{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:53:21Z","timestamp":1785380001251,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.virol.2016.04.027","type":"journal-article","created":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T11:07:58Z","timestamp":1463742478000},"page":"136-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Novel 6xHis tagged foot-and-mouth disease virus vaccine bound to nanolipoprotein adjuvant via metal ions provides antigenic distinction and effective protective immunity"],"prefix":"10.1016","volume":"495","author":[{"given":"Devendra K.","family":"Rai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayna Diaz-San","family":"Segundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Schafer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Burrage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis L.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"de los Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Hoeprich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Rieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2016.04.027_bib1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/337709a0","article-title":"The three-dimensional structure of foot-and-mouth disease virus at 2.9 A resolution","volume":"337","author":"Acharya","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.virol.2016.04.027_bib2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.biologicals.2015.06.001","article-title":"Engineering foot-and-mouth disease virus serotype O IND R2\/1975 for one-step purification by immobilized metal affinity chromatography","volume":"43","author":"Biswal","year":"2015","journal-title":"Biologicals"},{"key":"10.1016\/j.virol.2016.04.027_bib3","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1021\/bc100129s","article-title":"Kinetic analysis of his-tagged protein binding to nickel-chelating nanolipoprotein particles","volume":"21","author":"Blanchette","year":"2010","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.virol.2016.04.027_bib4","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.3390\/ijms10072958","article-title":"Characterization and purification of polydisperse reconstituted lipoproteins and nanolipoprotein particles","volume":"10","author":"Blanchette","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.virol.2016.04.027_bib5","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.1016\/j.vaccine.2007.07.067","article-title":"Further evaluation of higher potency vaccines for early protection of cattle against FMDV direct contact challenge","volume":"25","author":"Cox","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2016.04.027_bib6","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.1128\/JVI.03462-12","article-title":"Venezuelan equine encephalitis replicon particles can induce rapid protection against foot-and-mouth disease virus","volume":"87","author":"Diaz-San Segundo","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF01314726","article-title":"Comparative immunogenicity of 146S, 75S and 12S particles of foot-and-mouth disease virus","volume":"73","author":"Doel","year":"1982","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib8","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/0264-410X(94)90262-3","article-title":"Emergency vaccination against foot-and-mouth disease: rate of development of immunity and its implications for the carrier state","volume":"12","author":"Doel","year":"1994","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2016.04.027_bib9","doi-asserted-by":"crossref","first-page":"e11643","DOI":"10.1371\/journal.pone.0011643","article-title":"Isolation, characterization, and stability of discretely-sized nanolipoprotein particles assembled with apolipophorin-III","volume":"5","author":"Fischer","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2016.04.027_bib10","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1021\/bc100083d","article-title":"Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent West Nile encephalitis","volume":"21","author":"Fischer","year":"2010","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.virol.2016.04.027_bib11","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1021\/ja3063293","article-title":"Colocalized delivery of adjuvant and antigen using nanolipoprotein particles enhances the immune response to recombinant antigens","volume":"135","author":"Fischer","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.virol.2016.04.027_bib12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1586\/erv.11.198","article-title":"Progress in the development of DNA vaccines against foot-and-mouth disease","volume":"11","author":"Fowler","year":"2012","journal-title":"Expert Rev. Vaccin."},{"key":"10.1016\/j.virol.2016.04.027_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fcimb.2013.00013","article-title":"Vaccine delivery using nanoparticles","volume":"3","author":"Gregory","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.virol.2016.04.027_bib14","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1128\/CMR.17.2.465-493.2004","article-title":"Foot-and-mouth disease","volume":"17","author":"Grubman","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.virol.2016.04.027_bib15","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1099\/vir.0.068197-0","article-title":"Sequence adaptations affecting cleavage of the VP1\/2A junction by the 3C protease in foot-and-mouth disease virus-infected cells","volume":"95","author":"Gullberg","year":"2014","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib16","doi-asserted-by":"crossref","first-page":"11591","DOI":"10.1128\/JVI.01863-13","article-title":"Processing of the VP1\/2A junction is not necessary for production of foot-and-mouth disease virus empty capsids and infectious viruses: characterization of \u201cself-tagged\u201d particles","volume":"87","author":"Gullberg","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jmv.10450","article-title":"Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40","volume":"71","author":"Knowles","year":"2003","journal-title":"J. Med Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib19","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.virol.2012.11.001","article-title":"Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis","volume":"436","author":"Lawrence","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.virol.2016.04.027_bib20","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1099\/0022-1317-45-3-761","article-title":"Comparison of the antibodies elicited by the individual structural polypeptides of foot-and mouth disease and polio viruses","volume":"45","author":"Meloen","year":"1979","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib21","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.antiviral.2011.08.007","article-title":"Role of macrophages in early protective immune responses induced by two vaccines against foot and mouth disease","volume":"92","author":"Quattrocchi","year":"2011","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virol.2016.04.027_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0378-1135(94)90094-9","article-title":"Antibody response to 146S particle, 12S protein subunit and isolated VP1 polypeptide of foot-and-mouth disease virus type Asia-1","volume":"39","author":"Rao","year":"1994","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2016.04.027_bib23","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1128\/jvi.67.9.5139-5145.1993","article-title":"Genetically engineered foot-and-mouth disease viruses with poly(C) tracts of two nucleotides are virulent in mice","volume":"67","author":"Rieder","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib24","doi-asserted-by":"crossref","first-page":"12989","DOI":"10.1128\/JVI.79.20.12989-12998.2005","article-title":"Analysis of a foot-and-mouth disease virus type A24 isolate containing an SGD receptor recognition site in vitro and its pathogenesis in cattle","volume":"79","author":"Rieder","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1586\/erv.11.4","article-title":"Development of vaccines toward the global control and eradication of foot-and-mouth disease","volume":"10","author":"Rodriguez","year":"2011","journal-title":"Expert Rev. Vaccin."},{"issue":"Suppl 4","key":"10.1016\/j.virol.2016.04.027_bib26","doi-asserted-by":"crossref","first-page":"D90","DOI":"10.1016\/j.vaccine.2009.08.039","article-title":"Foot and mouth disease virus vaccines","volume":"27","author":"Rodriguez","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2016.04.027_bib27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1017\/S002217240005381X","article-title":"Microneutralization tests for serological typing and subtyping of foot-and-mouth disease virus strains","volume":"81","author":"Rweyemamu","year":"1978","journal-title":"J. Hyg. (Lond.)"},{"key":"10.1016\/j.virol.2016.04.027_bib28","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.virol.2004.11.005","article-title":"Foot-and-mouth disease virus (FMDV) causes an acute disease that can be lethal for adult laboratory mice","volume":"332","author":"Salguero","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.virol.2016.04.027_bib30","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0264-410X(90)90100-Z","article-title":"Antigenic analysis of serotype O foot-and-mouth disease virus isolates from the Middle East, 1981 to 1988","volume":"8","author":"Samuel","year":"1990","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2016.04.027_bib31","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1099\/vir.0.043521-0","article-title":"Characterization of epitope-tagged foot-and-mouth disease virus","volume":"93","author":"Seago","year":"2012","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib32","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1099\/vir.0.052308-0","article-title":"An infectious recombinant foot-and-mouth disease virus expressing a fluorescent marker protein","volume":"94","author":"Seago","year":"2013","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.vetmic.2008.07.011","article-title":"Rapid methodology for antigenic profiling of FMDV field strains and for the control of identity, purity and viral integrity in commercial virus vaccines using monoclonal antibodies","volume":"133","author":"Seki","year":"2009","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2016.04.027_bib34","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s007050050119","article-title":"Foot-and-mouth disease virus-infected but not vaccinated cattle develop antibodies against recombinant 3AB1 nonstructural protein","volume":"142","author":"Silberstein","year":"1997","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib35","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1016\/j.vaccine.2014.04.038","article-title":"Foot-and-mouth disease: technical and political challenges to eradication","volume":"32","author":"Smith","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2016.04.027_bib36","doi-asserted-by":"crossref","first-page":"11675","DOI":"10.1128\/JVI.01254-12","article-title":"A safe foot-and-mouth disease vaccine platform with two negative markers for differentiating infected from vaccinated animals","volume":"86","author":"Uddowla","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.04.027_bib37","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.virusres.2015.12.013","article-title":"The rescue and evaluation of FLAG and HIS epitope-tagged Asia 1 type foot-and-mouth disease viruses","volume":"213","author":"Yang","year":"2015","journal-title":"Virus Res."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682216300940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682216300940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T18:13:54Z","timestamp":1689704034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682216300940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":35,"alternative-id":["S0042682216300940"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2016.04.027","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel 6xHis tagged foot-and-mouth disease virus vaccine bound to nanolipoprotein adjuvant via metal ions provides antigenic distinction and effective protective immunity","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2016.04.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}