{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:07:16Z","timestamp":1774674436634,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":594,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"publisher","award":["20090071110076"],"award-info":[{"award-number":["20090071110076"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30772021"],"award-info":[{"award-number":["30772021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31070786"],"award-info":[{"award-number":["31070786"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.virol.2011.09.006","type":"journal-article","created":{"date-parts":[[2011,10,17]],"date-time":"2011-10-17T01:20:33Z","timestamp":1318814433000},"page":"78-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis"],"prefix":"10.1016","volume":"421","author":[{"given":"Yuquan","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruizhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xujie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeqing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingzhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunzeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haozhu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.virol.2011.09.006_bb0005","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1128\/JVI.78.5.2454-2459.2004","article-title":"Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens","volume":"78","author":"Aandahl","year":"2004","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2011.09.006_bb0010","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0002-9440(10)61685-9","article-title":"Experimental autoimmune myocarditis in A\/J mice is an interleukin-4-dependent disease with a Th2 phenotype","volume":"159","author":"Afanasyeva","year":"2001","journal-title":"Am. J. Pathol."},{"issue":"10","key":"10.1016\/j.virol.2011.09.006_bb0015","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1161\/CIRCRESAHA.109.213157","article-title":"Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy","volume":"106","author":"Baldeviano","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.virol.2011.09.006_bb0190","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"7090","author":"Bettelli","year":"2006","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.virol.2011.09.006_bb0025","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.pcad.2009.11.006","article-title":"Myocarditis","volume":"52","author":"Blauwet","year":"2010","journal-title":"Prog. Cardiovasc. Dis."},{"issue":"3","key":"10.1016\/j.virol.2011.09.006_bb0030","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.4049\/jimmunol.182.3.1247","article-title":"Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression","volume":"182","author":"Chauhan","year":"2009","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.virol.2011.09.006_bb0035","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.intimp.2009.07.014","article-title":"Coxsackievirus B3 infection promotes generation of myeloid dendritic cells from bone marrow and accumulation in the myocardium","volume":"9","author":"Chen","year":"2009","journal-title":"Int. Immunopharmacol."},{"issue":"2\u20133","key":"10.1016\/j.virol.2011.09.006_bb0040","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ejphar.2011.02.040","article-title":"Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-beta1 signaling in coxsackievirus B3-induced cardiomyopathy","volume":"658","author":"Chen","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.virol.2011.09.006_bb0045","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/ni.1741","article-title":"Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus","volume":"10","author":"Doreau","year":"2009","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.virol.2011.09.006_bb0050","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.4049\/jimmunol.174.7.4407","article-title":"Depletion of regulatory T cells in HIV infection is associated with immune activation","volume":"174","author":"Eggena","year":"2005","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.virol.2011.09.006_bb0055","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1086\/500368","article-title":"Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection","volume":"193","author":"Estes","year":"2006","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.virol.2011.09.006_bb0060","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4049\/jimmunol.174.1.261","article-title":"IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heart","volume":"174","author":"Fairweather","year":"2005","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.virol.2011.09.006_bb0065","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/jaut.2000.0492","article-title":"From infection to autoimmunity","volume":"16","author":"Fairweather","year":"2001","journal-title":"J. Autoimmun."},{"issue":"11","key":"10.1016\/j.virol.2011.09.006_bb0070","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1002\/eji.200737766","article-title":"IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells","volume":"37","author":"Fantini","year":"2007","journal-title":"Eur. J. Immunol."},{"issue":"19","key":"10.1016\/j.virol.2011.09.006_bb0075","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1056\/NEJM200011093431908","article-title":"Myocarditis","volume":"343","author":"Feldman","year":"2000","journal-title":"N. Engl. J. Med."},{"issue":"13","key":"10.1016\/j.virol.2011.09.006_bb0080","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1182\/blood-2008-06-162727","article-title":"Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells","volume":"113","author":"Figueiredo","year":"2009","journal-title":"Blood"},{"issue":"21","key":"10.1016\/j.virol.2011.09.006_bb0085","doi-asserted-by":"crossref","first-page":"10785","DOI":"10.1128\/JVI.76.21.10785-10790.2002","article-title":"Vgamma4(+) T cells promote autoimmune CD8(+) cytolytic T-lymphocyte activation in coxsackievirus B3-induced myocarditis in mice: role for CD4(+) Th1 cells","volume":"76","author":"Huber","year":"2002","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.virol.2011.09.006_bb0090","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.smim.2007.10.011","article-title":"Transcriptional regulation of Th17 cell differentiation","volume":"19","author":"Ivanov","year":"2007","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.virol.2011.09.006_bb0095","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 Cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.virol.2011.09.006_bb0100","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.immuni.2007.02.009","article-title":"Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation","volume":"26","author":"Laurence","year":"2007","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.virol.2011.09.006_bb0105","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2008.11.005","article-title":"Late developmental plasticity in the T helper 17 lineage","volume":"30","author":"Lee","year":"2009","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.virol.2011.09.006_bb0110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.virol.2009.12.016","article-title":"A TGF-beta mediated regulatory mechanism modulates the T cell immune response to rotavirus in adults but not in children","volume":"399","author":"Mesa","year":"2010","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.virol.2011.09.006_bb0115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/clin.1993.1104","article-title":"T cells in cardiac myosin-induced myocarditis","volume":"68","author":"Neu","year":"1993","journal-title":"Clin. Immunol. Immunopathol."},{"issue":"4","key":"10.1016\/j.virol.2011.09.006_bb0120","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/intimm\/10.4.371","article-title":"Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency","volume":"10","author":"Papiernik","year":"1998","journal-title":"Int. Immunol."},{"issue":"7","key":"10.1016\/j.virol.2011.09.006_bb0125","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1182\/blood-2009-12-255810","article-title":"Th17\/Treg ratio in human graft-versus-host disease","volume":"116","author":"Ratajczak","year":"2010","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.virol.2011.09.006_bb0130","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"issue":"24","key":"10.1016\/j.virol.2011.09.006_bb0135","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1161\/CIRCULATIONAHA.109.893248","article-title":"Regulatory T cells protect mice against coxsackievirus-induced myocarditis through the transforming growth factor beta-coxsackie-adenovirus receptor pathway","volume":"121","author":"Shi","year":"2010","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.virol.2011.09.006_bb0140","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1002\/eji.200636484","article-title":"Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis","volume":"36","author":"Sonderegger","year":"2006","journal-title":"Eur. J. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.virol.2011.09.006_bb0145","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.vetimm.2005.07.011","article-title":"The role of CD4+CD25+ regulatory T cells in viral infections","volume":"108","author":"Vahlenkamp","year":"2005","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"4","key":"10.1016\/j.virol.2011.09.006_bb0150","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.4049\/jimmunol.180.4.2686","article-title":"CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis","volume":"180","author":"Valaperti","year":"2008","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.virol.2011.09.006_bb0155","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.virol.2011.09.006_bb0160","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.0105-2896.2010.00896.x","article-title":"Perforin: structure, function, and role in human immunopathology","volume":"235","author":"Voskoboinik","year":"2010","journal-title":"Immunol. Rev."},{"issue":"2","key":"10.1016\/j.virol.2011.09.006_bb0165","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.virol.2006.06.017","article-title":"HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory","volume":"353","author":"Wherry","year":"2006","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.virol.2011.09.006_bb0170","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.virol.2010.12.015","article-title":"Induction and function of virus-specific CD4+ T cell responses","volume":"411","author":"Whitmire","year":"2011","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.virol.2011.09.006_bb0175","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/eji.201040682","article-title":"Human tumor-infiltrating Th17 cells have the capacity to differentiate into IFN-gamma+ and FOXP3+ T cells with potent suppressive function","volume":"41","author":"Ye","year":"2011","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.virol.2011.09.006_bb0180","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2009.05.001","article-title":"Plasticity of CD4+ T cell lineage differentiation","volume":"30","author":"Zhou","year":"2009","journal-title":"Immunity"},{"issue":"7192","key":"10.1016\/j.virol.2011.09.006_bb0185","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nature06878","article-title":"TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function","volume":"453","author":"Zhou","year":"2008","journal-title":"Nature"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682211004259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682211004259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:13:23Z","timestamp":1758586403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682211004259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0042682211004259"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2011.09.006","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2011.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}