{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:53:09Z","timestamp":1791287589820,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T00:00:00Z","timestamp":1443139200000},"content-version":"vor","delay-in-days":632,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.virol.2013.11.031","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T16:45:26Z","timestamp":1387557926000},"page":"297-303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["The human parvovirus B19 non-structural protein 1 N-terminal domain specifically binds to the origin of replication in the viral DNA"],"prefix":"10.1016","volume":"449","author":[{"given":"Sunil Kumar","family":"Tewary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2013.11.031_bib1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1128\/jcm.24.4.522-526.1986","article-title":"Detection of antibodies and antigens of human parvovirus B19 by enzyme-linked immunosorbent assay","volume":"24","author":"Anderson","year":"1986","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2013.11.031_bib2","series-title":"Human Parvovirus B19","first-page":"16","article-title":"B19 Parvovirus: biochemical and molecular features","author":"Astell","year":"1997"},{"issue":"Part 2","key":"10.1016\/j.virol.2013.11.031_bib3","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1101\/SQB.1983.047.01.086","article-title":"Structure and replication of minute virus of mice DNA","volume":"47","author":"Astell","year":"1983","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.virol.2013.11.031_bib4","series-title":"Fields' Virology","first-page":"2437","article-title":"Parvoviridae","author":"Berns","year":"2007"},{"key":"10.1016\/j.virol.2013.11.031_bib5","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1128\/JVI.80.2.810-820.2006","article-title":"Impact of capsid conformation and Rep-capsid interactions on adeno-associated virus type 2 genome packaging","volume":"80","author":"Bleker","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib6","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/0042-6822(87)90296-0","article-title":"In vitro identification of a B19 parvovirus promoter","volume":"157","author":"Blundell","year":"1987","journal-title":"Virology"},{"key":"10.1016\/j.virol.2013.11.031_bib7","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1182\/blood-2009-04-215756","article-title":"The small 11kDa nonstructural protein of human parvovirus B19 plays a key role in inducing apoptosis during B19 virus infection of primary erythroid progenitor cells","volume":"115","author":"Chen","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.virol.2013.11.031_bib8","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1128\/jvi.71.8.5733-5741.1997","article-title":"Parvovirus initiation factor PIF: a novel human DNA-binding factor which coordinately recognizes two ACGT motifs","volume":"71","author":"Christensen","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib9","doi-asserted-by":"crossref","first-page":"7741","DOI":"10.1128\/MCB.19.11.7741","article-title":"Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites","volume":"19","author":"Christensen","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.virol.2013.11.031_bib10","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1128\/JVI.75.15.7009-7017.2001","article-title":"Minute virus of mice initiator protein NS1 and a host KDWK family transcription factor must form a precise ternary complex with origin DNA for nicking to occur","volume":"75","author":"Christensen","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib11","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.1128\/JVI.76.13.6518-6531.2002","article-title":"Parvovirus initiator protein NS1 and RPA coordinate replication fork progression in a reconstituted DNA replication system","volume":"76","author":"Christensen","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib12","series-title":"Parvoviruses","first-page":"73","article-title":"Structure and organization of the viral genome","author":"Cotmore","year":"2005"},{"key":"10.1016\/j.virol.2013.11.031_bib13","doi-asserted-by":"crossref","first-page":"13015","DOI":"10.1128\/JVI.01703-07","article-title":"Replication initiator protein NS1 of the parvovirus minute virus of mice binds to modular divergent sites distributed throughout duplex viral DNA","volume":"81","author":"Cotmore","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib14","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.virol.2005.03.007","article-title":"Encapsidation of minute virus of mice DNA: aspects of the translocation mechanism revealed by the structure of partially packaged genomes","volume":"336","author":"Cotmore","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.virol.2013.11.031_bib15","series-title":"Parvoviruses","first-page":"73","article-title":"Structure and organization of the viral genome","author":"Cotmore","year":"2005"},{"key":"10.1016\/j.virol.2013.11.031_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0042-6822(90)90205-6","article-title":"Cloning of the human parvovirus B19 genome and structural analysis of its palindromic termini","volume":"175","author":"Deiss","year":"1990","journal-title":"Virology"},{"key":"10.1016\/j.virol.2013.11.031_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1128\/jvi.64.1.387-396.1990","article-title":"Nonstructural protein of parvoviruses B19 and minute virus of mice controls transcription","volume":"64","author":"Doerig","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/viro.2001.1217","article-title":"The small 11-kDa protein from B19 parvovirus binds growth factor receptor-binding protein 2 in vitro in a Src homology 3 domain\/ligand-dependent manner","volume":"291","author":"Fan","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.virol.2013.11.031_bib19","series-title":"Virus Taxonomy, VIIIth Report of the ICTV","first-page":"277","author":"Fauquet","year":"2004"},{"key":"10.1016\/j.virol.2013.11.031_bib20","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1128\/JVI.76.11.5395-5403.2002","article-title":"Regulation of tumor necrosis factor alpha promoter by human parvovirus B19 NS1 through activation of AP-1 and AP-2","volume":"76","author":"Fu","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1128\/JVI.72.1.609-616.1998","article-title":"Characterization of cis-acting and NS1 protein-responsive elements in the p6 promoter of parvovirus B19","volume":"72","author":"Gareus","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib22","doi-asserted-by":"crossref","first-page":"9541","DOI":"10.1128\/JVI.00702-09","article-title":"The genome of human parvovirus b19 can replicate in nonpermissive cells with the help of adenovirus genes and produces infectious virus","volume":"83","author":"Guan","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2012.12.006","article-title":"Periplaneta fuliginosa densovirus nonstructural protein NS1 contains an endonuclease activity that is regulated by its phosphorylation","volume":"437","author":"Han","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.virol.2013.11.031_bib24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1097-2765(04)00023-1","article-title":"The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces","volume":"13","author":"Hickman","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.virol.2013.11.031_bib25","first-page":"367","article-title":"Effects of human parvovirus B19 on expression of defensins and Toll-like receptors","volume":"54","author":"Hsu","year":"2011","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.virol.2013.11.031_bib26","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1093\/emboj\/20.12.3282","article-title":"DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids","volume":"20","author":"King","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.virol.2013.11.031_bib27","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1128\/MCB.15.1.524","article-title":"Transcriptional activation by the parvoviral nonstructural protein NS-1 is mediated via a direct interaction with Sp1","volume":"15","author":"Krady","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.virol.2013.11.031_bib28","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1128\/jvi.64.10.4654-4660.1990","article-title":"Mutation of lysine 405 to serine in the parvovirus H-1 NS1 abolishes its functions for viral DNA replication, late promoter trans activation, and cytotoxicity","volume":"64","author":"Li","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib29","doi-asserted-by":"crossref","first-page":"10748","DOI":"10.1128\/JVI.01007-12","article-title":"Human parvovirus B19 DNA replication induces a DNA damage response that is dispensable for cell cycle arrest at phase G2\/M","volume":"86","author":"Lou","year":"2012","journal-title":"J. Virol."},{"issue":"23","key":"10.1016\/j.virol.2013.11.031_bib30","doi-asserted-by":"crossref","first-page":"12766","DOI":"10.1128\/JVI.02333-13","article-title":"Human parvovirus B19 infection causes cell cycle arrest of human erythroid progenitors at late S phase that favors viral DNA replication","volume":"87","author":"Luo","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib31","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1128\/JVI.00831-11","article-title":"Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication","volume":"85","author":"Luo","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib32","doi-asserted-by":"crossref","first-page":"8485","DOI":"10.1128\/jvi.70.12.8485-8491.1996","article-title":"A cytotoxic nonstructural protein, NS1, of human parvovirus B19 induces activation of interleukin-6 gene expression","volume":"70","author":"Moffatt","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib33","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1128\/JVI.72.4.3018-3028.1998","article-title":"Human parvovirus B19 nonstructural (NS1) protein induces apoptosis in erythroid lineage cells","volume":"72","author":"Moffatt","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib34","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1128\/JVI.77.5.2915-2921.2003","article-title":"Human parvovirus B19 nonstructural protein (NS1) induces cell cycle arrest at G(1) phase","volume":"77","author":"Morita","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib35","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.virol.2004.09.008","article-title":"Human parvovirus B19 nonstructural protein transactivates the p21\/WAF1 through Sp1","volume":"329","author":"Nakashima","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.virol.2013.11.031_bib36","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1128\/jvi.61.8.2395-2406.1987","article-title":"Novel transcription map for the B19 (human) pathogenic parvovirus","volume":"61","author":"Ozawa","year":"1987","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib37","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1126\/science.3738514","article-title":"Replication of the B19 parvovirus in human bone marrow cell cultures","volume":"233","author":"Ozawa","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.virol.2013.11.031_bib38","doi-asserted-by":"crossref","first-page":"4822","DOI":"10.1128\/JVI.02598-10","article-title":"Structure of a packaging-defective mutant of minute virus of mice indicates that the genome is packaged via a pore at a 5-fold axis","volume":"85","author":"Plevka","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib39","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1006\/viro.2001.1285","article-title":"NS1 protein of parvovirus B19 interacts directly with DNA sequences of the p6 promoter and with the cellular transcription factors Sp1\/Sp3","volume":"293","author":"Raab","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.virol.2013.11.031_bib40","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000149587","article-title":"Characteristics and taxonomy of Parvoviridae","volume":"23","author":"Siegl","year":"1985","journal-title":"Intervirology"},{"key":"10.1016\/j.virol.2013.11.031_bib41","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1128\/JVI.02569-08","article-title":"Molecular characterization of infectious clones of the minute virus of canines reveals unique features of bocaviruses","volume":"83","author":"Sun","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib42","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1172\/JCI41805","article-title":"Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors","volume":"120","author":"Wan","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.virol.2013.11.031_bib43","series-title":"Parvoviruses","first-page":"189","article-title":"Replication of adeno-associated virus DNA","author":"Ward","year":"2005"},{"key":"10.1016\/j.virol.2013.11.031_bib44","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1128\/jvi.63.6.2422-2426.1989","article-title":"Propagation of human parvovirus B19 in primary culture of erythroid lineage cells derived from fetal liver","volume":"63","author":"Yaegashi","year":"1989","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib45","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1056\/NEJMra030840","article-title":"Parvovirus B19","volume":"350","author":"Young","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virol.2013.11.031_bib46","doi-asserted-by":"crossref","first-page":"5941","DOI":"10.1128\/JVI.02430-05","article-title":"Molecular and functional analyses of a human parvovirus B19 infectious clone demonstrates essential roles for NS1, VP1, and the 11-kilodalton protein in virus replication and infectivity","volume":"80","author":"Zhi","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2013.11.031_bib47","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.virol.2003.09.011","article-title":"Construction and sequencing of an infectious clone of the human parvovirus B19","volume":"318","author":"Zhi","year":"2004","journal-title":"Virology"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682213006533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682213006533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:25:40Z","timestamp":1758587140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682213006533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":47,"alternative-id":["S0042682213006533"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2013.11.031","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The human parvovirus B19 non-structural protein 1 N-terminal domain specifically binds to the origin of replication in the viral DNA","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2013.11.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}