{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:15:08Z","timestamp":1777727708378,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012428","name":"Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["1610312021011"],"award-info":[{"award-number":["1610312021011"]}],"id":[{"id":"10.13039\/501100012428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.virol.2023.05.001","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T10:16:21Z","timestamp":1684145781000},"page":"9-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Recombinant human adenovirus type 5 based vaccine candidates against GIIa- and GIIb-genotype porcine epidemic diarrhea virus induce robust humoral and cellular response in mice"],"prefix":"10.1016","volume":"584","author":[{"given":"Xin","family":"Miao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongwang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiming","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianliang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonglu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huichen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinsheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.virol.2023.05.001_bib1","first-page":"9","article-title":"One world--one health: the threat of emerging swine diseases","volume":"59","author":"Ayudhya","year":"2012","journal-title":"An Asian perspective. Transboundary and emerging diseases"},{"issue":"5","key":"10.1016\/j.virol.2023.05.001_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/v9050121","article-title":"Evaluation and comparison of the pathogenicity and host immune responses induced by a G2b taiwan porcine epidemic diarrhea virus (strain pintung 52) and its highly cell-culture passaged strain in conventional 5-week-old pigs","volume":"9","author":"Chang","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2023.05.001_bib3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12917-015-0357-1","article-title":"An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titration","volume":"11","author":"Collin","year":"2015","journal-title":"BMC Vet. Res."},{"issue":"2","key":"10.1016\/j.virol.2023.05.001_bib4","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1006\/viro.1994.1058","article-title":"Sequence analysis of the porcine epidemic diarrhea virus genome between the nucleocapsid and spike protein genes reveals a polymorphic ORF","volume":"198","author":"Duarte","year":"1994","journal-title":"Virology"},{"key":"10.1016\/j.virol.2023.05.001_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.197955","article-title":"Characterization, pathogenicity and protective efficacy of a cell culture-derived porcine deltacoronavirus","volume":"282","author":"Gao","year":"2020","journal-title":"Virus Res."},{"issue":"5","key":"10.1016\/j.virol.2023.05.001_bib6","first-page":"388","article-title":"Recombinant adenovirus type 5 HIV gag\/pol\/nef vaccine in South Africa: unblinded, long-term follow-up of the phase 2b HVTN 503\/Phambili study. The Lancet","volume":"14","author":"Gray","year":"2014","journal-title":"Infectious diseases"},{"issue":"1","key":"10.1016\/j.virol.2023.05.001_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/tbed.12991","article-title":"Evolutionary and genotypic analyses of global porcine epidemic diarrhea virus strains","volume":"66","author":"Guo","year":"2019","journal-title":"Transboundary and emerging diseases"},{"issue":"3","key":"10.1016\/j.virol.2023.05.001_bib8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/infdis\/jiy187","article-title":"Immunization with a novel human type 5 adenovirus-vectored vaccine expressing the premembrane and envelope proteins of zika virus provides consistent and sterilizing protection in multiple immunocompetent and immunocompromised animal models","volume":"218","author":"Guo","year":"2018","journal-title":"J. Infect. Dis."},{"issue":"10321","key":"10.1016\/j.virol.2023.05.001_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0140-6736(21)02753-7","volume":"399","author":"Halperin","year":"2022","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.virol.2023.05.001_bib10","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.3389\/fimmu.2020.02152","article-title":"Plant-derived trimeric CO-26K-equivalent epitope induced neutralizing antibodies against porcine epidemic diarrhea virus","volume":"11","author":"Ho","year":"2020","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.virol.2023.05.001_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00737-13","article-title":"Origin, evolution, and genotyping of emergent porcine epidemic diarrhea virus strains in the United States","volume":"4","author":"Huang","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.virol.2023.05.001_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198045","article-title":"Porcine epidemic diarrhea virus (PEDV): an update on etiology, transmission, pathogenesis, and prevention and control","volume":"286","author":"Jung","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2023.05.001_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.virol.2019.05.009","article-title":"Recombinant vesicular stomatitis virus expressing the spike protein of genotype 2b porcine epidemic diarrhea virus: a platform for vaccine development against emerging epidemic isolates","volume":"533","author":"Ke","year":"2019","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.virol.2023.05.001_bib14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3390\/vaccines9040370","article-title":"Construction of porcine epidemic diarrhea virus-like particles and its immunogenicity in mice","volume":"9","author":"Kim","year":"2021","journal-title":"Vaccines"},{"issue":"4","key":"10.1016\/j.virol.2023.05.001_bib15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.str.2020.12.003","article-title":"Structure and immune recognition of the porcine epidemic diarrhea virus spike protein","volume":"29","author":"Kirchdoerfer","year":"2021","journal-title":"Structure (London, England"},{"issue":"2","key":"10.1016\/j.virol.2023.05.001_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1023\/A:1011831902219","article-title":"Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence","volume":"23","author":"Kocherhans","year":"2001","journal-title":"Virus Gene."},{"issue":"658","key":"10.1016\/j.virol.2023.05.001_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn6868","article-title":"Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model","volume":"14","author":"Langel","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.virol.2023.05.001_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12985-015-0421-2","article-title":"Porcine epidemic diarrhea virus: an emerging and re-emerging epizootic swine virus","volume":"12","author":"Lee","year":"2015","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2023.05.001_bib19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.vetmic.2017.06.019","article-title":"Genetic characteristics, pathogenicity, and immunogenicity associated with cell adaptation of a virulent genotype 2b porcine epidemic diarrhea virus","volume":"207","author":"Lee","year":"2017","journal-title":"Vet. Microbiol."},{"issue":"29","key":"10.1016\/j.virol.2023.05.001_bib20","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1016\/j.vaccine.2018.05.124","article-title":"A flagellin-adjuvanted PED subunit vaccine improved protective efficiency against PEDV variant challenge in pigs","volume":"36","author":"Li","year":"2018","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.virol.2023.05.001_bib21","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.3201\/eid1803.120002","article-title":"New variants of porcine epidemic diarrhea virus, China, 2011","volume":"18","author":"Li","year":"2012","journal-title":"Emerg. Infect. Dis."},{"issue":"4","key":"10.1016\/j.virol.2023.05.001_bib22","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S1473-3099(19)30584-5","article-title":"Efficacy, immunogenicity, and safety of an oral influenza vaccine: a placebo-controlled and active-controlled phase 2 human challenge study","volume":"20","author":"Liebowitz","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.virol.2023.05.001_bib23","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.vetmic.2019.02.018","article-title":"Evaluation and comparison of immunogenicity and cross-protective efficacy of two inactivated cell culture-derived GIIa- and GIIb-genotype porcine epidemic diarrhea virus vaccines in suckling piglets","volume":"230","author":"Liu","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2023.05.001_bib24","article-title":"Evaluation of the efficacy of a recombinant adenovirus expressing the spike protein of porcine epidemic diarrhea virus in pigs","author":"Liu","year":"2019","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.virol.2023.05.001_bib25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF01317606","article-title":"A new coronavirus-like particle associated with diarrhea in swine","volume":"58","author":"Pensaert","year":"1978","journal-title":"Arch. Virol."},{"issue":"4","key":"10.1016\/j.virol.2023.05.001_bib26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/pathogens11040449","article-title":"Treatment with ad5-porcine interferon-\u03b1 attenuates ebolavirus disease in pigs","volume":"11","author":"Senthilkumaran","year":"2022","journal-title":"Pathogens"},{"issue":"1","key":"10.1016\/j.virol.2023.05.001_bib27","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3201\/eid1801.111259","article-title":"Outbreak of porcine epidemic diarrhea in suckling piglets, China","volume":"18","author":"Sun","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virol.2023.05.001_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.933249","article-title":"Enhancing epitope of PEDV spike protein","volume":"13","author":"Thavorasak","year":"2022","journal-title":"Front. Microbiol."},{"issue":"5","key":"10.1016\/j.virol.2023.05.001_bib29","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s12250-021-00364-0","article-title":"Porcine coronaviruses: Overview of the state of the art","volume":"36","author":"Turlewicz-Podbielska","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virol.2023.05.001_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.virusres.2016.05.026","article-title":"Porcine epidemic diarrhea in China","volume":"226","author":"Wang","year":"2016","journal-title":"Virus Res."},{"issue":"12","key":"10.1016\/j.virol.2023.05.001_bib31","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/vr.100.12.243","article-title":"An apparently new syndrome of porcine epidemic diarrhoea","volume":"100","author":"Wood","year":"1977","journal-title":"Vet. Rec."},{"issue":"23","key":"10.1016\/j.virol.2023.05.001_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00923-19","article-title":"The 3.1-angstrom cryo-electron microscopy structure of the porcine epidemic diarrhea virus spike protein in the prefusion conformation","volume":"93","author":"Wrapp","year":"2019","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.virol.2023.05.001_bib33","first-page":"1654","article-title":"Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label and randomised phase 1 clinical trial. The Lancet","volume":"21","author":"Wu","year":"2021","journal-title":"Infectious diseases"},{"issue":"11","key":"10.1016\/j.virol.2023.05.001_bib34","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.3390\/v14112434","article-title":"Porcine epidemic diarrhea virus: an updated Overview of virus epidemiology, virulence variation patterns and virus-host interactions","volume":"14","author":"Zhang","year":"2022","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.virol.2023.05.001_bib35","doi-asserted-by":"crossref","first-page":"e783","DOI":"10.1093\/cid\/ciab845","article-title":"Safety and immunogenicity of a recombinant adenovirus type-5-vectored coronavirus disease 2019 (COVID-19) vaccine with a homologous prime-boost regimen in healthy participants aged \u22656 Years: a randomized, double-blind, placebo-controlled, phase 2b trial","volume":"75","author":"Zhu","year":"2022","journal-title":"Clin. Infect. Dis.: an official publication of the Infectious Diseases Society of America"},{"issue":"10249","key":"10.1016\/j.virol.2023.05.001_bib36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0140-6736(20)31605-6","article-title":"Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial","volume":"396","author":"Zhu","year":"2020","journal-title":"Lancet (London, England)"},{"issue":"9984","key":"10.1016\/j.virol.2023.05.001_bib37","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/S0140-6736(15)60553-0","article-title":"Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in China: preliminary report of a randomised, double-blind, placebo-controlled, phase 1 trial","volume":"385","author":"Zhu","year":"2015","journal-title":"Lancet (London, England)"},{"issue":"10240","key":"10.1016\/j.virol.2023.05.001_bib38","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/S0140-6736(20)31208-3","article-title":"Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial","volume":"395","author":"Zhu","year":"2020","journal-title":"Lancet (London, England)"},{"issue":"10069","key":"10.1016\/j.virol.2023.05.001_bib39","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0140-6736(16)32617-4","article-title":"Safety and immunogenicity of a recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in Sierra Leone: a single-centre, randomised, double-blind, placebo-controlled, phase 2 trial","volume":"389","author":"Zhu","year":"2017","journal-title":"Lancet (London, England)"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268222300096X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268222300096X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:50:09Z","timestamp":1777459809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004268222300096X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":39,"alternative-id":["S004268222300096X"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2023.05.001","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant human adenovirus type 5 based vaccine candidates against GIIa- and GIIb-genotype porcine epidemic diarrhea virus induce robust humoral and cellular response in mice","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2023.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}