{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:53:49Z","timestamp":1765486429976,"version":"3.44.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.virol.2020.05.001","type":"journal-article","created":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T18:09:47Z","timestamp":1589134187000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Understanding the mechanism of action of cytomegalovirus-induced regulatory T cells"],"prefix":"10.1016","volume":"547","author":[{"given":"Adriana","family":"Tovar-Salazar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.virol.2020.05.001_bib1","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1128\/JVI.79.6.3675-3683.2005","article-title":"Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons","volume":"79","author":"Almanzar","year":"2005","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2020.05.001_bib2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S2055-6640(20)30456-8","article-title":"Human cytomegalovirus (CMV) in Africa: a neglected but important pathogen","volume":"2","author":"Bates","year":"2016","journal-title":"J. Virus Erad."},{"issue":"1","key":"10.1016\/j.virol.2020.05.001_bib3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4049\/jimmunol.1001505","article-title":"A major role for Bim in regulatory T cell homeostasis","volume":"186","author":"Chougnet","year":"2011","journal-title":"J. Immunol."},{"issue":"9427","key":"10.1016\/j.virol.2020.05.001_bib4","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/S0140-6736(04)16500-8","article-title":"Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy","volume":"363","author":"Deayton","year":"2004","journal-title":"Lancet"},{"issue":"Pt 12","key":"10.1016\/j.virol.2020.05.001_bib5","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1099\/vir.0.036004-0","article-title":"Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans","volume":"92","author":"Derhovanessian","year":"2011","journal-title":"J. Gen. Virol."},{"issue":"4","key":"10.1016\/j.virol.2020.05.001_bib6","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.vaccine.2012.11.041","article-title":"Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination","volume":"31","author":"Derhovanessian","year":"2013","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.virol.2020.05.001_bib7","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.4049\/jimmunol.1303361","article-title":"Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly","volume":"193","author":"Derhovanessian","year":"2014","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.virol.2020.05.001_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043937","article-title":"An analysis of regulatory T-cell and Th-17 cell dynamics during cytomegalovirus replication in solid organ transplant recipients","volume":"7","author":"Egli","year":"2012","journal-title":"PloS One"},{"issue":"12","key":"10.1016\/j.virol.2020.05.001_bib9","doi-asserted-by":"crossref","first-page":"8218","DOI":"10.4049\/jimmunol.175.12.8218","article-title":"Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion","volume":"175","author":"Fletcher","year":"2005","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.virol.2020.05.001_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11904-016-0297-9","article-title":"Partners in crime: the role of CMV in immune dysregulation and clinical outcome during HIV infection","volume":"13","author":"Freeman","year":"2016","journal-title":"Curr. HIV AIDS Rep."},{"issue":"Suppl. 2","key":"10.1016\/j.virol.2020.05.001_bib11","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1093\/infdis\/jiw217","article-title":"Cytomegalovirus and HIV: a dangerous pas de Deux","volume":"214","author":"Gianella","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2020.05.001_bib12","doi-asserted-by":"crossref","first-page":"7470124","DOI":"10.1155\/2016\/7470124","article-title":"NKG2C(+)CD57(+) natural killer cell expansion parallels cytomegalovirus-specific CD8(+) T cell evolution towards senescence","volume":"2016","author":"Heath","year":"2016","journal-title":"J Immunol. Res."},{"issue":"Suppl. 7","key":"10.1016\/j.virol.2020.05.001_bib13","doi-asserted-by":"crossref","first-page":"S701","DOI":"10.1093\/clinids\/12.Supplement_7.S701","article-title":"Epidemiology of cytomegalovirus infections","volume":"12","author":"Ho","year":"1990","journal-title":"Rev. Infect. Dis."},{"issue":"7","key":"10.1016\/j.virol.2020.05.001_bib14","first-page":"1452","article-title":"Cytomegalovirus seropositivity is associated with the expansion of CD4+CD28- and CD8+CD28- T cells in rheumatoid arthritis","volume":"26","author":"Hooper","year":"1999","journal-title":"J. Rheumatol."},{"issue":"9","key":"10.1016\/j.virol.2020.05.001_bib15","article-title":"Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents","volume":"9","author":"Johnstone","year":"2014","journal-title":"PloS One"},{"issue":"8","key":"10.1016\/j.virol.2020.05.001_bib16","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.4049\/jimmunol.170.8.4342","article-title":"Frequencies of circulating cytolytic, CD45RA+CD27-, CD8+ T lymphocytes depend on infection with CMV","volume":"170","author":"Kuijpers","year":"2003","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.virol.2020.05.001_bib17","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1128\/JVI.06251-11","article-title":"CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes","volume":"86","author":"Kwon","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2020.05.001_bib18","unstructured":"Jesser RD."},{"issue":"2","key":"10.1016\/j.virol.2020.05.001_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/infdis\/jiy005","article-title":"Relationship between T-cell responses to CMV, markers of inflammation, and frailty in HIV-uninfected and HIV-infected men in the multicenter AIDS cohort study","volume":"218","author":"Margolick","year":"2018","journal-title":"J. Infect. Dis."},{"issue":"14","key":"10.1016\/j.virol.2020.05.001_bib20","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1128\/JVI.01262-06","article-title":"The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire","volume":"81","author":"Pourgheysari","year":"2007","journal-title":"J. Virol."},{"issue":"Suppl. 4","key":"10.1016\/j.virol.2020.05.001_bib21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/ajt.12103","article-title":"Cytomegalovirus in solid organ transplantation","volume":"13","author":"Razonable","year":"2013","journal-title":"Am. J. Transplant."},{"issue":"24","key":"10.1016\/j.virol.2020.05.001_bib22","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1001\/jama.1989.03420240121038","article-title":"The indirect effects of cytomegalovirus infection on the outcome of organ transplantation","volume":"261","author":"Rubin","year":"1989","journal-title":"Jama"},{"issue":"Suppl. 7","key":"10.1016\/j.virol.2020.05.001_bib23","doi-asserted-by":"crossref","first-page":"S754","DOI":"10.1093\/clinids\/12.Supplement_7.S754","article-title":"Impact of cytomegalovirus infection on organ transplant recipients","volume":"12","author":"Rubin","year":"1990","journal-title":"Rev. Infect. Dis."},{"key":"10.1016\/j.virol.2020.05.001_bib24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.exger.2014.03.020","article-title":"New advances in CMV and immunosenescence","volume":"55","author":"Sansoni","year":"2014","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.virol.2020.05.001_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1073\/pnas.0910620107","article-title":"FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells","volume":"107","author":"Schildknecht","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.virol.2020.05.001_bib26","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.4049\/jimmunol.182.3.1469","article-title":"Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis","volume":"182","author":"Strauss","year":"2009","journal-title":"J. Immunol."},{"issue":"20","key":"10.1016\/j.virol.2020.05.001_bib27","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1182\/blood-2015-11-679639","article-title":"Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis","volume":"127","author":"Teira","year":"2016","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.virol.2020.05.001_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180691","article-title":"Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity","volume":"12","author":"Tovar-Salazar","year":"2017","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.virol.2020.05.001_bib29","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.virol.2009.11.038","article-title":"Regulatory function of cytomegalovirus-specific CD4+CD27-CD28- T cells","volume":"398","author":"Tovar-Salazar","year":"2010","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.virol.2020.05.001_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s11357-013-9557-4","article-title":"Rudimentary signs of immunosenescence in Cytomegalovirus-seropositive healthy young adults","volume":"36","author":"Turner","year":"2014","journal-title":"Age"},{"issue":"10","key":"10.1016\/j.virol.2020.05.001_bib31","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.4049\/jimmunol.174.10.5907","article-title":"License to heal: bidirectional interaction of antigen-specific regulatory T cells and tolerogenic APC","volume":"174","author":"Vlad","year":"2005","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.virol.2020.05.001_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/QAI.0000000000000095","article-title":"Regulatory T cells and the risk of CMV end-organ disease in patients with AIDS","volume":"66","author":"Weinberg","year":"2014","journal-title":"J. Acquir. Immune Defic. Syndr."},{"issue":"5","key":"10.1016\/j.virol.2020.05.001_bib33","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/gerona\/60.5.556","article-title":"An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans","volume":"60","author":"Wikby","year":"2005","journal-title":"J. Gerontol. Biol. Med. Sci."},{"issue":"2","key":"10.1016\/j.virol.2020.05.001_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nri.2017.112","article-title":"Immune checkpoint blockade in infectious diseases","volume":"18","author":"Wykes","year":"2018","journal-title":"Nat. Rev. Immunol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682220300805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682220300805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:51:56Z","timestamp":1758588716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682220300805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":34,"alternative-id":["S0042682220300805"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2020.05.001","relation":{},"ISSN":["0042-6822"],"issn-type":[{"type":"print","value":"0042-6822"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding the mechanism of action of cytomegalovirus-induced regulatory T cells","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2020.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}