{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:28:37Z","timestamp":1791386917917,"version":"4.3.3"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M711399"],"award-info":[{"award-number":["2022M711399"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M711398"],"award-info":[{"award-number":["2022M711398"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007540","name":"Jiangsu Agricultural Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["CX (22)3028"],"award-info":[{"award-number":["CX (22)3028"]}],"id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800803"],"award-info":[{"award-number":["2022YFD1800803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272996"],"award-info":[{"award-number":["32272996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002283"],"award-info":[{"award-number":["32002283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20221432"],"award-info":[{"award-number":["BK20221432"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.virol.2024.110150","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T20:59:04Z","timestamp":1718917144000},"page":"110150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A novel virus-like particles vaccine induces broad immune protective against deltacoronavirus in piglets"],"prefix":"10.1016","volume":"597","author":[{"given":"Baotai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baochao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-1834","authenticated-orcid":false,"given":"Jizong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2024.110150_bib1","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1038\/s41467-023-39788-5","article-title":"Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains","volume":"14","author":"Abendstein","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virol.2024.110150_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0168-3659(01)00549-1","article-title":"Targeting to macrophages: role of physicochemical properties of particulate carriers--liposomes and microspheres--on the phagocytosis by macrophages","volume":"79","author":"Ahsan","year":"2002","journal-title":"J. Contr. Release : Off. J. Contr. Release Soc."},{"key":"10.1016\/j.virol.2024.110150_bib3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nri2868","article-title":"Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns","volume":"10","author":"Bachmann","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.virol.2024.110150_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.virol.2024.110150_bib5","doi-asserted-by":"crossref","first-page":"8636","DOI":"10.1128\/JVI.72.11.8636-8643.1998","article-title":"Coronavirus pseudoparticles formed with recombinant M and E proteins induce alpha interferon synthesis by leukocytes","volume":"72","author":"Baudoux","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2024.110150_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.virol.2015.03.024","article-title":"Pathogenicity and pathogenesis of a United States porcine deltacoronavirus cell culture isolate in 5-day-old neonatal piglets","volume":"482","author":"Chen","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.virol.2024.110150_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-2427(01)00417-2","article-title":"Mucosal and systemic isotype-specific antibody responses and protection in conventional pigs exposed to virulent or attenuated porcine epidemic diarrhoea virus","volume":"85","author":"de Arriba","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virol.2024.110150_bib8","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1084\/jem.192.12.1685","article-title":"CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo","volume":"192","author":"den Haan","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2024.110150_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.1136080","article-title":"Differential antigen processing by dendritic cell subsets in vivo","volume":"315","author":"Dudziak","year":"2007","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.virol.2024.110150_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-0716-0900-2_6","article-title":"Isolation and tissue culture adaptation of porcine deltacoronavirus: a case study","volume":"2203","author":"Hu","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.virol.2024.110150_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12917-021-03115-1","article-title":"The recombinant pseudorabies virus expressing porcine deltacoronavirus spike protein is safe and effective for mice","volume":"18","author":"Huang","year":"2022","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.virol.2024.110150_bib12","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3201\/eid2204.151852","article-title":"Porcine deltacoronavirus, Thailand, 2015","volume":"22","author":"Janetanakit","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virol.2024.110150_bib13","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/s41467-022-29062-5","article-title":"Structures of a deltacoronavirus spike protein bound to porcine and human receptors","volume":"13","author":"Ji","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virol.2024.110150_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-021-04111-z","article-title":"Independent infections of porcine deltacoronavirus among Haitian children","volume":"600","author":"Lednicky","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.virol.2024.110150_bib15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12985-015-0421-2","article-title":"Porcine epidemic diarrhea virus: an emerging and re-emerging epizootic swine virus","volume":"12","author":"Lee","year":"2015","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2024.110150_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01191-14","article-title":"Complete genome characterization of Korean porcine deltacoronavirus strain KOR\/KNU14-04\/2014","volume":"2","author":"Lee","year":"2014","journal-title":"Genome Announc."},{"key":"10.1016\/j.virol.2024.110150_bib17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.7774\/cevr.2018.7.1.61","article-title":"Efficacy of inactivated variant porcine epidemic diarrhea virus vaccines in growing pigs","volume":"7","author":"Lee","year":"2018","journal-title":"Clin. Exp. Vaccine Res."},{"key":"10.1016\/j.virol.2024.110150_bib18","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3389\/fimmu.2019.01024","article-title":"Porcine deltacoronavirus nucleocapsid protein suppressed IFN-\u03b2 production by interfering porcine RIG-I dsRNA-binding and K63-linked polyubiquitination","volume":"10","author":"Likai","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2024.110150_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00064-15","article-title":"Origin, evolution, and virulence of porcine deltacoronaviruses in the United States","volume":"6","author":"Ma","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.virol.2024.110150_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jconrel.2017.02.031","article-title":"Delivering adjuvants and antigens in separate nanoparticles eliminates the need of physical linkage for effective vaccination","volume":"251","author":"Mohsen","year":"2017","journal-title":"J. Contr. Release : Off. J. Contr. Release Soc."},{"key":"10.1016\/j.virol.2024.110150_bib21","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/ni.1899","article-title":"Effector T cell plasticity: flexibility in the face of changing circumstances","volume":"11","author":"Murphy","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.virol.2024.110150_bib22","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1084\/jem.189.12.1981","article-title":"Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells","volume":"189","author":"Ohteki","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virol.2024.110150_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1140\/epjp\/s13360-023-03719-6","article-title":"Origin and evolution of SARS-CoV-2","volume":"138","author":"Pagani","year":"2023","journal-title":"Eur. Phy. J. Plus"},{"key":"10.1016\/j.virol.2024.110150_bib24","first-page":"1436","article-title":"First report and phylogenetic analysis of porcine deltacoronavirus in Mexico","volume":"66","author":"P\u00e9rez-Rivera","year":"2019","journal-title":"Transboundary Emerg. Dis."},{"key":"10.1016\/j.virol.2024.110150_bib25","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.rvsc.2006.03.007","article-title":"Oral efficacy of Vero cell attenuated porcine epidemic diarrhea virus DR13 strain","volume":"82","author":"Song","year":"2007","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.virol.2024.110150_bib26","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/tbed.12399","article-title":"Newly emerged porcine deltacoronavirus associated with diarrhoea in swine in China: identification, prevalence and full-length genome sequence analysis","volume":"62","author":"Song","year":"2015","journal-title":"Transboundary Emerg. Dis."},{"key":"10.1016\/j.virol.2024.110150_bib27","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.meegid.2018.03.030","article-title":"Genetic characterization and pathogenicity of Japanese porcine deltacoronavirus","volume":"61","author":"Suzuki","year":"2018","journal-title":"Infect. Genet. Evol. : J. Mol. Epidemiol. Evol. Genet. Infect. Dis."},{"key":"10.1016\/j.virol.2024.110150_bib28","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/j.1460-2075.1996.tb00553.x","article-title":"Nucleocapsid-independent assembly of coronavirus-like particles by co-expression of viral envelope protein genes","volume":"15","author":"Vennema","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.virol.2024.110150_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00945-15","article-title":"Complete genome sequence of porcine deltacoronavirus strain CH\/sichuan\/S27\/2012 from mainland China","volume":"3","author":"Wang","year":"2015","journal-title":"Genome Announc."},{"key":"10.1016\/j.virol.2024.110150_bib30","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1128\/JVI.06540-11","volume":"86","author":"Woo","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2024.110150_bib31","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1038\/emi.2017.37","article-title":"Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5'-untranslated region","volume":"6","author":"Woo","year":"2017","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.virol.2024.110150_bib32","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1128\/JVI.06540-11","volume":"86","author":"Woo","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2024.110150_bib33","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00705-018-4081-6","article-title":"Genomic characterization and pathogenicity of porcine deltacoronavirus strain CHN-HG-2017 from China","volume":"164","author":"Zhang","year":"2019","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2024.110150_bib34","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1016\/j.vaccine.2022.05.085","article-title":"Development and immunogenicity evaluation of porcine deltacoronavirus inactivated vaccine with different adjuvants in mice","volume":"40","author":"Zhao","year":"2022","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2024.110150_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002039","article-title":"CMPK2 is a host restriction factor that inhibits infection of multiple coronaviruses in a cell-intrinsic manner","volume":"21","author":"Zhu","year":"2023","journal-title":"PLoS Biol."},{"key":"10.1016\/j.virol.2024.110150_bib36","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12941-023-00595-x","article-title":"Description of pathogenic bacteria in patients with respiratory symptoms associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Colombia","volume":"22","author":"Zuluaga","year":"2023","journal-title":"Ann. Clin. Microbiol. Antimicrob."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682224001715?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682224001715?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:58:53Z","timestamp":1778633933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682224001715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":36,"alternative-id":["S0042682224001715"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2024.110150","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel virus-like particles vaccine induces broad immune protective against deltacoronavirus in piglets","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2024.110150","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110150"}}