{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:42:16Z","timestamp":1790790136032,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T00:00:00Z","timestamp":1379289600000},"content-version":"vor","delay-in-days":380,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"French Ministry of Research"},{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003323","name":"ANRS","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.virol.2012.05.008","type":"journal-article","created":{"date-parts":[[2012,6,2]],"date-time":"2012-06-02T21:53:34Z","timestamp":1338674014000},"page":"21-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Production of hepatitis B defective particles is dependent on liver status"],"prefix":"10.1016","volume":"431","author":[{"given":"Francois","family":"Redelsperger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouchra","family":"Lekbaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassmina","family":"Mandouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Giang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Duriez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Desire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-marie","family":"Roque Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Segolene","family":"Brichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Dubreuil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Dobrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Perlemuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Prevot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Didier","family":"Grange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadila","family":"Zatla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Le Pendeven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislas","family":"Pol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Strick-Marchand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Di Santo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Kremsdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Soussan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.virol.2012.05.008_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.virol.2008.06.021","article-title":"Characterization of the contribution of spliced RNAs of hepatitis B virus to DNA synthesis in transfected cultures of Huh7 and HepG2 cells","volume":"379","author":"Abraham","year":"2008","journal-title":"Virology"},{"issue":"5","key":"10.1016\/j.virol.2012.05.008_bib2","first-page":"492","article-title":"Proceedings: defective interfering particles","volume":"25","author":"Baltimore","year":"1975","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.virol.2012.05.008_bib3","doi-asserted-by":"crossref","first-page":"e25096","DOI":"10.1371\/journal.pone.0025096","article-title":"Antiviral activity of Bay 41-4109 on hepatitis B virus in humanized Alb-uPA\/SCID Mice","volume":"6","author":"Brezillon","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.virol.2012.05.008_bib4","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.cell.2009.02.011","article-title":"RNA and disease","volume":"136","author":"Cooper","year":"2009","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.virol.2012.05.008_bib5","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/jmv.22118","article-title":"Characterization of hepatitis B virus in Turkish blood donors, and the prevalence of the SP1 splice variant","volume":"83","author":"Cox","year":"2011","journal-title":"J. Med. Virol."},{"issue":"4","key":"10.1016\/j.virol.2012.05.008_bib6","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1053\/jhep.2001.23314","article-title":"Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus","volume":"33","author":"Dandri","year":"2001","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.virol.2012.05.008_bib7","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/embor.2008.189","article-title":"The emerging role of splicing factors in cancer","volume":"9","author":"Grosso","year":"2008","journal-title":"EMBO Rep."},{"issue":"9","key":"10.1016\/j.virol.2012.05.008_bib8","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1128\/jvi.69.9.5437-5444.1995","article-title":"A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients","volume":"69","author":"Gunther","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2012.05.008_bib9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/viro.1997.8863","article-title":"Heterogeneity and common features of defective hepatitis B virus genomes derived from spliced pregenomic RNA","volume":"238","author":"G\u00fcnther","year":"1997","journal-title":"Virology"},{"issue":"Pt 1","key":"10.1016\/j.virol.2012.05.008_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1099\/vir.0.004861-0","article-title":"Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells","volume":"90","author":"Hantz","year":"2009","journal-title":"J. Gen. Virol."},{"issue":"1","key":"10.1016\/j.virol.2012.05.008_bib11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/nar\/gkj440","article-title":"The hepatitis B virus PRE contains a splicing regulatory element","volume":"34","author":"Heise","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.virol.2012.05.008_bib12","first-page":"151","article-title":"Defective viral genomes","volume":"vol. 1","author":"Holland","year":"1990"},{"issue":"5243","key":"10.1016\/j.virol.2012.05.008_bib13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/226325a0","article-title":"Defective viral particles and viral disease processes","volume":"226","author":"Huang","year":"1970","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.virol.2012.05.008_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nsmb1209","article-title":"The gene encoding the splicing factor SF2\/ASF is a proto-oncogene","volume":"14","author":"Karni","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"Suppl. 5","key":"10.1016\/j.virol.2012.05.008_bib15","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1002\/hep.22881","article-title":"Hepatitis B: the virus and disease","volume":"49","author":"Liang","year":"2009","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.virol.2012.05.008_bib16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbrc.2006.10.002","article-title":"The HBSP gene is expressed during HBV replication, and its coded BH3-containing spliced viral protein induces apoptosis in HepG2 cells","volume":"351","author":"Lu","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.virol.2012.05.008_bib17","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1128\/JVI.02619-06","article-title":"Hepatitis B virus splice-generated protein induces T-cell responses in HLA-transgenic mice and hepatitis B virus-infected patients","volume":"81","author":"Mancini-Bourgine","year":"2007","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.virol.2012.05.008_bib18","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1086\/500840","article-title":"Liver-stage development of Plasmodium falciparum, in a humanized mouse model","volume":"193","author":"Morosan","year":"2006","journal-title":"J. Infect. Dis."},{"issue":"18","key":"10.1016\/j.virol.2012.05.008_bib19","doi-asserted-by":"crossref","first-page":"9079","DOI":"10.1128\/JVI.00308-09","article-title":"Naturally occurring hepatitis C virus subgenomic deletion mutants replicate efficiently in Huh-7 cells and are trans-packaged in vitro to generate infectious defective particles","volume":"83","author":"Pacini","year":"2009","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2012.05.008_bib20","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1128\/JVI.02701-09","article-title":"Induction of interferon and interferon signaling pathways by replication of defective interfering particle RNA in cells constitutively expressing vesicular stomatitis virus replication proteins","volume":"84","author":"Panda","year":"2010","journal-title":"J. Virol."},{"issue":"1\u20132","key":"10.1016\/j.virol.2012.05.008_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jviromet.2008.09.014","article-title":"Prospective comparison of Abbott RealTime HBV DNA and Versant HBV DNA 3.0 assays for hepatitis B DNA quantitation: impact on HBV genotype monitoring","volume":"154","author":"Pol","year":"2008","journal-title":"J. Virol. Methods"},{"issue":"3","key":"10.1016\/j.virol.2012.05.008_bib22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/hep.22386","article-title":"Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance","volume":"48","author":"Preiss","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.virol.2012.05.008_bib23","first-page":"10","article-title":"In vivo and in vitro expression of defective hepatitis B virus particles generated by spliced hepatitis B virus RNA","volume":"22","author":"Rosmorduc","year":"1995","journal-title":"Hepatology"},{"issue":"Pt 5","key":"10.1016\/j.virol.2012.05.008_bib24","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1099\/0022-1317-80-5-1253","article-title":"Inhibition of interferon-inducible MxA protein expression by hepatitis B virus capsid protein","volume":"80","author":"Rosmorduc","year":"1999","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2012.05.008_bib25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/1743-422X-8-212","article-title":"Defective interfering virus protects elderly mice from influenza","volume":"8","author":"Scott","year":"2011","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2012.05.008_bib26","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.2741\/3097","article-title":"Posttranscriptional control of HBV gene expression","volume":"13","author":"Sommer","year":"2008","journal-title":"Front. Biosci."},{"issue":"2","key":"10.1016\/j.virol.2012.05.008_bib27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/viro.2000.0331","article-title":"Genotype-specific synthesis and secretion of spliced hepatitis B virus genomes in hepatoma cells","volume":"271","author":"Sommer","year":"2000","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.virol.2012.05.008_bib28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI8098","article-title":"In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA","volume":"105","author":"Soussan","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.virol.2012.05.008_bib29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1086\/589623","article-title":"Expression of defective hepatitis B virus particles derived from singly spliced RNA is related to liver disease","volume":"198","author":"Soussan","year":"2008","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.virol.2012.05.008_bib30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0168-8278(02)00422-1","article-title":"The expression of hepatitis B spliced protein (HBSP) encoded by a spliced hepatitis B virus RNA is associated with viral replication and liver fibrosis","volume":"38","author":"Soussan","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.virol.2012.05.008_bib31","doi-asserted-by":"crossref","first-page":"8422","DOI":"10.1073\/pnas.86.21.8422","article-title":"Detection and mapping of spliced RNA from a human hepatoma cell line transfected with the hepatitis B virus genome","volume":"86","author":"Susuki","year":"1989","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.virol.2012.05.008_bib32","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1128\/jvi.65.10.5539-5543.1991","article-title":"Defective hepatitis B virus particles are generated by packaging and reverse transcription of spliced viral RNAs in vivo","volume":"65","author":"Terr\u00e9","year":"1991","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.virol.2012.05.008_bib33","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrg2164","article-title":"Splicing in disease: disruption of the splicing code and the decoding machinery","volume":"8","author":"Wang","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.virol.2012.05.008_bib34","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1128\/jvi.65.4.1680-1686.1991","article-title":"Characterization and genetic analysis of alternatively spliced transcripts of hepatitis B virus in infected human liver tissues and transfected Hep G2 cells","volume":"65","author":"Wu","year":"1991","journal-title":"J. Virol."},{"issue":"1\u20132","key":"10.1016\/j.virol.2012.05.008_bib35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.virusres.2011.03.001","article-title":"Identification of new defective interfering RNA species associated with porcine reproductive and respiratory syndrome virus infection","volume":"158","author":"Xiao","year":"2011","journal-title":"Virus Res."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682212002413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682212002413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:16:18Z","timestamp":1758586578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682212002413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":35,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0042682212002413"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2012.05.008","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Production of hepatitis B defective particles is dependent on liver status","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2012.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}