{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:13:33Z","timestamp":1790356413326,"version":"4.1.0"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SB\/S9\/Z-03\/2017-V"],"award-info":[{"award-number":["SB\/S9\/Z-03\/2017-V"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004541","name":"Ministry of Education, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI095366"],"award-info":[{"award-number":["AI095366"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR21935\/NNT\/28\/1217\/2017"],"award-info":[{"award-number":["BT\/PR21935\/NNT\/28\/1217\/2017"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.virol.2022.11.012","type":"journal-article","created":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T23:11:26Z","timestamp":1669590686000},"page":"92-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Surface decorated reporter-tagged chikungunya virus-like particles for clinical diagnostics and identification of virus entry inhibitors"],"prefix":"10.1016","volume":"578","author":[{"given":"Vedita Anand","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Shekhar","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baldeep","family":"Khare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manidipa","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailly","family":"Tomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2022.11.012_bib1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/viro.1999.9723","article-title":"The polysulfonated compound suramin blocks adsorption and lateral difusion of herpes simplex virus type-1 in Vero cells","volume":"258","author":"Aguilar","year":"1999","journal-title":"Virology"},{"key":"10.1016\/j.virol.2022.11.012_bib2","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nprot.2014.054","article-title":"Engineering and characterizing monomeric fluorescent proteins for live-cell imaging applications","volume":"9","author":"Ai","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.virol.2022.11.012_bib3","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nm.2105","article-title":"A virus-like particle vaccine for epidemic Chikungunya virus protects non-human primates against infection","volume":"16","author":"Akahata","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.virol.2022.11.012_bib4","doi-asserted-by":"crossref","first-page":"6970","DOI":"10.1016\/j.vaccine.2019.05.064","article-title":"Zika virus-like particles (VLPs): stable cell lines and continuous perfusion processes as a new potential vaccine manufacturing platform","volume":"37","author":"Alvim","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2022.11.012_bib96","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1017\/S1462399408000859","article-title":"Therapeutic and prophylactic applications of alphavirus vectors","volume":"10","author":"Atkins","year":"2008","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.virol.2022.11.012_bib5","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.bbrc.2014.09.113","article-title":"Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format","volume":"453","author":"Basavannacharya","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.virol.2022.11.012_bib6","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.cell.2019.04.006","article-title":"Cryo-EM structure of chikungunya virus in complex with the Mxra8 receptor","volume":"177","author":"Basore","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.virol.2022.11.012_bib7","series-title":"Advances in Virus Research","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/bs.aivir.2020.06.002","article-title":"Immunopathogenesis of alphaviruses","author":"Baxter","year":"2020"},{"key":"10.1016\/j.virol.2022.11.012_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005608","article-title":"Zika virus-like particle (VLP) based vaccine","volume":"11","author":"Boigard","year":"2017","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.virol.2022.11.012_bib9","doi-asserted-by":"crossref","first-page":"7728","DOI":"10.1016\/j.vaccine.2018.10.072","article-title":"Dengue-2 virus-like particle (VLP) based vaccine elicits the highest titers of neutralizing antibodies when produced at reduced temperature","volume":"36","author":"Boigard","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2022.11.012_bib10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000067930","article-title":"RNA bacteriophage capsid-mediated drug delivery and epitope presentation","volume":"45","author":"Brown","year":"2002","journal-title":"Intervirology"},{"key":"10.1016\/j.virol.2022.11.012_bib11","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.4269\/ajtmh.20-0408","article-title":"Endemic and epidemic human alphavirus infections in eastern Panama: an analysis of population-based cross-sectional surveys","volume":"103","author":"Carrera","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virol.2022.11.012_bib12","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1038\/s41598-018-19825-w","article-title":"Gene therapy for human glioblastoma using neurotropic JC virus-like particles as a gene delivery vector","volume":"8","author":"Chao","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2022.11.012_bib13","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/bc0402888","article-title":"Chemical conjugation of heterologous proteins on the surface of cowpea mosaic virus","volume":"15","author":"Chatterji","year":"2004","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.virol.2022.11.012_bib14","volume":"2","author":"Chen","year":"2012"},{"key":"10.1016\/j.virol.2022.11.012_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2021.198493","article-title":"Chikungunya virus titration, detection and diagnosis using N-Acetylglucosamine (GlcNAc) specific lectin based virus capture assay","volume":"302","author":"Choudhary","year":"2021","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2022.11.012_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171989","article-title":"The neutralizing role of IgM during early Chikungunya virus infection","volume":"12","author":"Chua","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2022.11.012_bib17","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.bbrc.2020.05.161","article-title":"Zika Virus-Like Particle (VLP) vaccine displaying Envelope (E) protein CD loop antigen elicits protective and specific immune response in a murine model","volume":"529","author":"Cimica","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.virol.2022.11.012_bib18","doi-asserted-by":"crossref","first-page":"11231","DOI":"10.1128\/JVI.01054-13","article-title":"Directed evolution of a virus exclusively utilizing human epidermal growth factor receptor as the entry receptor","volume":"87","author":"Dai","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.11.012_bib19","doi-asserted-by":"crossref","first-page":"11231","DOI":"10.1128\/JVI.01054-13","article-title":"Directed evolution of a virus exclusively utilizing human epidermal growth factor receptor as the entry receptor","volume":"87","author":"Dai","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.11.012_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01415-20","article-title":"Zika virus-like particles bearing a covalent dimer of envelope protein protect mice from lethal challenge","volume":"95","author":"De Lorenzo","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.11.012_bib21","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-4939-7808-3_16","article-title":"CCMV-based enzymatic nanoreactors","author":"de Ruiter","year":"2018"},{"key":"10.1016\/j.virol.2022.11.012_bib22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.29245\/2578-3009\/2018\/2.1118","article-title":"Advances and challenges in enveloped virus-like particle (VLP)-based vaccines","volume":"2","author":"Deng","year":"2018","journal-title":"J Immunol Sci"},{"key":"10.1016\/j.virol.2022.11.012_bib23","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1021\/acs.bioconjchem.6b00112","article-title":"NanoLuc: a small luciferase is brightening up the field of bioluminescence","volume":"27","author":"England","year":"2016","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.virol.2022.11.012_bib24","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/hep.21191","article-title":"Host cell responses induced by hepatitis C virus binding","volume":"43","author":"Fang","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.virol.2022.11.012_bib25","doi-asserted-by":"crossref","first-page":"7245","DOI":"10.1074\/jbc.272.11.7245","article-title":"Synthetic soluble analogs of galactosylceramide (GalCer) bind to the V3 domain of HIV-1 gp120 and inhibit HIV-1-induced fusion and entry","volume":"272","author":"Fantini","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2022.11.012_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2020.104808","article-title":"Alphavirus capsid protease inhibitors as potential antiviral agents for Chikungunya infection","volume":"179","author":"Fatma","year":"2020","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virol.2022.11.012_bib27","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1016\/j.vaccine.2015.03.088","article-title":"Immunogenic virus-like particles continuously expressed in mammalian cells as a veterinary rabies vaccine candidate","volume":"33","author":"Fontana","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2022.11.012_bib28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.virusres.2004.08.008","article-title":"Budding of alphaviruses","volume":"106","author":"Garoff","year":"2004","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2022.11.012_bib29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.antiviral.2009.07.007","article-title":"Understanding the alphaviruses: recent research on important emerging pathogens and progress towards their control","volume":"87","author":"Gould","year":"2010","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virol.2022.11.012_bib30","doi-asserted-by":"crossref","first-page":"P62","DOI":"10.1186\/1753-6561-7-S6-P62","article-title":"Characterization and quantitation of fluorescent Gag virus-like particles","volume":"7","author":"Guti\u00e9rrez-Granados","year":"2013","journal-title":"BMC Proc."},{"key":"10.1016\/j.virol.2022.11.012_bib31","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/S0140-6736(04)17398-4","article-title":"Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomized controlled trial","volume":"364","author":"Harper","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.virol.2022.11.012_bib101","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.3389\/fmicb.2017.02565","article-title":"Role of L-Particles during Herpes Simplex Virus Infection","volume":"8","author":"Heilingloh","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.virol.2022.11.012_bib33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12985-016-0607-2","article-title":"Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry","volume":"13","author":"Hen\u00df","year":"2016","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2022.11.012_bib97","doi-asserted-by":"crossref","first-page":"100181","DOI":"10.1016\/j.crmeth.2022.100181","article-title":"Development of a hybrid alphavirus-SARS-CoV-2 pseudovirion for rapid quantification of neutralization antibodies and antiviral drugs","volume":"2","author":"Hetrick","year":"2022","journal-title":"Cell Reports Methods"},{"key":"10.1016\/j.virol.2022.11.012_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133511","article-title":"Suramin inhibits chikungunya virus entry and transmission","volume":"10","author":"Ho","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2022.11.012_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-97038-4","article-title":"Virus-like particles with FLAG-tagged envelope protein as a tetravalent dengue vaccine candidate","volume":"11","author":"Imagawa","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2022.11.012_bib98","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2217\/fmb.09.59","article-title":"A structural and functional perspective of alphavirus replication and assembly","volume":"4","author":"Jose","year":"2009","journal-title":"Future Microbiol"},{"key":"10.1016\/j.virol.2022.11.012_bib36","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.3390\/v7122926","article-title":"Fluorescent protein-tagged Sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells","volume":"7","author":"Jose","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2022.11.012_bib37","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.3390\/v7122926","article-title":"Fluorescent protein-tagged Sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells","volume":"7","author":"Jose","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2022.11.012_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02294-16","article-title":"Spatial and temporal analysis of alphavirus replication and assembly in mammalian and mosquito cells","volume":"8","author":"Jose","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.virol.2022.11.012_bib39","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1038\/s41598-022-06667-w","article-title":"Real-time tracking of bioluminescent influenza A virus infection in mice","volume":"12","author":"Kim","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2022.11.012_bib40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.virol.2005.04.039","article-title":"Targeting Sindbis virus-based vectors to Fc receptor-positive cell types","volume":"338","author":"Klimstra","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.virol.2022.11.012_bib41","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1007\/s00253-020-10437-x","article-title":"Antibody-based therapeutic interventions: possible strategy to counter chikungunya viral infection","volume":"104","author":"Kumar","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.virol.2022.11.012_bib42","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.vaccine.2012.10.083","article-title":"Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development","volume":"31","author":"Kushnir","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2022.11.012_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001786","article-title":"Simple clinical and laboratory predictors of chikungunya versus dengue infections in adults","volume":"6","author":"Lee","year":"2012","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.virol.2022.11.012_bib44","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/s41598-019-38533-7","article-title":"Liver-specific gene delivery using engineered virus-like particles of hepatitis E virus","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2022.11.012_bib45","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0092-8674(01)00303-8","article-title":"The fusion glycoprotein shell of Semliki forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH","volume":"105","author":"Lescar","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.virol.2022.11.012_bib46","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.3389\/fmicb.2020.02100","article-title":"Development of HiBiT-tagged recombinant infectious bronchitis Coronavirus for efficient in vitro and in vivo viral quantification","volume":"11","author":"Liang","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virol.2022.11.012_bib47","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3390\/diagnostics11050819","article-title":"Analysis of a routinely used commercial anti-chikungunya IgM ELISA reveals cross-reactivities with dengue in Brazil: a new challenge for differential diagnosis?","volume":"11","author":"Lima","year":"2021","journal-title":"Diagnostics"},{"key":"10.1016\/j.virol.2022.11.012_bib48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/v12010105","article-title":"Reporter assays for Ebola virus nucleoprotein oligomerization, virion-like particle budding, and minigenome activity reveal the importance of nucleoprotein amino acid position 111","volume":"12","author":"Lin","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2022.11.012_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.600796","article-title":"Recovery of NanoLuc luciferase-tagged canine distemper virus for facilitating rapid screening of antivirals in vitro","volume":"7","author":"Liu","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.virol.2022.11.012_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/834371","article-title":"Diagnostic options and challenges for dengue and chikungunya viruses","author":"Mardekian","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.virol.2022.11.012_bib51","doi-asserted-by":"crossref","first-page":"6922","DOI":"10.1128\/JVI.00592-14","article-title":"Imaging the alphavirus exit pathway","volume":"88","author":"Martinez","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.11.012_bib52","doi-asserted-by":"crossref","first-page":"6922","DOI":"10.1128\/JVI.00592-14","article-title":"Imaging the alphavirus exit pathway","volume":"88","author":"Martinez","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.11.012_bib53","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.idc.2012.02.003","article-title":"Arboviruses and viral hemorrhagic fevers (VHF)","volume":"26","author":"Meltzer","year":"2012","journal-title":"Infect. Dis. Clin. North Am."},{"key":"10.1016\/j.virol.2022.11.012_bib54","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1126\/science.6091268","article-title":"Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III","volume":"226","author":"Mitsuya","year":"1984","journal-title":"Science (80-)"},{"key":"10.1016\/j.virol.2022.11.012_bib55","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1128\/JVI.73.5.4239-4250.1999","article-title":"Assembly of the herpes simplex virus procapsid from purified components and identification of small complexes containing the major capsid and scaffolding proteins","volume":"73","author":"Newcomb","year":"1999","journal-title":"J. Virol."},{"issue":"19","key":"10.1016\/j.virol.2022.11.012_bib56","first-page":"1","article-title":"Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers","volume":"191","author":"Nooraei","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.virol.2022.11.012_bib57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12951-021-00806-7","article-title":"Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers","volume":"19","author":"Nooraei","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.virol.2022.11.012_bib58","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.chom.2010.01.007","article-title":"Autophagy protects against Sindbis virus infection of the central nervous system","volume":"7","author":"Orvedahl","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.virol.2022.11.012_bib59","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1038\/nbt1204-1524","article-title":"A new harvest of fluorescent proteins","volume":"22","author":"Patterson","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.virol.2022.11.012_bib60","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-1-4939-7893-9_2","article-title":"Encapsulation of active enzymes within bacteriophage p22 virus-like particles","author":"Patterson","year":"2018"},{"key":"10.1016\/j.virol.2022.11.012_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1508","article-title":"Viral-based nanomaterials for plasmonic and photonic materials and devices","volume":"10","author":"Petrescu","year":"2018","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.virol.2022.11.012_bib62","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12985-022-01906-y","article-title":"A high-throughput screening assay to identify inhibitory antibodies targeting alphavirus release","volume":"19","author":"Ramjag","year":"2022","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2022.11.012_bib63","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1179\/2047773214Y.0000000163","article-title":"Dengue and chikungunya: long-distance spread and outbreaks in na\u00efve areas","volume":"108","author":"Rezza","year":"2014","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/j.virol.2022.11.012_bib64","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1196\/annals.1408.007","article-title":"The molecular and cellular aspects of arthritis due to alphavirus infections","volume":"1102","author":"Rulli","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.virol.2022.11.012_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004782","article-title":"Expression and characterization of yeast derived chikungunya virus like particles (CHIK-VLPs) and its evaluation as a potential vaccine candidate","volume":"10","author":"Saraswat","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.virol.2022.11.012_bib66","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrmicro2368","article-title":"Biology and pathogenesis of chikungunya virus","volume":"8","author":"Schwartz","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.virol.2022.11.012_bib67","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/nbt1037","article-title":"Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein","volume":"22","author":"Shaner","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.virol.2022.11.012_bib68","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biochi.2018.04.004","article-title":"Chikungunya virus inhibition by peptidomimetic inhibitors targeting virus-specific cysteine protease","volume":"149","author":"Singh","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.virol.2022.11.012_bib69","doi-asserted-by":"crossref","first-page":"10648","DOI":"10.1073\/pnas.92.23.10648","article-title":"Putative receptor binding sites on alphaviruses as visualized by cryoelectron microscopy","volume":"92","author":"Smith","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2022.11.012_bib70","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1128\/JVI.00039-11","article-title":"Rescue of infectious particles from preassembled alphavirus nucleocapsid cores","volume":"85","author":"Snyder","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.11.012_bib71","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fbioe.2020.00072","article-title":"Synthesis and assembly of hepatitis B virus-like particles in a Pichia pastoris cell-free system","volume":"8","author":"Spice","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.virol.2022.11.012_bib100","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3389\/fimmu.2020.00695","article-title":"Disease Resolution in Chikungunya\u2014What Decides the Outcome?","volume":"11","author":"Srivastava","year":"2020","journal-title":"Front Immunol"},{"issue":"374","key":"10.1016\/j.virol.2022.11.012_bib73","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.abl6184","article-title":"Rapid assessment of SARS-CoV-2\u2013evolved variants using virus-like particles","author":"Syed","year":"2021","journal-title":"Science (80-)"},{"key":"10.1016\/j.virol.2022.11.012_bib74","series-title":"Micro and Nanotechnology in Vaccine Development","first-page":"205","article-title":"Virus-like particles","author":"Tagliamonte","year":"2017"},{"key":"10.1016\/j.virol.2022.11.012_bib75","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fcimb.2022.821061","article-title":"Comodulation of dengue and chikungunya virus infection during a Co-infection scenario in human cell lines","volume":"12","author":"Taraphdar","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.virol.2022.11.012_bib76","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.virusres.2013.07.014","article-title":"Fusion of mApple and Venus fluorescent proteins to the Sindbis virus E2 protein leads to different cell-binding properties","volume":"177","author":"Tsvetkova","year":"2013","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2022.11.012_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2019.197732","article-title":"The use of green fluorescent protein-tagged virus-like particles as a tracer in the early phase of chikungunya infection","volume":"272","author":"Tumkosit","year":"2019","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2022.11.012_bib78","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01181-17","article-title":"An envelope-modified tetravalent dengue virus-like-particle vaccine has implications for flavivirus vaccine design","volume":"91","author":"Urakami","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2022.11.012_bib79","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.idc.2019.08.006","article-title":"Chikungunya","volume":"33","author":"Vairo","year":"2019","journal-title":"Infect. Dis. Clin. North Am."},{"key":"10.1016\/j.virol.2022.11.012_bib80","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009195","article-title":"Zika virus-like particle vaccine protects AG129 mice and rhesus macaques against Zika virus","volume":"15","author":"Vang","year":"2021","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.virol.2022.11.012_bib81","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1016\/j.vaccine.2017.06.024","article-title":"Process intensification for high yield production of influenza H1N1 Gag virus-like particles using an inducible HEK-293 stable cell line","volume":"35","author":"Venereo-Sanchez","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2022.11.012_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094401","article-title":"Enhanced production of chikungunya virus-like particles using a high-pH adapted spodoptera frugiperda insect cell line","volume":"9","author":"Wagner","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2022.11.012_bib83","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1074-5521(02)00165-5","article-title":"Natural supramolecular building blocks: wild-type Cowpea mosaic virus","volume":"9","author":"Wang","year":"2002","journal-title":"Chem. Biol."},{"key":"10.1016\/j.virol.2022.11.012_bib84","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJMra1406035","article-title":"Chikungunya virus and the global spread of a mosquito-borne disease","volume":"372","author":"Weaver","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virol.2022.11.012_bib85","article-title":"Global emergence of Alphaviruses that cause arthritis in humans","volume":"5","author":"Wesula Olivia","year":"2015","journal-title":"Infect. Ecol. Epidemiol."},{"key":"10.1016\/j.virol.2022.11.012_bib86","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01168-19","article-title":"100 Years of suramin","volume":"64","author":"Wiedemar","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.virol.2022.11.012_bib87","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.nbt.2018.04.003","article-title":"Nanoreactors: strategies to encapsulate enzyme biocatalysts in virus-like particles","volume":"44","author":"Wilkerson","year":"2018","journal-title":"N Biotechnol."},{"key":"10.1016\/j.virol.2022.11.012_bib88","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/22221751.2018.1559708","article-title":"Chikungunya virus in Asia \u2013 pacific: a systematic review","volume":"8","author":"Wimalasiri-Yapa","year":"2019","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.virol.2022.11.012_bib89","first-page":"375","article-title":"Suramin inhibits the in vitro expression of encephalitis B virus proteins NS3 and E","volume":"23","author":"Xu","year":"2003","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"10.1016\/j.virol.2022.11.012_bib90","doi-asserted-by":"crossref","first-page":"e753","DOI":"10.1371\/journal.pntd.0000753","article-title":"Evaluation of chikungunya diagnostic assays: differences in sensitivity of serology assays in two independent outbreaks","volume":"4","author":"Yap","year":"2010","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.virol.2022.11.012_bib91","doi-asserted-by":"crossref","first-page":"13703","DOI":"10.1073\/pnas.1713166114","article-title":"Structural studies of Chikungunya virus maturation","volume":"114","author":"Yap","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2022.11.012_bib93","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.virol.2004.11.043","article-title":"Heparin binding sites on Ross River virus revealed by electron cryo-microscopy","volume":"332","author":"Zhang","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.virol.2022.11.012_bib99","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12033-012-9598-4","article-title":"Construction and characterization of virus-like particles: A review","volume":"53","author":"Zeltins","year":"2013","journal-title":"Mol Biotechnol"},{"key":"10.1016\/j.virol.2022.11.012_bib94","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.3390\/molecules23092311","article-title":"Application of plant viruses as a biotemplate for nanomaterial fabrication","volume":"23","author":"Zhang","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.virol.2022.11.012_bib95","first-page":"925","article-title":"Co-immunization with CHIKV VLP and DNA vaccines induces a promising humoral response in mice","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682222002100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682222002100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:58:29Z","timestamp":1758589109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682222002100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":98,"alternative-id":["S0042682222002100"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2022.11.012","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surface decorated reporter-tagged chikungunya virus-like particles for clinical diagnostics and identification of virus entry inhibitors","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2022.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}