{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T17:25:41Z","timestamp":1777137941285,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.virol.2022.10.013","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T13:19:03Z","timestamp":1667567943000},"page":"131-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Antiviral effect of lysosomotropic disaccharide trehalose on porcine hemagglutinating encephalomyelitis virus, a highly neurotropic betacoronavirus"],"prefix":"10.1016","volume":"577","author":[{"given":"Xiaomin","family":"Ai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqi","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hujun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyu","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deguang","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yungang","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2022.10.013_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.293","article-title":"Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases","volume":"5","author":"Al-Bari","year":"2017","journal-title":"Pharmacol Res Perspect"},{"key":"10.1016\/j.virol.2022.10.013_bib2","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/bies.200900086","article-title":"The granulin gene family: from cancer to dementia","volume":"31","author":"Bateman","year":"2009","journal-title":"Bioessays"},{"key":"10.1016\/j.virol.2022.10.013_bib3","doi-asserted-by":"crossref","first-page":"32298","DOI":"10.1074\/jbc.R112.399170","article-title":"Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration","volume":"287","author":"Cenik","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2022.10.013_bib4","article-title":"Zika virus is transmitted in neural progenitor cells via cell-to-cell spread and infection is inhibited by the autophagy inducer trehalose","author":"Clark","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.10.013_bib5","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1007\/s00705-014-2070-y","article-title":"Identification and genetic characterization of porcine hemagglutinating encephalomyelitis virus from domestic piglets in China","volume":"159","author":"Dong","year":"2014","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2022.10.013_bib6","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.cell.2020.10.039","article-title":"Beta-coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway","volume":"183","author":"Ghosh","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.virol.2022.10.013_bib7","first-page":"49","article-title":"A hemagglutinating virus producing encephalomyelitis in baby pigs","volume":"26","author":"Greig","year":"1962","journal-title":"Can. J. Comp. Med. Vet. Sci."},{"key":"10.1016\/j.virol.2022.10.013_bib8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13024-016-0114-3","article-title":"Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia","volume":"11","author":"Holler","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.virol.2022.10.013_bib9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.virol.2022.10.013_bib10","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1080\/15548627.2021.1896906","article-title":"Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response","volume":"17","author":"Jeong","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.virol.2022.10.013_bib11","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11060-017-2742-z","article-title":"Higher levels of progranulin in cerebrospinal fluid of patients with lymphoma and carcinoma with CNS metastasis","volume":"137","author":"Kimura","year":"2018","journal-title":"J. Neuro Oncol."},{"key":"10.1016\/j.virol.2022.10.013_bib12","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.dsx.2020.06.062","article-title":"Neuroinvasive potential of a primary respiratory pathogen SARS- CoV2: summarizing the evidences","volume":"14","author":"Lahiri","year":"2020","journal-title":"Diabetes Metabol. Syndr."},{"key":"10.1016\/j.virol.2022.10.013_bib13","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1007\/s12035-020-02105-y","article-title":"An experimental model of neurodegenerative disease based on porcine hemagglutinating encephalomyelitis virus-related lysosomal abnormalities","volume":"57","author":"Lan","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.virol.2022.10.013_bib14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12250-020-00230-5","article-title":"On the calculation of TCID50 for quantitation of virus infectivity","volume":"36","author":"Lei","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virol.2022.10.013_bib15","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jmv.25728","article-title":"The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients","volume":"92","author":"Li","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virol.2022.10.013_bib16","doi-asserted-by":"crossref","first-page":"e2443","DOI":"10.7717\/peerj.2443","article-title":"The evidence of porcine hemagglutinating encephalomyelitis virus induced nonsuppurative encephalitis as the cause of death in piglets","volume":"4","author":"Li","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.virol.2022.10.013_bib17","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01736-18","article-title":"Porcine hemagglutinating encephalomyelitis virus activation of the integrin alpha5beta1-FAK-cofilin pathway causes cytoskeletal rearrangement to promote its invasion of N2a cells","volume":"93","author":"Lv","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.10.013_bib18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.vetmic.2019.04.029","article-title":"ATN-161 reduces virus proliferation in PHEV-infected mice by inhibiting the integrin alpha5beta1-FAK signaling pathway","volume":"233","author":"Lv","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2022.10.013_bib19","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.3389\/fimmu.2020.01623","article-title":"Potential fast COVID-19 containment with trehalose","volume":"11","author":"Martinon","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2022.10.013_bib20","series-title":"Detecting and Monitoring Porcine Hemagglutinating Encephalomyelitis Virus, an Underresearched Betacoronavirus","author":"Mora-Diaz","year":"2020"},{"key":"10.1016\/j.virol.2022.10.013_bib21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fvets.2019.00053","article-title":"Porcine hemagglutinating encephalomyelitis virus: a review","volume":"6","author":"Mora-Diaz","year":"2019","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.virol.2022.10.013_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02335-20","article-title":"Porcine hemagglutinating encephalomyelitis virus infection in vivo and ex vivo","volume":"95","author":"Mora-Diaz","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.10.013_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110582","article-title":"Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19","volume":"130","author":"Norinder","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.virol.2022.10.013_bib24","doi-asserted-by":"crossref","first-page":"e375","DOI":"10.1002\/hsr2.375","article-title":"Proposing a nasal trehalose-induced autophagy approach against SARS-CoV 2","volume":"4","author":"Pajokh","year":"2021","journal-title":"Health Sci Rep"},{"key":"10.1016\/j.virol.2022.10.013_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-018-1861-8","article-title":"The lysosomal function of progranulin, a guardian against neurodegeneration","volume":"136","author":"Paushter","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.virol.2022.10.013_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00237-20","article-title":"Trehalose inhibits human immunodeficiency virus type 1 infection in primary human macrophages and CD4(+) T lymphocytes through two distinct mechanisms","volume":"94","author":"Rawat","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.10.013_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01695-21","article-title":"The PERK\/PKR-eIF2alpha pathway negatively regulates porcine hemagglutinating encephalomyelitis virus replication by attenuating global protein translation and facilitating stress granule formation","volume":"96","author":"Shi","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.10.013_bib28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jviromet.2019.04.008","article-title":"Development of a triplex real-time RT-PCR assay for detection and differentiation of three US genotypes of porcine hemagglutinating encephalomyelitis virus","volume":"269","author":"Wang","year":"2019","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.virol.2022.10.013_bib29","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3389\/fcimb.2017.00402","article-title":"Trehalose may decrease the transmission of zika virus to the fetus by activating degradative autophagy","volume":"7","author":"Yuan","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682222001891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682222001891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T15:35:11Z","timestamp":1737646511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682222001891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":29,"alternative-id":["S0042682222001891"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2022.10.013","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiviral effect of lysosomotropic disaccharide trehalose on porcine hemagglutinating encephalomyelitis virus, a highly neurotropic betacoronavirus","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2022.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}