{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:20:30Z","timestamp":1792596030948,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":411,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIH\/National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["N01-AI-25489"],"award-info":[{"award-number":["N01-AI-25489"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1016\/j.virol.2012.02.016","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T23:25:00Z","timestamp":1331940300000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":261,"title":["Transmission dynamics of an insect-specific flavivirus in a naturally infected Culex pipiens laboratory colony and effects of co-infection on vector competence for West Nile virus"],"prefix":"10.1016","volume":"427","author":[{"given":"Bethany G.","family":"Bolling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Olea-Popelka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Eisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chester G.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol D.","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.virol.2012.02.016_bb0005","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4269\/ajtmh.2002.67.85","article-title":"Variation in vector competence for dengue 2 virus among 24 collections of Aedes aegypti from Mexico and the United States","volume":"67","author":"Bennett","year":"2002","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"4","key":"10.1016\/j.virol.2012.02.016_bb0010","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1603\/033.046.0428","article-title":"Genomic sequence and phylogenetic analysis of Culex flavivirus, an insect-specific flavivirus, isolated from Culex pipiens (Diptera: Culicidae) in Iowa","volume":"46","author":"Blitvich","year":"2009","journal-title":"J. Med. Entomol."},{"issue":"1","key":"10.1016\/j.virol.2012.02.016_bb0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4269\/ajtmh.2011.10-0474","article-title":"Insect-specific flaviviruses from Culex mosquitoes in Colorado, with evidence of vertical transmission","volume":"85","author":"Bolling","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"10","key":"10.1016\/j.virol.2012.02.016_bb0190","doi-asserted-by":"crossref","first-page":"e856","DOI":"10.1371\/journal.pntd.0000856","article-title":"C6\/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response","volume":"4","author":"Brackney","year":"2010","journal-title":"PLoS Negl Trop Dis."},{"issue":"2","key":"10.1016\/j.virol.2012.02.016_bb0020","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.virol.2004.08.032","article-title":"Markedly reduced severity of dengue virus infection in mosquito cell cultures persistently infected with Aedes albopictus densovirus (AalDNV)","volume":"329","author":"Burivong","year":"2004","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.virol.2012.02.016_bb0025","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00705-005-0626-6","article-title":"A multigene analysis of the phylogenetic relationships among the flaviviruses (Family: Flaviviridae) and the evolution of vector transmission","volume":"151","author":"Cook","year":"2006","journal-title":"Arch. Virol."},{"issue":"Pt 4","key":"10.1016\/j.virol.2012.02.016_bb0030","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1099\/vir.0.81475-0","article-title":"Isolation of a new strain of the flavivirus cell fusing agent virus in a natural mosquito population from Puerto Rico","volume":"87","author":"Cook","year":"2006","journal-title":"J. Gen. Virol."},{"issue":"Pt 11","key":"10.1016\/j.virol.2012.02.016_bb0035","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1099\/vir.0.014183-0","article-title":"Isolation of a novel species of flavivirus and a new strain of Culex flavivirus (Flaviviridae) from a natural mosquito population in Uganda","volume":"90","author":"Cook","year":"2009","journal-title":"J. Gen. Virol."},{"issue":"6","key":"10.1016\/j.virol.2012.02.016_bb0040","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00705-003-0019-7","article-title":"Genetic and phenotypic characterization of the newly described insect flavivirus, Kamiti River virus","volume":"148","author":"Crabtree","year":"2003","journal-title":"Arch. Virol."},{"issue":"5","key":"10.1016\/j.virol.2012.02.016_bb0045","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00705-009-0373-1","article-title":"Isolation and characterization of a new mosquito flavivirus, Quang Binh virus, from Vietnam","volume":"154","author":"Crabtree","year":"2009","journal-title":"Arch. Virol."},{"issue":"1","key":"10.1016\/j.virol.2012.02.016_bb0050","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1603\/ME11080","article-title":"Culex flavivirus and West Nile virus in Culex quinquefasciatus populations in the Southeastern United States","volume":"49","author":"Crockett","year":"2012","journal-title":"J. Med. Entomol."},{"issue":"1","key":"10.1016\/j.virol.2012.02.016_bb0055","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1128\/jvi.30.1.45-55.1979","article-title":"Heterologous interference in Aedes albopictus cells infected with alphaviruses","volume":"30","author":"Eaton","year":"1979","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2012.02.016_bb0060","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4269\/ajtmh.2009.80.85","article-title":"Detection of RNA from a novel West Nile-like virus and high prevalence of an insect-specific flavivirus in mosquitoes in the Yucatan Peninsula of Mexico","volume":"80","author":"Farfan-Ale","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"Pt 8","key":"10.1016\/j.virol.2012.02.016_bb0065","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1099\/0022-1317-82-8-1867","article-title":"Phylogenetic relationships of flaviviruses correlate with their epidemiology, disease association and biogeography","volume":"82","author":"Gaunt","year":"2001","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2012.02.016_bb0195","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/vim.2000.13.469","article-title":"West Nile virus in the United States: guidelines for detection, prevention, and control","volume":"13","author":"Gubler","year":"2000","journal-title":"Viral Immunol."},{"issue":"Pt 9","key":"10.1016\/j.virol.2012.02.016_bb0070","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1099\/vir.0.81950-0","article-title":"The 3\u2032 untranslated regions of Kamiti River virus and cell fusing agent virus originated by self-duplication","volume":"87","author":"Gritsun","year":"2006","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2012.02.016_bb0075","series-title":"Virus Taxonomy, 7th Report of the International Committee for the Taxonomy of Viruses","first-page":"859","article-title":"Family Flaviviridae","author":"Heinz","year":"2000"},{"issue":"2","key":"10.1016\/j.virol.2012.02.016_bb0080","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.virol.2006.09.039","article-title":"Genetic characterization of a new insect flavivirus isolated from Culex pipiens mosquito in Japan","volume":"359","author":"Hoshino","year":"2007","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.virol.2012.02.016_bb0085","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.virol.2009.06.025","article-title":"Isolation and characterization of a new insect flavivirus from Aedes albopictus and Aedes flavopictus mosquitoes in Japan","volume":"391","author":"Hoshino","year":"2009","journal-title":"Virology"},{"issue":"18","key":"10.1016\/j.virol.2012.02.016_bb0090","doi-asserted-by":"crossref","first-page":"9532","DOI":"10.1128\/JVI.00529-09","article-title":"Characterization of a novel flavivirus from mosquitoes in Northern Europe related to mosquito-borne flaviviruses of the tropics","volume":"83","author":"Huhtamo","year":"2009","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2012.02.016_bb0095","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1128\/JVI.00014-09","article-title":"A new flavivirus and a new vector: characterization of a novel flavivirus isolated from Uranotaenia mosquitoes from a tropical rain forest","volume":"83","author":"Junglen","year":"2009","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2012.02.016_bb0100","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1128\/jvi.71.9.7119-7123.1997","article-title":"Superinfection exclusion of alphaviruses in three mosquito cell lines persistently infected with Sindbis virus","volume":"71","author":"Karpf","year":"1997","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.virol.2012.02.016_bb0105","doi-asserted-by":"crossref","first-page":"e671","DOI":"10.1371\/journal.pntd.0000671","article-title":"Transmission of West Nile virus by Culex quinquefasciatus Say infected with Culex flavivirus Izabal","volume":"4","author":"Kent","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"1","key":"10.1016\/j.virol.2012.02.016_bb0110","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.virol.2008.12.034","article-title":"Characterization of Culex flavivirus (Flaviviridae) strains isolated from mosquitoes in the United States and Trinidad","volume":"386","author":"Kim","year":"2009","journal-title":"Virology"},{"issue":"5","key":"10.1016\/j.virol.2012.02.016_bb0115","doi-asserted-by":"crossref","first-page":"e646","DOI":"10.1371\/journal.pntd.0000646","article-title":"Consequences of the expanding global distribution of Aedes albopictus for dengue virus transmission","volume":"4","author":"Lambrechts","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"11","key":"10.1016\/j.virol.2012.02.016_bb0120","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1128\/JCM.38.11.4066-4071.2000","article-title":"Rapid detection of West Nile virus from human clinical specimens, field-collected mosquitoes, and avian samples by a TaqMan reverse transcriptase-PCR assay","volume":"38","author":"Lanciotti","year":"2000","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2012.02.016_bb0125","doi-asserted-by":"crossref","unstructured":"Lorenz, L., Beaty, B.J., Aitken, T.H.G., Wallis, G.P., Tabachnick, W.J., 1984. The effect of colonization upon Aedes aegypti susceptibility to oral infection with yellow fever virus. Am. J. Trop. Med. Hyg. 33 (4), 690-694.","DOI":"10.4269\/ajtmh.1984.33.690"},{"key":"10.1016\/j.virol.2012.02.016_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1673\/031.007.5501","article-title":"Infection and vertical transmission of Kamiti river virus in laboratory bred Aedes aegypti mosquitoes","volume":"7","author":"Lutomiah","year":"2007","journal-title":"J. Insect Sci."},{"issue":"6","key":"10.1016\/j.virol.2012.02.016_bb0135","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1093\/jmedent\/45.6.1187","article-title":"Culex flavivirus isolates from mosquitoes in Guatemala","volume":"45","author":"Morales-Betoulle","year":"2008","journal-title":"J. Med. Entomol."},{"issue":"6","key":"10.1016\/j.virol.2012.02.016_bb0140","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.4269\/ajtmh.1986.35.1296","article-title":"Experimental vertical transmission of Saint Louis encephalitis virus by Florida mosquitoes","volume":"35","author":"Nayar","year":"1986","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2012.02.016_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/vbz.2010.0144","article-title":"Culex flavivirus and West Nile virus mosquito coinfection and positive ecological association in Chicago, United States","volume":"11","author":"Newman","year":"2011","journal-title":"Vector Borne Zoonotic Dis."},{"key":"10.1016\/j.virol.2012.02.016_bb0150","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2180-8-28","article-title":"Asymmetric competitive suppression between strains of dengue virus","volume":"8","author":"Pepin","year":"2008","journal-title":"BMC Microbiol."},{"issue":"2","key":"10.1016\/j.virol.2012.02.016_bb0155","doi-asserted-by":"crossref","first-page":"398","DOI":"10.4269\/ajtmh.1987.37.398","article-title":"Sexual transmission of Dengue viruses by Aedes albopictus","volume":"37","author":"Rosen","year":"1987","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"5","key":"10.1016\/j.virol.2012.02.016_bb0160","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1603\/ME11043","article-title":"Evidence of efficient transovarial transmission of Culex flavivirus by Culex pipiens (Diptera: Culicidae)","volume":"48","author":"Saiyasombat","year":"2011","journal-title":"J. Med. Entomol."},{"issue":"6","key":"10.1016\/j.virol.2012.02.016_bb0165","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00705-003-0018-8","article-title":"Isolation of a new flavivirus related to cell fusing agent virus (CFAV) from field-collected flood-water Aedes mosquitoes sampled from a dambo in central Kenya","volume":"148","author":"Sang","year":"2003","journal-title":"Arch. Virol."},{"issue":"10","key":"10.1016\/j.virol.2012.02.016_bb0170","doi-asserted-by":"crossref","first-page":"e848","DOI":"10.1371\/journal.pntd.0000848","article-title":"Comparison of dengue virus type 2-specific small RNAs from RNA interference-competent and -incompetent mosquito cells","volume":"4","author":"Scott","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"3","key":"10.1016\/j.virol.2012.02.016_bb0175","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/jmedent\/27.3.334","article-title":"Venereal transmission of St. Louis Encephalitis virus by Culex quinquefasciatus males (Diptera: Culicidae)","volume":"27","author":"Shroyer","year":"1990","journal-title":"J. Med. Entomol."},{"issue":"2","key":"10.1016\/j.virol.2012.02.016_bb0180","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0042-6822(75)90113-0","article-title":"An agent in the Aedes aegypti cell line (Peleg) which causes fusion of Aedes albopictus cells","volume":"64","author":"Stollar","year":"1975","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.virol.2012.02.016_bb0185","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4269\/ajtmh.2011.10-0469","article-title":"Phylogenetic analysis of a novel mosquito flavivirus present in Culex tarsalis mosquitoes collected in western Canada and the states of California and Colorado","volume":"85","author":"Tyler","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682212001353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682212001353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:16:02Z","timestamp":1758586562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682212001353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0042682212001353"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2012.02.016","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transmission dynamics of an insect-specific flavivirus in a naturally infected Culex pipiens laboratory colony and effects of co-infection on vector competence for West Nile virus","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2012.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}