{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:08:41Z","timestamp":1791425321572,"version":"4.3.3"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1878,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.virol.2008.03.028","type":"journal-article","created":{"date-parts":[[2008,5,4]],"date-time":"2008-05-04T01:38:40Z","timestamp":1209865120000},"page":"429-435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":188,"title":["Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever"],"prefix":"10.1016","volume":"376","author":[{"given":"Anna P.","family":"Durbin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberli","family":"Wanionek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha N.","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubree","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crisanta","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Balmaseda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2008.03.028_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1574-695X.2003.tb00646.x","article-title":"Anti-TNF antibody treatment reduces mortality in experimental dengue virus infection","volume":"35","author":"Atrasheuskaya","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.virol.2008.03.028_bib2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1078\/0171-2985-00058","article-title":"Characterisation of lymphocyte response and cytokine patterns in patients with dengue fever","volume":"204","author":"Azeredo","year":"2001","journal-title":"Immunobiology"},{"key":"10.1016\/j.virol.2008.03.028_bib3","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1365-3156.2006.01641.x","article-title":"High seroprevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua","volume":"11","author":"Balmaseda","year":"2006","journal-title":"Trop. Med. Int. Health."},{"key":"10.1016\/j.virol.2008.03.028_bib4","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1086\/517807","article-title":"Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever","volume":"177","author":"Bethell","year":"1998","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.03.028_bib5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.imlet.2005.11.019","article-title":"B7-1 and B7-2: similar costimulatory ligands with different biochemical, oligomeric and signaling properties","volume":"104","author":"Bhatia","year":"2006","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.virol.2008.03.028_bib6","first-page":"1043","article-title":"Flaviviruses","volume":"Vol. 1","author":"Burke","year":"2001"},{"key":"10.1016\/j.virol.2008.03.028_bib7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4269\/ajtmh.1988.38.172","article-title":"A prospective study of dengue infections in Bangkok","volume":"38","author":"Burke","year":"1988","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2008.03.028_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/(SICI)1096-9071(199911)59:3<335::AID-JMV13>3.0.CO;2-E","article-title":"Sequential production of cytokines by dengue virus-infected human peripheral blood leukocyte cultures","volume":"59","author":"Chaturvedi","year":"1999","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virol.2008.03.028_bib9","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/eji.1830260614","article-title":"Differential modulation of B7-1 and B7-2 isoform expression on human monocytes by cytokines which influence the development of T helper cell phenotype","volume":"26","author":"Creery","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.virol.2008.03.028_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jviromet.2004.06.013","article-title":"In vitro assessment of human endothelial cell permeability: effects of inflammatory cytokines and dengue virus infection","volume":"121","author":"Dewi","year":"2004","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.virol.2008.03.028_bib11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1590\/S0074-02761990000300012","article-title":"Serological diagnosis of dengue by an ELISA inhibition method (EIM)","volume":"85","author":"Fernandez","year":"1990","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.virol.2008.03.028_bib12","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1136\/bmj.324.7353.1563","article-title":"Dengue: an escalating problem","volume":"324","author":"Gibbons","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.virol.2008.03.028_bib13","doi-asserted-by":"crossref","first-page":"9422","DOI":"10.1073\/pnas.0703498104","article-title":"Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention","volume":"104","author":"Goncalvez","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virol.2008.03.028_bib14","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1086\/315072","article-title":"Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever","volume":"180","author":"Green","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.03.028_bib15","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1086\/314680","article-title":"Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity","volume":"179","author":"Green","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.03.028_bib16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/infdis\/140.4.527","article-title":"In vivo enhancement of dengue virus infection in rhesus monkeys by passively transferred antibody","volume":"140","author":"Halstead","year":"1979","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.03.028_bib17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/00001432-200210000-00003","article-title":"Dengue","volume":"15","author":"Halstead","year":"2002","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.virol.2008.03.028_bib18","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.2105\/AJPH.55.9.1386","article-title":"Recent epidemics of hemorrhagic fever in Thailand. Observations related to pathogenesis of a \"new\" dengue disease","volume":"55","author":"Halstead","year":"1965","journal-title":"J. Am. Pub. Health Assoc."},{"key":"10.1016\/j.virol.2008.03.028_bib19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1084\/jem.146.1.201","article-title":"Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody","volume":"146","author":"Halstead","year":"1977","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2008.03.028_bib20","first-page":"24","article-title":"Immunologic enhancement of dengue virus replication","volume":"243","author":"Halstead","year":"1973","journal-title":"Nat. New Biol."},{"key":"10.1016\/j.virol.2008.03.028_bib21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1084\/jem.146.1.218","article-title":"Dengue viruses and mononuclear phagocytes. II. Identity of blood and tissue leukocytes supporting in vitro infection","volume":"146","author":"Halstead","year":"1977","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2008.03.028_bib22","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.4269\/ajtmh.2005.73.1063","article-title":"Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua","volume":"73","author":"Hammond","year":"2005","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2008.03.028_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4269\/ajtmh.2000.63.5","article-title":"Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua","volume":"63","author":"Harris","year":"2000","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2008.03.028_bib24","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1348-0421.1996.tb01110.x","article-title":"High levels of sTNFR p75 and TNFa in dengue-infected patients","volume":"40","author":"Hober","year":"1996","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.virol.2008.03.028_bib25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1086\/380762","article-title":"Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles","volume":"189","author":"Hung","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.03.028_bib26","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1086\/383043","article-title":"Localization of dengue virus in naturally infected human tissues, by immunohistochemistry and in situ hybridization","volume":"189","author":"Jessie","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.03.028_bib27","first-page":"718","article-title":"B cells are the principal circulating mononuclear cells infected by dengue virus","volume":"30","author":"King","year":"1999","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.virol.2008.03.028_bib28","doi-asserted-by":"crossref","first-page":"444","DOI":"10.4269\/ajtmh.1989.40.444","article-title":"Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever","volume":"40","author":"Kliks","year":"1989","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2008.03.028_bib29","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1128\/jvi.62.11.3928-3933.1988","article-title":"Gamma interferon augments Fc gamma receptor-mediated dengue virus infection of human monocytic cells","volume":"62","author":"Kontny","year":"1988","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2008.03.028_bib30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jmv.21051","article-title":"Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells","volume":"80","author":"Kou","year":"2008","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virol.2008.03.028_bib31","first-page":"121","article-title":"Immunity and immunopathology in dengue virus infections","volume":"4","author":"Kurane","year":"1992","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.virol.2008.03.028_bib32","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1006\/smvy.1994.1050","article-title":"Cytokines in dengue virus infections: role of cytokines in the pathogenesis of dengue hemorrhagic fever","volume":"5","author":"Kurane","year":"1994","journal-title":"Semin. Virol."},{"key":"10.1016\/j.virol.2008.03.028_bib33","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1172\/JCI115457","article-title":"Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue","volume":"88","author":"Kurane","year":"1991","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.virol.2008.03.028_bib34","first-page":"35","article-title":"T cell activation in vivo by dengue virus infection","volume":"46","author":"Kurane","year":"1995","journal-title":"J. Clin. Lab. Immunol."},{"key":"10.1016\/j.virol.2008.03.028_bib35","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1128\/JVI.79.12.7291-7299.2005","article-title":"Dendritic cell precursors are permissive to dengue virus and human immunodeficiency virus infection","volume":"79","author":"Kwan","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2008.03.028_bib36","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1086\/518007","article-title":"Dengue virus infects macrophages and dendritic cells in a mouse model of infection","volume":"195","author":"Kyle","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.03.028_bib37","first-page":"963","article-title":"Flaviviridae: the viruses and their replication","volume":"Vol. 1","author":"Lindenback","year":"2001"},{"key":"10.1016\/j.virol.2008.03.028_bib38","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.4049\/jimmunol.144.8.3183","article-title":"Human IgG Fc receptor II mediates antibody-dependent enhancement of dengue virus infection","volume":"144","author":"Littaua","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2008.03.028_bib39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.0022-202x.2001.00037.x","article-title":"Human dendritic cells as targets of dengue virus infection","volume":"6","author":"Marovich","year":"2001","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"10.1016\/j.virol.2008.03.028_bib40","doi-asserted-by":"crossref","first-page":"644","DOI":"10.4269\/ajtmh.1991.45.644","article-title":"Growth of dengue type 2 virus isolates in human peripheral blood leukocytes correlates with severe and mild dengue disease","volume":"45","author":"Morens","year":"1991","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2008.03.028_bib41","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/(SICI)1096-9071(200004)60:4<432::AID-JMV11>3.0.CO;2-7","article-title":"Prospective study of the duration and magnitude of viraemia in children hospitalised during the 1996\u20131997 dengue-2 outbreak in French Polynesia","volume":"60","author":"Murgue","year":"2000","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virol.2008.03.028_bib42","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1590\/S0074-02761999000300019","article-title":"Increased pro-inflammatory cytokines (TNF-alpha and IL-6) and anti-inflammatory compounds (sTNFRp55 and sTNFRp75) in Brazilian patients during exanthematic dengue fever","volume":"94","author":"Pinto","year":"1999","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.virol.2008.03.028_bib43","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1056\/NEJM199610313351807","article-title":"Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases","volume":"335","author":"Reiser","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virol.2008.03.028_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/viro.1999.9656","article-title":"Immunopathogenesis of dengue hemorrhagic fever","volume":"257","author":"Rothman","year":"1999","journal-title":"Virology"},{"key":"10.1016\/j.virol.2008.03.028_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/infdis\/141.1.1","article-title":"Isolation of dengue viruses peripheral blood leukocytes of patients with hemorrhagic fever","volume":"141","author":"Scott","year":"1980","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.03.028_bib46","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1128\/JVI.00062-06","article-title":"Murine model for dengue virus-induced lethal disease with increased vascular permeability","volume":"80","author":"Shresta","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2008.03.028_bib47","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.20021840","article-title":"DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells","volume":"197","author":"Tassaneetrithep","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2008.03.028_bib48","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.03.028_bib49","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4269\/ajtmh.1985.34.380","article-title":"Low rates of antigen detection and virus isolation from the peripheral blood leukocytes of dengue fever patients","volume":"34","author":"Waterman","year":"1985","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2008.03.028_bib50","series-title":"Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control, 2nd Edition","author":"WHO","year":"1997"},{"key":"10.1016\/j.virol.2008.03.028_bib51","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/77553","article-title":"Human skin Langerhans cells are targets of dengue virus infection","volume":"6","author":"Wu","year":"2000","journal-title":"Nat. Med."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682208001992?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682208001992?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:54:17Z","timestamp":1758585257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682208001992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0042682208001992"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2008.03.028","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1116058.572031","asserted-by":"object"}]},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenotyping of peripheral blood mononuclear cells during acute dengue illness demonstrates infection and increased activation of monocytes in severe cases compared to classic dengue fever","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2008.03.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}