{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:24:12Z","timestamp":1781796252376,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["31572502"],"award-info":[{"award-number":["31572502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds","award":["KYHW201702"],"award-info":[{"award-number":["KYHW201702"]}]},{"DOI":"10.13039\/501100012421","name":"Agricultural Science and Technology Innovation Program","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012421","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Priority Academic Program Development"},{"DOI":"10.13039\/501100012166","name":"National\u00a0Key\u00a0Research\u00a0and\u00a0Development\u00a0Program\u00a0of China","doi-asserted-by":"crossref","award":["2017YFD0500702"],"award-info":[{"award-number":["2017YFD0500702"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National\u00a0Key\u00a0Research\u00a0and\u00a0Development\u00a0Program\u00a0of China","doi-asserted-by":"crossref","award":["2017YFD0502302"],"award-info":[{"award-number":["2017YFD0502302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Agriculture\u00a0Commission","award":["201702080008F00068"],"award-info":[{"award-number":["201702080008F00068"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.virol.2017.11.004","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T19:40:26Z","timestamp":1513280426000},"page":"230-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Inhibition of neddylation pathway represses influenza virus replication and pro-inflammatory responses"],"prefix":"10.1016","volume":"514","author":[{"given":"Haiwei","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjuan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Sam","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2017.11.004_bib1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1158\/0008-5472.CAN-12-1729","article-title":"Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924","volume":"73","author":"Blank","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.virol.2017.11.004_bib2","doi-asserted-by":"crossref","first-page":"39021","DOI":"10.1074\/jbc.M112.390328","article-title":"Skp1-Cul1-F-box ubiquitin ligase (SCF(betaTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry","volume":"287","author":"Burrows","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2017.11.004_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.tube.2015.05.014","article-title":"Suppressive role of neddylation in dendritic cells during Mycobacterium tuberculosis infection","author":"Chadha","year":"2015","journal-title":"Tuberculosis"},{"key":"10.1016\/j.virol.2017.11.004_bib4","doi-asserted-by":"crossref","first-page":"35756","DOI":"10.1074\/jbc.M112.397703","article-title":"Inhibition of neddylation represses lipopolysaccharide-induced proinflammatory cytokine production in macrophage cells","volume":"287","author":"Chang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2017.11.004_bib5","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/nm1477","article-title":"Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia","volume":"12","author":"de Jong","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.virol.2017.11.004_bib6","doi-asserted-by":"crossref","first-page":"11461","DOI":"10.1128\/JVI.01071-08","article-title":"Role of hypercytokinemia in NF-kappaB p50-deficient mice after H5N1 influenza A virus infection","volume":"82","author":"Droebner","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2017.11.004_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pep.2009.11.001","article-title":"Cloning, expression and purification of the influenza A (H9N2) virus M2e antigen and truncated Mycobacterium tuberculosis HSP70 as a fusion protein in Pichia pastoris","volume":"70","author":"Ebrahimi","year":"2010","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.virol.2017.11.004_bib8","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1128\/JVI.02082-06","article-title":"Influenza A virus NS1 protein activates the PI3K\/Akt pathway to mediate antiapoptotic signaling responses","volume":"81","author":"Ehrhardt","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2017.11.004_bib9","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/bph.12998","article-title":"MLN4924 sensitizes monocytes and maturing dendritic cells for TNF-dependent and -independent necroptosis","volume":"172","author":"El-Mesery","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.virol.2017.11.004_bib10","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3109\/08820139.2015.1099663","article-title":"Up-regulation of pro-inflammatory cytokines and chemokine production in avian influenza H9N2 virus-infected human lung epithelial cell line (A549)","volume":"45","author":"Farzin","year":"2016","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.virol.2017.11.004_bib11","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.2353\/ajpath.2010.100066","article-title":"Influenza virus receptor specificity: disease and transmission","volume":"176","author":"Garcia-Sastre","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.virol.2017.11.004_bib12","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1125676","article-title":"Type 1 interferons and the virus-host relationship: a lesson in detente","volume":"312","author":"Garcia-Sastre","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.virol.2017.11.004_bib13","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1158\/1078-0432.CCR-13-0987","article-title":"The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-kappaB activation and induces apoptosis in chronic lymphocytic leukemia B cells","volume":"20","author":"Godbersen","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.virol.2017.11.004_bib14","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.3109\/10428194.2014.990901","article-title":"Targeting neddylation effectively antagonizes nuclear factor-kappaB in chronic lymphocytic leukemia B-cells","volume":"56","author":"Godbersen","year":"2015","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.virol.2017.11.004_bib15","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1182\/blood-2013-08-521914","article-title":"MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells","volume":"123","author":"Gu","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.virol.2017.11.004_bib16","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1042\/BJ20111671","article-title":"Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes","volume":"441","author":"Hjerpe","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.virol.2017.11.004_bib17","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1038\/leu.2015.106","article-title":"Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia","volume":"29","author":"Khalife","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.virol.2017.11.004_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nature05495","article-title":"Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus","volume":"445","author":"Kobasa","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.virol.2017.11.004_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2015.01.015","article-title":"MLN4924, a novel protein neddylation inhibitor, suppresses proliferation and migration of human urothelial carcinoma: in vitro and in vivo studies","volume":"363","author":"Kuo","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.virol.2017.11.004_bib20","doi-asserted-by":"crossref","first-page":"19977","DOI":"10.1038\/srep19977","article-title":"Broad and potent antiviral activity of the NAE inhibitor MLN4924","volume":"6","author":"Le-Trilling","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2017.11.004_bib21","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbrc.2013.02.028","article-title":"Neddylation pathway regulates the proliferation and survival of macrophages","volume":"432","author":"Li","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.virol.2017.11.004_bib22","first-page":"3350","article-title":"MLN4924, a novel NEDD8-activating enzyme inhibitor, exhibits antitumor activity and enhances cisplatin-induced cytotoxicity in human cervical carcinoma: in vitro and in vivo study","volume":"5","author":"Lin","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.virol.2017.11.004_bib23","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.4161\/auto.21484","article-title":"Inactivation of the Cullin (CUL)-RING E3 ligase by the NEDD8-activating enzyme inhibitor MLN4924 triggers protective autophagy in cancer cells","volume":"8","author":"Luo","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.virol.2017.11.004_bib24","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1158\/0008-5472.CAN-12-0388","article-title":"The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth","volume":"72","author":"Luo","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.virol.2017.11.004_bib25","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/embor.2013.173","article-title":"Building and remodelling Cullin-RING E3 ubiquitin ligases","volume":"14","author":"Lydeard","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.virol.2017.11.004_bib26","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/onc.2012.153","article-title":"WEE1 accumulation and deregulation of S-phase proteins mediate MLN4924 potent inhibitory effect on Ewing sarcoma cells","volume":"32","author":"Mackintosh","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.virol.2017.11.004_bib27","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3390\/biom4040897","article-title":"Cullin E3 ligases and their rewiring by viral factors","volume":"4","author":"Mahon","year":"2014","journal-title":"Biomolecules"},{"key":"10.1016\/j.virol.2017.11.004_bib28","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1182\/blood-2013-02-486373","article-title":"Neddylation plays an important role in the regulation of murine and human dendritic cell function","volume":"122","author":"Mathewson","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.virol.2017.11.004_bib29","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bbrc.2010.03.166","article-title":"Characterization of the interaction of influenza virus NS1 with Akt","volume":"395","author":"Matsuda","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.virol.2017.11.004_bib30","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1007\/s00018-009-8712-7","article-title":"Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization","volume":"66","author":"Merlet","year":"2009","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.virol.2017.11.004_bib31","doi-asserted-by":"crossref","first-page":"e1005437","DOI":"10.1371\/journal.ppat.1005437","article-title":"Protein kinase R degradation is essential for rift valley fever virus infection and is regulated by SKP1-CUL1-F-box (SCF)FBXW11-NSs E3 ligase","volume":"12","author":"Mudhasani","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virol.2017.11.004_bib32","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1517\/13543784.2012.707192","article-title":"MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy","volume":"21","author":"Nawrocki","year":"2012","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.virol.2017.11.004_bib33","doi-asserted-by":"crossref","first-page":"e1807","DOI":"10.1038\/cddis.2015.161","article-title":"Targeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agents","volume":"6","author":"Paiva","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.virol.2017.11.004_bib34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.vetmic.2017.02.015","article-title":"Co-infection of H9N2 subtype avian influenza virus and infectious bronchitis virus decreases SP-A expression level in chickens","volume":"203","author":"Qi Huang","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2017.11.004_bib35","first-page":"3400","article-title":"Molecular dynamics simulation on the low sensitivity of mutants of NEDD-8 activating enzyme for MLN4924 inhibitor as a cancer drug","volume":"5","author":"Rashidieh","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.virol.2017.11.004_bib36","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1158\/1078-0432.CCR-15-1338","article-title":"Phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924\/MLN4924) in patients with advanced solid tumors","volume":"22","author":"Sarantopoulos","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.virol.2017.11.004_bib37","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1501752","article-title":"MLN4924, a first-in-class NEDD8-activating enzyme inhibitor, attenuates IFN-beta production","author":"Song","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2017.11.004_bib38","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/bjh.13323","article-title":"Pevonedistat (MLN4924), a First-in-Class NEDD8-activating enzyme inhibitor, in patients with acute myeloid leukaemia and myelodysplastic syndromes: a phase 1 study","volume":"169","author":"Swords","year":"2015","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.virol.2017.11.004_bib39","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1007\/s00134-010-1830-8","article-title":"Hypercytokinemia with 2009 pandemic H1N1 (pH1N1) influenza successfully treated with polymyxin B-immobilized fiber column hemoperfusion","volume":"36","author":"Takeda","year":"2010","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.virol.2017.11.004_bib40","article-title":"Radiosensitization of human colorectal cancer cells by MLN4924: an inhibitor of NEDD8-activating enzyme","author":"Wan","year":"2015","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.virol.2017.11.004_bib41","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1080\/15384047.2014.1003003","article-title":"Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells","volume":"16","author":"Wang","year":"2015","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.virol.2017.11.004_bib42","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/JVI.02568-13","article-title":"A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation","volume":"88","author":"Wei","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2017.11.004_bib43","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1086\/649785","article-title":"Cytokine profiles induced by the novel swine-origin influenza A\/H1N1 virus: implications for treatment strategies","volume":"201","author":"Woo","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2017.11.004_bib44","doi-asserted-by":"crossref","first-page":"30931","DOI":"10.1074\/jbc.M403258200","article-title":"NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas\/FasL is crucial for efficient influenza virus propagation","volume":"279","author":"Wurzer","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2017.11.004_bib45","doi-asserted-by":"crossref","first-page":"e34079","DOI":"10.1371\/journal.pone.0034079","article-title":"The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2017.11.004_bib46","doi-asserted-by":"crossref","first-page":"e1001145","DOI":"10.1371\/journal.ppat.1001145","article-title":"Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype?","volume":"6","author":"Ye","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virol.2017.11.004_bib47","first-page":"189","article-title":"Human infection by avian influenza A H5N1","volume":"11","author":"Yuen","year":"2005","journal-title":"Hong. Kong Med. J."},{"key":"10.1016\/j.virol.2017.11.004_bib48","doi-asserted-by":"crossref","first-page":"43691","DOI":"10.1038\/srep43691","article-title":"NEDDylation of PB2 reduces its stability and blocks the replication of influenza A virus","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2017.11.004_bib49","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/cmi.2015.35","article-title":"Neddylation is required for herpes simplex virus type I (HSV-1)-induced early phase interferon-beta production","volume":"13","author":"Zhang","year":"2016","journal-title":"Cell Mol. Immunol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268221730377X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268221730377X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:45:30Z","timestamp":1758588330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004268221730377X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":49,"alternative-id":["S004268221730377X"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2017.11.004","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of neddylation pathway represses influenza virus replication and pro-inflammatory responses","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2017.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}