{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:02:11Z","timestamp":1781762531359,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T00:00:00Z","timestamp":1701475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M023362\/1"],"award-info":[{"award-number":["BB\/M023362\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/S011269\/1"],"award-info":[{"award-number":["BB\/S011269\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/X006166\/1"],"award-info":[{"award-number":["BB\/X006166\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBS\/E\/I\/00007031"],"award-info":[{"award-number":["BBS\/E\/I\/00007031"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBS\/E\/I\/00007035"],"award-info":[{"award-number":["BBS\/E\/I\/00007035"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBS\/E\/I\/00007037"],"award-info":[{"award-number":["BBS\/E\/I\/00007037"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBS\/E\/I\/00007039"],"award-info":[{"award-number":["BBS\/E\/I\/00007039"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000870","name":"Pirbright Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000870","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.virol.2023.109954","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T16:02:09Z","timestamp":1701532929000},"page":"109954","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Recombinant A(H6N1)-H274Y avian influenza virus with dual drug resistance does not require permissive mutations to retain the replicative fitness in vitro and in ovo"],"prefix":"10.1016","volume":"590","author":[{"given":"Dagmara","family":"Bialy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-3832","authenticated-orcid":false,"given":"Samuel","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1264-6987","authenticated-orcid":false,"given":"Klaudia","family":"Chrzastek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1869-6176","authenticated-orcid":false,"given":"Sushant","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0470-2611","authenticated-orcid":false,"given":"Noemi","family":"Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8186-2638","authenticated-orcid":false,"given":"Graham","family":"Freimanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5776-0735","authenticated-orcid":false,"given":"Holly","family":"Shelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2023.109954_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.antiviral.2014.12.006","article-title":"Permissive changes in the neuraminidase play a dominant role in improving the viral fitness of oseltamivir-resistant seasonal influenza A(H1N1) strains","volume":"114","author":"Abed","year":"2015","journal-title":"Antivir. Res."},{"issue":"12","key":"10.1016\/j.virol.2023.109954_bib2","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1086\/508777","article-title":"Characterization of multidrug-resistant influenza A\/H3N2 viruses shed during 1 year by an immunocompromised child","volume":"43","author":"Baz","year":"2006","journal-title":"Clin. Infect. Dis."},{"issue":"5","key":"10.1016\/j.virol.2023.109954_bib3","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1086\/650464","article-title":"Effect of the neuraminidase mutation H274Y conferring resistance to oseltamivir on the replicative capacity and virulence of old and recent human influenza A(H1N1) viruses","volume":"201","author":"Baz","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virol.2023.109954_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2020.104886","article-title":"Functional neuraminidase inhibitor resistance motifs in avian influenza A(H5Nx) viruses","volume":"182","author":"Bialy","year":"2020","journal-title":"Antivir. Res."},{"issue":"5983","key":"10.1016\/j.virol.2023.109954_bib5","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1126\/science.1187816","article-title":"Permissive secondary mutations enable the evolution of influenza oseltamivir resistance","volume":"328","author":"Bloom","year":"2010","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.virol.2023.109954_bib6","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3201\/eid1506.081357","article-title":"Oseltamivir- and amantadine-resistant influenza viruses A (H1N1)","volume":"15","author":"Cheng","year":"2009","journal-title":"Emerg. Infect. Dis."},{"issue":"1","key":"10.1016\/j.virol.2023.109954_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01580-17","article-title":"Screening for neuraminidase inhibitor resistance markers among avian influenza viruses of the N4, N5, N6, and N8 neuraminidase subtypes","volume":"92","author":"Choi","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2023.109954_bib8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.virol.2018.02.016","article-title":"Characterization of H9N2 avian influenza viruses from the Middle East demonstrates heterogeneity at amino acid position 226 in the hemagglutinin and potential for transmission to mammals","volume":"518","author":"Chrzastek","year":"2018","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.virol.2023.109954_bib9","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s12864-022-08563-z","article-title":"A random priming amplification method for whole genome sequencing of SARS-CoV-2 virus","volume":"23","author":"Chrzastek","year":"2022","journal-title":"BMC Genom."},{"issue":"9","key":"10.1016\/j.virol.2023.109954_bib10","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.15252\/emmm.201707726","article-title":"A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors","volume":"9","author":"de Vries","year":"2017","journal-title":"EMBO Mol. Med."},{"issue":"2","key":"10.1016\/j.virol.2023.109954_bib11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1086\/518936","article-title":"Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide","volume":"196","author":"Deyde","year":"2007","journal-title":"J. Infect. Dis."},{"issue":"7","key":"10.1016\/j.virol.2023.109954_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001022","article-title":"Oseltamivir-resistant pandemic H1N1\/2009 influenza virus possesses lower transmissibility and fitness in ferrets","volume":"6","author":"Duan","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virol.2023.109954_bib13","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1038\/ncomms6029","article-title":"Epistatic interactions between neuraminidase mutations facilitated the emergence of the oseltamivir-resistant H1N1 influenza viruses","volume":"5","author":"Duan","year":"2014","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.virol.2023.109954_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ph15010028","article-title":"Baloxavir marboxil: an original new drug against influenza","volume":"15","author":"Dufrasne","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"2","key":"10.1016\/j.virol.2023.109954_bib15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jiph.2009.04.004","article-title":"Oseltamivir resistance mutation N294S in human influenza A(H5N1) virus in Egypt","volume":"2","author":"Earhart","year":"2009","journal-title":"J Infect Public Health"},{"key":"10.1016\/j.virol.2023.109954_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-4614-0204-6_8","article-title":"Influenza pandemics","volume":"719","author":"Elderfield","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"issue":"9","key":"10.1016\/j.virol.2023.109954_bib17","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3201\/eid1509.090452","article-title":"Genomic diversity of oseltamivir-resistant influenza virus A (H1N1), Luxembourg, 2007-08","volume":"15","author":"Gerloff","year":"2009","journal-title":"Emerg. Infect. Dis."},{"issue":"16","key":"10.1016\/j.virol.2023.109954_bib18","doi-asserted-by":"crossref","first-page":"8042","DOI":"10.1128\/JVI.00689-10","article-title":"Competitive fitness of oseltamivir-sensitive and -resistant highly pathogenic H5N1 influenza viruses in a ferret model","volume":"84","author":"Govorkova","year":"2010","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2023.109954_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.antiviral.2013.02.013","article-title":"Antiviral resistance among highly pathogenic influenza A (H5N1) viruses isolated worldwide in 2002-2012 shows need for continued monitoring","volume":"98","author":"Govorkova","year":"2013","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virol.2023.109954_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-4939-2438-7_6","article-title":"The preparation of chicken kidney cell cultures for virus propagation","volume":"1282","author":"Hennion","year":"2015","journal-title":"Methods Mol. Biol."},{"issue":"9","key":"10.1016\/j.virol.2023.109954_bib21","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1086\/424572","article-title":"Influenza viruses resistant to the antiviral drug oseltamivir: transmission studies in ferrets","volume":"190","author":"Herlocher","year":"2004","journal-title":"J. Infect. Dis."},{"issue":"11","key":"10.1016\/j.virol.2023.109954_bib22","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1073\/pnas.100133697","article-title":"A DNA transfection system for generation of influenza A virus from eight plasmids","volume":"97","author":"Hoffmann","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"12","key":"10.1016\/j.virol.2023.109954_bib23","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s007050170002","article-title":"Universal primer set for the full-length amplification of all influenza A viruses","volume":"146","author":"Hoffmann","year":"2001","journal-title":"Arch. Virol."},{"issue":"3","key":"10.1016\/j.virol.2023.109954_bib24","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.antiviral.2006.10.004","article-title":"Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes","volume":"73","author":"Hurt","year":"2007","journal-title":"Antivir. Res."},{"issue":"18","key":"10.1016\/j.virol.2023.109954_bib25","doi-asserted-by":"crossref","first-page":"9427","DOI":"10.1128\/JVI.00373-10","article-title":"Assessing the viral fitness of oseltamivir-resistant influenza viruses in ferrets, using a competitive-mixtures model","volume":"84","author":"Hurt","year":"2010","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2023.109954_bib26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0166-3542(02)00053-0","article-title":"The H274Y mutation in the influenza A\/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo","volume":"55","author":"Ives","year":"2002","journal-title":"Antivir. Res."},{"issue":"5","key":"10.1016\/j.virol.2023.109954_bib27","doi-asserted-by":"crossref","DOI":"10.2807\/ese.13.05.08026-en","article-title":"Emergence of resistance to oseltamivir among influenza A(H1N1) viruses in Europe","volume":"13","author":"Lackenby","year":"2008","journal-title":"Euro Surveill."},{"issue":"2","key":"10.1016\/j.virol.2023.109954_bib28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/infdis\/jiu447","article-title":"Characterization of drug-resistant influenza A(H7N9) variants isolated from an oseltamivir-treated patient in Taiwan","volume":"211","author":"Marjuki","year":"2015","journal-title":"J. Infect. Dis."},{"issue":"9","key":"10.1016\/j.virol.2023.109954_bib29","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.3201\/eid1309.070164","article-title":"Reduced sensitivity of influenza A (H5N1) to oseltamivir","volume":"13","author":"McKimm-Breschkin","year":"2007","journal-title":"Emerg. Infect. Dis."},{"issue":"12","key":"10.1016\/j.virol.2023.109954_bib30","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1517\/14656566.2015.1066336","article-title":"Peramivir: an intravenous neuraminidase inhibitor","volume":"16","author":"McLaughlin","year":"2015","journal-title":"Expet Opin. Pharmacother."},{"issue":"9","key":"10.1016\/j.virol.2023.109954_bib31","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1086\/651605","article-title":"Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts","volume":"50","author":"Memoli","year":"2010","journal-title":"Clin. Infect. Dis."},{"issue":"3","key":"10.1016\/j.virol.2023.109954_bib32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/infdis\/jiq067","article-title":"Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferrets","volume":"203","author":"Memoli","year":"2011","journal-title":"J. Infect. Dis."},{"issue":"10","key":"10.1016\/j.virol.2023.109954_bib33","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1056\/NEJMp0900648","article-title":"Global transmission of oseltamivir-resistant influenza","volume":"360","author":"Moscona","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.virol.2023.109954_bib34","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0003-2697(79)90362-2","article-title":"Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-alpha-D-N-acetylneuraminate) substrate","volume":"94","author":"Potier","year":"1979","journal-title":"Anal. Biochem."},{"issue":"11","key":"10.1016\/j.virol.2023.109954_bib35","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1128\/AAC.00645-06","article-title":"Natural variation can significantly alter the sensitivity of influenza A (H5N1) viruses to oseltamivir","volume":"50","author":"Rameix-Welti","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7","key":"10.1016\/j.virol.2023.109954_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000103","article-title":"Enzymatic properties of the neuraminidase of seasonal H1N1 influenza viruses provide insights for the emergence of natural resistance to oseltamivir","volume":"4","author":"Rameix-Welti","year":"2008","journal-title":"PLoS Pathog."},{"issue":"7","key":"10.1016\/j.virol.2023.109954_bib37","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"issue":"21","key":"10.1016\/j.virol.2023.109954_bib38","doi-asserted-by":"crossref","first-page":"11219","DOI":"10.1128\/JVI.01424-10","article-title":"Oseltamivir-resistant variants of the 2009 pandemic H1N1 influenza A virus are not attenuated in the Guinea pig and ferret transmission models","volume":"84","author":"Seibert","year":"2010","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virol.2023.109954_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/infdis\/jiq005","article-title":"Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010","volume":"203","author":"Sheu","year":"2011","journal-title":"J. Infect. Dis."},{"issue":"11","key":"10.1016\/j.virol.2023.109954_bib40","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s13238-013-3083-0","article-title":"Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan","volume":"4","author":"Shi","year":"2013","journal-title":"Protein Cell"},{"issue":"1","key":"10.1016\/j.virol.2023.109954_bib41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1086\/375799","article-title":"High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenza","volume":"188","author":"Shiraishi","year":"2003","journal-title":"J. Infect. Dis."},{"issue":"21","key":"10.1016\/j.virol.2023.109954_bib42","doi-asserted-by":"crossref","first-page":"10891","DOI":"10.1128\/JVI.01514-15","article-title":"Unique determinants of neuraminidase inhibitor resistance among N3, N7, and N9 avian influenza viruses","volume":"89","author":"Song","year":"2015","journal-title":"J. Virol."},{"issue":"9","key":"10.1016\/j.virol.2023.109954_bib43","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1128\/JCM.40.9.3256-3260.2002","article-title":"Development of a real-time reverse transcriptase PCR assay for type A influenza virus and the avian H5 and H7 hemagglutinin subtypes","volume":"40","author":"Spackman","year":"2002","journal-title":"J. Clin. Microbiol."},{"issue":"1","key":"10.1016\/j.virol.2023.109954_bib44","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12985-019-1194-9","article-title":"Highly pathogenic avian influenza H7N9 viruses with reduced susceptibility to neuraminidase inhibitors showed comparable replication capacity to their sensitive counterparts","volume":"16","author":"Tang","year":"2019","journal-title":"Virol. J."},{"issue":"3","key":"10.1016\/j.virol.2023.109954_bib45","first-page":"346","article-title":"Treatment-emergent influenza variant viruses with reduced Baloxavir susceptibility: impact on clinical and virologic outcomes in uncomplicated influenza","volume":"221","author":"Uehara","year":"2020","journal-title":"J. Infect. Dis."},{"issue":"12","key":"10.1016\/j.virol.2023.109954_bib46","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.15252\/embj.201590960","article-title":"Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference","volume":"34","author":"Wang","year":"2015","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.virol.2023.109954_bib47","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S2213-2600(13)70221-2","article-title":"Human infection with avian influenza A H6N1 virus: an epidemiological analysis","volume":"1","author":"Wei","year":"2013","journal-title":"Lancet Respir. Med."},{"issue":"39","key":"10.1016\/j.virol.2023.109954_bib48","first-page":"369","article-title":"Meetings of the WHO working group on surveillance of influenza antiviral susceptibility - Geneva, November 2011 and June 2012","volume":"87","author":"WHO","year":"2012","journal-title":"Wkly. Epidemiol. Rec."},{"key":"10.1016\/j.virol.2023.109954_bib49","series-title":"Manual for the Laboratory Diagnosis and Virological Surveillance of Influenza","author":"World Health","year":"2011"},{"key":"10.1016\/j.virol.2023.109954_bib50","series-title":"Regional Office for the Western, P., Avian Influenza Weekly Update 2023","author":"World Health Organization","year":"2023"},{"issue":"1","key":"10.1016\/j.virol.2023.109954_bib51","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.antiviral.2011.11.006","article-title":"The 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses","volume":"93","author":"Wu","year":"2012","journal-title":"Antivir. Res."},{"issue":"4","key":"10.1016\/j.virol.2023.109954_bib52","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/jac\/dkl321","article-title":"Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro","volume":"58","author":"Zurcher","year":"2006","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682223002738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682223002738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T06:14:47Z","timestamp":1738390487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682223002738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":52,"alternative-id":["S0042682223002738"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2023.109954","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant A(H6N1)-H274Y avian influenza virus with dual drug resistance does not require permissive mutations to retain the replicative fitness in vitro and in ovo","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2023.109954","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109954"}}