"1989","journal-title":"J. Gen. Virol."},{"issue":"2","key":"10.1016\/j.virol.2007.10.009_bib8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/viro.1997.8690","article-title":"The immunoreceptor tyrosine-based activation motif of Epstein\u2013Barr virus LMP2A is essential for blocking BCR-mediated signal transduction","volume":"235","author":"Fruehling","year":"1997","journal-title":"Virology"},{"issue":"9","key":"10.1016\/j.virol.2007.10.009_bib7","doi-asserted-by":"crossref","first-page":"6216","DOI":"10.1128\/jvi.70.9.6216-6226.1996","article-title":"Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction","volume":"70","author":"Fruehling","year":"1996","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.virol.2007.10.009_bib9","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.1128\/JVI.72.10.7796-7806.1998","article-title":"Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein\u2013Barr virus latency","volume":"72","author":"Fruehling","year":"1998","journal-title":"J. Virol."},{"issue":"17","key":"10.1016\/j.virol.2007.10.009_bib10","doi-asserted-by":"crossref","first-page":"9299","DOI":"10.1128\/JVI.00537-07","article-title":"Epstein\u2013Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras\/PI3-K\/Akt Pathway","volume":"81","author":"Fukuda","year":"2007","journal-title":"J. Virol."},{"issue":"13","key":"10.1016\/j.virol.2007.10.009_bib11","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1128\/JVI.75.13.5899-5912.2001","article-title":"Notch1IC partially replaces EBNA2 function in B cells immortalized by Epstein\u2013Barr virus","volume":"75","author":"Gordadze","year":"2001","journal-title":"J. Virol."},{"issue":"16","key":"10.1016\/j.virol.2007.10.009_bib12","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1073\/pnas.91.16.7568","article-title":"The Epstein\u2013Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding protein","volume":"91","author":"Grossman","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.virol.2007.10.009_bib14","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1128\/JVI.73.4.2770-2780.1999","article-title":"Activated mouse Notch1 transactivates Epstein\u2013Barr virus nuclear antigen 2-regulated viral promoters","volume":"73","author":"Hofelmayr","year":"1999","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.virol.2007.10.009_bib13","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1128\/JVI.75.5.2033-2040.2001","article-title":"Activated Notch1 can transiently substitute for EBNA2 in the maintenance of proliferation of LMP1-expressing immortalized B cells","volume":"75","author":"Hofelmayr","year":"2001","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2007.10.009_bib15","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1128\/jvi.71.3.1938-1945.1997","article-title":"Epstein\u2013Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation","volume":"71","author":"Hsieh","year":"1997","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.virol.2007.10.009_bib16","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1128\/MCB.02256-06","article-title":"Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination","volume":"27","author":"Huye","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.virol.2007.10.009_bib17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1006\/viro.1999.0166","article-title":"The Epstein\u2013Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases","volume":"268","author":"Ikeda","year":"2000","journal-title":"Virology"},{"issue":"12","key":"10.1016\/j.virol.2007.10.009_bib18","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1128\/JVI.75.12.5711-5718.2001","article-title":"PY motifs of Epstein\u2013Barr virus LMP2A regulate protein stability and phosphorylation of LMP2A-associated proteins","volume":"75","author":"Ikeda","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2007.10.009_bib19","series-title":"Epstein Barr Virus","author":"Ikeda","year":"2005"},{"issue":"10","key":"10.1016\/j.virol.2007.10.009_bib20","doi-asserted-by":"crossref","first-page":"8033","DOI":"10.1074\/jbc.M108552200","article-title":"c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1","volume":"277","author":"Jehn","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.virol.2007.10.009_bib21","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1182\/blood.V99.9.3398","article-title":"Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma","volume":"99","author":"Jundt","year":"2002","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.virol.2007.10.009_bib22","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1182\/blood.V99.8.3060","article-title":"Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease","volume":"99","author":"Jundt","year":"2002","journal-title":"Blood"},{"issue":"24","key":"10.1016\/j.virol.2007.10.009_bib23","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1038\/sj.onc.1205487","article-title":"Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations","volume":"21","author":"Kawamata","year":"2002","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.virol.2007.10.009_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/path.1711740302","article-title":"The role of Epstein\u2013Barr virus in the pathogenesis of Hodgkin's disease","volume":"174","author":"Khan","year":"1994","journal-title":"J. Pathol."},{"key":"10.1016\/j.virol.2007.10.009_bib25","article-title":"Epstein\u2013Barr Virus and its Replication","volume":"vol. II","author":"Kieff","year":"2007"},{"issue":"Pt 6","key":"10.1016\/j.virol.2007.10.009_bib26","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1099\/0022-1317-82-6-1451","article-title":"Role of Epstein\u2013Barr virus-encoded latent membrane protein 2A on virus-induced immortalization and virus activation","volume":"82","author":"Konishi","year":"2001","journal-title":"J. Gen. Virol."},{"issue":"Suppl 1","key":"10.1016\/j.virol.2007.10.009_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/annonc\/13.S1.11","article-title":"Biology of Hodgkin's lymphoma","volume":"13","author":"Kuppers","year":"2002","journal-title":"Ann. Oncol."},{"issue":"9","key":"10.1016\/j.virol.2007.10.009_bib28","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1128\/jvi.68.9.5375-5383.1994","article-title":"EBNA-2 upregulation of Epstein\u2013Barr virus latency promoters and the cellular CD23 promoter utilizes a common targeting intermediate, CBF1","volume":"68","author":"Ling","year":"1994","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.virol.2007.10.009_bib29","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1158\/0008-5472.CAN-05-3589","article-title":"Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase\/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression","volume":"66","author":"Liu","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.virol.2007.10.009_bib30","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0065-230X(00)79006-3","article-title":"Epstein\u2013Barr virus latency: LMP2, a regulator or means for Epstein\u2013Barr virus persistence?","volume":"79","author":"Longnecker","year":"2000","journal-title":"Adv. Cancer Res."},{"issue":"7","key":"10.1016\/j.virol.2007.10.009_bib31","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1128\/jvi.65.7.3681-3692.1991","article-title":"An Epstein\u2013Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase","volume":"65","author":"Longnecker","year":"1991","journal-title":"J. Virol."},{"issue":"13","key":"10.1016\/j.virol.2007.10.009_bib32","doi-asserted-by":"crossref","first-page":"8806","DOI":"10.1074\/jbc.M507305200","article-title":"Syk tyrosine kinase mediates Epstein\u2013Barr virus latent membrane protein 2A-induced cell migration in epithelial cells","volume":"281","author":"Lu","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.virol.2007.10.009_bib33","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1074-7613(03)00325-X","article-title":"Notch and the immune system","volume":"19","author":"Maillard","year":"2003","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.virol.2007.10.009_bib34","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1128\/jvi.63.7.3135-3141.1989","article-title":"5-Azacytidine up regulates the expression of Epstein\u2013Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line rael","volume":"63","author":"Masucci","year":"1989","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2007.10.009_bib35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ni1285","article-title":"Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma","volume":"7","author":"Mathas","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.virol.2007.10.009_bib36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2121-7-10","article-title":"Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals","volume":"7","author":"McKenzie","year":"2006","journal-title":"BMC Cell Biol."},{"issue":"19","key":"10.1016\/j.virol.2007.10.009_bib37","doi-asserted-by":"crossref","first-page":"9115","DOI":"10.1128\/JVI.74.19.9115-9124.2000","article-title":"The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo","volume":"74","author":"Merchant","year":"2000","journal-title":"J. Virol."},{"issue":"22","key":"10.1016\/j.virol.2007.10.009_bib38","doi-asserted-by":"crossref","first-page":"12276","DOI":"10.1128\/JVI.77.22.12276-12284.2003","article-title":"Epstein\u2013Barr virus latent membrane protein 2A activates beta-catenin signaling in epithelial cells","volume":"77","author":"Morrison","year":"2003","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.virol.2007.10.009_bib39","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1128\/JVI.79.4.2375-2382.2005","article-title":"Roles of the ITAM and PY motifs of Epstein\u2013Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling","volume":"79","author":"Morrison","year":"2005","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2007.10.009_bib40","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1158\/0008-5472.CAN-05-3830","article-title":"Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53","volume":"66","author":"Mungamuri","year":"2006","journal-title":"Cancer Res."},{"issue":"17","key":"10.1016\/j.virol.2007.10.009_bib41","doi-asserted-by":"crossref","first-page":"9359","DOI":"10.1128\/JVI.77.17.9359-9368.2003","article-title":"Interferon regulatory factor 7 regulates expression of Epstein\u2013Barr virus latent membrane protein 1: a regulatory circuit","volume":"77","author":"Ning","year":"2003","journal-title":"J. Virol."},{"issue":"18","key":"10.1016\/j.virol.2007.10.009_bib42","doi-asserted-by":"crossref","first-page":"11671","DOI":"10.1128\/JVI.79.18.11671-11676.2005","article-title":"Interferon regulatory factor 5 represses expression of the Epstein\u2013Barr virus oncoprotein LMP1: braking of the IRF7\/LMP1 regulatory circuit","volume":"79","author":"Ning","year":"2005","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.virol.2007.10.009_bib43","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1074-7613(00)80140-5","article-title":"Notch and the immune system","volume":"11","author":"Osborne","year":"1999","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.virol.2007.10.009_bib44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/viro.2002.1457","article-title":"Methylation of the EBV genome and establishment of restricted latency in low-passage EBV-infected 293 epithelial cells","volume":"299","author":"Paulson","year":"2002","journal-title":"Virology"},{"issue":"12","key":"10.1016\/j.virol.2007.10.009_bib45","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1182\/blood-2003-04-1018","article-title":"Epstein\u2013Barr virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma","volume":"102","author":"Portis","year":"2003","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.virol.2007.10.009_bib46","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.it.2004.05.009","article-title":"Epstein\u2013Barr virus LMP2A: regulating cellular ubiquitination processes for maintenance of viral latency?","volume":"25","author":"Portis","year":"2004","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.virol.2007.10.009_bib47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1128\/JVI.77.1.105-114.2003","article-title":"Epstein\u2013Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development","volume":"77","author":"Portis","year":"2003","journal-title":"J. Virol."},{"issue":"53","key":"10.1016\/j.virol.2007.10.009_bib48","doi-asserted-by":"crossref","first-page":"8619","DOI":"10.1038\/sj.onc.1207905","article-title":"Epstein\u2013Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras\/PI3K\/Akt pathway","volume":"23","author":"Portis","year":"2004","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.virol.2007.10.009_bib49","first-page":"297","article-title":"Epstein\u2013Barr virus and nasopharyngeal carcinoma","volume":"3","author":"Raab-Traub","year":"1992","journal-title":"Semin. Cancer Biol."},{"issue":"4","key":"10.1016\/j.virol.2007.10.009_bib50","first-page":"173","article-title":"Epstein\u2013Barr virus infection in nasopharyngeal carcinoma","volume":"1","author":"Raab-Traub","year":"1992","journal-title":"Infect. Agents Dis."},{"issue":"4","key":"10.1016\/j.virol.2007.10.009_bib51","first-page":"449","article-title":"EBV associated malignancies","volume":"3","author":"Raab-Traub","year":"1987","journal-title":"J. Exp. Pathol."},{"issue":"Pt 5","key":"10.1016\/j.virol.2007.10.009_bib52","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1099\/vir.0.82790-0","article-title":"Silencing of latent membrane protein 2B reduces susceptibility to activation of lytic Epstein\u2013Barr virus in Burkitt's lymphoma Akata cells","volume":"88","author":"Rechsteiner","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2007.10.009_bib53","article-title":"Epstein\u2013Barr virus","volume":"vol. II","author":"Rickinson","year":"2007"},{"issue":"11","key":"10.1016\/j.virol.2007.10.009_bib54","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1182\/blood.V90.11.4480","article-title":"Methylation of the Epstein\u2013Barr virus genome in normal lymphocytes","volume":"90","author":"Robertson","year":"1997","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.virol.2007.10.009_bib56","doi-asserted-by":"crossref","first-page":"6550","DOI":"10.1073\/pnas.88.15.6550","article-title":"Exclusive expression of Epstein\u2013Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes","volume":"88","author":"Schaefer","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.virol.2007.10.009_bib55","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1128\/MCB.17.1.364","article-title":"Host-cell-determined methylation of specific Epstein\u2013Barr virus promoters regulates the choice between distinct viral latency programs","volume":"17","author":"Schaefer","year":"1997","journal-title":"Mol. Cell. Biol."},{"issue":"22","key":"10.1016\/j.virol.2007.10.009_bib57","doi-asserted-by":"crossref","first-page":"10681","DOI":"10.1128\/JVI.74.22.10681-10689.2000","article-title":"Epstein\u2013Barr virus LMP2A transforms epithelial cells, inhibits cell differentiation, and activates Akt","volume":"74","author":"Scholle","year":"2000","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.virol.2007.10.009_bib58","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1128\/JVI.73.6.4767-4775.1999","article-title":"Epithelial cell adhesion to extracellular matrix proteins induces tyrosine phosphorylation of the Epstein\u2013Barr virus latent membrane protein 2: a role for C-terminal Src kinase","volume":"73","author":"Scholle","year":"1999","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2007.10.009_bib59","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/viro.2001.1197","article-title":"Analysis of the phosphorylation status of Epstein\u2013Barr virus LMP2A in epithelial cells","volume":"291","author":"Scholle","year":"2001","journal-title":"Virology"},{"issue":"6683","key":"10.1016\/j.virol.2007.10.009_bib60","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/30756","article-title":"Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain","volume":"393","author":"Schroeter","year":"1998","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.virol.2007.10.009_bib61","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1074-7613(02)00472-7","article-title":"Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1","volume":"17","author":"Souabni","year":"2002","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.virol.2007.10.009_bib62","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1128\/JVI.74.4.1727-1735.2000","article-title":"Activated Notch1 modulates gene expression in B cells similarly to Epstein\u2013Barr viral nuclear antigen 2","volume":"74","author":"Strobl","year":"2000","journal-title":"J. Virol."},{"issue":"22","key":"10.1016\/j.virol.2007.10.009_bib63","doi-asserted-by":"crossref","first-page":"10838","DOI":"10.1128\/JVI.74.22.10838-10845.2000","article-title":"Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-kinase\/Akt pathway","volume":"74","author":"Swart","year":"2000","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.virol.2007.10.009_bib64","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1182\/blood.V91.4.1373","article-title":"Epstein\u2013Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue","volume":"91","author":"Tao","year":"1998","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.virol.2007.10.009_bib65","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jaci.2005.05.038","article-title":"EBV the prototypical human tumor virus\u2014just how bad is it?","volume":"116","author":"Thorley-Lawson","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"issue":"13","key":"10.1016\/j.virol.2007.10.009_bib66","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1056\/NEJMra032015","article-title":"Persistence of the Epstein\u2013Barr virus and the origins of associated lymphomas","volume":"350","author":"Thorley-Lawson","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.virol.2007.10.009_bib67","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/ijc.10372","article-title":"Promiscuous expression of Epstein\u2013Barr virus genes in Burkitt's lymphoma from the central African country Malawi","volume":"99","author":"Xue","year":"2002","journal-title":"Int. J. Cancer"},{"issue":"Pt 5","key":"10.1016\/j.virol.2007.10.009_bib68","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1099\/0022-1317-69-5-1051","article-title":"Epstein\u2013Barr virus gene expression in nasopharyngeal carcinoma","volume":"69","author":"Young","year":"1988","journal-title":"J. Gen. Virol."},{"issue":"1","key":"10.1016\/j.virol.2007.10.009_bib69","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1128\/jvi.65.1.415-423.1991","article-title":"Epstein\u2013Barr virus nuclear antigen 2 activates transcription of the terminal protein gene","volume":"65","author":"Zimber-Strobl","year":"1991","journal-title":"J. Virol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682207006666?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682207006666?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:56:42Z","timestamp":1758585402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682207006666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0042682207006666"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2007.10.009","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An auto-regulatory loop for EBV LMP2A involves activation of Notch","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2007.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}