{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:50:11Z","timestamp":1791208211753,"version":"4.1.0"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011410","name":"University of South Carolina School of Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011410","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.virol.2014.03.002","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T15:52:44Z","timestamp":1395762764000},"page":"1-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytes"],"prefix":"10.1016","volume":"456-457","author":[{"given":"Ashok","family":"Chauhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Mehla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theophilus Sunder","family":"Vijayakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indhira","family":"Handy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2014.03.002_bib1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1128\/jvi.59.2.284-291.1986","article-title":"Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone","volume":"59","author":"Adachi","year":"1986","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib2","doi-asserted-by":"crossref","first-page":"11916","DOI":"10.1128\/JVI.78.21.11916-11925.2004","article-title":"Interaction between the cytoplasmic domain of ICAM-1 and Pr55Gag leads to acquisition of host ICAM-1 by human immunodeficiency virus type 1","volume":"78","author":"Beausejour","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/13550289909021993","article-title":"Replication of different clones of human immunodeficiency virus type 1 in primary fetal human astrocytes: enhancement of viral gene expression by Nef","volume":"5","author":"Bencheikh","year":"1999","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.virol.2014.03.002_bib4","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1096\/fj.04-1755fje","article-title":"The importance of virus-associated host ICAM-1 in human immunodeficiency virus type 1 dissemination depends on the cellular context","volume":"18","author":"Bounou","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.virol.2014.03.002_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/glia.1051","article-title":"Isolated human astrocytes are not susceptible to infection by M- and T-tropic HIV-1 strains despite functional expression of the chemokine receptors CCR5 and CXCR4","volume":"34","author":"Boutet","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.virol.2014.03.002_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00002030-199901140-00003","article-title":"Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis","volume":"13","author":"Brack-Werner","year":"1999","journal-title":"Aids"},{"key":"10.1016\/j.virol.2014.03.002_bib7","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1091\/mbc.11.2.467","article-title":"Rab7: a key to lysosome biogenesis","volume":"11","author":"Bucci","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.virol.2014.03.002_bib8","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1002\/eji.200939351","article-title":"The C-type lectin DC-SIGN internalizes soluble antigens and HIV-1 virions via a clathrin-dependent mechanism","volume":"39","author":"Cambi","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.virol.2014.03.002_bib9","doi-asserted-by":"crossref","first-page":"7925","DOI":"10.1128\/JVI.75.17.7925-7933.2001","article-title":"Highly productive infection with pseudotyped human immunodeficiency virus type 1 (HIV-1) indicates no intracellular restrictions to HIV-1 replication in primary human astrocytes","volume":"75","author":"Canki","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.virol.2010.10.018","article-title":"HIV-1 infects macrophages by exploiting an endocytic route dependent on dynamin, Rac1 and Pak1","volume":"409","author":"Carter","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.virol.2014.03.002_bib11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1096\/fj.06-7054com","article-title":"Molecular programming of endothelin-1 in HIV-infected brain: role of Tat in up-regulation of ET-1 and its inhibition by statins","volume":"21","author":"Chauhan","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.virol.2014.03.002_bib12","doi-asserted-by":"crossref","first-page":"13512","DOI":"10.1074\/jbc.M209381200","article-title":"Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport","volume":"278","author":"Chauhan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2014.03.002_bib13","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1128\/jvi.61.4.1244-1247.1987","article-title":"Infection of brain-derived cells with the human immunodeficiency virus","volume":"61","author":"Chiodi","year":"1987","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib14","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/13550280600748946","article-title":"Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues","volume":"12","author":"Churchill","year":"2006","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.virol.2014.03.002_bib15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ana.21697","article-title":"Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia","volume":"66","author":"Churchill","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.virol.2014.03.002_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.virol.2005.12.004","article-title":"Novel pathway of human immunodeficiency virus type 1 uptake and release in astrocytes","volume":"348","author":"Clarke","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.virol.2014.03.002_bib17","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1128\/JVI.79.3.1581-1594.2005","article-title":"Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry","volume":"79","author":"Daecke","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib18","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1089\/aid.2006.22.1152","article-title":"CCR5-, DC-SIGN-dependent endocytosis and delayed reverse transcription after human immunodeficiency virus type 1 infection in human astrocytes","volume":"22","author":"Deiva","year":"2006","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.virol.2014.03.002_bib19","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1128\/jvi.61.12.3774-3782.1987","article-title":"Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV","volume":"61","author":"Dewhurst","year":"1987","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1089\/aid.1.1983.1.447","article-title":"HTLV-III\/LAV-like retrovirus particles in the brains of patients with AIDS encephalopathy","volume":"1","author":"Epstein","year":"1984","journal-title":"AIDS Res."},{"key":"10.1016\/j.virol.2014.03.002_bib21","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0960-9822(00)00654-0","article-title":"Endocytic entry of HIV-1","volume":"10","author":"Fackler","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.virol.2014.03.002_bib22","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1002\/j.1460-2075.1994.tb06728.x","article-title":"Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA","volume":"13","author":"Fischer","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.virol.2014.03.002_bib23","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1128\/jvi.71.5.3588-3596.1997","article-title":"Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhance viral infectivity","volume":"71","author":"Fortin","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib24","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1128\/JVI.72.3.2105-2112.1998","article-title":"T cells expressing activated LFA-1 are more susceptible to infection with human immunodeficiency virus type 1 particles bearing host-encoded ICAM-1","volume":"72","author":"Fortin","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/319008a0","article-title":"AIDS in the human brain","volume":"319","author":"Fox","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.virol.2014.03.002_bib26","doi-asserted-by":"crossref","first-page":"11440","DOI":"10.1128\/JVI.76.22.11440-11446.2002","article-title":"Inhibition of endosomal\/lysosomal degradation increases the infectivity of human immunodeficiency virus","volume":"76","author":"Fredericksen","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ana.410200304","article-title":"Immunohistochemical identification of HTLV-III antigen in brains of patients with AIDS","volume":"20","author":"Gabuzda","year":"1986","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.virol.2014.03.002_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2012.09.013","article-title":"SnapShot: mammalian Rab proteins in endocytic trafficking","volume":"151","author":"Galvez","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.virol.2014.03.002_bib29","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1001\/jama.1986.03380170081023","article-title":"Virus isolation from and identification of HTLV-III\/LAV-producing cells in brain tissue from a patient with AIDS","volume":"256","author":"Gartner","year":"1986","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.virol.2014.03.002_bib30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/jnr.490360609","article-title":"Reactive mononuclear phagocytes release neurotoxins after ischemic and traumatic injury to the central nervous system","volume":"36","author":"Giulian","year":"1993","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.virol.2014.03.002_bib31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3109\/13550289809114536","article-title":"Restricted HIV-1 infection of human astrocytes: potential role of nef in the regulation of virus replication","volume":"4","author":"Gorry","year":"1998","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.virol.2014.03.002_bib32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1128\/JVI.73.1.352-361.1999","article-title":"Diminished production of human immunodeficiency virus type 1 in astrocytes results from inefficient translation of gag, env, and nef mRNAs despite efficient expression of Tat and Rev","volume":"73","author":"Gorry","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib33","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(91)90316-Q","article-title":"rab5 controls early endosome fusion in vitro","volume":"64","author":"Gorvel","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.virol.2014.03.002_bib34","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/vim.1990.3.289","article-title":"CD11a\/CD18 (LFA-1) epitopes involved in syncytium formation among CD4+ T-cells following cell free HIV-1 infection","volume":"3","author":"Goudsmit","year":"1990","journal-title":"Viral Immunol."},{"key":"10.1016\/j.virol.2014.03.002_bib35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jneumeth.2005.06.016","article-title":"Characterization of an improved procedure for the removal of microglia from confluent monolayers of primary astrocytes","volume":"150","author":"Hamby","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.virol.2014.03.002_bib36","doi-asserted-by":"crossref","first-page":"6705","DOI":"10.1128\/jvi.69.11.6705-6711.1995","article-title":"Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity","volume":"69","author":"He","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib37","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.virol.2007.11.007","article-title":"Human macrophages support persistent transcription from unintegrated HIV-1 DNA","volume":"372","author":"Kelly","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.virol.2014.03.002_bib38","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.3016903","article-title":"Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy","volume":"233","author":"Koenig","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.virol.2014.03.002_bib39","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.3646751","article-title":"Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms","volume":"236","author":"Koyanagi","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.virol.2014.03.002_bib40","doi-asserted-by":"crossref","first-page":"8776","DOI":"10.1128\/JVI.76.17.8776-8786.2002","article-title":"Direct and quantitative single-cell analysis of human immunodeficiency virus type 1 reactivation from latency","volume":"76","author":"Kutsch","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib41","first-page":"586","article-title":"Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms","volume":"2","author":"Levy","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.virol.2014.03.002_bib42","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1128\/jvi.66.11.6587-6600.1992","article-title":"Complete nucleotide sequence, genome organization, and biological properties of human immunodeficiency virus type 1 in vivo: evidence for limited defectiveness and complementation","volume":"66","author":"Li","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib43","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1128\/jvi.65.8.3973-3985.1991","article-title":"Molecular characterization of human immunodeficiency virus type 1 cloned directly from uncultured human brain tissue: identification of replication-competent and -defective viral genomes","volume":"65","author":"Li","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib44","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/088922200309232","article-title":"Increased infectivity of HIV type 1 particles bound to cell surface and solid-phase ICAM-1 and VCAM-1 through acquired adhesion molecules LFA-1 and VLA-4","volume":"16","author":"Liao","year":"2000","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.virol.2014.03.002_bib45","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1128\/JVI.78.8.4120-4133.2004","article-title":"CD4-independent infection of astrocytes by human immunodeficiency virus type 1: requirement for the human mannose receptor","volume":"78","author":"Liu","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib46","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1128\/JVI.00393-13","article-title":"Regulation of hepatitis B virus infection by Rab5, Rab7, and the endolysosomal compartment","volume":"87","author":"Macovei","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib47","doi-asserted-by":"crossref","first-page":"8346","DOI":"10.1128\/JVI.00100-12","article-title":"Transport to late endosomes is required for efficient reovirus infection","volume":"86","author":"Mainou","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib48","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/338254a0","article-title":"The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA","volume":"338","author":"Malim","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.virol.2014.03.002_bib49","doi-asserted-by":"crossref","first-page":"11166","DOI":"10.1128\/JVI.75.22.11166-11177.2001","article-title":"Human immunodeficiency virus type 1 entry into macrophages mediated by macropinocytosis","volume":"75","author":"Marechal","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0167-4889(98)00050-0","article-title":"Rab proteins","volume":"1404","author":"Martinez","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.virol.2014.03.002_bib51","doi-asserted-by":"crossref","first-page":"e27915","DOI":"10.1371\/journal.pone.0027915","article-title":"A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function","volume":"6","author":"Mehla","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2014.03.002_bib52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/1742-2094-9-239","article-title":"Programming of neurotoxic cofactor CXCL-10 in HIV-1-associated dementia: abrogation of CXCL-10-induced neuro-glial toxicity in vitro by PKC activator","volume":"9","author":"Mehla","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.virol.2014.03.002_bib53","doi-asserted-by":"crossref","first-page":"e11160","DOI":"10.1371\/journal.pone.0011160","article-title":"Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner","volume":"5","author":"Mehla","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2014.03.002_bib54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0042-6822(92)90058-W","article-title":"Analysis of HIV particle formation using transient expression of subviral constructs in mammalian cells","volume":"186","author":"Mergener","year":"1992","journal-title":"Virology"},{"key":"10.1016\/j.virol.2014.03.002_bib55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1741-7007-11-89","article-title":"Organization and regulation of intracellular plasma membrane-connected HIV-1 assembly compartments in macrophages","volume":"11","author":"Mlcochova","year":"2013","journal-title":"BMC Biol."},{"key":"10.1016\/j.virol.2014.03.002_bib56","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/096876899294797","article-title":"Regulation of membrane transport through the endocytic pathway by rabGTPases","volume":"16","author":"Mohrmann","year":"1999","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.virol.2014.03.002_bib57","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/eji.200838751","article-title":"DC contact with HIV-1-infected cells leads to high levels of Env-mediated virion endocytosis coupled with enhanced HIV-1 Ag presentation","volume":"39","author":"Muratori","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.virol.2014.03.002_bib58","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/00005072-199505000-00005","article-title":"Infection of human fetal astrocytes with HIV-1: viral tropism and the role of cell to cell contact in viral transmission","volume":"54","author":"Nath","year":"1995","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.virol.2014.03.002_bib59","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/ana.410190603","article-title":"The AIDS dementia complex: II. Neuropathology","volume":"19","author":"Navia","year":"1986","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.virol.2014.03.002_bib60","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1128\/jvi.69.4.2159-2167.1995","article-title":"Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function","volume":"69","author":"Neumann","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib61","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/immu.200310024","article-title":"Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages","volume":"33","author":"Nguyen","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.virol.2014.03.002_bib62","doi-asserted-by":"crossref","first-page":"e51393","DOI":"10.1371\/journal.pone.0051393","article-title":"HIV-1 suppressive sequences are modulated by Rev transport of unspliced RNA and are required for efficient HIV-1 production","volume":"7","author":"Noguchi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2014.03.002_bib63","doi-asserted-by":"crossref","first-page":"9329","DOI":"10.1128\/JVI.72.11.9329-9336.1998","article-title":"Level of ICAM-1 surface expression on virus producer cells influences both the amount of virion-bound host ICAM-1 and human immunodeficiency virus type 1 infectivity","volume":"72","author":"Paquette","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib64","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1056\/NEJM198504043121402","article-title":"Vacuolar myelopathy pathologically resembling subacute combined degeneration in patients with the acquired immunodeficiency syndrome","volume":"312","author":"Petito","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virol.2014.03.002_bib65","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.4049\/jimmunol.152.7.3578","article-title":"Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons","volume":"152","author":"Piani","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2014.03.002_bib66","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/ana.410210513","article-title":"HIV antigen in the brains of patients with the AIDS dementia complex","volume":"21","author":"Pumarola-Sune","year":"1987","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.virol.2014.03.002_bib67","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1212\/WNL.0b013e318278b5b4","article-title":"Structural brain alterations can be detected early in HIV infection","volume":"79","author":"Ragin","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.virol.2014.03.002_bib68","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1212\/WNL.38.1.9","article-title":"Early penetration of the blood-brain-barrier by HIV","volume":"38","author":"Resnick","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.virol.2014.03.002_bib69","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1089\/aid.1996.12.855","article-title":"Lack of correlation between V3 amino acid sequence and syncytium-inducing capacity of some HIV type 1 isolates","volume":"12","author":"Sabri","year":"1996","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.virol.2014.03.002_bib70","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1128\/JVI.78.3.1375-1383.2004","article-title":"Compensatory link between fusion and endocytosis of human immunodeficiency virus type 1 in human CD4 T lymphocytes","volume":"78","author":"Schaeffer","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib71","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1089\/088922201316912745","article-title":"HIV type 1 infection of human astrocytes is restricted by inefficient viral entry","volume":"17","author":"Schweighardt","year":"2001","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.virol.2014.03.002_bib72","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/13550280152058816","article-title":"CD4\/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1","volume":"7","author":"Schweighardt","year":"2001","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.virol.2014.03.002_bib73","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.lfs.2003.09.009","article-title":"Regulation of G protein-coupled receptor endocytosis and trafficking by Rab GTPases","volume":"74","author":"Seachrist","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.virol.2014.03.002_bib74","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1084\/jem.20061604","article-title":"Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells","volume":"204","author":"Smith","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2014.03.002_bib75","doi-asserted-by":"crossref","first-page":"7654","DOI":"10.1128\/jvi.70.11.7654-7662.1996","article-title":"Infection of primary human microglia and monocyte-derived macrophages with human immunodeficiency virus type 1 isolates: evidence of differential tropism","volume":"70","author":"Strizki","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib76","doi-asserted-by":"crossref","first-page":"a006924","DOI":"10.1101\/cshperspect.a006924","article-title":"HIV-1 assembly, budding, and maturation","volume":"2","author":"Sundquist","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.virol.2014.03.002_bib77","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/ana.20304","article-title":"Astrocyte specific viral strains in HIV dementia","volume":"56","author":"Thompson","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.virol.2014.03.002_bib78","doi-asserted-by":"crossref","first-page":"6094","DOI":"10.1128\/jvi.65.11.6094-6100.1991","article-title":"Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta","volume":"65","author":"Tornatore","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.03.002_bib79","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1750-3639.2003.tb00014.x","article-title":"Detection of HIV-1 DNA in microglia\/macrophages, astrocytes and neurons isolated from brain tissue with HIV-1 encephalitis by laser capture microdissection","volume":"13","author":"Trillo-Pazos","year":"2003","journal-title":"Brain Pathol."},{"key":"10.1016\/j.virol.2014.03.002_bib80","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1083\/jcb.135.4.913","article-title":"Rab11 regulates recycling through the pericentriolar recycling endosome","volume":"135","author":"Ullrich","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.virol.2014.03.002_bib81","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0014-5793(93)81707-7","article-title":"Rab11, a small GTPase associated with both constitutive and regulated secretory pathways in PC12 cells","volume":"334","author":"Urbe","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.virol.2014.03.002_bib82","first-page":"403","article-title":"AIDS subacute encephalitis. Identification of HIV-infected cells","volume":"126","author":"Vazeux","year":"1987","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.virol.2014.03.002_bib83","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.4049\/jimmunol.175.10.6517","article-title":"Rab5 and Rab7, but not ARF6, govern the early events of HIV-1 infection in polarized human placental cells","volume":"175","author":"Vidricaire","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2014.03.002_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2008.07.039","article-title":"Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection","volume":"381","author":"Vijaykumar","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.virol.2014.03.002_bib85","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nature04472","article-title":"Eisosomes mark static sites of endocytosis","volume":"439","author":"Walther","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.virol.2014.03.002_bib86","first-page":"252","article-title":"No evidence of significant abortive HIV infection of the brain","volume":"11","author":"Wiley","year":"1997","journal-title":"Aids"},{"key":"10.1016\/j.virol.2014.03.002_bib87","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1073\/pnas.83.18.7089","article-title":"Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients","volume":"83","author":"Wiley","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2014.03.002_bib88","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/35052055","article-title":"Rab proteins as membrane organizers","volume":"2","author":"Zerial","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.virol.2014.03.002_bib89","doi-asserted-by":"crossref","first-page":"e15620","DOI":"10.1371\/journal.pone.0015620","article-title":"Perturbation of host nuclear membrane component RanBP2 impairs the nuclear import of human immunodeficiency virus-1 preintegration complex (DNA)","volume":"5","author":"Zhang","year":"2010","journal-title":"PLoS One"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682214000841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682214000841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:23:41Z","timestamp":1758587021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682214000841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":89,"alternative-id":["S0042682214000841"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2014.03.002","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytes","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2014.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}