{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:42:16Z","timestamp":1772750536338,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1811,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.virol.2008.05.021","type":"journal-article","created":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T04:51:29Z","timestamp":1214628689000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets"],"prefix":"10.1016","volume":"378","author":[{"given":"Tomy","family":"Joseph","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"McAuliffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leatrice","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Swayne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Kemble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanta","family":"Subbarao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2008.05.021_bib1","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1637\/7218-060304R","article-title":"Virus characterization, clinical presentation, and pathology associated with H7N3 avian influenza in British Columbia broiler breeder chickens in 2004","volume":"48","author":"Bowes","year":"2004","journal-title":"Avian Dis."},{"issue":"6","key":"10.1016\/j.virol.2008.05.021_bib2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/infdis\/122.6.513","article-title":"Fowl plague virus from man","volume":"122","author":"Campbell","year":"1970","journal-title":"J. Infect. Dis.x"},{"key":"10.1016\/j.virol.2008.05.021_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1099\/vir.0.83111-0","article-title":"Molecular analysis of avian H7 influenza viruses circulating in Eurasia in 1999 2005: detection of multiple reassortant virus genotypes","volume":"89","author":"Campitelli","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2008.05.021_bib4","first-page":"743","article-title":"H7N3 avian influenza in Italy","volume":"151","author":"Capua","year":"2002","journal-title":"Vet. Rec."},{"key":"10.1016\/j.virol.2008.05.021_bib5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/03079450410001724085","article-title":"Avian influenza: recent developments","volume":"33","author":"Capua","year":"2004","journal-title":"Avian Pathol."},{"key":"10.1016\/j.virol.2008.05.021_bib6","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1016\/S0264-410X(03)00430-4","article-title":"Generation and characterization of a cold-adapted influenza A H9N2 reassortant as a live pandemic influenza virus vaccine candidate","volume":"21","author":"Chen","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2008.05.021_bib7","doi-asserted-by":"crossref","first-page":"12401","DOI":"10.1128\/JVI.79.19.12401-12407.2005","article-title":"Protection of mice against lethal infection with highly pathogenic H7N7 influenza A virus by using a recombinant low-pathogenicity vaccine strain","volume":"79","author":"de Wit","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2008.05.021_bib8","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1073\/pnas.0308352100","article-title":"Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome","volume":"101","author":"Fouchier","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virol.2008.05.021_bib9","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.3201\/eid1012.040743","article-title":"Novel avian influenza H7N3 strain outbreak, British Columbia","volume":"10","author":"Hirst","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virol.2008.05.021_bib10","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1073\/pnas.100133697","article-title":"A DNA transfection system for generation of influenza A virus from eight plasmids","volume":"97","author":"Hoffmann","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virol.2008.05.021_bib11","unstructured":"http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm5325a1.htm. Centers for Disease Control and Prevention. Update: influenza activity\u2014United States and worldwide, 2003\u201304 season, and composition of the 2004\u201305 influenza vaccine. MMWR Morb. Mortal Wkly. Rep. 2004 Jul 2; 53(25), 547\u2013552."},{"key":"10.1016\/j.virol.2008.05.021_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0042-6822(02)00035-1","article-title":"Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A\/Ann Arbor\/6\/60","volume":"306","author":"Jin","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.virol.2008.05.021_bib13","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1128\/JVI.78.2.995-998.2004","article-title":"Imparting temperature sensitivity and attenuation in ferrets to A\/Puerto Rico\/8\/34 influenza virus by transferring the genetic signature for temperature sensitivity from cold-adapted A\/Ann Arbor\/6\/60","volume":"78","author":"Jin","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2008.05.021_bib14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1637\/7080","article-title":"Comparative pathobiology of low and high pathogenicity H7N3 Chilean avian influenza viruses in chickens","volume":"48","author":"Jones","year":"2004","journal-title":"Avian Dis."},{"key":"10.1016\/j.virol.2008.05.021_bib15","doi-asserted-by":"crossref","first-page":"10558","DOI":"10.1128\/JVI.00970-07","article-title":"Evaluation of replication and pathogenicity of avian influenza A H7 subtype viruses in a mouse model","volume":"81","author":"Joseph","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2008.05.021_bib16","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0140-6736(04)15589-X","article-title":"Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands","volume":"363","author":"Koopmans","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.virol.2008.05.021_bib17","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0140-6736(05)64783-6","article-title":"Avian influenza virus isolated from a woman with conjunctivitis","volume":"348","author":"Kurtz","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.virol.2008.05.021_bib18","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1086\/314713","article-title":"Recombinant influenza A virus vaccines for the pathogenic human A\/Hong Kong\/97 (H5N1) viruses","volume":"179","author":"Li","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.05.021_bib19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/(SICI)1099-1654(199910\/12)9:4<237::AID-RMV252>3.0.CO;2-G","article-title":"The development of live attenuated cold-adapted influenza virus vaccine for humans","volume":"9","author":"Maassab","year":"1999","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.virol.2008.05.021_bib20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/08828240260066242","article-title":"Principles underlying the development and use of live attenuated cold-adapted influenza A and B virus vaccines","volume":"15","author":"Murphy","year":"2002","journal-title":"Viral Immunol."},{"key":"10.1016\/j.virol.2008.05.021_bib21","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1086\/518579","article-title":"Infection due to 3 avian influenza subtypes in United States veterinarians","volume":"45","author":"Myers","year":"2007","journal-title":"Clin. Infect. Dis."},{"issue":"5","key":"10.1016\/j.virol.2008.05.021_bib22","article-title":"Outbreak of low pathogenicity H7N3 avian influenza in UK, including associated case of human conjunctivitis","volume":"11","author":"Nguyen-Van-Tam","year":"2006","journal-title":"Euro Surveill."},{"key":"10.1016\/j.virol.2008.05.021_bib23","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1128\/CVI.00174-07","article-title":"Development and evaluation of an Influenza virus subtype H7N2 vaccine candidate for pandemic preparedness","volume":"14","author":"Pappas","year":"2007","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.virol.2008.05.021_bib24","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1099\/vir.0.80478-0","article-title":"Intersegmental recombination between the haemagglutinin and matrix genes was responsible for the emergence of a highly pathogenic H7N3 avian influenza virus in British Columbia","volume":"86","author":"Pasick","year":"2005","journal-title":"J. Gen.Virol."},{"key":"10.1016\/j.virol.2008.05.021_bib25","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1086\/444390","article-title":"Serological analysis of serum samples from humans exposed to avian H7 influenza viruses in Italy between 1999 and 2003","volume":"192","author":"Puzelli","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.05.021_bib26","first-page":"493","article-title":"A simple method of estimation fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Hyg."},{"key":"10.1016\/j.virol.2008.05.021_bib27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nri2054","article-title":"Scientific barriers to developing vaccines against avian influenza viruses","volume":"7","author":"Subbarao","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.virol.2008.05.021_bib28","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1371\/journal.pmed.0030360","article-title":"Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets","volume":"3","author":"Suguitan","year":"2006","journal-title":"PLoS. Med."},{"issue":"2","key":"10.1016\/j.virol.2008.05.021_bib29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/bjo.61.2.86","article-title":"A case report of fowl plague keratoconjunctivitis","volume":"61","author":"Taylor","year":"1977","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.virol.2008.05.021_bib30","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.3201\/eid1012.040961","article-title":"Human illness from avian influenza H7N3, British Columbia","volume":"10","author":"Tweed","year":"2004","journal-title":"Emerg. Infect. Dis."},{"issue":"15","key":"10.1016\/j.virol.2008.05.021_bib31","first-page":"9","article-title":"Conjunctivitis in human beings caused by influenza A virus of seals","volume":"304","author":"Webster","year":"1981","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virol.2008.05.021_bib32","series-title":"Report of the Committee on Transmissible Diseases of Poultry and Other Avian Species. Criteria for determining that an AI virus isolation causing an outbreak must be considered for eradication.","first-page":"522","author":"USAHA","year":"1994"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682208003607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682208003607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:53:08Z","timestamp":1758585188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682208003607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0042682208003607"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2008.05.021","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2008.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}