{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:00:19Z","timestamp":1788872419000,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1811,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008054","name":"Fundaci\u00f3n Ram\u00f3n Areces","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.virol.2008.05.016","type":"journal-article","created":{"date-parts":[[2008,6,25]],"date-time":"2008-06-25T05:27:46Z","timestamp":1214371666000},"page":"185-192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus"],"prefix":"10.1016","volume":"378","author":[{"given":"Ver\u00f3nica","family":"Mart\u00edn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Grande-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.virol.2008.05.016_bib1","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1128\/jvi.62.9.3301-3308.1988","article-title":"Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus","volume":"62","author":"Ahmed","year":"1988","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2008.05.016_bib2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.micro.58.030603.123649","article-title":"Viral error catastrophe by mutagenic nucleosides","volume":"58","author":"Anderson","year":"2004","journal-title":"Annu. Rev., Microbiol."},{"issue":"5","key":"10.1016\/j.virol.2008.05.016_bib3","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.jmb.2005.09.022","article-title":"Mutant viral polymerase in the transition of virus to error catastrophe identifies a critical site for RNA binding","volume":"353","author":"Arias","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.virol.2008.05.016_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1742-4690-4-78","article-title":"HIV-1 drug-resistance and drug-dependence","volume":"4","author":"Baldwin","year":"2007","journal-title":"Retrovirology"},{"issue":"2","key":"10.1016\/j.virol.2008.05.016_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.virusres.2004.11.002","article-title":"The error threshold","volume":"107","author":"Biebricher","year":"2005","journal-title":"Virus Res."},{"issue":"1","key":"10.1016\/j.virol.2008.05.016_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2217\/17460794.2.1.35","article-title":"The advantage of the high genetic diversity in RNA viruses","volume":"2","author":"Biebricher","year":"2007","journal-title":"Future Virol."},{"key":"10.1016\/j.virol.2008.05.016_bib7","series-title":"Fields Virology","first-page":"1791","article-title":"Arenaviridae: the viruses and their replication","author":"Buchmeier","year":"2007"},{"key":"10.1016\/j.virol.2008.05.016_bib8","series-title":"Origin and evolution of viruses","first-page":"207","article-title":"Lethal Mutagenesis","author":"Bull","year":"2008"},{"issue":"2","key":"10.1016\/j.virol.2008.05.016_bib9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.virusres.2004.11.004","article-title":"Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective","volume":"107","author":"Castro","year":"2005","journal-title":"Virus Res."},{"issue":"12","key":"10.1016\/j.virol.2008.05.016_bib10","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1371\/journal.ppat.0020136","article-title":"The fittest versus the flattest: experimental confirmation of the quasispecies effect with subviral pathogens","volume":"2","author":"Codoner","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virol.2008.05.016_bib11","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/82191","article-title":"The broad-spectrum antiviral ribonucleotide, ribavirin, is an RNA virus mutagen","volume":"6","author":"Crotty","year":"2000","journal-title":"Nat. Med"},{"issue":"12","key":"10.1016\/j.virol.2008.05.016_bib12","doi-asserted-by":"crossref","first-page":"6895","DOI":"10.1073\/pnas.111085598","article-title":"RNA virus error catastrophe: direct molecular test by using ribavirin","volume":"98","author":"Crotty","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.virol.2008.05.016_bib13","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/ng1583","article-title":"Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses","volume":"37","author":"Crowder","year":"2005","journal-title":"Nat. Genet."},{"issue":"9","key":"10.1016\/j.virol.2008.05.016_bib14","first-page":"1959","article-title":"Perspective: evolution and detection of genetic robustness","volume":"57","author":"de Visser","year":"2003","journal-title":"Evolut. Int. J. Org. Evolut."},{"key":"10.1016\/j.virol.2008.05.016_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-3-0348-8012-1_4","article-title":"Quasispecies and the development of new antiviral strategies","volume":"60","author":"Domingo","year":"2003","journal-title":"Prog. Drug Res."},{"key":"10.1016\/j.virol.2008.05.016_bib16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.virusres.2004.11.001","article-title":"Virus entry into error catastrophe as a new antiviral strategy","volume":"107","author":"Domingo","year":"2005","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2008.05.016_bib17","series-title":"Fields Virology","first-page":"389","article-title":"Virus evolution","author":"Domingo","year":"2007"},{"key":"10.1016\/j.virol.2008.05.016_bib18","series-title":"Quasispecies and RNA Virus Evolution: Principles and Consequences","author":"Domingo","year":"2001"},{"key":"10.1016\/j.virol.2008.05.016_bib19","series-title":"Origin and Evolution of viruses","first-page":"87","article-title":"Viral quasiespecies:dynamics, interactions and pathogenesis","author":"Domingo","year":"2008"},{"key":"10.1016\/j.virol.2008.05.016_bib20","doi-asserted-by":"crossref","first-page":"13910","DOI":"10.1073\/pnas.96.24.13910","article-title":"Mutation rates among RNA viruses","volume":"96","author":"Drake","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.virol.2008.05.016_bib21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/BF00623322","article-title":"Selforganization of matter and the evolution of biological macromolecules","volume":"58","author":"Eigen","year":"1971","journal-title":"Naturwissenschaften"},{"issue":"21","key":"10.1016\/j.virol.2008.05.016_bib22","doi-asserted-by":"crossref","first-page":"13374","DOI":"10.1073\/pnas.212514799","article-title":"Error catastrophe and antiviral strategy","volume":"99","author":"Eigen","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virol.2008.05.016_bib23","series-title":"The Hypercycle. A Principle of Natural Self-organization","author":"Eigen","year":"1979"},{"key":"10.1016\/j.virol.2008.05.016_bib24","series-title":"RNA Genetics","first-page":"211","article-title":"Sequence space and quasispecies distribution","author":"Eigen","year":"1988"},{"key":"10.1016\/j.virol.2008.05.016_bib25","doi-asserted-by":"crossref","first-page":"6881","DOI":"10.1021\/j100335a010","article-title":"Molecular quasi-species","volume":"92","author":"Eigen","year":"1988","journal-title":"J. Phys. Chem."},{"issue":"3","key":"10.1016\/j.virol.2008.05.016_bib26","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/j.1558-5646.2007.00064.x","article-title":"Effects of population size and mutation rate on the evolution of mutational robustness","volume":"61","author":"Elena","year":"2007","journal-title":"Evolut. Int. J. Org. Evolut."},{"issue":"2","key":"10.1016\/j.virol.2008.05.016_bib27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jmb.2007.11.042","article-title":"Repeated bottleneck transfers can lead to non-cytocidal forms of a cytopathic virus: implications for viral extinction","volume":"376","author":"Escarm\u00eds","year":"2008","journal-title":"J. Mol. Biol."},{"issue":"4","key":"10.1016\/j.virol.2008.05.016_bib28","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/med.10045","article-title":"Genetic variability: the key problem in the prevention and therapy of RNA-based virus infections","volume":"23","author":"Figlerowicz","year":"2003","journal-title":"Med Res. Rev."},{"issue":"21","key":"10.1016\/j.virol.2008.05.016_bib29","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMoa053240","article-title":"Transmission of lymphocytic choriomeningitis virus by organ transplantation","volume":"354","author":"Fischer","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.virol.2008.05.016_bib30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.drup.2003.12.003","article-title":"Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance?","volume":"7","author":"Freistadt","year":"2004","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.virol.2008.05.016_bib31","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.meegid.2005.05.001","article-title":"Invariant aphthovirus consensus nucleotide sequence in the transition to error catastrophe","volume":"5","author":"Gonz\u00e1lez-L\u00f3pez","year":"2005","journal-title":"Infect. Genet. Evolut."},{"issue":"7","key":"10.1016\/j.virol.2008.05.016_bib32","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1128\/JVI.78.7.3319-3324.2004","article-title":"Preextinction viral RNA can interfere with infectivity","volume":"78","author":"Gonz\u00e1lez-L\u00f3pez","year":"2004","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2008.05.016_bib33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/viro.2002.1487","article-title":"Quasispecies, error catastrophe, and the antiviral activity of ribavirin","volume":"298","author":"Graci","year":"2002","journal-title":"Virology"},{"issue":"20","key":"10.1016\/j.virol.2008.05.016_bib34","doi-asserted-by":"crossref","first-page":"11256","DOI":"10.1128\/JVI.01028-07","article-title":"Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue","volume":"81","author":"Graci","year":"2007","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2008.05.016_bib35","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1128\/AAC.01056-07","article-title":"Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues","volume":"52","author":"Graci","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"issue":"20","key":"10.1016\/j.virol.2008.05.016_bib36","doi-asserted-by":"crossref","first-page":"12938","DOI":"10.1073\/pnas.182426999","article-title":"Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity","volume":"99","author":"Grande-P\u00e9rez","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"16","key":"10.1016\/j.virol.2008.05.016_bib37","doi-asserted-by":"crossref","first-page":"10451","DOI":"10.1128\/JVI.79.16.10451-10459.2005","article-title":"Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence","volume":"79","author":"Grande-P\u00e9rez","year":"2005","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.virol.2008.05.016_bib38","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1073\/pnas.0408871102","article-title":"Suppression of viral infectivity through lethal defection","volume":"102","author":"Grande-P\u00e9rez","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"21","key":"10.1016\/j.virol.2008.05.016_bib39","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1021\/jm060872x","article-title":"Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases","volume":"49","author":"Harki","year":"2006","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.virol.2008.05.016_bib40","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/cbic.200700160","article-title":"Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase","volume":"8","author":"Harki","year":"2007","journal-title":"Chembiochem"},{"issue":"1","key":"10.1016\/j.virol.2008.05.016_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2005.03.004","article-title":"KP-1212\/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis","volume":"67","author":"Harris","year":"2005","journal-title":"Antiviral Res."},{"key":"10.1016\/j.virol.2008.05.016_bib42","first-page":"371","article-title":"Transitions in understanding of RNA viruses: an historical perspective","volume":"299","author":"Holland","year":"2006","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.virol.2008.05.016_bib43","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1128\/jvi.64.8.3960-3962.1990","article-title":"Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis","volume":"64","author":"Holland","year":"1990","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.virol.2008.05.016_bib44","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.ajog.2005.06.062","article-title":"Emerging infectious disease outbreaks: old lessons and new challenges for obstetrician\u2013gynecologists","volume":"194","author":"Jamieson","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"17","key":"10.1016\/j.virol.2008.05.016_bib45","doi-asserted-by":"crossref","first-page":"8675","DOI":"10.1128\/JVI.76.17.8675-8681.2002","article-title":"Modeling viral genome fitness evolution associated with serial bottleneck events: evidence of stationary states of fitness","volume":"76","author":"L\u00e1zaro","year":"2002","journal-title":"J. Virol."},{"issue":"19","key":"10.1016\/j.virol.2008.05.016_bib46","doi-asserted-by":"crossref","first-page":"10830","DOI":"10.1073\/pnas.1332668100","article-title":"Resistance of virus to extinction on bottleneck passages: study of a decaying and fluctuating pattern of fitness loss","volume":"100","author":"Lazaro","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.virol.2008.05.016_bib47","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1128\/jvi.71.5.3636-3640.1997","article-title":"Negative effects of chemical mutagenesis on the adaptive behavior of vesicular stomatitis virus","volume":"71","author":"Lee","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2008.05.016_bib48","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1073\/pnas.96.4.1492","article-title":"Lethal mutagenesis of HIV with mutagenic nucleoside analogs","volume":"96","author":"Loeb","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.virol.2008.05.016_bib49","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.gene.2004.12.033","article-title":"High mutation rates, bottlenecks, and robustness of RNA viral quasispecies","volume":"347","author":"Manrubia","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.virol.2008.05.016_bib50","first-page":"139","article-title":"Arenaviruses: genomic RNAs transcription, and replication.","volume":"262","author":"Meyer","year":"2002"},{"issue":"11","key":"10.1016\/j.virol.2008.05.016_bib51","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.1371\/journal.pbio.0030381","article-title":"Evolution of mutational robustness in an RNA virus","volume":"3","author":"Montville","year":"2005","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.virol.2008.05.016_bib52","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1021\/jm7009952","article-title":"Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity","volume":"51","author":"Moriyama","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.virol.2008.05.016_bib53","series-title":"Evolutionary Dynamics","author":"Nowak","year":"2006"},{"key":"10.1016\/j.virol.2008.05.016_bib54","series-title":"Arenaviruses I and II","year":"2002"},{"issue":"20","key":"10.1016\/j.virol.2008.05.016_bib55","doi-asserted-by":"crossref","first-page":"9723","DOI":"10.1128\/JVI.75.20.9723-9730.2001","article-title":"Efficient virus extinction by combinations of a mutagen and antiviral inhibitors","volume":"75","author":"Pariente","year":"2001","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.virol.2008.05.016_bib56","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.1128\/JVI.77.12.7131-7138.2003","article-title":"Mutagenesis versus inhibition in the efficiency of extinction of foot-and-mouth disease virus","volume":"77","author":"Pariente","year":"2003","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2008.05.016_bib57","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.virusres.2004.11.008","article-title":"Action of mutagenic agents and antiviral inhibitors on foot-and-mouth disease virus","volume":"107","author":"Pariente","year":"2005","journal-title":"Virus Res."},{"issue":"4","key":"10.1016\/j.virol.2008.05.016_bib58","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jmb.2007.03.074","article-title":"Insights into RNA virus mutant spectrum and lethal mutagenesis events: replicative interference and complementation by multiple point mutants","volume":"369","author":"Perales","year":"2007","journal-title":"J. Mol. Biol."},{"issue":"12","key":"10.1016\/j.virol.2008.05.016_bib59","doi-asserted-by":"crossref","first-page":"7289","DOI":"10.1073\/pnas.1232294100","article-title":"A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity","volume":"100","author":"Pfeiffer","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virol.2008.05.016_bib60","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1371\/journal.ppat.0010011","article-title":"Increased fidelity reduces poliovirus fitness under selective pressure in mice","volume":"1","author":"Pfeiffer","year":"2005","journal-title":"PLoS Pathogens"},{"issue":"4","key":"10.1016\/j.virol.2008.05.016_bib61","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1128\/JVI.79.4.2346-2355.2005","article-title":"Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA","volume":"79","author":"Pfeiffer","year":"2005","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2008.05.016_bib62","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1006\/jmbi.1996.0654","article-title":"Reproducible nonlinear population dynamics and critical points during replicative competitions of RNA virus quasispecies","volume":"264","author":"Quer","year":"1996","journal-title":"J. Mol. Biol."},{"issue":"16","key":"10.1016\/j.virol.2008.05.016_bib63","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1128\/JVI.75.16.7315-7320.2001","article-title":"Contingent neutrality in competing viral populations","volume":"75","author":"Quer","year":"2001","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2008.05.016_bib64","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0042-6822(02)00046-6","article-title":"Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV)","volume":"308","author":"Ruiz-Jarabo","year":"2003","journal-title":"Virology"},{"issue":"6","key":"10.1016\/j.virol.2008.05.016_bib65","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1371\/journal.pgen.0030093","article-title":"Selection for robustness in mutagenized RNA viruses","volume":"3","author":"Sanjuan","year":"2007","journal-title":"PLoS Genet."},{"issue":"6","key":"10.1016\/j.virol.2008.05.016_bib66","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0092-8240(88)80059-4","article-title":"Stationary mutant distributions and evolutionary optimization","volume":"50","author":"Schuster","year":"1988","journal-title":"Bull. Math. Biol."},{"key":"10.1016\/j.virol.2008.05.016_bib67","series-title":"Origin and evolution of viruses","first-page":"1","article-title":"Early replicons: origin and evolution","author":"Schuster","year":"2008"},{"key":"10.1016\/j.virol.2008.05.016_bib68","doi-asserted-by":"crossref","first-page":"8316","DOI":"10.1128\/JVI.74.18.8316-8323.2000","article-title":"Response of foot-and-mouth disease virus to increased mutagenesis. Influence of viral load and fitness in loss of infectivity","volume":"74","author":"Sierra","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2008.05.016_bib69","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1128\/JVI.01606-06","article-title":"Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastrophe","volume":"81","author":"Sierra","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2008.05.016_bib70","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2148-7-15","article-title":"Error-threshold exists in fitness landscapes with lethal mutants","volume":"7","author":"Takeuchi","year":"2007","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.virol.2008.05.016_bib71","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature04388","article-title":"Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population","volume":"439","author":"Vignuzzi","year":"2006","journal-title":"Nature"},{"issue":"35","key":"10.1016\/j.virol.2008.05.016_bib72","doi-asserted-by":"crossref","first-page":"10462","DOI":"10.1021\/bi0344681","article-title":"Mutagenic and inhibitory effects of ribavirin on hepatitis C virus RNA polymerase","volume":"42","author":"Vo","year":"2003","journal-title":"Biochemistry"},{"issue":"1\u20132","key":"10.1016\/j.virol.2008.05.016_bib73","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0027-5107(02)00307-X","article-title":"Evolution of mutational robustness","volume":"522","author":"Wilke","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.virol.2008.05.016_bib74","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0370-1573(00)00118-6","article-title":"Dynamic fitness landscapes in molecular evolution","volume":"349","author":"Wilke","year":"2001","journal-title":"Phys. Rep."},{"key":"10.1016\/j.virol.2008.05.016_bib75","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/genetics\/16.2.97","article-title":"Evolution in Mendelian populations","volume":"16","author":"Wright","year":"1931","journal-title":"Genetics"},{"key":"10.1016\/j.virol.2008.05.016_bib76","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2307\/2408092","article-title":"Character change, speciation, and the higher taxa","volume":"36","author":"Wright","year":"1982","journal-title":"Evolution"},{"issue":"4","key":"10.1016\/j.virol.2008.05.016_bib77","first-page":"869","article-title":"Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy","volume":"38","author":"Young","year":"2003","journal-title":"Hepatology"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682208003437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682208003437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:53:34Z","timestamp":1758585214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682208003437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0042682208003437"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2008.05.016","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"No evidence of selection for mutational robustness during lethal mutagenesis of lymphocytic choriomeningitis virus","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2008.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}