{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:59:32Z","timestamp":1791644372258,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31470892"],"award-info":[{"award-number":["31470892"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670536"],"award-info":[{"award-number":["81670536"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Project","award":["2016YFC1200900"],"award-info":[{"award-number":["2016YFC1200900"]}]},{"name":"Guangzhou Health Care and Cooperative Innovation Major Project","award":["201508020252"],"award-info":[{"award-number":["201508020252"]}]},{"name":"Science and Technology Program of Guangzhou","award":["201504010032"],"award-info":[{"award-number":["201504010032"]}]},{"DOI":"10.13039\/501100009334","name":"Pearl River S&T Nova Program of Guangzhou","doi-asserted-by":"crossref","award":["201506010076"],"award-info":[{"award-number":["201506010076"]}],"id":[{"id":"10.13039\/501100009334","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CAS Youth Innovation Promotion Association","award":["2014328"],"award-info":[{"award-number":["2014328"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.virol.2018.03.002","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T05:44:14Z","timestamp":1521092654000},"page":"272-283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity"],"prefix":"10.1016","volume":"518","author":[{"given":"Ying","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xikui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianmiao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhua","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chufang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2018.03.002_bib1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1089\/104303404322886147","article-title":"Quantitative adenovirus neutralization assays based on the secreted alkaline phosphatase reporter gene: application in epidemiologic studies and in the design of adenovector vaccines","volume":"15","author":"Aste-Amezaga","year":"2004","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.virol.2018.03.002_bib2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0952-7915(00)00216-8","article-title":"B lymphocyte activation by contact-mediated interactions with T lymphocytes","volume":"13","author":"Bishop","year":"2001","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.virol.2018.03.002_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093235","article-title":"Effect of MHC haplotype on immune response upon experimental SHIVSF162P4cy infection of Mauritian cynomolgus macaques","volume":"9","author":"Borsetti","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2018.03.002_bib4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1128\/JVI.06254-11","article-title":"Adenovirus serotype 5 neutralizing antibodies target both hexon and fiber following vaccination and natural infection","volume":"86","author":"Bradley","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2018.03.002_bib5","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1128\/JVI.06165-11","article-title":"Adenovirus serotype 5-specific neutralizing antibodies target multiple hexon hypervariable regions","volume":"86","author":"Bradley","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2018.03.002_bib6","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.3201\/1708.101760","article-title":"Deaths associated with human adenovirus-14p1 infections, Europe, 2009\u20132010","volume":"17","author":"Carr","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virol.2018.03.002_bib7","article-title":"Adenoviruses associated with acute respiratory diseases reported in Beijing from 2011 to 2013","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2018.03.002_bib8","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/jmv.20441","article-title":"Respiratory disease caused by a species B2 adenovirus in a military camp in Turkey","volume":"77","author":"Chmielewicz","year":"2005","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virol.2018.03.002_bib9","doi-asserted-by":"crossref","first-page":"7439","DOI":"10.1073\/pnas.1200566109","article-title":"Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions","volume":"109","author":"de Alwis","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2018.03.002_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00038-17","article-title":"Beta-Propiolactone Inactivation of Coxsackievirus A16 Induces Structural Alteration and Surface Modification of Viral Capsids","volume":"91","author":"Fan","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2018.03.002_bib11","doi-asserted-by":"crossref","first-page":"10366","DOI":"10.1128\/JVI.77.19.10366-10375.2003","article-title":"Identification of adenovirus (ad) penton base neutralizing epitopes by use of sera from patients who had received conditionally replicative ad (addl1520) for treatment of liver tumors","volume":"77","author":"Hong","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2018.03.002_bib12","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/irv.12118","article-title":"Outbreak of febrile respiratory illness associated with human adenovirus type 14p1 in Gansu Province, China","volume":"7","author":"Huang","year":"2013","journal-title":"Influenza Other Respir. Virus."},{"key":"10.1016\/j.virol.2018.03.002_bib13","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1128\/JCM.01928-09","article-title":"Outbreak of febrile respiratory illness associated with adenovirus 11a infection in a Singapore military training cAMP","volume":"48","author":"Kajon","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2018.03.002_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1086\/653083","article-title":"Molecular epidemiology and brief history of emerging adenovirus 14-associated respiratory disease in the United States","volume":"202","author":"Kajon","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2018.03.002_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095647","article-title":"Unique epitopes recognized by antibodies induced in Chikungunya virus-infected non-human primates: implications for the study of immunopathology and vaccine development","volume":"9","author":"Kam","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2018.03.002_bib16","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.3201\/eid2211.160728","article-title":"Severe pneumonia associated with adenovirus type 55 infection, France, 2014","volume":"22","author":"Lafolie","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virol.2018.03.002_bib17","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1086\/598521","article-title":"A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14","volume":"199","author":"Lewis","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2018.03.002_bib18","article-title":"In vitro characterization of human adenovirus type 55 in comparison with its parental adenoviruses, types 11 and 14","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2018.03.002_bib19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/irv.12232","article-title":"Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009\u20132012","volume":"8","author":"Lu","year":"2014","journal-title":"Influenza Other Respir. Virus."},{"key":"10.1016\/j.virol.2018.03.002_bib20","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1016\/j.vaccine.2015.10.117","article-title":"Neutralizing epitopes mapping of human adenovirus type 14 hexon","volume":"33","author":"Ma","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2018.03.002_bib21","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1086\/522970","article-title":"Abrupt emergence of diverse species B adenoviruses at US military recruit training centers","volume":"196","author":"Metzgar","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2018.03.002_bib22","article-title":"Insights into adenovirus uncoating from interactions with integrins and mediators of host immunity","volume":"8","author":"Nemerow","year":"2016","journal-title":"Virus.-Basel"},{"key":"10.1016\/j.virol.2018.03.002_bib23","doi-asserted-by":"crossref","first-page":"7764","DOI":"10.1128\/JVI.00748-14","article-title":"Roles of major histocompatibility complex class II in inducing protective immune responses to influenza vaccination","volume":"88","author":"O","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2018.03.002_bib24","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1128\/JVI.02023-06","article-title":"Structure-based identification of a major neutralizing site in an adenovirus hexon","volume":"81","author":"Pichla-Gollon","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2018.03.002_bib25","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1128\/JVI.07076-11","article-title":"Serotype-specific neutralizing antibody epitopes of human adenovirus type 3 (HAdV-3) and HAdV-7 reside in multiple hexon hypervariable regions","volume":"86","author":"Qiu","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2018.03.002_bib26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nature04721","article-title":"Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity","volume":"441","author":"Roberts","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.virol.2018.03.002_bib27","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1128\/JVI.02889-14","article-title":"Conformational changes in the adenovirus hexon subunit responsible for regulating cytoplasmic dynein recruitment","volume":"89","author":"Scherer","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2018.03.002_bib28","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jcv.2013.09.025","article-title":"Characterizing, typing, and naming human adenovirus type 55 in the era of whole genome data","volume":"58","author":"Seto","year":"2013","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.virol.2018.03.002_bib29","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/emboj\/16.6.1189","article-title":"Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization","volume":"16","author":"Stewart","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.virol.2018.03.002_bib30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1186\/s13054-014-0456-6","article-title":"Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study","volume":"18","author":"Sun","year":"2014","journal-title":"Crit. Care"},{"key":"10.1016\/j.virol.2018.03.002_bib31","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1016\/j.vaccine.2011.03.042","article-title":"Epidemiology of adenovirus type 5 neutralizing antibodies in healthy people and AIDS patients in Guangzhou, southern China","volume":"29","author":"Sun","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2018.03.002_bib32","article-title":"Severe community-acquired pneumonia caused by human adenovirus in immunocompetent adults: a multicenter case series","volume":"11","author":"Tan","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2018.03.002_bib33","doi-asserted-by":"crossref","first-page":"803","DOI":"10.21037\/jtd.2016.03.29","article-title":"Prevalence of neutralizing antibodies to common respiratory viruses in intravenous immunoglobulin and in healthy donors in southern China","volume":"8","author":"Tian","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.virol.2018.03.002_bib34","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.3390\/v7102896","article-title":"Identification and application of neutralizing epitopes of human adenovirus type 55 hexon protein","volume":"7","author":"Tian","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2018.03.002_bib35","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1128\/am.15.3.516-527.1967","article-title":"Inactivation of adenovirus and simian virus 40 tumorigenicity in hamsters by vaccine processing methods","volume":"15","author":"Truffelli","year":"1967","journal-title":"Appl. Microbiol."},{"key":"10.1016\/j.virol.2018.03.002_bib36","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1128\/JCM.01694-09","article-title":"Computational analysis identifies human adenovirus type 55 as a re-emergent acute respiratory disease pathogen","volume":"48","author":"Walsh","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2018.03.002_bib37","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/jmv.24749","article-title":"First isolation of a new type of human adenovirus (genotype 79), species Human mastadenovirus B (B2) from sewage water in Japan","volume":"89","author":"Yoshitomi","year":"2017","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virol.2018.03.002_bib38","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/1547691X.2015.1046572","article-title":"Comparative human and mouse antibody responses against tetanus toxin at clonal level","volume":"13","author":"Yousefi","year":"2016","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.virol.2018.03.002_bib39","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.virol.2012.12.014","article-title":"Characteristics of neutralizing antibodies to adenovirus capsid proteins in human and animal sera","volume":"437","author":"Yu","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.virol.2018.03.002_bib40","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1016\/j.vaccine.2009.06.041","article-title":"Molecular modeling and epitopes mapping of human adenovirus type 3 hexon protein","volume":"27","author":"Yuan","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2018.03.002_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/emi.2017.29","article-title":"Seroprevalence of neutralizing antibodies against adenovirus type 14 and 55 in healthy adults in Southern China","volume":"6","author":"Zheng","year":"2017","journal-title":"Emerg. Microbes Infect."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682218300801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682218300801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:47:49Z","timestamp":1758588469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682218300801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":41,"alternative-id":["S0042682218300801"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2018.03.002","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2018.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}