{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:31:46Z","timestamp":1792024306370,"version":"4.4.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK, London","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MRC New Investigator"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.virol.2014.10.030","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T22:16:12Z","timestamp":1416003372000},"page":"117-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"special_numbering":"C","title":["Unexpected patterns of Epstein\u2013Barr virus transcription revealed by a High throughput PCR array for absolute quantification of viral mRNA"],"prefix":"10.1016","volume":"474","author":[{"given":"Rosemary J","family":"Tierney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire D","family":"Shannon-Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7401-0186","authenticated-orcid":false,"given":"Leah","family":"Fitzsimmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew I","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2014.10.030_bib1","doi-asserted-by":"crossref","first-page":"e99163","DOI":"10.1371\/journal.pone.0099163","article-title":"Epstein\u2013Barr virus-encoded small RNAs (EBERs) are present in fractions related to exosomes released by EBV-transformed cells","volume":"9","author":"Ahmed","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2014.10.030_bib2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0042-6822(91)90893-G","article-title":"Early events in Epstein\u2013Barr virus infection of human B lymphocytes","volume":"181","author":"Alfieri","year":"1991","journal-title":"Virology"},{"issue":"Pt 7","key":"10.1016\/j.virol.2014.10.030_bib3","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1099\/0022-1317-70-7-1755","article-title":"Epstein\u2013Barr virus latent gene expression during the initiation of B cell immortalization","volume":"70","author":"Allday","year":"1989","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib4","doi-asserted-by":"crossref","first-page":"e404","DOI":"10.1371\/journal.pbio.0030404","article-title":"Epstein\u2013Barr virus provides a new paradigm: a requirement for the immediate inhibition of apoptosis","volume":"3","author":"Altmann","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.virol.2014.10.030_bib5","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1128\/JVI.01528-10","article-title":"Quantitative studies of Epstein\u2013Barr virus-encoded microRNAs provide novel insights into their regulation","volume":"85","author":"Amoroso","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib6","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1128\/jvi.41.2.376-389.1982","article-title":"Characterization of the major Epstein\u2013Barr virus-specific RNA in Burkitt lymphoma-derived cells","volume":"41","author":"Arrand","year":"1982","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/JVI.79.1.441-449.2005","article-title":"The Epstein\u2013Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase","volume":"79","author":"Beisser","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib8","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1099\/vir.0.81906-0","article-title":"Analysis of Epstein\u2013Barr virus latent gene expression in endemic Burkitt\u2019s lymphoma and nasopharyngeal carcinoma tumour cells by using quantitative real-time PCR assays","volume":"87","author":"Bell","year":"2006","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib9","doi-asserted-by":"crossref","first-page":"e1001114","DOI":"10.1371\/journal.ppat.1001114","article-title":"CpG-methylation regulates a class of Epstein\u2013Barr virus promoters","volume":"6","author":"Bergbauer","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virol.2014.10.030_bib10","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1128\/jvi.66.5.2689-2697.1992","article-title":"Epstein\u2013Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1, and LMP2 transcripts","volume":"66","author":"Brooks","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib11","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1074-7613(00)80623-8","article-title":"Epstein\u2013Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals","volume":"9","author":"Caldwell","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.virol.2014.10.030_bib12","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1128\/JVI.01412-07","article-title":"Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein\u2013Barr virus latency promoter Cp","volume":"82","author":"Chau","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib13","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1182\/blood.V93.9.3026.409k28_3026_3032","article-title":"Expression of Epstein\u2013Barr virus BamHI-A rightward transcripts in latently infected B cells from peripheral blood","volume":"93","author":"Chen","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.virol.2014.10.030_bib14","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1128\/JVI.06537-11","article-title":"Identification of new viral genes and transcript isoforms during Epstein\u2013Barr virus reactivation using RNA-Seq","volume":"86","author":"Concha","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib15","doi-asserted-by":"crossref","first-page":"e1000490","DOI":"10.1371\/journal.ppat.1000490","article-title":"Stage-specific inhibition of MHC class I presentation by the Epstein\u2013Barr virus BNLF2a protein during virus lytic cycle","volume":"5","author":"Croft","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virol.2014.10.030_bib16","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1128\/JVI.73.4.3154-3161.1999","article-title":"Expression of EBNA-1 mRNA is regulated by cell cycle during Epstein\u2013Barr virus type I latency","volume":"73","author":"Davenport","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib17","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1099\/vir.0.19054-0","article-title":"Updated Epstein\u2013Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV","volume":"84","author":"de Jesus","year":"2003","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib18","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1084\/jem.177.2.339","article-title":"Epstein\u2013Barr virus and Hodgkin\u2019s disease: transcriptional analysis of virus latency in the malignant cells","volume":"177","author":"Deacon","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2014.10.030_bib19","first-page":"2010","article-title":"Transcription profile of Kaposi\u2019s sarcoma-associated herpesvirus in primary Kaposi\u2019s sarcoma lesions as determined by real-time PCR arrays","volume":"63","author":"Dittmer","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.virol.2014.10.030_bib20","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1128\/JVI.02630-07","article-title":"Distinct ex vivo susceptibility of B-cell subsets to epstein\u2013barr virus infection according to differentiation status and tissue origin","volume":"82","author":"Dorner","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib21","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1128\/JVI.76.12.6213-6223.2002","article-title":"Charting latency transcripts in Kaposi\u2019s sarcoma-associated herpesvirus by whole-genome real-time quantitative PCR","volume":"76","author":"Fakhari","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib22","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1093\/emboj\/19.12.3080","article-title":"The Epstein\u2013Barr virus lytic program is controlled by the co-operative functions of two transactivators","volume":"19","author":"Feederle","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.virol.2014.10.030_bib23","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1128\/jvi.64.10.4948-4956.1990","article-title":"Novel transcription from the Epstein\u2013Barr virus terminal EcoRI fragment, DIJhet, in a nasopharyngeal carcinoma","volume":"64","author":"Gilligan","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib24","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1099\/0022-1317-71-7-1481","article-title":"Different Epstein\u2013Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt lymphoma cell line","volume":"71","author":"Gregory","year":"1990","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib25","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1128\/JVI.73.2.965-975.1999","article-title":"Epstein\u2013Barr virus nuclear antigen 1 sequences in endemic and sporadic Burkitt\u2019s lymphoma reflect virus strains prevalent in different geographic areas","volume":"73","author":"Habeshaw","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib26","doi-asserted-by":"crossref","first-page":"E1396","DOI":"10.1073\/pnas.1115906109","article-title":"RNAs in Epstein\u2013Barr virions control early steps of infection","volume":"109","author":"Jochum","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.virol.2014.10.030_bib27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/JVI.06314-11","article-title":"The lytic phase of epstein\u2013barr virus requires a viral genome with 5-methylcytosine residues in CpG sites","volume":"86","author":"Kalla","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejcb.2011.01.014","article-title":"Human B cells on their route to latent infection\u2014early but transient expression of lytic genes of Epstein\u2013Barr virus","volume":"91","author":"Kalla","year":"2012","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.virol.2014.10.030_bib29","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1073\/pnas.0911948107","article-title":"AP-1 homolog BZLF1 of Epstein\u2013Barr virus has two essential functions dependent on the epigenetic state of the viral genome","volume":"107","author":"Kalla","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.virol.2014.10.030_bib30","doi-asserted-by":"crossref","first-page":"7004","DOI":"10.1128\/JVI.78.13.7004-7015.2004","article-title":"Production of high-titer Epstein\u2013Barr virus recombinants derived from Akata cells by using a bacterial artificial chromosome system","volume":"78","author":"Kanda","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib31","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/nm758","article-title":"Epstein\u2013Barr virus-associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2","volume":"8","author":"Kelly","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.virol.2014.10.030_bib32","doi-asserted-by":"crossref","first-page":"e1000341","DOI":"10.1371\/journal.ppat.1000341","article-title":"An Epstein\u2013Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in Burkitt lymphomagenesis: the Wp\/BHRF1 link","volume":"5","author":"Kelly","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virol.2014.10.030_bib33","doi-asserted-by":"crossref","first-page":"14935","DOI":"10.1073\/pnas.0509988103","article-title":"Three restricted forms of Epstein\u2013Barr virus latency counteracting apoptosis in c-myc-expressing Burkitt lymphoma cells","volume":"103","author":"Kelly","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.virol.2014.10.030_bib34","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1128\/JVI.79.16.10709-10717.2005","article-title":"Epstein\u2013Barr virus nuclear antigen 2 (EBNA2) gene deletion is consistently linked with EBNA3A, -3B, and -3C expression in Burkitt\u2019s lymphoma cells and with increased resistance to apoptosis","volume":"79","author":"Kelly","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib35","series-title":"Epstein\u2013Barr Virus and its Replication, Fields Virology","first-page":"2603","author":"Kieff","year":"2007"},{"key":"10.1016\/j.virol.2014.10.030_bib36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jviromet.2007.08.012","article-title":"One-step multiplex real-time PCR assay to analyse the latency patterns of Epstein\u2013Barr virus infection","volume":"147","author":"Kubota","year":"2008","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.virol.2014.10.030_bib37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1182\/blood-2004-09-3748","article-title":"Azidothymidine inhibits NF-kappaB and induces Epstein\u2013Barr virus gene expression in Burkitt lymphoma","volume":"106","author":"Kurokawa","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.virol.2014.10.030_bib38","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1073\/pnas.78.2.805","article-title":"Two small RNAs encoded by Epstein\u2013Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus","volume":"78","author":"Lerner","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.virol.2014.10.030_bib39","doi-asserted-by":"crossref","first-page":"13053","DOI":"10.1128\/JVI.01521-10","article-title":"Quantitative and qualitative RNA-Seq-based evaluation of Epstein\u2013Barr virus transcription in type I latency Burkitt\u2019s lymphoma cells","volume":"84","author":"Lin","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib40","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1038\/onc.2010.173","article-title":"Cell transformation mediated by the Epstein\u2013Barr virus G protein-coupled receptor BILF1 is dependent on constitutive signaling","volume":"29","author":"Lyngaa","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.virol.2014.10.030_bib41","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1182\/blood-2007-05-090142","article-title":"Epstein\u2013Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survival","volume":"110","author":"Mancao","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.virol.2014.10.030_bib42","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1182\/blood.V86.2.659.bloodjournal862659","article-title":"Heterogeneous expression of Epstein\u2013Barr virus latent proteins in endemic Burkitt\u2019s lymphoma","volume":"86","author":"Niedobitek","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.virol.2014.10.030_bib43","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1128\/jvi.70.1.623-627.1996","article-title":"Transcription start sites downstream of the Epstein\u2013Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein","volume":"70","author":"Nonkwelo","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib44","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1128\/JVI.79.1.536-546.2005","article-title":"Epstein\u2013Barr virus-encoded BILF1 is a constitutively active G protein-coupled receptor","volume":"79","author":"Paulsen","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib45","doi-asserted-by":"crossref","first-page":"6328","DOI":"10.1073\/pnas.0914843107","article-title":"Functional delivery of viral miRNAs via exosomes","volume":"107","author":"Pegtel","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.virol.2014.10.030_bib46","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1096781","article-title":"Identification of virus-encoded microRNAs","volume":"304","author":"Pfeffer","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.virol.2014.10.030_bib47","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1128\/JVI.06334-11","article-title":"Dynamic chromatin environment of key lytic cycle regulatory regions of the Epstein\u2013Barr virus genome","volume":"86","author":"Ramasubramanyan","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib48","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.4049\/jimmunol.174.11.6829","article-title":"Impaired transporter associated with antigen processing-dependent peptide transport during productive EBV infection","volume":"174","author":"Ressing","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2014.10.030_bib49","series-title":"Fields Virology","first-page":"2655","article-title":"Epstein\u2013Barr virus","author":"Rickinson","year":"2007"},{"key":"10.1016\/j.virol.2014.10.030_bib50","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1128\/jvi.66.1.122-131.1992","article-title":"Three pathways of Epstein\u2013Barr virus gene activation from EBNA1-positive latency in B lymphocytes","volume":"66","author":"Rowe","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib51","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1128\/jvi.69.2.1132-1141.1995","article-title":"Structural analyses of the Epstein\u2013Barr virus BamHI A transcripts","volume":"69","author":"Sadler","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib52","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1128\/jvi.69.8.5039-5047.1995","article-title":"The Epstein\u2013Barr virus BamHI F promoter is an early lytic promoter: lack of correlation with EBNA 1 gene transcription in group 1 Burkitt\u2019s lymphoma cell lines","volume":"69","author":"Schaefer","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib53","doi-asserted-by":"crossref","first-page":"10565","DOI":"10.1073\/pnas.92.23.10565","article-title":"Redefining the Epstein\u2013Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell lines","volume":"92","author":"Schaefer","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.virol.2014.10.030_bib54","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanhausser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.virol.2014.10.030_bib55","doi-asserted-by":"crossref","first-page":"7749","DOI":"10.1128\/JVI.00108-09","article-title":"Features distinguishing Epstein\u2013Barr virus infections of epithelial cells and B cells: viral genome expression, genome maintenance, and genome amplification","volume":"83","author":"Shannon-Lowe","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib56","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1099\/vir.0.81153-0","article-title":"Epstein\u2013Barr virus-induced B-cell transformation: quantitating events from virus binding to cell outgrowth","volume":"86","author":"Shannon-Lowe","year":"2005","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib57","doi-asserted-by":"crossref","first-page":"e1662","DOI":"10.1371\/journal.pone.0001662","article-title":"High throughput gene expression measurement with real time PCR in a microfluidic dynamic array","volume":"3","author":"Spurgeon","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2014.10.030_bib58","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1128\/jvi.63.1.445-449.1989","article-title":"Synchronous and sequential activation of latently infected Epstein\u2013Barr virus genomes","volume":"63","author":"Takada","year":"1989","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib59","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1182\/blood.V91.4.1373","article-title":"Epstein\u2013Barr virus (EBV) in endemic Burkitt\u2019s lymphoma: molecular analysis of primary tumor tissue","volume":"91","author":"Tao","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.virol.2014.10.030_bib60","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.coviro.2013.04.005","article-title":"The pathogenesis of Epstein\u2013Barr virus persistent infection","volume":"3","author":"Thorley-Lawson","year":"2013","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib61","doi-asserted-by":"crossref","first-page":"12362","DOI":"10.1128\/JVI.06059-11","article-title":"Epstein\u2013Barr virus BamHI W repeat number limits EBNA2\/EBNA-LP coexpression in newly infected B cells and the efficiency of B-cell transformation: a rationale for the multiple W repeats in wild-type virus strains","volume":"85","author":"Tierney","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib62","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1099\/vir.0.80763-0","article-title":"Epstein\u2013Barr virus EBNA3 proteins bind to the C8\/alpha7 subunit of the 20S proteasome and are degraded by 20S proteasomes in vitro, but are very stable in latently infected B cells","volume":"86","author":"Touitou","year":"2005","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib63","doi-asserted-by":"crossref","first-page":"12108","DOI":"10.1128\/JVI.01575-09","article-title":"Maribavir inhibits Epstein\u2013Barr virus transcription in addition to viral DNA replication","volume":"83","author":"Wang","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib64","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1128\/JVI.01416-06","article-title":"Epstein\u2013Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytes","volume":"81","author":"Wen","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib65","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.1128\/JVI.03505-12","article-title":"Maribavir inhibits Epstein\u2013Barr virus transcription through the EBV protein kinase","volume":"87","author":"Whitehurst","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib66","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1073\/pnas.87.5.1725","article-title":"Promoter switching in Epstein\u2013Barr virus during the initial stages of infection of B lymphocytes","volume":"87","author":"Woisetschlaeger","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.virol.2014.10.030_bib67","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/ijc.10372","article-title":"Promiscuous expression of Epstein\u2013Barr virus genes in Burkitt\u2019s lymphoma from the central African country Malawi","volume":"99","author":"Xue","year":"2002","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.virol.2014.10.030_bib68","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1128\/jvi.66.9.5646-5650.1992","article-title":"Characterization of the deletion and rearrangement in the BamHI C region of the X50-7 Epstein\u2013Barr virus genome, a mutant viral strain which exhibits constitutive BamHI W promoter activity","volume":"66","author":"Yandava","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2014.10.030_bib69","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1128\/JVI.80.5.2548-2565.2006","article-title":"Virus and cell RNAs expressed during Epstein\u2013Barr virus replication","volume":"80","author":"Yuan","year":"2006","journal-title":"J. Virol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682214004875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682214004875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:29:20Z","timestamp":1758587360000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682214004875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":69,"alternative-id":["S0042682214004875"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2014.10.030","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unexpected patterns of Epstein\u2013Barr virus transcription revealed by a High throughput PCR array for absolute quantification of viral mRNA","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2014.10.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}