{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:13:59Z","timestamp":1790356439611,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:00:00Z","timestamp":1696636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2602901"],"award-info":[{"award-number":["2022YFC2602901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.virol.2023.109900","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T11:09:59Z","timestamp":1696676999000},"page":"109900","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Identification of tyrphostin AG879 and A9 inhibiting replication of chikungunya virus by screening of a kinase inhibitor library"],"prefix":"10.1016","volume":"588","author":[{"given":"Yanhua","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhendong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongtian","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-8852","authenticated-orcid":false,"given":"Hailin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.virol.2023.109900_bib1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3201\/eid2602.171636","article-title":"Emergence of chikungunya virus, Pakistan, 2016-2017","volume":"26","author":"Badar","year":"2020","journal-title":"Emerg. Infect. Dis."},{"issue":"11","key":"10.1016\/j.virol.2023.109900_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02143-19","article-title":"Epidermal growth factor receptor and Abl 2 kinase regulate distinct steps of human papillomavirus 16 endocytosis","volume":"94","author":"Bannach","year":"2020","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virol.2023.109900_bib3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3390\/v11030294","article-title":"Chikungunya in infants and children: is pathogenesis increasing?","volume":"11","author":"Barr","year":"2019","journal-title":"Viruses"},{"issue":"7","key":"10.1016\/j.virol.2023.109900_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/v13071307","article-title":"Antivirals against the chikungunya virus","volume":"13","author":"Battisti","year":"2021","journal-title":"Viruses"},{"issue":"9","key":"10.1016\/j.virol.2023.109900_bib5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1473-3099(06)70559-X","article-title":"How did chikungunya reach the Indian Ocean?","volume":"6","author":"Bonn","year":"2006","journal-title":"Lancet Infect. Dis."},{"issue":"4","key":"10.1016\/j.virol.2023.109900_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02325-18","article-title":"Src family kinase inhibitors block translation of alphavirus subgenomic mRNAs","volume":"63","author":"Broeckel","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.virol.2023.109900_bib7","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/S1473-3099(16)30385-1","article-title":"Chikungunya virus: an update on the biology and pathogenesis of this emerging pathogen","volume":"17","author":"Burt","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.virol.2023.109900_bib8","article-title":"Cytopathic effect (CPE)-Based drug screening assay for SARS-CoV-2","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.virol.2023.109900_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002471","article-title":"Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor library","volume":"7","author":"Cruz","year":"2013","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"1","key":"10.1016\/j.virol.2023.109900_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12977-022-00605-4","article-title":"Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency","volume":"19","author":"Dahal","year":"2022","journal-title":"Retrovirology"},{"issue":"2","key":"10.1016\/j.virol.2023.109900_bib11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.virusres.2011.12.009","article-title":"Characterization of Chikungunya virus infection in human neuroblastoma SH-SY5Y cells: role of apoptosis in neuronal cell death","volume":"163","author":"Dhanwani","year":"2012","journal-title":"Virus Res."},{"issue":"8","key":"10.1016\/j.virol.2023.109900_bib12","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1128\/AAC.03036-14","article-title":"Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection","volume":"58","author":"Dyall","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1\u20132","key":"10.1016\/j.virol.2023.109900_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000511280","article-title":"SARS-CoV-2 and the possible role of Raf\/MEK\/ERK pathway in viral survival: is this a potential therapeutic strategy for COVID-19?","volume":"106","author":"Ghasemnejad-Berenji","year":"2021","journal-title":"Pharmacology"},{"issue":"8","key":"10.1016\/j.virol.2023.109900_bib14","first-page":"2022","article-title":"The origin and continuing adaptive evolution of chikungunya virus","volume":"167","author":"Hakim","year":"2022","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2023.109900_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2020.618624","article-title":"Current and promising antivirals against chikungunya virus","volume":"8","author":"Hucke","year":"2020","journal-title":"Front. Public Health"},{"issue":"11","key":"10.1016\/j.virol.2023.109900_bib16","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1517\/14656566.2010.496453","article-title":"Sorafenib: a clinical and pharmacologic review","volume":"11","author":"Iyer","year":"2010","journal-title":"Expet Opin. Pharmacother."},{"issue":"4","key":"10.1016\/j.virol.2023.109900_bib17","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jcv.2014.01.011","article-title":"Inflammation of the external ear in acute chikungunya infection: experience from the outbreak in Johor Bahru, Malaysia, 2008","volume":"59","author":"Javelle","year":"2014","journal-title":"J. Clin. Virol."},{"issue":"12","key":"10.1016\/j.virol.2023.109900_bib18","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.3201\/eid1212.060710","article-title":"Chikungunya disease outbreak, reunion island","volume":"12","author":"Josseran","year":"2006","journal-title":"Emerg. Infect. Dis."},{"issue":"15","key":"10.1016\/j.virol.2023.109900_bib19","article-title":"Bortezomib inhibits chikungunya virus replication by interfering with viral protein synthesis","volume":"14","author":"Kaur","year":"2020","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"9","key":"10.1016\/j.virol.2023.109900_bib20","article-title":"The role of regorafenib in the management of advanced gastrointestinal stromal tumors: a systematic review","volume":"14","author":"Khachatryan","year":"2022","journal-title":"Cureus"},{"issue":"6","key":"10.1016\/j.virol.2023.109900_bib21","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1128\/JVI.01969-10","article-title":"Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication","volume":"85","author":"Kumar","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2023.109900_bib22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.virol.2021.05.013","article-title":"Identification and evaluation of antiviral potential of thymoquinone, a natural compound targeting Chikungunya virus capsid protein","volume":"561","author":"Kumar","year":"2021","journal-title":"Virology"},{"issue":"Pt 9","key":"10.1016\/j.virol.2023.109900_bib23","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1099\/vir.0.043752-0","article-title":"Construction of an infectious Chikungunya virus cDNA clone and stable insertion of mCherry reporter genes at two different sites","volume":"93","author":"K\u00fcmmerer","year":"2012","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2023.109900_bib24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.antiviral.2018.07.005","article-title":"Repurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses","volume":"157","author":"Lundberg","year":"2018","journal-title":"Antivir. Res."},{"issue":"2","key":"10.1016\/j.virol.2023.109900_bib25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3390\/v11020171","article-title":"Influenza virus infections and cellular kinases","volume":"11","author":"Meineke","year":"2019","journal-title":"Viruses"},{"issue":"6","key":"10.1016\/j.virol.2023.109900_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1348-0421.2012.00461.x","article-title":"Herpes simplex virus US3 protein kinase regulates host responses and determines neurovirulence","volume":"56","author":"Mori","year":"2012","journal-title":"Microbiol. Immunol."},{"issue":"23","key":"10.1016\/j.virol.2023.109900_bib27","doi-asserted-by":"crossref","first-page":"7043","DOI":"10.1158\/0008-5472.CAN-13-1825","article-title":"Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma","volume":"73","author":"Nakamura","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.virol.2023.109900_bib28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12916-015-0348-x","article-title":"Emergence and potential for spread of Chikungunya virus in Brazil","volume":"13","author":"Nunes","year":"2015","journal-title":"BMC Med."},{"issue":"6","key":"10.1016\/j.virol.2023.109900_bib29","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3390\/v14061123","article-title":"A novel sphingosine kinase inhibitor suppresses chikungunya virus infection","volume":"14","author":"Oyewole","year":"2022","journal-title":"Viruses"},{"issue":"19","key":"10.1016\/j.virol.2023.109900_bib30","doi-asserted-by":"crossref","first-page":"10073","DOI":"10.1128\/JVI.01707-15","article-title":"Pim kinase interacts with nonstructural 5A protein and regulates hepatitis C virus entry","volume":"89","author":"Park","year":"2015","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.virol.2023.109900_bib31","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1515\/BC.2008.145","article-title":"RNA viruses and the mitogenic Raf\/MEK\/ERK signal transduction cascade","volume":"389","author":"Pleschka","year":"2008","journal-title":"Biol. Chem."},{"issue":"10","key":"10.1016\/j.virol.2023.109900_bib32","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1002\/jcp.25014","article-title":"GRP78\/Dna K is a target for nexavar\/stivarga\/votrient in the treatment of human malignancies, viral infections and bacterial diseases","volume":"230","author":"Roberts","year":"2015","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.virol.2023.109900_bib33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0035-9203(55)90080-8","article-title":"An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features","volume":"49","author":"Robinson","year":"1955","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"5","key":"10.1016\/j.virol.2023.109900_bib34","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/v10050268","article-title":"Paradoxical effect of chloroquine treatment in enhancing chikungunya virus infection","volume":"10","author":"Roques","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2023.109900_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.antiviral.2016.01.006","article-title":"Mefenamic acid in combination with ribavirin shows significant effects in reducing chikungunya virus infection in vitro and in vivo","volume":"127","author":"Rothan","year":"2016","journal-title":"Antivir. Res."},{"issue":"20","key":"10.1016\/j.virol.2023.109900_bib36","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01195-21","article-title":"The epidermal growth factor receptor is a relevant host factor in the early stages of the Zika virus life cycle in vitro","volume":"95","author":"Sabino","year":"2021","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.virol.2023.109900_bib37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrmicro2368","article-title":"Biology and pathogenesis of chikungunya virus","volume":"8","author":"Schwartz","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.virol.2023.109900_bib38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cellsig.2018.05.002","article-title":"Role of mitogen-activated protein kinase signaling in the pathogenesis of dengue virus infection","volume":"48","author":"Sreekanth","year":"2018","journal-title":"Cell. Signal."},{"issue":"21","key":"10.1016\/j.virol.2023.109900_bib39","doi-asserted-by":"crossref","first-page":"9743","DOI":"10.1128\/JVI.01382-16","article-title":"The antiviral alkaloid berberine reduces chikungunya virus-induced mitogen-activated protein kinase signaling","volume":"90","author":"Varghese","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2023.109900_bib40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.virol.2013.11.039","article-title":"Sphingosine kinase 1 regulates measles virus replication","volume":"450\u2013451","author":"Vijayan","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.virol.2023.109900_bib41","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.virol.2014.09.005","article-title":"Inhibition of host extracellular signal-regulated kinase (ERK) activation decreases new world alphavirus multiplication in infected cells","volume":"468","author":"Voss","year":"2014","journal-title":"Virology"},{"issue":"13","key":"10.1016\/j.virol.2023.109900_bib42","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJMra1406035","article-title":"Chikungunya virus and the global spread of a mosquito-borne disease","volume":"372","author":"Weaver","year":"2015","journal-title":"N. Engl. J. Med."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682223002192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682223002192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T06:55:15Z","timestamp":1730444115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682223002192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":42,"alternative-id":["S0042682223002192"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2023.109900","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of tyrphostin AG879 and A9 inhibiting replication of chikungunya virus by screening of a kinase inhibitor library","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2023.109900","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109900"}}