{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:41:10Z","timestamp":1792298470987,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":379,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Postgraduate Research Fund, University of Malaya","award":["UM.C\/625\/1\/HIR\/MOHE\/MED\/06"],"award-info":[{"award-number":["UM.C\/625\/1\/HIR\/MOHE\/MED\/06"]}]},{"name":"Postgraduate Research Fund, University of Malaya","award":["PG285\u20132016A"],"award-info":[{"award-number":["PG285\u20132016A"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.virol.2018.10.015","type":"journal-article","created":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T11:57:38Z","timestamp":1543060658000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Neuronal transcriptomic responses to Japanese encephalitis virus infection with a special focus on chemokine CXCL11 and pattern recognition receptors RIG-1 and MDA5"],"prefix":"10.1016","volume":"527","author":[{"given":"Shu Pin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kien Chai","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Perera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kum Thong","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.virol.2018.10.015_bib1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1179\/016164106X98062","article-title":"Inflammatory markers in the patients of Japanese encephalitis","volume":"28","author":"Babu","year":"2006","journal-title":"Neurol. Res."},{"issue":"3","key":"10.1016\/j.virol.2018.10.015_bib2","first-page":"907","article-title":"Chemokines and their receptors in disease","volume":"20","author":"Bendall","year":"2005","journal-title":"Histol. Histopathol."},{"issue":"1","key":"10.1016\/j.virol.2018.10.015_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neulet.2006.11.070","article-title":"Induction of IP-10 (CXCL10) in astrocytes following Japanese encephalitis","volume":"414","author":"Bhowmick","year":"2007","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.virol.2018.10.015_bib4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng1201-365","article-title":"Minimum information about a microarray experiment (MIAME)\u2014toward standards for microarray data","volume":"29","author":"Brazma","year":"2001","journal-title":"Nat. Genet."},{"issue":"22","key":"10.1016\/j.virol.2018.10.015_bib5","doi-asserted-by":"crossref","first-page":"12107","DOI":"10.1128\/JVI.78.22.12107-12119.2004","article-title":"Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection","volume":"78","author":"Chen","year":"2004","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.virol.2018.10.015_bib6","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1084\/jem.187.12.2009","article-title":"Interferon\u2013inducible T cell alpha chemoattractant (I-TAC): a novel Non-ELR CXC Chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3","volume":"187","author":"Cole","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2018.10.015_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01488-13","article-title":"The essential, non-redundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection","author":"Errett","year":"2013","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.virol.2018.10.015_bib8","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1089\/vim.2013.0016","article-title":"Innate immune mechanisms in Japanese encephalitis virus infection: effect on transcription of pattern recognition receptors in mouse neuronal cells and brain tissue","volume":"26","author":"Fadnis","year":"2013","journal-title":"Viral Immunol."},{"issue":"2","key":"10.1016\/j.virol.2018.10.015_bib9","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1128\/JVI.01305-07","article-title":"Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1","volume":"82","author":"Fredericksen","year":"2008","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.virol.2018.10.015_bib10","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.trstmh.2006.02.008","article-title":"A preliminary neuropathological study of Japanese encephalitis in humans and a mouse model","volume":"100","author":"German","year":"2006","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"1","key":"10.1016\/j.virol.2018.10.015_bib11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jcv.2010.06.009","article-title":"Expression profile of Japanese encephalitis virus induced neuroinflammation and its implication in disease severity","volume":"49","author":"Gupta","year":"2010","journal-title":"J. Clin. Virol."},{"issue":"1","key":"10.1016\/j.virol.2018.10.015_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.virusres.2009.10.018","article-title":"Chemokine profiling of Japanese encephalitis virus-infected mouse neuroblastoma cells by microarray and real-time RT-PCR: implication in neuropathogenesis","volume":"147","author":"Gupta","year":"2010","journal-title":"Virus Res."},{"issue":"1","key":"10.1016\/j.virol.2018.10.015_bib13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1743-422X-8-92","article-title":"Transcriptomic profile of host response in Japanese encephalitis virus infection","volume":"8","author":"Gupta","year":"2011","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2018.10.015_bib14","first-page":"2015","article-title":"The involvement of microtubules and actin during the infection of Japanese encephalitis virus in neuroblastoma cell line, IMR32","author":"Henry Sum","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.virol.2018.10.015_bib15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neulet.2010.02.017","article-title":"Cytokines and chemokines in viral encephalitis: a clinicoradiological correlation","volume":"473","author":"Kalita","year":"2010","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.virol.2018.10.015_bib16","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/BF01863914","article-title":"Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche","volume":"162","author":"K\u00e4rber","year":"1931","journal-title":"Naunyn-Schmiede. Arch. Exp. Pathol. Pharmakol."},{"issue":"7089","key":"10.1016\/j.virol.2018.10.015_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature04734","article-title":"Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses","volume":"441","author":"Kato","year":"2006","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.virol.2018.10.015_bib18","doi-asserted-by":"crossref","first-page":"11457","DOI":"10.1128\/JVI.79.17.11457-11466.2005","article-title":"Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis","volume":"79","author":"Klein","year":"2005","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2018.10.015_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1742-2094-7-73","article-title":"Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death","volume":"7","author":"Kumar","year":"2010","journal-title":"J. Neuroinflamm."},{"issue":"2","key":"10.1016\/j.virol.2018.10.015_bib20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuron.2013.04.005","article-title":"Innate immunity in the CNS: redefining the relationship between the CNS and Its environment","volume":"78","author":"Lampron","year":"2013","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.virol.2018.10.015_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1600-0404.2006.00726.x","article-title":"Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick\u2010borne encephalitis","volume":"115","author":"Lepej","year":"2007","journal-title":"Acta Neurol. Scand."},{"issue":"2","key":"10.1016\/j.virol.2018.10.015_bib22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0035-9203(02)90294-4","article-title":"Clinical and immunological risk factors for severe disease in Japanese encephalitis","volume":"96","author":"Libraty","year":"2002","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"4","key":"10.1016\/j.virol.2018.10.015_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"5","key":"10.1016\/j.virol.2018.10.015_bib24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.immuni.2011.05.003","article-title":"Immune signaling by RIG-I-like receptors","volume":"34","author":"Loo","year":"2011","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.virol.2018.10.015_bib25","first-page":"1112","article-title":"Cytokines profile in JE and non JE encephalitis","volume":"5","author":"Mahima","year":"2016","journal-title":"Int. J. Sci. Res."},{"issue":"2","key":"10.1016\/j.virol.2018.10.015_bib26","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.pneurobio.2010.01.008","article-title":"Overview: japanese encephalitis","volume":"91","author":"Misra,","year":"2010","journal-title":"Prog. Neurobiol."},{"issue":"2","key":"10.1016\/j.virol.2018.10.015_bib27","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Pathogen recognition and inflammatory signaling in innate immune defenses","volume":"22","author":"Mogensen","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.virol.2018.10.015_bib28","doi-asserted-by":"crossref","first-page":"e926","DOI":"10.1371\/journal.pntd.0000926","article-title":"RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection","volume":"5","author":"Nasirudeen","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"6","key":"10.1016\/j.virol.2018.10.015_bib29","doi-asserted-by":"crossref","first-page":"e21761","DOI":"10.1371\/journal.pone.0021761","article-title":"RIG-I mediates innate immune response in mouse neurons following Japanese encephalitis virus infection","volume":"6","author":"Nazmi","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.virol.2018.10.015_bib30","doi-asserted-by":"crossref","first-page":"420","DOI":"10.6026\/97320630001420","article-title":"GeneVenn-A web application for comparing gene lists using Venn diagrams","volume":"1","author":"Pirooznia","year":"2007","journal-title":"Bioinformation"},{"issue":"2","key":"10.1016\/j.virol.2018.10.015_bib31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/(SICI)1096-9071(199702)51:2<132::AID-JMV8>3.0.CO;2-8","article-title":"Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients","volume":"51","author":"Ravi","year":"1997","journal-title":"J. Med. Virol."},{"issue":"5","key":"10.1016\/j.virol.2018.10.015_bib32","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1128\/jcm.20.5.1017-1019.1984","article-title":"Titration of dengue viruses by immunofluorescence in microtiter plates","volume":"20","author":"Schoepp","year":"1984","journal-title":"J. Clin. Microbiol."},{"issue":"7","key":"10.1016\/j.virol.2018.10.015_bib33","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1099\/0022-1317-49-7-607","article-title":"Secretion of the chemokine interleukin-8 during Japanese encephalitis virus infection","volume":"49","author":"Singh","year":"2000","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.virol.2018.10.015_bib34","series-title":"Japanese Encephalitis and West Nile Viruses","first-page":"171","article-title":"Pathogenesis and clinical features of Japanese encephalitis and West Nile virus infections","author":"Solomon","year":"2002"},{"issue":"918","key":"10.1016\/j.virol.2018.10.015_bib35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/pmj.78.918.205","article-title":"Japanese viral encephalitis","volume":"78","author":"Tiroumourougane","year":"2002","journal-title":"Postgrad. Med. J."},{"issue":"4","key":"10.1016\/j.virol.2018.10.015_bib36","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.micinf.2011.01.002","article-title":"Japanese encephalitis virus: from genome to infectome","volume":"13","author":"Unni","year":"2011","journal-title":"Microbes Infect."},{"issue":"1","key":"10.1016\/j.virol.2018.10.015_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.virol.2005.07.013","article-title":"Gene expression in mice infected with West Nile virus strains of different neurovirulence","volume":"342","author":"Venter","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.virol.2018.10.015_bib38","unstructured":"WHO, 2015, December 2015. Japanese encephalitis. Retrieved Jun, 2017, 2017, from \u3008http:\/\/www.who.int\/mediacentre\/factsheets\/fs386\/en\/\u3009."},{"issue":"9","key":"10.1016\/j.virol.2018.10.015_bib39","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1086\/423328","article-title":"Proinflammatory cytokines and chemokines in humans with Japanese encephalitis","volume":"190","author":"Winter","year":"2004","journal-title":"J. Infect. Dis."},{"issue":"5","key":"10.1016\/j.virol.2018.10.015_bib40","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1365-2990.2011.01247.x","article-title":"Enterovirus 71 encephalomyelitis and Japanese encephalitis can be distinguished by topographic distribution of inflammation and specific intraneuronal detection of viral antigen and RNA","volume":"38","author":"Wong","year":"2012","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"2","key":"10.1016\/j.virol.2018.10.015_bib41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2478\/v10039-011-0033-z","article-title":"Evaluation of CXCL10, CXCL11, CXCL12 and CXCL13 chemokines in serum and cerebrospinal fluid in patients with tick borne encephalitis (TBE)","volume":"56","author":"Zajkowska","year":"2011","journal-title":"Adv. Med. Sci."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682218303271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682218303271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:47:37Z","timestamp":1758588457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682218303271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":41,"alternative-id":["S0042682218303271"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2018.10.015","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuronal transcriptomic responses to Japanese encephalitis virus infection with a special focus on chemokine CXCL11 and pattern recognition receptors RIG-1 and MDA5","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2018.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}