{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:48:56Z","timestamp":1781714936504,"version":"3.54.5"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Li Ka-Shing Foundation of Canada"},{"name":"Immune Diagnostics & Research"},{"DOI":"10.13039\/501100011840","name":"Shantou University Medical College","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011840","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.virol.2014.07.013","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:45:10Z","timestamp":1406853910000},"page":"177-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Impaired heterologous immunity in aged ferrets during sequential influenza A H1N1 infection"],"prefix":"10.1016","volume":"464-465","author":[{"given":"St\u00e9phane G.","family":"Paquette","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.H.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Banner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoling","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Le\u03ccn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson A.","family":"Kelvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Kelvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2014.07.013_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.0105-2896.2010.00907.x","article-title":"Functional dissection of the granzyme family: cell death and inflammation","volume":"235","author":"Anthony","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.virol.2014.07.013_bib2","first-page":"437","article-title":"The origin and implication of thymic involution","volume":"2","author":"Aw","year":"2011","journal-title":"Aging Dis."},{"key":"10.1016\/j.virol.2014.07.013_bib3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3855\/jidc.2666","article-title":"The current state of H5N1 vaccines and the use of the ferret model for influenza therapeutic and prophylactic development","volume":"6","author":"Banner","year":"2012","journal-title":"J. Infect. Dev. Ctries."},{"key":"10.1016\/j.virol.2014.07.013_bib4","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1093\/infdis\/jir769","article-title":"GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults","volume":"205","author":"Behzad","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2014.07.013_bib5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1242\/dmm.007823","article-title":"The ferret as a model organism to study influenza A virus infection","volume":"4","author":"Belser","year":"2011","journal-title":"Dis. Models Mech."},{"key":"10.1016\/j.virol.2014.07.013_bib6","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/infdis\/168.4.873","article-title":"Heterotypic immune mice lose protection against influenza virus infection with senescence","volume":"168","author":"Bender","year":"1993","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2014.07.013_bib7","first-page":"1","article-title":"Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"49","author":"Bridges","year":"2000","journal-title":"MMWR Recomm. Rep."},{"key":"10.1016\/j.virol.2014.07.013_bib8","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.coi.2011.05.002","article-title":"CD8+ T cell differentiation in the aging immune system: until the last clone standing","volume":"23","author":"Buchholz","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.virol.2014.07.013_bib9","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1086\/313947","article-title":"Clinical relevance of age-related immune dysfunction","volume":"31","author":"Castle","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.virol.2014.07.013_bib10","first-page":"473","article-title":"Influenza activity\u2014United States, 2012-13 season and composition of the 2013-14 influenza vaccine","volume":"62","author":"Centers for Disease Control and Prevention (CDC)","year":"2013","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.virol.2014.07.013_bib11","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/infdis\/jit207","article-title":"Evaluation of the humoral and cellular immune responses elicited by the live attenuated and inactivated influenza vaccines and their roles in heterologous protection in ferrets","volume":"208","author":"Cheng","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2014.07.013_bib12","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1086\/655904","article-title":"Adult hospitalizations for laboratory-positive influenza during the 2005\u20132006 through 2007\u20132008 seasons in the United States","volume":"202","author":"Dao","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2014.07.013_bib13","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.4049\/jimmunol.0902063","article-title":"Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infection","volume":"184","author":"Decman","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2014.07.013_bib14","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.4049\/jimmunol.172.6.3437","article-title":"Age-related impaired type 1 T cell responses to influenza: reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly","volume":"172","author":"Deng","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2014.07.013_bib15","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1084\/jem.20041395","article-title":"Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses","volume":"200","author":"Eaton","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2014.07.013_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1615\/CritRevImmunol.v23.i12.30","article-title":"CD8 T cells and aging","volume":"23","author":"Effros","year":"2003","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.virol.2014.07.013_bib17","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1128\/JVI.05540-11","article-title":"Seasonal H1N1 influenza virus infection induces cross-protective pandemic H1N1 virus immunity through a CD8-independent, B cell-dependent mechanism","volume":"86","author":"Fang","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.07.013_bib18","first-page":"93","article-title":"Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages\/neutrophils: protective and deleterious effects","volume":"22","author":"Grivennikov","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.virol.2014.07.013_bib19","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1128\/JVI.01812-10","article-title":"T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model","volume":"85","author":"Guo","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.07.013_bib20","doi-asserted-by":"crossref","first-page":"e34681","DOI":"10.1371\/journal.pone.0034681","article-title":"Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging","volume":"7","author":"Guo","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2014.07.013_bib21","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1084\/jem.20041933","article-title":"Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen","volume":"201","author":"Haynes","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2014.07.013_bib22","doi-asserted-by":"crossref","first-page":"13187","DOI":"10.1128\/JVI.01456-12","article-title":"Differential pathological and immune responses in newly weaned ferrets are associated with a mild clinical outcome of pandemic 2009 H1N1 infection","volume":"86","author":"Huang","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.07.013_bib23","doi-asserted-by":"crossref","first-page":"e27512","DOI":"10.1371\/journal.pone.0027512","article-title":"Comparative analyses of pandemic H1N1 and seasonal H1N1, H3N2, and influenza B infections depict distinct clinical pictures in ferrets","volume":"6","author":"Huang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2014.07.013_bib24","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/srep01698","article-title":"Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure","volume":"3","author":"Huang","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2014.07.013_bib25","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.vaccine.2012.12.072","article-title":"Cold-adapted X-31 live attenuated 2009 pandemic H1N1 influenza vaccine elicits protective immune responses in mice and ferrets","volume":"31","author":"Jang","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2014.07.013_bib26","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.4049\/jimmunol.0901296","article-title":"TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism","volume":"185","author":"Jones","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2014.07.013_bib27","doi-asserted-by":"crossref","first-page":"11115","DOI":"10.1128\/JVI.01571-12","article-title":"Increased viral loads and exacerbated innate host responses in aged macaques infected with the 2009 pandemic H1N1 influenza A virus","volume":"86","author":"Josset","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.07.013_bib28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.virol.2014.01.030","article-title":"Lack of group X secreted phospholipase A2 increases survival following pandemic H1N1 influenza infection","volume":"454\u2013455","author":"Kelvin","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.virol.2014.07.013_bib29","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.vaccine.2005.04.019","article-title":"The unmet need in the elderly: designing new influenza vaccines for older adults","volume":"23","author":"McElhaney","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2014.07.013_bib30","doi-asserted-by":"crossref","first-page":"383","DOI":"10.7883\/yoken.65.383","article-title":"Pathological examination of lung tissues in influenza A virus-infected mice","volume":"65","author":"Muto","year":"2012","journal-title":"Jpn. J. Infect. Dis."},{"key":"10.1016\/j.virol.2014.07.013_bib31","doi-asserted-by":"crossref","first-page":"7446","DOI":"10.4049\/jimmunol.174.11.7446","article-title":"The influence of age on T cell generation and TCR diversity","volume":"174","author":"Naylor","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2014.07.013_bib32","doi-asserted-by":"crossref","first-page":"8625","DOI":"10.1128\/JVI.00147-12","article-title":"Effect of priming with H1N1 influenza viruses of variable antigenic distances on challenge with 2009 pandemic H1N1 virus","volume":"86","author":"O\u2019Donnell","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.07.013_bib33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.virol.2013.09.022","article-title":"Pandemic H1N1 influenza A directly induces a robust and acute inflammatory gene signature in primary human bronchial epithelial cells downstream of membrane fusion","volume":"448","author":"Paquette","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.virol.2014.07.013_bib34","doi-asserted-by":"crossref","first-page":"10293","DOI":"10.1128\/JVI.01131-12","article-title":"NS1-truncated live attenuated virus vaccine provides robust protection to aged mice from viral challenge","volume":"86","author":"Pica","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.07.013_bib35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.virol.2010.02.020","article-title":"Modeling host responses in ferrets during A\/California\/07\/2009 influenza infection","volume":"401","author":"Rowe","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.virol.2014.07.013_bib36","doi-asserted-by":"crossref","first-page":"13694","DOI":"10.1073\/pnas.1107594108","article-title":"Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor: pMHC interactions","volume":"108","author":"Rudd","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2014.07.013_bib37","doi-asserted-by":"crossref","first-page":"15818","DOI":"10.1073\/pnas.2636938100","article-title":"Antigen-driven effector CD8 T cell function regulated by T-bet","volume":"100","author":"Sullivan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2014.07.013_bib38","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","article-title":".1A novel transcription factor, T-bet, directs Th1 lineage commitment","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.virol.2014.07.013_bib39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/jama.289.2.179","article-title":"Mortality associated with influenza and respiratory syncytial virus in the United States","volume":"289","author":"Thompson","year":"2003","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.virol.2014.07.013_bib40","doi-asserted-by":"crossref","first-page":"6527","DOI":"10.1128\/JVI.00519-10","article-title":"Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus","volume":"84","author":"Tu","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.07.013_bib41","doi-asserted-by":"crossref","first-page":"721","DOI":"10.4049\/jimmunol.173.2.721","article-title":"Cutting edge: pulmonary immunopathology mediated by antigen-specific expression of TNF-\u03b1 by antiviral CD8+ T cells","volume":"173","author":"Xu","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2014.07.013_bib42","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1084\/jem.20071140","article-title":"Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus","volume":"205","author":"Yager","year":"2008","journal-title":"J. Exp. Med."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682214003195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682214003195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:27:46Z","timestamp":1758587266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682214003195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":42,"alternative-id":["S0042682214003195"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2014.07.013","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired heterologous immunity in aged ferrets during sequential influenza A H1N1 infection","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2014.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}