{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:05:28Z","timestamp":1784765128605,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1725,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.virol.2008.09.019","type":"journal-article","created":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T05:09:56Z","timestamp":1224652196000},"page":"226-238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Interferon-\u03b2 expressed by a rabies virus-based HIV-1 vaccine vector serves as a molecular adjuvant and decreases pathogenicity"],"prefix":"10.1016","volume":"382","author":[{"given":"Elizabeth J.","family":"Faul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestine N.","family":"Wanjalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"McGettigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias J.","family":"Schnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.virol.2008.09.019_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/cimm.1999.1632","article-title":"Differential expansion and survival of high and low avidity cytotoxic T cell populations during the immune response to a viral infection","volume":"201","author":"Alexander-Miller","year":"2000","journal-title":"Cell Immunol."},{"issue":"12","key":"10.1016\/j.virol.2008.09.019_bib2","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1128\/JVI.79.12.7673-7681.2005","article-title":"Identification of the rabies virus alpha\/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3","volume":"79","author":"Brzozka","year":"2005","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.virol.2008.09.019_bib3","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1128\/JVI.80.6.2675-2683.2006","article-title":"Inhibition of interferon signaling by rabies virus phosphoprotein P: activation-dependent binding of STAT1 and STAT2","volume":"80","author":"Brzozka","year":"2006","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.virol.2008.09.019_bib4","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.4049\/jimmunol.174.8.4465","article-title":"Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation","volume":"174","author":"Curtsinger","year":"2005","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.virol.2008.09.019_bib5","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1586\/14760584.2.3.399","article-title":"New approaches to the prevention and eradication of rabies","volume":"2","author":"Dietzschold","year":"2003","journal-title":"Expert Rev. Vaccines"},{"issue":"2","key":"10.1016\/j.virol.2008.09.019_bib6","doi-asserted-by":"crossref","first-page":"749","DOI":"10.4049\/jimmunol.170.2.749","article-title":"Down-modulation of responses to type I IFN upon T cell activation","volume":"170","author":"Dondi","year":"2003","journal-title":"J. Immunol."},{"issue":"Pt 5","key":"10.1016\/j.virol.2008.09.019_bib7","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1099\/vir.0.80844-0","article-title":"A single immunization with a rhabdovirus-based vector expressing severe acute respiratory syndrome coronavirus (SARS-CoV) S protein results in the production of high levels of SARS-CoV-neutralizing antibodies","volume":"86","author":"Faber","year":"2005","journal-title":"J. Gen. Virol."},{"issue":"Pt 6","key":"10.1016\/j.virol.2008.09.019_bib8","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1099\/vir.0.19128-0","article-title":"Rabies virus matrix protein regulates the balance of virus transcription and replication","volume":"84","author":"Finke","year":"2003","journal-title":"J. Gen. Virol."},{"issue":"4","key":"10.1016\/j.virol.2008.09.019_bib9","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.4049\/jimmunol.178.4.2182","article-title":"TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses","volume":"178","author":"Heer","year":"2007","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.virol.2008.09.019_bib10","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.4049\/jimmunol.175.9.6032","article-title":"Dendritic cell maturation, but not CD8+ T cell induction, is dependent on type I IFN signaling during vaccination with adenovirus vectors","volume":"175","author":"Hensley","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2008.09.019_bib11","first-page":"137","article-title":"Nude mice in immunology","volume":"26","author":"Kindred","year":"1979","journal-title":"Prog. Allergy"},{"issue":"4","key":"10.1016\/j.virol.2008.09.019_bib12","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/eji.1830170407","article-title":"Functional alpha and beta T cell chain receptor messages can be detected in old but not in young athymic mice","volume":"17","author":"Kishihara","year":"1987","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.virol.2008.09.019_bib13","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1084\/jem.20050821","article-title":"Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection","volume":"202","author":"Kolumam","year":"2005","journal-title":"J. Exp. Med."},{"issue":"12","key":"10.1016\/j.virol.2008.09.019_bib14","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nri1959","article-title":"Progress and obstacles in the development of an AIDS vaccine","volume":"6","author":"Letvin","year":"2006","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.virol.2008.09.019_bib15","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1086\/368381","article-title":"Type I interferon induction pathway, but not released interferon, participates in the maturation of dendritic cells induced by negative-strand RNA viruses","volume":"187","author":"Lopez","year":"2003","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.virol.2008.09.019_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1084\/jem.189.3.521","article-title":"Type I interferons keep activated T cells alive","volume":"189","author":"Marrack","year":"1999","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.virol.2008.09.019_bib17","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1128\/JVI.80.3.1130-1139.2006","article-title":"Protection against respiratory syncytial virus by a recombinant Newcastle disease virus vector","volume":"80","author":"Martinez-Sobrido","year":"2006","journal-title":"J. Virol."},{"issue":"18","key":"10.1016\/j.virol.2008.09.019_bib18","doi-asserted-by":"crossref","first-page":"8724","DOI":"10.1128\/JVI.75.18.8724-8732.2001","article-title":"Expression and immunogenicity of human immunodeficiency virus type 1 Gag expressed by a replication-competent rhabdovirus-based vaccine vector","volume":"75","author":"McGettigan","year":"2001","journal-title":"J. Virol."},{"issue":"20","key":"10.1016\/j.virol.2008.09.019_bib19","doi-asserted-by":"crossref","first-page":"10889","DOI":"10.1128\/JVI.77.20.10889-10899.2003","article-title":"Functional human immunodeficiency virus type 1 (HIV-1) Gag-Pol or HIV-1 Gag-Pol and env expressed from a single rhabdovirus-based vaccine vector genome","volume":"77","author":"McGettigan","year":"2003","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2008.09.019_bib20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1128\/JVI.77.1.237-244.2003","article-title":"Second-generation rabies virus-based vaccine vectors expressing human immunodeficiency virus type 1 gag have greatly reduced pathogenicity but are highly immunogenic","volume":"77","author":"McGettigan","year":"2003","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2008.09.019_bib21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.virol.2005.09.004","article-title":"Enhanced humoral HIV-1-specific immune responses generated from recombinant rhabdoviral-based vaccine vectors co-expressing HIV-1 proteins and IL-2","volume":"344","author":"McGettigan","year":"2006","journal-title":"Virology"},{"issue":"23","key":"10.1016\/j.virol.2008.09.019_bib22","doi-asserted-by":"crossref","first-page":"12782","DOI":"10.1128\/JVI.77.23.12782-12794.2003","article-title":"Covalently linked human immunodeficiency virus type 1 gp120\/gp41 is stably anchored in rhabdovirus particles and exposes critical neutralizing epitopes","volume":"77","author":"McKenna","year":"2003","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.virol.2008.09.019_bib23","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1086\/512243","article-title":"Highly attenuated rabies virus-based vaccine vectors expressing simian-human immunodeficiency virus89.6P Env and simian immunodeficiency virusmac239 Gag are safe in rhesus macaques and protect from an AIDS-like disease","volume":"195","author":"McKenna","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2008.09.019_bib24","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0092-8674(00)81072-7","article-title":"Budding of rabies virus particles in the absence of the spike glycoprotein","volume":"84","author":"Mebatsion","year":"1996","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.virol.2008.09.019_bib25","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1128\/JVI.73.1.242-250.1999","article-title":"Matrix protein of rabies virus is responsible for the assembly and budding of bullet-shaped particles and interacts with the transmembrane spike glycoprotein G","volume":"73","author":"Mebatsion","year":"1999","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.virol.2008.09.019_bib26","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.4049\/jimmunol.174.4.1851","article-title":"Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFN","volume":"174","author":"Montoya","year":"2005","journal-title":"J. Immunol."},{"issue":"5167","key":"10.1016\/j.virol.2008.09.019_bib27","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1126\/science.8009221","article-title":"Functional role of type I and type II interferons in antiviral defense","volume":"264","author":"Muller","year":"1994","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.virol.2008.09.019_bib28","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.4049\/jimmunol.177.3.2006","article-title":"Complex T cell memory repertoires participate in recall responses at extremes of antigenic load","volume":"177","author":"Naumov","year":"2006","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.virol.2008.09.019_bib29","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.jaci.2006.09.037","article-title":"Smallpox vaccines: past, present, and future","volume":"118","author":"Parrino","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.virol.2008.09.019_bib30","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.4049\/jimmunol.173.6.4108","article-title":"Herpes simplex virus type-1-induced activation of myeloid dendritic cells: the roles of virus cell interaction and paracrine type I IFN secretion","volume":"173","author":"Pollara","year":"2004","journal-title":"J. Immunol."},{"issue":"Pt 1","key":"10.1016\/j.virol.2008.09.019_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/vir.0.83391-0","article-title":"Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures","volume":"89","author":"Randall","year":"2008","journal-title":"J. Gen. Virol."},{"issue":"10","key":"10.1016\/j.virol.2008.09.019_bib32","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.4049\/jimmunol.170.10.5195","article-title":"Monocyte-derived dendritic cells generated after a short-term culture with IFN-alpha and granulocyte-macrophage colony-stimulating factor stimulate a potent Epstein-Barr virus-specific CD8+ T cell response","volume":"170","author":"Santodonato","year":"2003","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.virol.2008.09.019_bib33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1006\/viro.2001.1212","article-title":"Live and killed rhabdovirus-based vectors as potential hepatitis C vaccines","volume":"292","author":"Siler","year":"2002","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.virol.2008.09.019_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1535-6108(03)00241-1","article-title":"VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents","volume":"4","author":"Stojdl","year":"2003","journal-title":"Cancer Cell"},{"issue":"17","key":"10.1016\/j.virol.2008.09.019_bib35","doi-asserted-by":"crossref","first-page":"7229","DOI":"10.1073\/pnas.0701397104","article-title":"The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription","volume":"104","author":"Tan","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"2","key":"10.1016\/j.virol.2008.09.019_bib36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.virol.2005.01.009","article-title":"VSV replication in neurons is inhibited by type I IFN at multiple stages of infection","volume":"333","author":"Trottier","year":"2005","journal-title":"Virology"},{"issue":"22","key":"10.1016\/j.virol.2008.09.019_bib37","doi-asserted-by":"crossref","first-page":"14411","DOI":"10.1128\/JVI.79.22.14411-14420.2005","article-title":"Rabies virus P protein interacts with STAT1 and inhibits interferon signal transduction pathways","volume":"79","author":"Vidy","year":"2005","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.virol.2008.09.019_bib38","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1128\/JVI.01930-06","article-title":"The nucleocytoplasmic rabies virus P protein counteracts interferon signaling by inhibiting both nuclear accumulation and DNA binding of STAT1","volume":"81","author":"Vidy","year":"2007","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.virol.2008.09.019_bib39","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.4049\/jimmunol.156.4.1442","article-title":"Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development","volume":"156","author":"Wenner","year":"1996","journal-title":"J. Immunol."},{"issue":"6096","key":"10.1016\/j.virol.2008.09.019_bib40","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/324482a0","article-title":"Athymic mice express a high level of functional gamma-chain but greatly reduced levels of alpha- and beta-chain T-cell receptor messages","volume":"324","author":"Yoshikai","year":"1986","journal-title":"Nature"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682208005953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682208005953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:56:05Z","timestamp":1758585365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682208005953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0042682208005953"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2008.09.019","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interferon-\u03b2 expressed by a rabies virus-based HIV-1 vaccine vector serves as a molecular adjuvant and decreases pathogenicity","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2008.09.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}