{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:21:29Z","timestamp":1779189689740,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.virol.2016.07.023","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T11:17:50Z","timestamp":1470309470000},"page":"251-261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Characterization and functional studies of fowl adenovirus 9 dUTPase"],"prefix":"10.1016","volume":"497","author":[{"given":"Li","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobing","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Krell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayan","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2016.07.023_bib1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1128\/JVI.73.1.751-753.1999","article-title":"\u201c Hidden \u201d dUTPase sequence in human immunodeficiency virus type 1 gp120","volume":"73","author":"Abergel","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0166-0934(98)00062-7","article-title":"Growth characteristics of fowl adenovirus type 8 in a chicken hepatoma cell line","volume":"74","author":"Alexander","year":"1998","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.virol.2016.07.023_bib3","doi-asserted-by":"crossref","first-page":"17264","DOI":"10.1073\/pnas.0407639101","article-title":"The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter","volume":"101","author":"Andrejeva","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2016.07.023_bib4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3389\/fmicb.2014.00504","article-title":"Human herpesviruses-encoded dUTPases: a family of proteins that modulate dendritic cell function and innate immunity","volume":"5","author":"Ariza","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virol.2016.07.023_bib5","doi-asserted-by":"crossref","first-page":"e69827","DOI":"10.1371\/journal.pone.0069827","article-title":"Epstein-Barr virus encoded dUTPase containing exosomes modulate innate and adaptive immune responses in human dendritic cells and peripheral blood mononuclear cells","volume":"8","author":"Ariza","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2016.07.023_bib6","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1099\/0022-1317-79-10-2507","article-title":"Sequence and transcriptional analysis of terminal regions of the fowl adenovirus type 8 genome","volume":"79","author":"Cao","year":"1998","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib7","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1128\/jvi.71.4.3168-3177.1997","article-title":"Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus","volume":"71","author":"Chiocca","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib8","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1128\/jvi.70.5.2939-2949.1996","article-title":"The complete DNA sequence and genomic organization of the avian adenovirus CELO","volume":"70","author":"Chiocca","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11262-005-0031-y","article-title":"Sequence analysis of the left end of fowl adenovirus genomes","volume":"33","author":"Corredor","year":"2006","journal-title":"Virus Genes"},{"key":"10.1016\/j.virol.2016.07.023_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1099\/vir.0.013839-0","article-title":"A region at the left end of the fowl adenovirus 9 genome that is non-essential in vitro has consequences in vivo","volume":"91","author":"Corredor","year":"2010","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.virusres.2010.01.014","article-title":"The non-essential left end region of the fowl adenovirus 9 genome is suitable for foreign gene insertion\/replacement","volume":"149","author":"Corredor","year":"2010","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2016.07.023_bib12","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1099\/0022-1317-83-5-1043","article-title":"Orf virus encodes a functional dUTPase gene","volume":"83","author":"Cottone","year":"2002","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1046-5928(03)00108-6","article-title":"Cloning, expression, and purification of the His6-tagged hyper-thermostable dUPTase from Pyrococcus woesei in Eschericia coli: application in PCR","volume":"31","author":"Dabrowski","year":"2003","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.virol.2016.07.023_bib14","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1099\/vir.0.19497-0","article-title":"Genetic content and evolution of adenoviruses","volume":"84","author":"Davison","year":"2003","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib15","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1128\/CVI.00187-13","article-title":"Oral inoculation of chickens with a candidate fowl adenovirus 9 vector","volume":"20","author":"Deng","year":"2013","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.virol.2016.07.023_bib16","doi-asserted-by":"crossref","first-page":"25280","DOI":"10.1074\/jbc.M109.019315","article-title":"The flexible motif V of Epstein-Barr virus deoxyuridine 5 -triphosphate pyrophosphatase is essential for catalysis","volume":"284","author":"Freeman","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2016.07.023_bib17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.virol.2005.10.034","article-title":"EBV-encoded dUTPase induces immune dysregulation: implications for the pathophysiology of EBV-associated disease","volume":"346","author":"Glaser","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.virol.2016.07.023_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.virusres.2011.01.002","article-title":"Pathogenicity and complete genome sequence of a fowl adenovirus serotype 8 isolate","volume":"156","author":"Grgi\u0107","year":"2011","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2016.07.023_bib19","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1099\/vir.0.030064-0","article-title":"Coding potential and transcript analysis of fowl adenovirus 4: insight into upstream ORFs as common sequence features in adenoviral transcripts","volume":"92","author":"Griffin","year":"2011","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib20","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1099\/vir.0.2008\/004606-0","article-title":"The multifunctional NS1 protein of influenza A viruses","volume":"10","author":"Hale","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/jmbi.1999.2680","article-title":"Structure\/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target","volume":"288","author":"Harris","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.virol.2016.07.023_bib22","series-title":"Diseases of Poultry","first-page":"289","article-title":"Aviadenovirus infections","author":"Hess","year":"2013"},{"key":"10.1016\/j.virol.2016.07.023_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ni1303","article-title":"Innate immune recognition of viral infection","volume":"7","author":"Kawai","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.virol.2016.07.023_bib24","doi-asserted-by":"crossref","first-page":"e1002292","DOI":"10.1371\/journal.ppat.1002292","article-title":"The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection","volume":"7","author":"Leang","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virol.2016.07.023_bib25","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1128\/JVI.73.8.6517-6525.1999","article-title":"Characterization of CELO virus proteins that modulate the pRb\/E2F pathway","volume":"73","author":"Lehrmann","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib26","doi-asserted-by":"crossref","first-page":"17717","DOI":"10.1073\/pnas.0508531102","article-title":"Hepatitis C virus protease NS3\/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity","volume":"102","author":"Li","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2016.07.023_bib27","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.vetmic.2013.05.017","article-title":"The first whole genome sequence of a Fowl adenovirus B strain enables interspecies comparisons within the genus Aviadenovirus","volume":"166","author":"Marek","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2016.07.023_bib28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2174\/1389203013380964","article-title":"Evolution of the dUTPase gene of mammalian and avian herpesviruses","volume":"44","author":"McGeehan","year":"2001","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.virol.2016.07.023_bib29","first-page":"1833","article-title":"The complete nucleotide sequence of fowl adenovirus type 8","volume":"81","author":"Ojki\u0107","year":"2000","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/viro.2000.0890","article-title":"The long repeat region is dispensable for fowl adenovirus replication in vitro","volume":"283","author":"Ojki\u0107","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.virol.2016.07.023_bib31","doi-asserted-by":"crossref","first-page":"8934","DOI":"10.1128\/JVI.73.11.8934-8943.1999","article-title":"African swine fever virus dUTPase is a highly specific enzyme required for efficient replication in swine macrophages","volume":"73","author":"Oliveros","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib32","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2174\/1389203013381008","article-title":"The Role of Retroviral dUTPases in replication and virulence","volume":"2","author":"Payne","year":"2001","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.virol.2016.07.023_bib33","doi-asserted-by":"crossref","first-page":"9538","DOI":"10.1128\/JVI.00177-13","article-title":"An intact sialoadhesin (Sn\/SIGLEC1\/CD169) is not required for attachment\/internalization of the porcine reproductive and respiratory syndrome virus","volume":"87","author":"Prather","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib34","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1128\/jvi.66.11.6706-6713.1992","article-title":"Herpes simplex virus type 1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latency","volume":"66","author":"Pyles","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib35","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.4049\/jimmunol.173.4.2675","article-title":"Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima","volume":"173","author":"Rothwell","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2016.07.023_bib36","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1089\/aid.2009.0290","article-title":"Detection of HIV gp120 in plasma during early HIV infection is associated with increased proinflammatory and immunoregulatory cytokines","volume":"26","author":"Rychert","year":"2010","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.virol.2016.07.023_bib37","unstructured":"Schat, K.A., Purchase, H.G., 1989. Cell culture methods, In: A Laboratory Manual for the Isolation and Identification of Avian Pathogens 3rd edition.,\u00a0American Association of Avian Pathologists, USA, 167\u2013175."},{"key":"10.1016\/j.virol.2016.07.023_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0167-4838(96)00229-4","article-title":"Characterization and mutational studies of equine infectious anemia virus dUTPase","volume":"1339","author":"Shao","year":"1997","journal-title":"Biochim. Biophys. Acta - Protein Struct. Mol. Enzymol."},{"key":"10.1016\/j.virol.2016.07.023_bib39","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1462-5822.2006.00716.x","article-title":"Interferon signalling network in innate defence","volume":"8","author":"Takaoka","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.virol.2016.07.023_bib40","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/35073080","article-title":"A weak signal for strong responses: interferon-\u03b1\/\u03b2","volume":"2","author":"Taniguchi","year":"2001","journal-title":"Nat. Rev. Cell Biol."},{"key":"10.1016\/j.virol.2016.07.023_bib41","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.str.2005.06.009","article-title":"The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases","volume":"13","author":"Tarbouriech","year":"2005","journal-title":"Structure"},{"key":"10.1016\/j.virol.2016.07.023_bib42","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1586\/erv.09.29","article-title":"Strategies to overcome host immunity to adenovirus vectors in vaccine development","volume":"8","author":"Thacker","year":"2009","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.virol.2016.07.023_bib43","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1128\/jvi.67.5.2592-2600.1993","article-title":"Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPAase-deficient mutant","volume":"67","author":"Threadgill","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/ni0103-8","article-title":"Novel interferons","volume":"4","author":"Vilcek","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.virol.2016.07.023_bib45","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1742-4690-11-60","article-title":"The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein","volume":"11","author":"Voronin","year":"2014","journal-title":"Retrovirology"},{"key":"10.1016\/j.virol.2016.07.023_bib46","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1089\/vim.2004.17.498","article-title":"Inverse interference: how viruses fight the interferon system","volume":"17","author":"Weber","year":"2004","journal-title":"Viral Immunol."},{"key":"10.1016\/j.virol.2016.07.023_bib47","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1128\/jvi.71.3.1857-1870.1997","article-title":"Human adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes","volume":"71","author":"Weiss","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib48","doi-asserted-by":"crossref","first-page":"17286","DOI":"10.1073\/pnas.1009823107","article-title":"Induction of type I interferon by adenovirus-encoded small RNAs","volume":"107","author":"Yamaguchi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2016.07.023_bib49","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1128\/JVI.02146-12","article-title":"Determination of spontaneous mutation frequencies in measles virus under nonselective conditions","volume":"87","author":"Zhang","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2016.07.023_bib50","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1637\/8169-110607-ResNote.1","article-title":"Identification and characterization of duck enteritis virus dUTPase gene","volume":"52","author":"Zhao","year":"2008","journal-title":"Avian Dis."},{"key":"10.1016\/j.virol.2016.07.023_bib51","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.virusres.2006.08.007","article-title":"Characterization of an early gene encoding for dUTPase in Rana grylio virus","volume":"123","author":"Zhao","year":"2007","journal-title":"Virus Res."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682216301994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682216301994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:38:23Z","timestamp":1758587903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682216301994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":51,"alternative-id":["S0042682216301994"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2016.07.023","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization and functional studies of fowl adenovirus 9 dUTPase","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2016.07.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}