{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T15:54:29Z","timestamp":1777996469891,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology (DST), New Delhi, India","doi-asserted-by":"publisher","award":["EEQ\/2016\/00055"],"award-info":[{"award-number":["EEQ\/2016\/00055"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.virol.2020.12.006","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T08:00:56Z","timestamp":1609315256000},"page":"10-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugs"],"prefix":"10.1016","volume":"555","author":[{"given":"Shweta A.","family":"More","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akshay S.","family":"Patil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil S.","family":"Sakle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh N.","family":"Mokale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.virol.2020.12.006_bib1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007161","article-title":"HIV-1 antiretroviral drug therapy","volume":"2","author":"Arts","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"3","key":"10.1016\/j.virol.2020.12.006_bib2","first-page":"199","article-title":"The p38 MAP kinase family as regulators of proinflammatory cytokine production in degenerative diseases of the CNS","volume":"1","author":"Bachstetter","year":"2010","journal-title":"Aging Dis."},{"issue":"23","key":"10.1016\/j.virol.2020.12.006_bib3","article-title":"Combination therapy in combating cancer","volume":"8","author":"Bayat Mokhtari","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.virol.2020.12.006_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00705-005-0632-8","article-title":"Bcl-2 inhibits the caspase-dependent apoptosis induced by SARS-CoV without affecting virus replication kinetics","volume":"151","author":"Bordi","year":"2006","journal-title":"Arch. Virol."},{"issue":"6","key":"10.1016\/j.virol.2020.12.006_bib5","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1529\/biophysj.105.064485","article-title":"A network representation of protein structures: implications for protein stability","volume":"89","author":"Brinda","year":"2005","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.virol.2020.12.006_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases [published correction appears in Microbiol Mol Biol Rev","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.virol.2020.12.006_bib7","author":"ClinicalReferenceGroupSBAR"},{"issue":"5\u20136","key":"10.1016\/j.virol.2020.12.006_bib8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1101\/gad.334425.119","article-title":"The impact of PARPs and ADP-ribosylation on inflammation and host-pathogen interactions","volume":"34","author":"Fehr","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.virol.2020.12.006_bib9","article-title":"Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial [published online ahead of print, 2020 Mar 20]","author":"Gautret","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"5","key":"10.1016\/j.virol.2020.12.006_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007756","article-title":"The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression","volume":"15","author":"Grunewald","year":"2019","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.virol.2020.12.006_bib11","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/gut.52.1.144","article-title":"Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets","volume":"52","author":"Hommes","year":"2003","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.virol.2020.12.006_bib17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev-virology-110615-042301","article-title":"Structure, function, and evolution of coronavirus spike proteins","volume":"3","author":"Li","year":"2016","journal-title":"Annu. Rev. Virol."},{"issue":"8","key":"10.1016\/j.virol.2020.12.006_bib18","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s00705-020-04693-5","article-title":"The potential of drug repositioning as a short-term strategy for the control and treatment of COVID-19 (SARS-CoV-2): a systematic review","volume":"165","author":"Lima","year":"2020","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2020.12.006_bib19","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.virol.2020.12.006_bib20","first-page":"1","article-title":"SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes","author":"Nikolich-Zugich","year":"2020","journal-title":"GeroScience"},{"issue":"1","key":"10.1016\/j.virol.2020.12.006_bib21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/ijp.IJP_115_20","article-title":"Drug targets for corona virus: a systematic review","volume":"52","author":"Prajapat","year":"2020","journal-title":"Indian J. Pharmacol."},{"issue":"18","key":"10.1016\/j.virol.2020.12.006_bib22","first-page":"1824","article-title":"Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review","volume":"323","author":"Sanders","year":"2020","journal-title":"J. Am. Med. Assoc."},{"issue":"4","key":"10.1016\/j.virol.2020.12.006_bib23","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nchembio.1199","article-title":"Target identification and mechanism of action in chemical biology and drug discovery","volume":"9","author":"Schenone","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.virol.2020.12.006_bib24","first-page":"1","article-title":"Drug repurposing approach to fight COVID-19 [published online ahead of print, 2020 Sep 5]","author":"Singh","year":"2020","journal-title":"Pharmacol. Rep."},{"issue":"12","key":"10.1016\/j.virol.2020.12.006_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00182-17","article-title":"Overactive epidermal growth factor receptor signaling leads to increased fibrosis after severe acute respiratory syndrome coronavirus infection","volume":"91","author":"Venkataraman","year":"2017","journal-title":"J. Virol."},{"issue":"1\u20132","key":"10.1016\/j.virol.2020.12.006_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2007.02.007","article-title":"Up-regulation of IL-6 and TNF-alpha induced by SARS-coronavirus spike protein in murine macrophages via NF-kappaB pathway","volume":"128","author":"Wang","year":"2007","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2020.12.006_bib27","article-title":"Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods [published online ahead of print, 2020 Feb 27]","author":"Wu","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.virol.2020.12.006_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41421-020-0153-3","article-title":"Network-based drug repurposing for novel coronavirus 2019-nCoV\/SARS-CoV-2","volume":"6","author":"Zhou","year":"2020","journal-title":"Cell Discov."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682220302464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682220302464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:53:10Z","timestamp":1758588790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682220302464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":23,"alternative-id":["S0042682220302464"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2020.12.006","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugs","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2020.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}