{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:47:59Z","timestamp":1791388079172,"version":"4.3.3"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972693"],"award-info":[{"award-number":["31972693"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32273024"],"award-info":[{"award-number":["32273024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["ZD2021CY001"],"award-info":[{"award-number":["ZD2021CY001"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005196","name":"Chinese Academy of Agricultural Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012421","name":"Agricultural Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["CAAS-ZDRW202203"],"award-info":[{"award-number":["CAAS-ZDRW202203"]}],"id":[{"id":"10.13039\/501100012421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.virol.2024.110083","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T15:12:10Z","timestamp":1714144330000},"page":"110083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Porcine reproductive and respiratory syndrome virus nsp4-mediated \u03b22M downregulation contributes to SLA-I decrease and virus infection in vivo and in vitro"],"prefix":"10.1016","volume":"595","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7715-8487","authenticated-orcid":false,"given":"Lei","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Wahaab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianchao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghua","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2024.110083_bib1","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1128\/JVI.74.22.10834-10837.2000","article-title":"Porcine reproductive and respiratory syndrome virus: description of persistence in individual pigs upon experimental infection","volume":"74","author":"Allende","year":"2000","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.virol.2024.110083_bib2","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.1073\/pnas.102672999","article-title":"Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy","volume":"99","author":"Antonio Valentin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2024.110083_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0092-8674(95)90365-8","article-title":"The ctls kiss of death","volume":"81","author":"Berke","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.virol.2024.110083_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.virol.2016.01.021","article-title":"The non-structural protein Nsp2TF of porcine reproductive and respiratory syndrome virus down-regulates the expression of Swine Leukocyte Antigen class I","volume":"491","author":"Cao","year":"2016","journal-title":"Virology"},{"key":"10.1016\/j.virol.2024.110083_bib5","article-title":"Evasion strategies of porcine reproductive and respiratory syndrome virus","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virol.2024.110083_bib6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/34929","article-title":"HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes","volume":"391","author":"Collins","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.virol.2024.110083_bib7","article-title":"Identification of CYCLE targets that contribute diverse features of circadian rhythms in the mosquito Culex pipiens","volume":"48","author":"Dhungana","year":"2023","journal-title":"Comp. Biochem. Physiol. Genom. Proteonomics"},{"key":"10.1016\/j.virol.2024.110083_bib8","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1128\/JVI.02307-15","article-title":"Targeting swine leukocyte antigen class I molecules for proteasomal degradation by the nsp1 alpha replicase protein of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus strain JXwn06","volume":"90","author":"Du","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2024.110083_bib9","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1354\/vp.36-3-262","article-title":"\u201cThe clinical scope of porcine reproductive and respiratory syndrome virus infection has expanded since 1987\u201d: an alternative perspective","volume":"36","author":"Ellis","year":"1999","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.virol.2024.110083_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/v14092025","article-title":"Antiretroviral drug discovery targeting the HIV-1 Nef virulence factor","volume":"14","author":"Emert-Sedlak","year":"2022","journal-title":"Viruses-Basel"},{"key":"10.1016\/j.virol.2024.110083_bib11","article-title":"Highly pathogenic porcine reproductive and respiratory syndrome virus Nsp4 cleaves VISA to impair antiviral responses mediated by RIG-I-like receptors","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.virol.2024.110083_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01979-16","article-title":"Thymidine kinase-negative Herpes simplex virus 1 can efficiently establish persistent infection in neural tissues of nude mice","volume":"91","author":"Huang","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2024.110083_bib13","article-title":"A polysaccharide from the whole plant of plantago asiatica L. Enhances the antitumor activity of dendritic cell-based immunotherapy against breast cancer","volume":"12","author":"Jiafeng Gao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.virol.2024.110083_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2023.109767","article-title":"Porcine reproductive and respiratory syndrome virus infection inhibits NF-kappa B signaling pathway through cleavage of IKK beta by Nsp4","volume":"282","author":"Jiao","year":"2023","journal-title":"Vet. Microbiol."},{"issue":"6","key":"10.1016\/j.virol.2024.110083_bib15","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.immuni.2015.05.018","article-title":"GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c+MHCII+ macrophages and dendritic cells","volume":"42","author":"Julie Helft","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.virol.2024.110083_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01017","article-title":"Cytotoxic activity and memory T cell subset distribution of in vitro-stimulated CD8+ T cells specific for HER2\/neu epitopes","volume":"10","author":"Kuznetsova","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2024.110083_bib17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.dci.2016.07.012","article-title":"The role of porcine reproductive and respiratory syndrome virus infection in immune phenotype and Th1\/Th2 balance of dendritic cells","volume":"65","author":"Liu","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.virol.2024.110083_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetimm.2015.07.003","article-title":"Innate and adaptive immunity against porcine reproductive and respiratory syndrome virus","volume":"167","author":"Loving","year":"2015","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virol.2024.110083_bib19","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s12026-017-8920-4","article-title":"Effector functions of memory CTLs can be affected by signals received during reactivation","volume":"65","author":"Lv","year":"2017","journal-title":"Immunol. Res."},{"key":"10.1016\/j.virol.2024.110083_bib20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.coviro.2015.09.003","article-title":"How do persistent infections with hepatitis C virus cause liver cancer?","volume":"14","author":"Mitchell","year":"2015","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.virol.2024.110083_bib21","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01755-16","article-title":"Nonstructural protein 4 of porcine reproductive and respiratory syndrome virus modulates cell surface swine leukocyte antigen class I expression by downregulating beta2-microglobulin transcription","volume":"91","author":"Qi","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2024.110083_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01755-16","article-title":"Nonstructural protein 4 of porcine reproductive and respiratory syndrome virus modulates cell surface swine leukocyte antigen class I expression by downregulating beta 2-microglobulin transcription","volume":"91","author":"Qi","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2024.110083_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10061339","article-title":"SARS-CoV-2: a master of immune evasion","volume":"10","author":"Rubio-Casillas","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.virol.2024.110083_bib24","doi-asserted-by":"crossref","DOI":"10.4172\/2157-7412.1000303","article-title":"PARP1 differentially interacts with promoter region of DUX4 gene in FSHD myoblasts","volume":"7","author":"Sharma","year":"2016","journal-title":"J. Genet. Syndr. Gene Ther."},{"key":"10.1016\/j.virol.2024.110083_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000526","article-title":"Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark","volume":"2","author":"Tian","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2024.110083_bib26","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jmb.2009.07.062","article-title":"Structure and cleavage specificity of the chymotrypsin-like serine protease (3CLSP\/nsp4) of porcine reproductive and respiratory syndrome virus (PRRSV)","volume":"392","author":"Tian","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.virol.2024.110083_bib27","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.coi.2021.04.012","article-title":"Dynamics of MHC-I molecules in the antigen processing and presentation pathway","volume":"70","author":"Truong","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.virol.2024.110083_bib28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.vetimm.2012.06.004","article-title":"Early-life longitudinal survey of peripheral blood lymphocyte subsets in Beagle dogs","volume":"149","author":"Villaescusa","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virol.2024.110083_bib29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.vetimm.2012.04.015","article-title":"Bovine herpesvirus type 1 (BHV-1) mutant lacking U(L)49.5 luminal domain residues 30-32 and cytoplasmic tail residues 80-96 induces more rapid onset of virus neutralizing antibody and cellular immune responses in calves than the wild-type strain Cooper","volume":"147","author":"Wei","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virol.2024.110083_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.virol.2020.04.007","article-title":"Aspartic acid at residue 185 modulates the capacity of HP-PRRSV nsp4 to antagonize IFN-I expression","volume":"546","author":"Wei","year":"2020","journal-title":"Virology"},{"key":"10.1016\/j.virol.2024.110083_bib31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1128\/JCM.41.1.58-62.2003","article-title":"Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus","volume":"41","author":"Wills","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2024.110083_bib32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0378-1135(96)01337-5","article-title":"Porcine reproductive and respiratory syndrome virus: a persistent infection","volume":"55","author":"Wills","year":"1997","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2024.110083_bib33","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1128\/JVI.78.11.5923-5933.2004","article-title":"The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load","volume":"78","author":"Xiao","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2024.110083_bib34","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1128\/JVI.76.4.1626-1631.2002","article-title":"Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes","volume":"76","author":"Yang","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2024.110083_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108863","article-title":"Porcine reproductive and respiratory syndrome virus Nsp4 cleaves ZAP to antagonize its antiviral activity","volume":"250","author":"Zhao","year":"2020","journal-title":"Vet. Microbiol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682224001041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682224001041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:20:04Z","timestamp":1751383204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682224001041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":35,"alternative-id":["S0042682224001041"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2024.110083","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Porcine reproductive and respiratory syndrome virus nsp4-mediated \u03b22M downregulation contributes to SLA-I decrease and virus infection in vivo and in vitro","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2024.110083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110083"}}