{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:37:59Z","timestamp":1790231879023,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"National Major Scientific and Technological Special Project","award":["2012ZX10002006-002-003"],"award-info":[{"award-number":["2012ZX10002006-002-003"]}]},{"name":"National High Technology Research and Development Program of China","award":["2011AA02A114"],"award-info":[{"award-number":["2011AA02A114"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31370927"],"award-info":[{"award-number":["31370927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30571650"],"award-info":[{"award-number":["30571650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Innovation Action Plan of Shanghai","award":["13431900602"],"award-info":[{"award-number":["13431900602"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.virol.2016.06.019","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T15:15:19Z","timestamp":1469114119000},"page":"102-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Rabies virus lipopeptide conjugated to a TLR7 agonist improves the magnitude and quality of the Th1-biased humoral immune response in mice"],"prefix":"10.1016","volume":"497","author":[{"given":"Rui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inamullah","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naishuo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2016.06.019_bib1","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1128\/IAI.00923-13","article-title":"Toll-like receptor 7 mediates early innate immune responses to malaria","volume":"81","author":"Baccarella","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.virol.2016.06.019_bib2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1128\/JVI.01572-14","article-title":"Expression of interferon gamma by a recombinant rabies virus strongly attenuates the pathogenicity of the virus via induction of type I interferon","volume":"89","author":"Barkhouse","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.06.019_bib3","doi-asserted-by":"crossref","first-page":"7673","DOI":"10.1128\/JVI.79.12.7673-7681.2005","article-title":"Identification of the rabies virus alpha\/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3","volume":"79","author":"Brzozka","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.06.019_bib4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.it.2013.10.012","article-title":"Innate antiviral signalling in the central nervous system","volume":"35","author":"Carty","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib5","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1021\/bc900054q","article-title":"Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates","volume":"20","author":"Chan","year":"2009","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.virol.2016.06.019_bib6","doi-asserted-by":"crossref","first-page":"948","DOI":"10.4049\/jimmunol.1102725","article-title":"TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8alpha+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface","volume":"190","author":"Crespo","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2217\/nnm.13.66","article-title":"Liposomes containing NYESO1\/tetanus toxoid and adjuvant peptides targeted to human dendritic cells via the Fc receptor for cancer vaccines","volume":"9","author":"Cruz","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.virol.2016.06.019_bib8","first-page":"re3","article-title":"The interleukin-1 receptor\/Toll-like receptor superfamily: signal transduction during inflammation and host defense","author":"Dunne","year":"2003","journal-title":"Sci. STKE"},{"key":"10.1016\/j.virol.2016.06.019_bib9","doi-asserted-by":"crossref","first-page":"e1001016","DOI":"10.1371\/journal.ppat.1001016","article-title":"Rabies virus infection induces type I interferon production in an IPS-1 dependent manner while dendritic cell activation relies on IFNAR signaling","volume":"6","author":"Faul","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virol.2016.06.019_bib10","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1128\/JVI.01870-09","article-title":"Characterization of a single-cycle rabies virus-based vaccine vector","volume":"84","author":"Gomme","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.06.019_bib11","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.20.100301.064828","article-title":"Antigen presentation and T cell stimulation by dendritic cells","volume":"20","author":"Guermonprez","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib12","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1128\/JVI.01486-14","article-title":"Activation of NF-kappaB via endosomal Toll-like receptor 7 (TLR7) or TLR9 suppresses murine herpesvirus 68 reactivation","volume":"88","author":"Haas","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.06.019_bib13","doi-asserted-by":"crossref","first-page":"e0003709","DOI":"10.1371\/journal.pntd.0003709","article-title":"Estimating the global burden of endemic canine rabies","volume":"9","author":"Hampson","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.virol.2016.06.019_bib14","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.4049\/jimmunol.178.4.2182","article-title":"TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses","volume":"178","author":"Heer","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib15","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.4049\/jimmunol.0901648","article-title":"Critical role of IkappaB Kinase alpha in TLR7\/9-induced type I IFN production by conventional dendritic cells","volume":"184","author":"Hoshino","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib16","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.4049\/jimmunol.178.4.2415","article-title":"TLR9 signaling in B cells determines class switch recombination to IgG2a","volume":"178","author":"Jegerlehner","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib17","doi-asserted-by":"crossref","first-page":"10988","DOI":"10.1128\/JVI.01064-12","article-title":"TLR7 recognition is dispensable for influenza virus A infection but important for the induction of hemagglutinin-specific antibodies in response to the 2009 pandemic split vaccine in mice","volume":"86","author":"Jeisy-Scott","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.06.019_bib18","doi-asserted-by":"crossref","first-page":"e25242","DOI":"10.1371\/journal.pone.0025242","article-title":"Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice","volume":"6","author":"Jeisy-Scott","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2016.06.019_bib19","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1016\/j.vaccine.2010.03.039","article-title":"The immune response to rabies virus infection and vaccination","volume":"28","author":"Johnson","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2016.06.019_bib20","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/ni1569","article-title":"TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta","volume":"9","author":"Kagan","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib21","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature09737","article-title":"Programming the magnitude and persistence of antibody responses with innate immunity","volume":"470","author":"Kasturi","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.virol.2016.06.019_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/cmi.2014.34","article-title":"rIL-22 as an adjuvant enhances the immunogenicity of rGroEL in mice and its protective efficacy against S. Typhi and S. Typhimurium","volume":"12","author":"Kaur","year":"2015","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib23","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/icb.2011.19","article-title":"siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo","volume":"90","author":"Khairuddin","year":"2012","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.virol.2016.06.019_bib25","doi-asserted-by":"crossref","first-page":"25ra24","DOI":"10.1126\/scitranslmed.3000759","article-title":"Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes","volume":"2","author":"Koyama","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.virol.2016.06.019_bib26","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1189\/jlb.0808504","article-title":"TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation","volume":"85","author":"Larange","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.virol.2016.06.019_bib27","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.jmb.2013.11.024","article-title":"Toll-like receptors in antiviral innate immunity","volume":"426","author":"Lester","year":"2014","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.virol.2016.06.019_bib28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/B978-0-12-387040-7.00007-X","article-title":"The role of toll-like receptors in the induction of immune responses during rabies virus infection","volume":"79","author":"Li","year":"2011","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.virol.2016.06.019_bib29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.virusres.2016.05.007","article-title":"A novel rabies virus lipopeptide provides a better protection by improving the magnitude of DCs activation and T cell responses","volume":"221","author":"Liu","year":"2016","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2016.06.019_bib30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of Toll-like receptors \u2013 redefining innate immunity","volume":"13","author":"O\u2019Neill","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib31","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1021\/acs.bioconjchem.5b00285","article-title":"Enhancement of the immunostimulatory activity of a TLR7 ligand by conjugation to polysaccharides","volume":"26","author":"Shinchi","year":"2015","journal-title":"Bioconjug.Chem."},{"key":"10.1016\/j.virol.2016.06.019_bib32","doi-asserted-by":"crossref","first-page":"12578","DOI":"10.1038\/srep12578","article-title":"A TLR9 agonist enhances the anti-tumor immunity of peptide and lipopeptide vaccines via different mechanisms","volume":"5","author":"Song","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2016.06.019_bib33","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1126\/science.aaa1342","article-title":"Humoral immunity. Apoptosis and antigen affinity limit effector cell differentiation of a single naive B cell","volume":"347","author":"Taylor","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.virol.2016.06.019_bib34","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.4049\/jimmunol.1402918","article-title":"Viremic HIV controllers exhibit high plasmacytoid dendritic cell-reactive opsonophagocytic IgG antibody responses against HIV-1 p24 associated with greater antibody isotype diversification","volume":"194","author":"Tjiam","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib35","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.18632\/oncotarget.2757","article-title":"The TLR7 agonist induces tumor regression both by promoting CD4(+)T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.virol.2016.06.019_bib36","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.vaccine.2008.01.043","article-title":"A CpG oligodeoxynucleotide acts as a potent adjuvant for inactivated rabies virus vaccine","volume":"26","author":"Wang","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2016.06.019_bib37","doi-asserted-by":"crossref","first-page":"7676","DOI":"10.4049\/jimmunol.174.12.7676","article-title":"Immunization with HIV-1 Gag protein conjugated to a TLR7\/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8+ T cell responses","volume":"174","author":"Wille-Reece","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2016.06.019_bib38","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1016\/j.vaccine.2016.03.070","article-title":"A rabies vaccine adjuvanted with saponins from leaves of the soap tree (Quillaja brasiliensis) induces specific immune responses and protects against lethal challenge","volume":"34","author":"Yendo","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2016.06.019_bib39","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1128\/CVI.00816-13","article-title":"Toll-like receptor 7 agonist imiquimod in combination with influenza vaccine expedites and augments humoral immune responses against influenza A(H1N1)pdm09 virus infection in BALB\/c mice","volume":"21","author":"Zhang","year":"2014","journal-title":"Clin. Vaccine Immunol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682216301611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682216301611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:36:47Z","timestamp":1758587807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682216301611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":39,"alternative-id":["S0042682216301611"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2016.06.019","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rabies virus lipopeptide conjugated to a TLR7 agonist improves the magnitude and quality of the Th1-biased humoral immune response in mice","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2016.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}