{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:40:57Z","timestamp":1793137257664,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.virol.2019.07.022","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T08:07:33Z","timestamp":1564128453000},"page":"32-38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["A chimpanzee adenoviral vector-based rabies vaccine protects beagle dogs from lethal rabies virus challenge"],"prefix":"10.1016","volume":"536","author":[{"given":"Xiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudan","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2019.07.022_bib1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.tim.2018.07.001","article-title":"Rabies virus","volume":"26","author":"Brunker","year":"2018","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.virol.2019.07.022_bib2","first-page":"267","article-title":"Human contacts with oral rabies vaccine baits distributed for wildlife rabies management--Ohio, 2012","volume":"62","author":"Centers for Disease Control Prevention","year":"2013","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.virol.2019.07.022_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0022-1759(97)00212-3","article-title":"Development of a fluorescent antibody virus neutralisation test (FAVN test) for the quantitation of rabies-neutralising antibody","volume":"212","author":"Cliquet","year":"1998","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.virol.2019.07.022_bib4","doi-asserted-by":"crossref","first-page":"e515","DOI":"10.1371\/journal.pntd.0000515","article-title":"Novel vaccines to human rabies","volume":"3","author":"Ertl","year":"2009","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.virol.2019.07.022_bib5","article-title":"New human rabies vaccines in the pipeline","author":"Fooks","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2019.07.022_bib6","doi-asserted-by":"crossref","first-page":"17091","DOI":"10.1038\/nrdp.2017.91","article-title":"Rabies","volume":"3","author":"Fooks","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.virol.2019.07.022_bib7","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1016\/j.vaccine.2017.08.055","article-title":"A novel approach to a rabies vaccine based on a recombinant single-cycle flavivirus vector","volume":"35","author":"Giel-Moloney","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2019.07.022_bib8","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1080\/21645515.2017.1419108","article-title":"Development of novel vaccine vectors: chimpanzee adenoviral vectors","volume":"14","author":"Guo","year":"2018","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.virol.2019.07.022_bib9","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1016\/j.vaccine.2009.08.005","article-title":"Safety studies on an adenovirus recombinant vaccine for rabies (AdRG1.3-ONRAB) in target and non-target species","volume":"27","author":"Knowles","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2019.07.022_bib10","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1586\/erv.10.105","article-title":"Experimental rabies vaccines for humans","volume":"9","author":"McGettigan","year":"2010","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.virol.2019.07.022_bib11","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1016\/S0264-410X(00)00088-8","article-title":"Adult dogs receiving a rabies booster dose with a recombinant adenovirus expressing rabies virus glycoprotein develop high titers of neutralizing antibodies","volume":"18","author":"Tims","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2019.07.022_bib12","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1099\/0022-1317-82-9-2191","article-title":"Immunogenicity of an E1-deleted recombinant human adenovirus against rabies by different routes of administration","volume":"82","author":"Vos","year":"2001","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2019.07.022_bib13","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1007\/s00705-015-2512-1","article-title":"Glycoprotein from street rabies virus BD06 induces early and robust immune responses when expressed from a non-replicative adenovirus recombinant","volume":"160","author":"Wang","year":"2015","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2019.07.022_bib14","first-page":"e30","article-title":"Neutralizing antibody responses to enterovirus and adenovirus in healthy adults in China","volume":"3","author":"Wang","year":"2014","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.virol.2019.07.022_bib15","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1128\/jvi.71.5.3677-3683.1997","article-title":"The use of an E1-deleted, replication-defective adenovirus recombinant expressing the rabies virus glycoprotein for early vaccination of mice against rabies virus","volume":"71","author":"Wang","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2019.07.022_bib16","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1016\/j.vaccine.2009.09.033","article-title":"Poxvirus-vectored vaccines for rabies--a review","volume":"27","author":"Weyer","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2019.07.022_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejpb.2010.06.003","article-title":"Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs","volume":"76","author":"Willmann","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.virol.2019.07.022_bib18","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1128\/JVI.76.6.2667-2675.2002","article-title":"Novel, chimpanzee serotype 68-based adenoviral vaccine carrier for induction of antibodies to a transgene product","volume":"76","author":"Xiang","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2019.07.022_bib19","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.4049\/jimmunol.171.8.4287","article-title":"Mucosally delivered E1-deleted adenoviral vaccine carriers induce transgene product-specific antibody responses in neonatal mice","volume":"171","author":"Xiang","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2019.07.022_bib20","doi-asserted-by":"crossref","first-page":"10780","DOI":"10.1128\/JVI.77.20.10780-10789.2003","article-title":"Oral vaccination of mice with adenoviral vectors is not impaired by preexisting immunity to the vaccine carrier","volume":"77","author":"Xiang","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2019.07.022_bib21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.virol.2013.12.029","article-title":"Protection of non-human primates against rabies with an adenovirus recombinant vaccine","volume":"450\u2013451","author":"Xiang","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.virol.2019.07.022_bib22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/viro.1996.0239","article-title":"A replication-defective human adenovirus recombinant serves as a highly efficacious vaccine carrier","volume":"219","author":"Xiang","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.virol.2019.07.022_bib23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12250-013-3321-x","article-title":"Establishment and preliminary application of a rapid fluorescent focus inhibition test (RFFIT) for rabies virus","volume":"28","author":"Yu","year":"2013","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virol.2019.07.022_bib24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-6869-5_1","article-title":"Development of novel vaccines against infectious diseases based on chimpanzee adenoviral vector","volume":"1581","author":"Zhang","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.virol.2019.07.022_bib25","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1080\/21645515.2016.1165908","article-title":"Adenoviral vector-based strategies against infectious disease and cancer","volume":"12","author":"Zhang","year":"2016","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.virol.2019.07.022_bib26","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/jmv.23546","article-title":"Seroprevalence of neutralizing antibodies to human adenoviruses type-5 and type-26 and chimpanzee adenovirus type-68 in healthy Chinese adults","volume":"85","author":"Zhang","year":"2013","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virol.2019.07.022_bib27","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ymthe.2006.03.027","article-title":"A chimpanzee-origin adenovirus vector expressing the rabies virus glycoprotein as an oral vaccine against inhalation infection with rabies virus","volume":"14","author":"Zhou","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.virol.2019.07.022_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004874","article-title":"Human rabies in China, 1960-2014: a descriptive epidemiological study","volume":"10","author":"Zhou","year":"2016","journal-title":"PLoS Neglected Trop. Dis."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682219301989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682219301989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:49:07Z","timestamp":1758588547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682219301989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":28,"alternative-id":["S0042682219301989"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2019.07.022","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A chimpanzee adenoviral vector-based rabies vaccine protects beagle dogs from lethal rabies virus challenge","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2019.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}