{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:11:36Z","timestamp":1770988296033,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.virol.2015.08.033","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T12:03:10Z","timestamp":1443700990000},"page":"134-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Addition of N-glycosylation sites on the globular head of the H5 hemagglutinin induces the escape of highly pathogenic avian influenza A H5N1 viruses from vaccine-induced immunity"],"prefix":"10.1016","volume":"486","author":[{"given":"Pierre-Louis","family":"Herv\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Lorin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9gory","family":"Jouvion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Escriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2015.08.033_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/1743-422X-8-283","article-title":"Genetic drift evolution under vaccination pressure among H5N1 Egyptian isolates","volume":"8","author":"Abdel-Moneim","year":"2011","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2015.08.033_bib2","doi-asserted-by":"crossref","first-page":"9605","DOI":"10.1128\/JVI.78.18.9605-9611.2004","article-title":"Effect of the Addition of Oligosaccharides on the Biological Activities and Antigenicity of Influenza A\/H3N2 Virus Hemagglutinin","volume":"78","author":"Abe","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0168-1702(01)00272-6","article-title":"Glycosylation of haemagglutinin and stalk-length of neuraminidase combine to regulate the growth of avian influenza viruses in tissue culture","volume":"79","author":"Baigent","year":"2001","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2015.08.033_bib4","doi-asserted-by":"crossref","first-page":"C8","DOI":"10.1016\/j.vaccine.2008.04.011","article-title":"Vaccination and antigenic drift in influenza","volume":"26","author":"Boni","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2015.08.033_bib5","doi-asserted-by":"crossref","first-page":"11869","DOI":"10.1073\/pnas.95.20.11869","article-title":"Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D","volume":"95","author":"Botas","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2015.08.033_bib6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/jvi.48.1.52-60.1983","article-title":"Antigenic drift in influenza virus H3 hemagglutinin from 1968 to 1980\u202f: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites","volume":"48","author":"Both","year":"1983","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0092-8674(82)90135-0","article-title":"The antigenic structure of the influenza virus A\/PR\/8\/34 hemagglutinin (H1 subtype)","volume":"31","author":"Caton","year":"1982","journal-title":"Cell"},{"key":"10.1016\/j.virol.2015.08.033_bib8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.20506\/rst.28.1.1860","article-title":"Avian influenza vaccination: the experience in China","volume":"28","author":"Chen","year":"2009","journal-title":"Rev. Sci. Tech."},{"key":"10.1016\/j.virol.2015.08.033_bib9","doi-asserted-by":"crossref","first-page":"e38794","DOI":"10.1371\/journal.pone.0038794","article-title":"Two glycosylation sites in H5N1 influenza virus hemagglutinin that affect binding preference by computer-based analysis","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2015.08.033_bib10","doi-asserted-by":"crossref","first-page":"15808","DOI":"10.1016\/S0021-9258(17)40752-6","article-title":"Recombinant pulmonary surfactant protein D. Post-translational modification and molecular assembly","volume":"269","author":"Crouch","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2015.08.033_bib11","first-page":"63","article-title":"Haemagglutination-inhibiting antibody to influenza virus","volume":"115","author":"De Jong","year":"2003"},{"key":"10.1016\/j.virol.2015.08.033_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.virol.2010.03.047","article-title":"The influenza A virus hemagglutinin glycosylation state affects receptor-binding specificity","volume":"403","author":"De Vries","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.virol.2015.08.033_bib13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1126\/science.1171491","article-title":"Antibody recognition of a highly conserved influenza virus epitope","volume":"324","author":"Ekiert","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.virol.2015.08.033_bib14","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1006\/viro.1998.9224","article-title":"Effects of host-dependent glycosylation of hemagglutinin on receptor-binding properties on H1N1 human influenza A virus grown in MDCK cells and in embryonated eggs","volume":"247","author":"Gambaryan","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.virol.2015.08.033_bib15","doi-asserted-by":"crossref","first-page":"28403","DOI":"10.1074\/jbc.R110.129809","article-title":"Influenza hemagglutinin and neuraminidase membrane glycoproteins","volume":"285","author":"Gamblin","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2015.08.033_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1465-9921-9-65","article-title":"Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D","volume":"9","author":"Hartshorn","year":"2008","journal-title":"Respir. Res."},{"key":"10.1016\/j.virol.2015.08.033_bib17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.virusres.2012.08.003","article-title":"The number and position of N-linked glycosylation sites in the hemagglutinin determine differential recognition of seasonal and 2009 pandemic H1N1 influenza virus by porcine surfactant protein D","volume":"169","author":"Hillaire","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2015.08.033_bib18","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1016\/S0264-410X(02)00268-2","article-title":"Eight-plasmid system for rapid generation of influenza virus vaccines","volume":"20","author":"Hoffmann","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2015.08.033_bib19","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s007050170002","article-title":"Universal primer set for the full-length amplification of all influenza A viruses","volume":"146","author":"Hoffmann","year":"2001","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib20","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.celrep.2015.05.012","article-title":"Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway","volume":"11","author":"Hrincius","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.virol.2015.08.033_bib21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.virol.2008.03.036","article-title":"Genetically destined potentials for N-linked glycosylation of influenza virus hemagglutinin","volume":"376","author":"Igarashi","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.virol.2015.08.033_bib22","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.4049\/jimmunol.1202433","article-title":"Addition of Glycosylation to Influenza A Virus Hemagglutinin Modulates Antibody-Mediated Recognition of H1N1 2009 Pandemic Viruses","volume":"190","author":"Job","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2015.08.033_bib23","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.1073\/pnas.84.19.6869","article-title":"Antigen-presenting B cells and helper T cells cooperatively mediate intravirionic antigenic competition between influenza A virus surface glycoproteins","volume":"84","author":"Johansson","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2015.08.033_bib24","doi-asserted-by":"crossref","first-page":"12911","DOI":"10.1128\/JVI.01522-07","article-title":"Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies","volume":"81","author":"Kaverin","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib25","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1099\/0022-1317-83-10-2497","article-title":"Structure of antigenic sites on the haemagglutinin molecule of H5 avian influenza virus and phenotypic variation of escape mutants","volume":"83","author":"Kaverin","year":"2002","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3201\/eid1201.051254","article-title":"Influenza pandemics of the 20th century","volume":"12","author":"Kilbourne","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virol.2015.08.033_bib27","doi-asserted-by":"crossref","first-page":"28438","DOI":"10.1074\/jbc.273.43.28438","article-title":"Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo","volume":"273","author":"Korfhagen","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2015.08.033_bib28","doi-asserted-by":"crossref","first-page":"e57894","DOI":"10.1371\/journal.pone.0057894","article-title":"Kinetic characterization of PB1-F2-mediated immunopathology during highly pathogenic avian H5N1 influenza virus infection","volume":"8","author":"Leymarie","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2015.08.033_bib29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature02746","article-title":"Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia","volume":"430","author":"Li","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.virol.2015.08.033_bib30","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1865-1682.2011.01229.x","article-title":"Recent avian influenza virus A\/H5N1 evolution in vaccinated and unvaccinated poultry from farms in Southern Vietnam, January-March 2010","volume":"58","author":"Long","year":"2011","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.virol.2015.08.033_bib31","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1743-422X-3-63","article-title":"New low-viscosity overlay medium for viral plaque assays","volume":"3","author":"Matrosovich","year":"2006","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2015.08.033_bib32","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1128\/JVI.73.2.1146-1155.1999","article-title":"The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties","volume":"73","author":"Matrosovich","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib33","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1128\/JVI.01987-08","article-title":"Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice","volume":"83","author":"Matsuoka","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib34","doi-asserted-by":"crossref","first-page":"187ra70","DOI":"10.1126\/scitranslmed.3005996","article-title":"Glycosylations in the globular head of the hemagglutinin protein modulate the virulence and antigenic properties of the H1N1 influenza viruses","volume":"5","author":"Medina","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.virol.2015.08.033_bib35","doi-asserted-by":"crossref","first-page":"8377","DOI":"10.1128\/jvi.71.11.8377-8384.1997","article-title":"Regulation of receptor binding affinity of influenza virus hemagglutinin by its carbohydrate moiety","volume":"71","author":"Ohuchi","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib36","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1128\/CMR.00037-06","article-title":"Avian influenza virus (H5N1): a threat to human health","volume":"20","author":"Peiris","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.virol.2015.08.033_bib37","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1128\/JVI.02165-08","article-title":"Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection","volume":"83","author":"Prabhu","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1465-9921-10-117","article-title":"Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice","volume":"10","author":"Reading","year":"2009","journal-title":"Respir. Res."},{"key":"10.1016\/j.virol.2015.08.033_bib39","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.virol.2015.08.033_bib40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.vaccine.2012.10.039","article-title":"Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins","volume":"31","author":"Richards","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2015.08.033_bib41","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/vim.2009.0086","article-title":"Antigenic epitopes in the hemagglutinin of Qinghai-type influenza H5N1 virus","volume":"23","author":"Rudneva","year":"2010","journal-title":"Viral. Immunol."},{"key":"10.1016\/j.virol.2015.08.033_bib42","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1073\/pnas.81.6.1779","article-title":"A carbohydrate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibody","volume":"81","author":"Skehel","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2015.08.033_bib43","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.biochem.69.1.531","article-title":"Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin","volume":"69","author":"Skehel","year":"2000","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.virol.2015.08.033_bib44","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nature08182","article-title":"Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic","volume":"459","author":"Smith","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.virol.2015.08.033_bib45","doi-asserted-by":"crossref","first-page":"8756","DOI":"10.1128\/JVI.00593-13","article-title":"N-linked glycosylation of the hemagglutinin protein influences virulence and antigenicity of the 1918 pandemic and seasonal H1N1 influenza A viruses","volume":"87","author":"Sun","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib46","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.virol.2011.01.036","article-title":"Glycosylation of the hemagglutinin modulates the sensitivity of H3N2 influenza viruses to innate proteins in airway secretions and virulence in mice","volume":"413","author":"Tate","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.virol.2015.08.033_bib47","doi-asserted-by":"crossref","first-page":"e14582","DOI":"10.1371\/journal.pone.0014582","article-title":"Highly pathogenic avian influenza (H5N1): pathways of exposure at the animal-human interface, a systematic review","volume":"6","author":"Van Kerkhove","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2015.08.033_bib48","doi-asserted-by":"crossref","first-page":"8593","DOI":"10.1128\/JVI.00769-07","article-title":"N-linked glycosylation attenuates H3N2 influenza viruses","volume":"81","author":"Vigerust","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib49","doi-asserted-by":"crossref","first-page":"18137","DOI":"10.1073\/pnas.0909696106","article-title":"Glycans on influenza hemagglutinin affect receptor binding and immune response","volume":"106","author":"Wang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2015.08.033_bib50","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0140-6736(08)60493-6","article-title":"Probable limited person-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China","volume":"371","author":"Wang","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.virol.2015.08.033_bib51","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.1128\/JVI.00221-10","article-title":"Glycosylation at 158N of the hemagglutinin protein and receptor binding specificity synergistically affect the antigenicity and immunogenicity of a live attenuated H5N1 A\/Vietnam\/1203\/2004 vaccine virus in ferrets","volume":"84","author":"Wang","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2015.08.033_bib52","doi-asserted-by":"crossref","first-page":"24ra21","DOI":"10.1126\/scitranslmed.3000799","article-title":"Cross-neutralization of 1918 and 2009 influenza viruses: role of glycans in viral evolution and vaccine design","volume":"2","author":"Wei","year":"2010","journal-title":"Sci. Trans. Med."},{"key":"10.1016\/j.virol.2015.08.033_bib53","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/289373a0","article-title":"Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation","volume":"289","author":"Wiley","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.virol.2015.08.033_bib54","unstructured":"World Health Organization, 2015. Cumulative number of confirmed human cases for avian influenza A(H5N1) reported to WHO. [WWW Document]. \u3008http:\/\/www.who.int\/influenza\/human_animal_interface\/EN_GIP_20150623cumulativeNumberH5N1cases.pdf\u3009."},{"key":"10.1016\/j.virol.2015.08.033_bib55","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature05264","article-title":"Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors","volume":"444","author":"Yamada","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.virol.2015.08.033_bib56","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/glycob\/cwh106","article-title":"Tracking global patterns of N-linked glycosylation site variation in highly variable viral glycoproteins: HIV, SIV, and HCV envelopes and influenza hemagglutinin","volume":"14","author":"Zhang","year":"2004","journal-title":"Glycobiology"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682215003918?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682215003918?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:32:16Z","timestamp":1758587536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682215003918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":56,"alternative-id":["S0042682215003918"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2015.08.033","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Addition of N-glycosylation sites on the globular head of the H5 hemagglutinin induces the escape of highly pathogenic avian influenza A H5N1 viruses from vaccine-induced immunity","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2015.08.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}