{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T13:54:20Z","timestamp":1772546060962,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"National Special Research Programs for Non-Profit Trades, Ministry of Agriculture","award":["200803015"],"award-info":[{"award-number":["200803015"]}]},{"name":"National Special Research Programs for Cultivating New Transgenic Organisms, Ministry of Agriculture","award":["2009ZX08006-007B"],"award-info":[{"award-number":["2009ZX08006-007B"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.virol.2014.01.025","type":"journal-article","created":{"date-parts":[[2014,2,22]],"date-time":"2014-02-22T02:31:10Z","timestamp":1393036270000},"page":"48-59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Effective inhibition of Japanese encephalitis virus replication by shRNAs targeting various viral genes in vitro and in vivo"],"prefix":"10.1016","volume":"454-455","author":[{"given":"Ting","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denian","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruibing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.virol.2014.01.025_bib1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.antiviral.2008.12.007","article-title":"Effective siRNA targeting of the 3\u05f3 untranslated region of the West Nile virus genome","volume":"82","author":"Anthony","year":"2009","journal-title":"Antiviral Res."},{"issue":"7","key":"10.1016\/j.virol.2014.01.025_bib2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2893.2006.00818.x","article-title":"Opportunities for treating chronic hepatitis B and C virus infection using RNA interference","volume":"14","author":"Arbuthnot","year":"2007","journal-title":"J. Viral Hepat."},{"issue":"2","key":"10.1016\/j.virol.2014.01.025_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.antiviral.2009.11.009","article-title":"Structure and functionality in flavivirus NS-proteins: perspectives for drug design","volume":"87","author":"Bollati","year":"2010","journal-title":"Antivir. Res."},{"issue":"2","key":"10.1016\/j.virol.2014.01.025_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35000102","article-title":"RNA interference: genetic wand and genetic watchdog","volume":"2","author":"Bosher","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.virol.2014.01.025_bib5","series-title":"Fields Virology","first-page":"1043","author":"Burke","year":"2001"},{"issue":"10","key":"10.1016\/j.virol.2014.01.025_bib6","doi-asserted-by":"crossref","first-page":"766","DOI":"10.2471\/BLT.10.085233","article-title":"Estimated global incidence of Japanese encephalitis: a systematic review","volume":"89","author":"Campbell","year":"2011","journal-title":"Bull. World Health Organ."},{"issue":"4","key":"10.1016\/j.virol.2014.01.025_bib7","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.bbrc.2006.01.085","article-title":"No induction of anti-viral responses in human cell lines HeLa and MCF-7 when transfecting with siRNA or siLNA","volume":"341","author":"Dahlgren","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.virol.2014.01.025_bib8","first-page":"457","article-title":"Killing the messenger: short RNAs silence gene expression","volume":"4","author":"Dykxhoorn","year":"2003"},{"issue":"6836","key":"10.1016\/j.virol.2014.01.025_bib9","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/35078107","article-title":"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.virol.2014.01.025_bib10","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1371\/journal.pntd.0002208","article-title":"Review of climate, landscape, and viral genetics as drivers of the Japanese Encephalitis Virus ecology","volume":"7","author":"Flohic","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"6","key":"10.1016\/j.virol.2014.01.025_bib11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrd2310","article-title":"Interfering with disease: a progress report on siRNA-based therapeutics","volume":"6","author":"de Fougerolles","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.virol.2014.01.025_bib12","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1371\/journal.pntd.0000437","article-title":"Japanese encephalitis\u2014a pathological and clinical perspective","volume":"3","author":"Ghosh","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"6894","key":"10.1016\/j.virol.2014.01.025_bib13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/418244a","article-title":"RNA interference","volume":"418","author":"Hannon","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.virol.2014.01.025_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-9255-7-1","article-title":"Signaling pathways involved in LPS induced TNFalpha production in human adipocytes","volume":"7","author":"Hoareau","year":"2010","journal-title":"J. Inflamm."},{"key":"10.1016\/j.virol.2014.01.025_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev.ento.54.110807.090510","article-title":"Ecology and geographical expansion of Japanese encephalitis virus","volume":"54","author":"van de Hurk","year":"2009","journal-title":"Annu. Rev. Entomol."},{"issue":"7210","key":"10.1016\/j.virol.2014.01.025_bib16","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature07207","article-title":"RNA interference screen for human genes associated with West Nile virus infection","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.virol.2014.01.025_bib17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1371\/journal.pmed.0030096","article-title":"A single siRNA suppresses fetal encephalitis induced by two different Flaviviruses","volume":"3","author":"Kumar","year":"2006","journal-title":"PLoS Med."},{"issue":"9","key":"10.1016\/j.virol.2014.01.025_bib18","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nbt.2666","article-title":"MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies","volume":"31","author":"Langlois","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.virol.2014.01.025_bib19","series-title":"Fields Virology","first-page":"1101","article-title":"Flaviviridae: the viruses and their replication","author":"Lindenbach","year":"2007"},{"issue":"1","key":"10.1016\/j.virol.2014.01.025_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11262-005-0039-3","article-title":"Inhibition of Japanese encephalitis virus NS1 protein expression in cell by small interfering RNAs","volume":"33","author":"Liu","year":"2006","journal-title":"Virus Genes"},{"key":"10.1016\/j.virol.2014.01.025_bib21","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1128\/JVI.06072-11","article-title":"Crystal structure of the Japanese encephalitis virus envelope protein","volume":"86","author":"Luca","year":"2012","journal-title":"J. Virol."},{"issue":"6-7","key":"10.1016\/j.virol.2014.01.025_bib25","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1863-2378.2008.01208.x","article-title":"The zoonotic flaviviruses of southern, south-eastern and eastern Asia, and Australasia: the potential for emergent viruses","volume":"56","author":"Mackenzie","year":"2009","journal-title":"Zoonoses Publ. Health"},{"issue":"7155","key":"10.1016\/j.virol.2014.01.025_bib22","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nature06042","article-title":"Small self-RNA generated by RNase L amplifies antiviral innate immunity","volume":"448","author":"Malathi","year":"2007","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.virol.2014.01.025_bib23","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1086\/605847","article-title":"Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2phosphorylation","volume":"200","author":"Mazzon","year":"2009","journal-title":"J. Infect. Dis."},{"issue":"5","key":"10.1016\/j.virol.2014.01.025_bib24","doi-asserted-by":"crossref","first-page":"37169","DOI":"10.1371\/journal.pone.0037169","article-title":"MicroRNA regulation of human protease genes essential for influenza virus replication","volume":"7","author":"Meliopoulos","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.virol.2014.01.025_bib26","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1348-0421.2005.tb03701.x","article-title":"Inhibitory effect of RNAi on Japanese encephalitis virus replication in vitro and in vivo","volume":"49","author":"Murakami","year":"2005","journal-title":"Microbiol. Immunol."},{"issue":"11","key":"10.1016\/j.virol.2014.01.025_bib27","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1073\/pnas.0812071106","article-title":"Atomic structure reveals the unique capsid organization of a dsRNA virus","volume":"106","author":"Pan","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.virol.2014.01.025_bib28","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1136\/gutjnl-2011-300449","article-title":"Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi)","volume":"61","author":"Pan","year":"2012","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.virol.2014.01.025_bib29","doi-asserted-by":"crossref","first-page":"51952","DOI":"10.1371\/journal.pone.0051952","article-title":"Specific micro RNA-regulated TetR-KRAB transcriptional control of transgene expression in viral vector-transduced cells","volume":"7","author":"Pichard","year":"2012","journal-title":"PLoS One"},{"issue":"1\u20132","key":"10.1016\/j.virol.2014.01.025_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.virusres.2007.11.014","article-title":"Effective inhibition of Japanese encephalitis virus replication by small interfering RNAs targeting the NS5 gene","volume":"132","author":"Qi","year":"2008","journal-title":"Virus Res."},{"issue":"24","key":"10.1016\/j.virol.2014.01.025_bib31","doi-asserted-by":"crossref","first-page":"13486","DOI":"10.1128\/JVI.01104-12","article-title":"Noncoding flavivirus RNA displays RNA interference suppressor activity in insect and Mammalian cells","volume":"86","author":"Schnettler","year":"2012","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2014.01.025_bib32","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/ncb1038","article-title":"Activation of the interferon system by short-interfering RNAs","volume":"5","author":"Sledz","year":"2003","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.virol.2014.01.025_bib33","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1038\/mt.2012.119","article-title":"Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate model","volume":"20","author":"Suhy","year":"2012","journal-title":"Mol. Ther."},{"issue":"2","key":"10.1016\/j.virol.2014.01.025_bib34","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0042-6822(87)90144-9","article-title":"Complete nucleotide sequence of the Japanese encephalitis virus genome RNA","volume":"161","author":"Sumiyoshi","year":"1987","journal-title":"Virology"},{"issue":"6","key":"10.1016\/j.virol.2014.01.025_bib35","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1128\/AAC.01626-08","article-title":"Inhibition of vaccinia virus replication by two small interfering RNAs targeting B1R and G7L genes and their synergistic combination with cidofovir","volume":"53","author":"Vigne.","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"issue":"25","key":"10.1016\/j.virol.2014.01.025_bib36","doi-asserted-by":"crossref","first-page":"18484","DOI":"10.1074\/jbc.M113.458158","article-title":"Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a\/miR-16-1 inhepatocytes","volume":"288","author":"Wang","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.virol.2014.01.025_bib37","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrmicro1006","article-title":"Transmission cycles, host range, evolution and emergence of arboviral disease","volume":"2","author":"Weaver","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.virol.2014.01.025_bib38","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/mt.2013.31","article-title":"Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection","volume":"21","author":"Wooddell","year":"2013","journal-title":"Mol. Ther."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682214000385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682214000385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:25:20Z","timestamp":1758587120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682214000385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":38,"alternative-id":["S0042682214000385"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2014.01.025","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effective inhibition of Japanese encephalitis virus replication by shRNAs targeting various viral genes in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2014.01.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}