{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:46:06Z","timestamp":1770471966882,"version":"3.49.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1293,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.virol.2009.10.033","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T04:49:02Z","timestamp":1258087742000},"page":"329-338","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Direct random insertion of an influenza virus immunologic determinant into the NS1 glycoprotein of a vaccine flavivirus"],"prefix":"10.1016","volume":"396","author":[{"given":"Alexander A.","family":"Rumyantsev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-sheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Kleanthous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Delagrave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farshad","family":"Guirakhoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc S.","family":"Collett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin V.","family":"Pugachev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2009.10.033_bib1","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1128\/JVI.02746-06","article-title":"Development of Sindbis viruses encoding nsP2\/GFP chimeric proteins and their application for studying nsP2 functioning","volume":"81","author":"Atasheva","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib2","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1084\/jem.20051352","article-title":"Live attenuated yellow fever 17D infects human DCs and allows for presentation of endogenous and recombinant T cell epitopes","volume":"202","author":"Barba-Spaeth","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2009.10.033_bib3","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1006\/jmbi.2001.5258","article-title":"Surface expression of an immunodominant malaria protein B cell epitope by yellow fever virus","volume":"315","author":"Bonaldo","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.virol.2009.10.033_bib4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1385\/CBB:44:3:313","article-title":"Expression of foreign protein epitopes at the surface of recombinant yellow fever 17D viruses based on three-dimensional modeling of its envelope protein","volume":"44","author":"Bonaldo","year":"2006","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.virol.2009.10.033_bib5","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.4049\/jimmunol.105.6.1565","article-title":"Partial purification and characterization of a dengue virus soluble complement-fixing antigen","volume":"105","author":"Brandt","year":"1970","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2009.10.033_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.virol.2005.12.001","article-title":"A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins","volume":"345","author":"Bredenbeek","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.virol.2009.10.033_bib7","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/7914","article-title":"Rapid identification of essential and nonessential herpesvirus genes by direct transposon mutagenesis","volume":"17","author":"Brune","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.virol.2009.10.033_bib8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1073\/pnas.0609330104","article-title":"Ab and T cell epitopes of influenza A virus, knowledge and opportunities","volume":"104","author":"Bui","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virol.2009.10.033_bib9","series-title":"Fields Virology","first-page":"1043","article-title":"Flaviviruses","author":"Burke","year":"2001"},{"key":"10.1016\/j.virol.2009.10.033_bib10","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1128\/JVI.73.4.3095-3101.1999","article-title":"Yellow fever\/Japanese encephalitis chimeric viruses: construction and biological properties","volume":"73","author":"Chambers","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib11","doi-asserted-by":"crossref","first-page":"19111","DOI":"10.1073\/pnas.0605668103","article-title":"West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H","volume":"103","author":"Chung","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virol.2009.10.033_bib12","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1099\/vir.0.82609-0","article-title":"In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 protein","volume":"88","author":"Clark","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib13","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1099\/0022-1317-75-12-3453","article-title":"The NS1 protein of tick-borne encephalitis virus forms multimeric species upon secretion from the host cell","volume":"75","author":"Crooks","year":"1994","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib14","doi-asserted-by":"crossref","first-page":"8101","DOI":"10.1128\/JVI.79.13.8101-8112.2005","article-title":"Role of the hypervariable hinge region of phosphoprotein P of vesicular stomatitis virus in viral RNA synthesis and assembly of infectious virus particles","volume":"79","author":"Das","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib15","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.1016\/j.vaccine.2008.09.038","article-title":"Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies","volume":"26","author":"De Filette","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2009.10.033_bib16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.virusres.2004.02.030","article-title":"A \u201cuniversal\u201d human influenza A vaccine","volume":"103","author":"Fiers","year":"2004","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2009.10.033_bib17","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1128\/JVI.73.7.6104-6110.1999","article-title":"Dengue virus type 1 nonstructural glycoprotein NS1 is secreted from mammalian cells as a soluble hexamer in a glycosylation-dependent fashion","author":"Flamand","year":"1999","journal-title":"J. Virol."},{"issue":"18","key":"10.1016\/j.virol.2009.10.033_bib18","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1128\/JVI.00850-09","article-title":"Random insertion mutagenesis of Sindbis virus nsP2 and selection of variants incapable of downregulating cellular transcription","volume":"83","author":"Frolov","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib19","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.vaccine.2008.12.034","article-title":"Comparative immunogenicity evaluations of influenza A virus M2 peptide as recombinant virus like particle or conjugate vaccines in mice and monkeys","volume":"27","author":"Fu","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2009.10.033_bib20","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1099\/vir.0.80677-0","article-title":"Heterologous gene expression by infectious and replicon vectors derived from tick-borne encephalitis virus and direct comparison of this flavivirus system with an alphavirus replicon","volume":"86","author":"Gehrke","year":"2005","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib21","series-title":"Fields Virology","first-page":"1153","article-title":"Flaviviruses","author":"Gubler","year":"2007"},{"key":"10.1016\/j.virol.2009.10.033_bib22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/viro.1999.9695","article-title":"Immunogenicity, genetic stability, and protective efficacy of a recombinant, chimeric yellow fever-Japanese encephalitis virus (ChimeriVax-JE) as a live, attenuated vaccine candidate against Japanese encephalitis","volume":"257","author":"Guirakhoo","year":"1999","journal-title":"Virology"},{"key":"10.1016\/j.virol.2009.10.033_bib23","doi-asserted-by":"crossref","first-page":"7290","DOI":"10.1128\/JVI.75.16.7290-7304.2001","article-title":"Construction, safety, and immunogenicity in nonhuman primates of a chimeric yellow fever-dengue virus tetravalent vaccine","volume":"75","author":"Guirakhoo","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib24","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1006\/viro.2002.1462","article-title":"Viremia and immunogenicity in nonhuman primates of a tetravalent yellow fever-dengue chimeric vaccine: genetic reconstructions, dose adjustment, and antibody responses against wild-type dengue virus isolates","volume":"298","author":"Guirakhoo","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.virol.2009.10.033_bib25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4161\/hv.2.2.2555","article-title":"Live attenuated chimeric yellow fever dengue type 2 (ChimeriVax-DEN2) vaccine: phase I clinical trial for safety and immunogenicity: effect of yellow fever pre-immunity in induction of cross neutralizing antibody responses to all 4 dengue serotypes","volume":"2","author":"Guirakhoo","year":"2006","journal-title":"Hum. Vaccin."},{"key":"10.1016\/j.virol.2009.10.033_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/viro.1999.9956","article-title":"Loss of dimerisation of the nonstructural protein NS1 of Kunjin virus delays viral replication and reduces virulence in mice, but still allows secretion of NS1","volume":"264","author":"Hall","year":"1999","journal-title":"Virology"},{"key":"10.1016\/j.virol.2009.10.033_bib27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.vaccine.2007.10.062","article-title":"Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin","volume":"26","author":"Huleatt","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2009.10.033_bib28","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.4049\/jimmunol.172.9.5598","article-title":"Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity","volume":"172","author":"Jegerlehner","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2009.10.033_bib29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.virol.2004.10.034","article-title":"Construction and applications of yellow fever virus replicons","volume":"331","author":"Jones","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.virol.2009.10.033_bib30","unstructured":"Kleanthous, H., Miller, C., Oros, L., 2002. Chimeric flavivirus vectors. US patent 7569383."},{"key":"10.1016\/j.virol.2009.10.033_bib31","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1128\/JVI.73.6.4611-4621.1999","article-title":"Genetic interaction of flavivirus nonstructural protein NS1 and NS4A as a determinant of replicase function","volume":"73","author":"Lindenbach","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0065-3527(03)59002-9","article-title":"Molecular biology of flaviviruses","volume":"59","author":"Lindenbach","year":"2003","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.virol.2009.10.033_bib33","series-title":"Fields Virology","first-page":"1101","article-title":"Flaviviridae: the viruses and their replication","author":"Lindenbach","year":"2007"},{"key":"10.1016\/j.virol.2009.10.033_bib34","doi-asserted-by":"crossref","first-page":"9197","DOI":"10.1128\/JVI.74.19.9197-9205.2000","article-title":"Recombinant yellow fever viruses are effective therapeutic vaccines for treatment of murine experimental solid tumors and pulmonary metastases","volume":"74","author":"McAllister","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib35","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1086\/378356","article-title":"Chimeric live, attenuated vaccine against Japanese encephalitis (ChimeriVax-JE): phase 2 clinical trials for safety and immunogenicity, effect of vaccine dose and schedule, and memory response to challenge with inactivated Japanese encephalitis antigen","volume":"188","author":"Monath","year":"2003","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2009.10.033_bib36","doi-asserted-by":"crossref","first-page":"6694","DOI":"10.1073\/pnas.0601932103","article-title":"A live, attenuated recombinant West Nile virus vaccine","volume":"103","author":"Monath","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virol.2009.10.033_bib37","series-title":"Vaccines","first-page":"959","article-title":"Yellow fever vaccine","author":"Monath","year":"2008"},{"key":"10.1016\/j.virol.2009.10.033_bib38","doi-asserted-by":"crossref","first-page":"7400","DOI":"10.1128\/JVI.78.14.7400-7409.2004","article-title":"Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes","volume":"78","author":"Moradpour","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1128\/jvi.71.1.291-298.1997","article-title":"Genetic analysis of the yellow fever virus NS1 protein: identification of a temperature-sensitive mutation which blocks RNA accumulation","volume":"71","author":"Muylaert","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib40","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.virol.2007.01.006","article-title":"Functional characterization of the Sindbis virus E2 glycoprotein by transposon linker-insertion mutagenesis","volume":"363","author":"Navaratnarajah","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.virol.2009.10.033_bib41","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/13484","article-title":"A universal influenza A vaccine based on the extracellular domain of the M2 protein","volume":"5","author":"Neirynck","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.virol.2009.10.033_bib42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4269\/ajtmh.2007.77.159","article-title":"Flavivirus serology by Western blot analysis","volume":"77","author":"Oceguera","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2009.10.033_bib43","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1586\/14760584.7.8.1239","article-title":"Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus","volume":"7","author":"Olson","year":"2008","journal-title":"Expert. Rev. Vaccines"},{"key":"10.1016\/j.virol.2009.10.033_bib44","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1099\/vir.0.82272-0","article-title":"Restricted replication and lysosomal trafficking of yellow fever 17D vaccine virus in human dendritic cells","volume":"88","author":"Palmer","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib45","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4269\/ajtmh.2008.78.434","article-title":"Serologic diagnosis of West Nile and St. Louis encephalitis virus infections in domestic chickens","volume":"78","author":"Patiris","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2009.10.033_bib46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1517\/14712598.6.2.135","article-title":"Kunjin virus replicons: an RNA-based, non-cytopathic viral vector system for protein production, vaccine and gene therapy applications","volume":"6","author":"Pijlman","year":"2006","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.virol.2009.10.033_bib47","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0020-7519(03)00063-8","article-title":"Traditional and novel approaches to flavivirus vaccines","volume":"33","author":"Pugachev","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.virol.2009.10.033_bib48","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1084\/jem.20051720","article-title":"Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity","volume":"203","author":"Querec","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2009.10.033_bib49","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jviromet.2006.01.014","article-title":"A novel method for cloning of non-cytolytic viruses","volume":"135","author":"Rang","year":"2006","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.virol.2009.10.033_bib50","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.virol.2005.08.015","article-title":"Mutation of E1 glycoprotein of classical swine fever virus affects viral virulence in swine","volume":"343","author":"Risatti","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.virol.2009.10.033_bib51","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1128\/JVI.80.3.1427-1439.2006","article-title":"A tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient mice","volume":"80","author":"Rumyantsev","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib52","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.4049\/jimmunol.135.4.2805","article-title":"Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the nonstructural glycoprotein gp48 and by active immunization with gp48","volume":"135","author":"Schlesinger","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2009.10.033_bib53","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1099\/0022-1317-68-3-853","article-title":"Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1","volume":"68","author":"Schlesinger","year":"1987","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib54","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1586\/erv.09.6","article-title":"Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments","volume":"8","author":"Schotsaert","year":"2009","journal-title":"Expert Rev.Vaccines"},{"key":"10.1016\/j.virol.2009.10.033_bib55","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1084\/jem.20041526","article-title":"Yellow fever 17D as a vaccine vector for microbial CTL epitopes: protection in a rodent malaria model","volume":"201","author":"Tao","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2009.10.033_bib56","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/B:VIRU.0000012266.04871.ce","article-title":"Genetic vaccination of mice with plasmids encoding the NS1 non-structural protein from tick-borne encephalitis virus and dengue 2 virus","volume":"28","author":"Timofeev","year":"2004","journal-title":"Virus Genes"},{"key":"10.1016\/j.virol.2009.10.033_bib57","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1128\/jvi.64.3.1375-1377.1990","article-title":"Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice","volume":"64","author":"Treanor","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib58","doi-asserted-by":"crossref","first-page":"8262","DOI":"10.1128\/JVI.00226-08","article-title":"West Nile virus nonstructural protein 1 inhibits TLR3 signal transduction","volume":"82","author":"Wilson","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2009.10.033_bib59","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0042-6822(88)90408-4","article-title":"Evidence that the mature form of the flavivirus nonstructural protein NS1 is a dimer","volume":"162","author":"Winkler","year":"1988","journal-title":"Virology"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682209006576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682209006576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:03:02Z","timestamp":1758585782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682209006576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0042682209006576"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2009.10.033","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct random insertion of an influenza virus immunologic determinant into the NS1 glycoprotein of a vaccine flavivirus","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2009.10.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}