{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:55:09Z","timestamp":1783540509761,"version":"3.55.0"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIH NIAID","doi-asserted-by":"publisher","award":["R01AI153076"],"award-info":[{"award-number":["R01AI153076"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIH NIAID","doi-asserted-by":"publisher","award":["R01AI162631"],"award-info":[{"award-number":["R01AI162631"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.virol.2024.110367","type":"journal-article","created":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T10:04:09Z","timestamp":1734861849000},"page":"110367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Multiple sphingolipid-metabolizing enzymes modulate influenza virus replication"],"prefix":"10.1016","volume":"603","author":[{"given":"Savannah","family":"McKenna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Il","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Jin","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0083-6129","authenticated-orcid":false,"given":"Bumsuk","family":"Hahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2024.110367_bib3","series-title":"A Multicenter, Phase 4, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Recombinant Alpha-Galactosidase A (Agalsidase Beta, FABRAZYME) in Heterozygous Females for Fabry Disease","year":"2007"},{"issue":"6","key":"10.1016\/j.virol.2024.110367_bib4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1212\/WNL.0000000000003595","article-title":"Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy","volume":"88","author":"Atkinson","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.virol.2024.110367_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.00612","article-title":"Depletion of host and viral sphingomyelin impairs influenza virus infection","volume":"11","author":"Audi","year":"2020","journal-title":"Front. Microbiol."},{"issue":"6","key":"10.1016\/j.virol.2024.110367_bib6","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.braindev.2018.02.008","article-title":"A novel mutation in sphingosine-1-phosphate lyase causing congenital brain malformation","volume":"40","author":"Bamborschke","year":"2018","journal-title":"Brain Dev."},{"issue":"5","key":"10.1016\/j.virol.2024.110367_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molmed.2007.03.005","article-title":"Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren","volume":"13","author":"Bandhuvula","year":"2007","journal-title":"Trends Mol. Med."},{"issue":"2","key":"10.1016\/j.virol.2024.110367_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2024.04.007","article-title":"Bacterial sphingolipids exacerbate colitis by inhibiting ILC3-derived IL-22 production","volume":"18","author":"Bao","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"Suppl. l","key":"10.1016\/j.virol.2024.110367_bib9","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1194\/jlr.R800080-JLR200","article-title":"Bioactive sphingolipids: metabolism and function","volume":"50","author":"Bartke","year":"2009","journal-title":"J. Lipid Res."},{"issue":"14","key":"10.1016\/j.virol.2024.110367_bib10","doi-asserted-by":"crossref","first-page":"10880","DOI":"10.1074\/jbc.M109.081489","article-title":"Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver","volume":"285","author":"Bektas","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.virol.2024.110367_bib11","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nrd3248","article-title":"Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis","volume":"9","author":"Brinkmann","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.virol.2024.110367_bib12","series-title":"Bristol Myers Squibb Announces positive topline results from pivotal phase 3 true north trial evaluating zeposia (ozanimod) in patients with moderate to severe ulcerative colitis","year":"2020"},{"issue":"8","key":"10.1016\/j.virol.2024.110367_bib13","article-title":"Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cells","volume":"1","author":"Carpinteiro","year":"2020","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.virol.2024.110367_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100701","article-title":"Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells","volume":"296","author":"Carpinteiro","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2024.110367_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2022.01.001","article-title":"Influenza D virus Matrix protein 1 restricts the type I interferon response by degrading TRAF6","volume":"568","author":"Chen","year":"2022","journal-title":"Virology"},{"key":"10.1016\/j.virol.2024.110367_bib16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jbior.2018.09.004","article-title":"Sphingosine phosphate lyase insufficiency syndrome (SPLIS): a novel inborn error of sphingolipid metabolism","volume":"71","author":"Choi","year":"2019","journal-title":"Adv. Biolog. Regul."},{"key":"10.1016\/j.virol.2024.110367_bib17","article-title":"The functional role of sphingosine kinase 2","volume":"8","author":"Diaz","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"5","key":"10.1016\/j.virol.2024.110367_bib18","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001593","article-title":"Differential role of sphingomyelin in influenza virus, rhinovirus and SARS-CoV-2 infection of Calu-3 cells","volume":"102","author":"Dissanayake","year":"2021","journal-title":"J. Gen. Virol."},{"issue":"21","key":"10.1016\/j.virol.2024.110367_bib19","doi-asserted-by":"crossref","first-page":"15833","DOI":"10.1074\/jbc.M609124200","article-title":"Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues","volume":"282","author":"Don","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.virol.2024.110367_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00017-19","article-title":"Glucosylceramidase maintains influenza virus infection by regulating endocytosis","volume":"93","author":"Drews","year":"2019","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virol.2024.110367_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228735","article-title":"Glucosylceramide synthase maintains influenza virus entry and infection","volume":"15","author":"Drews","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2024.110367_bib22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12985-020-01348-4","article-title":"Influenza a virus antagonizes type I and type II interferon responses via SOCS1-dependent ubiquitination and degradation of JAK1","volume":"17","author":"Du","year":"2020","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2024.110367_bib23","series-title":"Novel Off-Label Use of Desipramine in Infantile Neuroaxonal Dystrophy: Targeting the Sphingolipid Metabolism Pathway to Reduce Accumulation of Ceramide","year":"2020"},{"issue":"37","key":"10.1016\/j.virol.2024.110367_bib62","doi-asserted-by":"crossref","first-page":"12892","DOI":"10.1021\/bi980744d","article-title":"N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide","volume":"37","author":"Edsall","year":"1998","journal-title":"Biochemistry"},{"issue":"45","key":"10.1016\/j.virol.2024.110367_bib24","doi-asserted-by":"crossref","first-page":"15174","DOI":"10.1074\/jbc.RA120.015249","article-title":"Sphingosine prevents binding of SARS\u2013CoV-2 spike to its cellular receptor ACE2","volume":"295","author":"Edwards","year":"2020","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.virol.2024.110367_bib25","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3390\/cancers16040789","article-title":"Therapeutic potential for sphingolipids in inflammatory bowel disease and colorectal cancer","volume":"16","author":"Espinoza","year":"2024","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1124\/jpet.109.163444","article-title":"Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2","volume":"333","author":"French","year":"2010","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.virol.2024.110367_bib2","article-title":"An update on sphingosine-1-phosphate and other sphingolipid mediators","author":"Fryst","year":"2010","journal-title":"Nat. Chem. Biol."},{"issue":"9","key":"10.1016\/j.virol.2024.110367_bib27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bbalip.2008.05.005","article-title":"Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight","volume":"1781","author":"Fyrst","year":"2008","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbalip.2012.07.002","article-title":"Targeting the sphingosine kinase\/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors","volume":"1831","author":"Gandy","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.virol.2024.110367_bib29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.chom.2017.07.012","article-title":"Ten strategies of interferon evasion by viruses","volume":"22","author":"Garc\u00eda-Sastre","year":"2017","journal-title":"Cell Host Microbe."},{"issue":"9","key":"10.1016\/j.virol.2024.110367_bib30","doi-asserted-by":"crossref","first-page":"PC3131","DOI":"10.1016\/S0021-9258(18)51879-2","article-title":"Enzymic hydrolysis and synthesis of ceramides","volume":"238","author":"Gatt","year":"1963","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2024.110367_bib31","author":"Genzyme","year":"2024"},{"issue":"7","key":"10.1016\/j.virol.2024.110367_bib32","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.cmet.2021.06.006","article-title":"Sphingolipids in metabolic disease: the good, the bad, and the unknown","volume":"33","author":"Green","year":"2021","journal-title":"Cell Metabol."},{"issue":"8","key":"10.1016\/j.virol.2024.110367_bib33","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.3390\/cancers13081898","article-title":"Targeting the sphingosine kinase\/sphingosine-1-phosphate signaling Axis in drug discovery for cancer therapy","volume":"13","author":"Gupta","year":"2021","journal-title":"Cancers"},{"issue":"5945","key":"10.1016\/j.virol.2024.110367_bib34","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.1176709","article-title":"Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate","volume":"325","author":"Hait","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.virol.2024.110367_bib35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/B978-0-12-394274-6.00007-8","article-title":"Sphingosine kinase 1 in cancer","volume":"117","author":"Heffernan-Stroud","year":"2013","journal-title":"Adv. Cancer Res."},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib36","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1128\/IAI.74.1.28-39.2006","article-title":"Role of sphingolipids in microbial pathogenesis","volume":"74","author":"Heung","year":"2006","journal-title":"Infect. Immun."},{"issue":"9","key":"10.1016\/j.virol.2024.110367_bib37","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1038\/s41380-021-01021-4","article-title":"Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study","volume":"26","author":"Hoertel","year":"2021","journal-title":"Mol. Psychiatr."},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41531-021-00241-3","article-title":"Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson\u2019s disease enrolled in PPMI","volume":"7","author":"Huh","year":"2021","journal-title":"npj Parkinsons Dis."},{"issue":"19","key":"10.1016\/j.virol.2024.110367_bib39","doi-asserted-by":"crossref","first-page":"10664","DOI":"10.1073\/pnas.1934494100","article-title":"VEGF induces S1P1 receptors in endothelial cells: implications for cross-talk between sphingolipid and growth factor receptors","volume":"100","author":"Igarashi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.virol.2024.110367_bib41","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1016\/j.celrep.2020.01.015","article-title":"OTUB1 is a key regulator of RIG-I-dependent immune signaling and is targeted for proteasomal degradation by influenza A NS1","volume":"30","author":"Jahan","year":"2020","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.virol.2024.110367_bib42","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.3390\/cancers14092183","article-title":"Targeting sphingolipid metabolism as a therapeutic strategy in cancer treatment","volume":"14","author":"Janneh","year":"2022","journal-title":"Cancers"},{"issue":"9","key":"10.1016\/j.virol.2024.110367_bib43","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.3390\/v15091916","article-title":"Protective versus pathogenic type I interferon responses during virus infections","volume":"15","author":"Jung","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2024.110367_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1216278","article-title":"Altered sphingolipid pathway in SARS-CoV-2 infected human lung tissue","volume":"14","author":"Khan","year":"2023","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.virol.2024.110367_bib45","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s12276-023-01018-9","article-title":"Functional roles of sphingolipids in immunity and their implication in disease","volume":"55","author":"Lee","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"36","key":"10.1016\/j.virol.2024.110367_bib46","doi-asserted-by":"crossref","first-page":"33621","DOI":"10.1074\/jbc.M104952200","article-title":"Glucosylceramide synthases, a gene family responsible for the biosynthesis of glucosphingolipids in animals, plants, and fungi","volume":"276","author":"Leipelt","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2024.110367_bib47","article-title":"The key role of sphingolipid metabolism in cancer: new therapeutic targets, diagnostic and prognostic values, and anti-tumor immunotherapy resistance","volume":"12","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"issue":"26","key":"10.1016\/j.virol.2024.110367_bib48","doi-asserted-by":"crossref","first-page":"19513","DOI":"10.1074\/jbc.M002759200","article-title":"Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform","volume":"275","author":"Liu","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.virol.2024.110367_bib50","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1172\/JCI89626","article-title":"Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency","volume":"127","author":"Lovric","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"44","key":"10.1016\/j.virol.2024.110367_bib51","doi-asserted-by":"crossref","first-page":"37118","DOI":"10.1074\/jbc.M502207200","article-title":"SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism","volume":"280","author":"Maceyka","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"5566","key":"10.1016\/j.virol.2024.110367_bib52","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1126\/science.1070238","article-title":"Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists","volume":"296","author":"Mandala","year":"2002","journal-title":"Science"},{"issue":"16","key":"10.1016\/j.virol.2024.110367_bib53","doi-asserted-by":"crossref","first-page":"11144","DOI":"10.1016\/S0021-9258(19)49887-6","article-title":"Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver","volume":"267","author":"Mandon","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1139\/o03-091","article-title":"Acid and neutral sphingomyelinases: roles and mechanisms of regulation","volume":"82","author":"Marchesini","year":"2004","journal-title":"Biochem. Cell. Biol."},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib55","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202013424","article-title":"Decreased serum level of sphingosine\u20101\u2010phosphate: a novel predictor of clinical severity in COVID\u201019","volume":"13","author":"Marfia","year":"2021","journal-title":"EMBO Mol. Med."},{"issue":"6972","key":"10.1016\/j.virol.2024.110367_bib56","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature02284","article-title":"Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1","volume":"427","author":"Matloubian","year":"2004","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib57","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13023-017-0572-x","article-title":"Disease manifestations and burden of illness in patients with acid sphingomyelinase deficiency (ASMD)","volume":"12","author":"McGovern","year":"2017","journal-title":"Orphanet J. Rare Dis."},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib58","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1128\/EC.4.1.178-189.2005","article-title":"Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin","volume":"4","author":"Min","year":"2005","journal-title":"Eukaryot. Cell"},{"issue":"8","key":"10.1016\/j.virol.2024.110367_bib59","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1158\/1541-7786.MCR-07-0100","article-title":"(Dihydro)ceramide synthase 1\u2013regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1","volume":"5","author":"Min","year":"2007","journal-title":"Mol. Cancer Res."},{"issue":"20","key":"10.1016\/j.virol.2024.110367_bib60","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1242\/jcs.114.20.3727","article-title":"Nuclear localization of neutral sphingomyelinase 1: biochemical and immunocytochemical analyses","volume":"114","author":"Mizutani","year":"2001","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.virol.2024.110367_bib63","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1016\/S0021-9258(17)41744-3","article-title":"Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation","volume":"269","author":"Okazaki","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virol.2024.110367_bib64","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-1-4419-6741-1_13","article-title":"Cancer treatment strategies targeting sphingolipid metabolism","volume":"688","author":"Oskouian","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib61","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1165\/rcmb.2020-0391OC","article-title":"NMI Facilitates Influenza A Virus Infection by Promoting Degradation of IRF7 through TRIM21","volume":"65","author":"Ouyang","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.virol.2024.110367_bib65","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.chemphyslip.2018.11.003","article-title":"Visualizing sphingolipid biosynthesis in cells","volume":"218","author":"Parashuraman","year":"2019","journal-title":"Chem. Phys. Lipids"},{"issue":"10","key":"10.1016\/j.virol.2024.110367_bib66","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899475","article-title":"Co\u2010degradation of interferon signaling factor DDX3 by PB1\u2010F2 as a basis for high virulence of 1918 pandemic influenza","volume":"38","author":"Park","year":"2019","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.virol.2024.110367_bib67","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1182\/blood-2008-02-138958","article-title":"A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia","volume":"112","author":"Paugh","year":"2008","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.virol.2024.110367_bib68","doi-asserted-by":"crossref","first-page":"11854","DOI":"10.1021\/acsnano.1c02957","article-title":"Glucosylceramide associated with gaucher disease forms amyloid-like twisted ribbon fibrils that induce \u03b1-synuclein aggregation","volume":"15","author":"Paul","year":"2021","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.virol.2024.110367_bib69","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.tibs.2010.08.001","article-title":"Regulation of sphingosine kinase and sphingolipid signaling","volume":"36","author":"Pitson","year":"2011","journal-title":"Trends Biochem. Sci."},{"issue":"3","key":"10.1016\/j.virol.2024.110367_bib70","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1172\/JCI90171","article-title":"Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome","volume":"127","author":"Prasad","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"27","key":"10.1016\/j.virol.2024.110367_bib71","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1016\/j.vaccine.2018.05.057","article-title":"Economic burden of seasonal influenza in the United States","volume":"36","author":"Putri","year":"2018","journal-title":"Vaccine"},{"issue":"21","key":"10.1016\/j.virol.2024.110367_bib72","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.1158\/0008-5472.CAN-11-2364","article-title":"Sphingosine kinase inhibitors and cancer: seeking the golden sword of hercules","volume":"71","author":"Pyne","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.virol.2024.110367_bib73","series-title":"Cellular Lipid in Health and Disease","first-page":"1","article-title":"Chapter 1 - structure and function of mammalian sphingolipids in health and disease","author":"Rabionet","year":"2023"},{"issue":"11","key":"10.1016\/j.virol.2024.110367_bib75","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/glycob\/cwab046","article-title":"Glucosylceramide and galactosylceramide, small glycosphingolipids with significant impact on health and disease","volume":"31","author":"Reza","year":"2021","journal-title":"Glycobiology"},{"issue":"22","key":"10.1016\/j.virol.2024.110367_bib76","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1101\/gad.1588907","article-title":"Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants","volume":"21","author":"Samuelson","year":"2007","journal-title":"Genes Dev."},{"issue":"31","key":"10.1016\/j.virol.2024.110367_bib77","doi-asserted-by":"crossref","first-page":"18431","DOI":"10.1074\/jbc.271.31.18431","article-title":"Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene","volume":"271","author":"Schissel","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib78","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1080\/22221751.2020.1829082","article-title":"Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine","volume":"9","author":"Schloer","year":"2020","journal-title":"Emerg. Microb. Infect."},{"issue":"13","key":"10.1016\/j.virol.2024.110367_bib79","doi-asserted-by":"crossref","first-page":"8531","DOI":"10.1016\/S0021-9258(18)93007-3","article-title":"Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs","volume":"266","author":"Schuchman","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"16","key":"10.1016\/j.virol.2024.110367_bib80","doi-asserted-by":"crossref","first-page":"8124","DOI":"10.1128\/JVI.00510-10","article-title":"Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity","volume":"84","author":"Seo","year":"2010","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.virol.2024.110367_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075005","article-title":"Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection","volume":"8","author":"Seo","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib82","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.advenzreg.2009.10.024","article-title":"Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function","volume":"50","author":"Serra","year":"2010","journal-title":"Adv. Enzym. Regul."},{"issue":"5","key":"10.1016\/j.virol.2024.110367_bib83","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1210\/jc.2018-02238","article-title":"SGPL1 deficiency: a rare cause of primary adrenal insufficiency","volume":"104","author":"Settas","year":"2019","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib84","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4103\/0976-500X.77118","article-title":"Fingolimod (FTY720): first approved oral therapy for multiple sclerosis","volume":"2","author":"Sharma","year":"2011","journal-title":"J. Pharmacol. Pharmacother."},{"issue":"4","key":"10.1016\/j.virol.2024.110367_bib85","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.plipres.2013.05.001","article-title":"Biological functions of sphingomyelins","volume":"52","author":"Slotte","year":"2013","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.virol.2024.110367_bib86","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.2147\/DDDT.S367612","article-title":"Recent progress in the development of opaganib for the treatment of covid-19","volume":"16","author":"Smith","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"issue":"7","key":"10.1016\/j.virol.2024.110367_bib87","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1158\/1078-0432.CCR-10-0720","article-title":"Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K\/Akt\/NF-\u03baB pathway in human non\u2013small cell lung cancer","volume":"17","author":"Song","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.virol.2024.110367_bib88","series-title":"A Phase I Study of Intravenous (Emulsion) Fenretinide (4-HPR, NSC 374551) in Children with Recurrent or Resistant Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML), and Non-hodgkin\u2019s Lymphoma (NHL) IND #70,058","year":"2022"},{"issue":"6","key":"10.1016\/j.virol.2024.110367_bib89","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nri2974","article-title":"The outs and the ins of sphingosine-1-phosphate in immunity","volume":"11","author":"Spiegel","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib90","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0009-3084(99)00079-1","article-title":"Functional analysis of acid and neutral sphingomyelinases in vitro and in vivo","volume":"102","author":"Stoffel","year":"1999","journal-title":"Chem. Phys. Lipids"},{"issue":"12","key":"10.1016\/j.virol.2024.110367_bib91","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1172\/JCI125297","article-title":"Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence","volume":"130","author":"Studstill","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"24","key":"10.1016\/j.virol.2024.110367_bib92","doi-asserted-by":"crossref","first-page":"17537","DOI":"10.1074\/jbc.M702423200","article-title":"Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells","volume":"282","author":"Tafesse","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"16","key":"10.1016\/j.virol.2024.110367_bib93","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1073\/pnas.1219909110","article-title":"Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins","volume":"110","author":"Tafesse","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.virol.2024.110367_bib49","first-page":"482","article-title":"Loss of sphingosine kinase\u20101 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis FASEB","volume":"20","author":"Taha","year":"2006","journal-title":"J"},{"issue":"6","key":"10.1016\/j.virol.2024.110367_bib94","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.chom.2010.05.009","article-title":"Influenza virus evolution, host adaptation and pandemic formation","volume":"7","author":"Taubenberger","year":"2010","journal-title":"Cell Host Microbe."},{"issue":"12","key":"10.1016\/j.virol.2024.110367_bib95","doi-asserted-by":"crossref","first-page":"102698","DOI":"10.1016\/j.jbc.2022.102698","article-title":"The E3 ligase subunit FBXO45 binds the interferon-\u03bb receptor and promotes its degradation during influenza virus infection","volume":"298","author":"Tsai","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.virol.2024.110367_bib96","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4049\/jimmunol.1601959","article-title":"Sphingosine 1-phosphate lyase enhances the activation of IKK\u03b5 to promote type I interferon-mediated innate immune response to influenza A virus infection","volume":"199","author":"Vijayan","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2024.110367_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100470","article-title":"Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and influenza virus","volume":"296","author":"Vitner","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.virol.2024.110367_bib98","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.3390\/v11121097","article-title":"Emerging connections of S1P-metabolizing enzymes with host defense and immunity during virus infections","volume":"11","author":"Wolf","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2024.110367_bib99","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.virol.2021.02.006","article-title":"Influenza A virus NS1 induces degradation of sphingosine 1-phosphate lyase to obstruct the host innate immune response","volume":"558","author":"Wolf","year":"2021","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.virol.2024.110367_bib100","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1089\/dna.2022.0071","article-title":"Analyzing opposing interactions between sphingosine 1-phosphate lyase and influenza A virus","volume":"41","author":"Wolf","year":"2022","journal-title":"DNA Cell Biol."},{"issue":"5","key":"10.1016\/j.virol.2024.110367_bib101","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1128\/JVI.02749-15","article-title":"Hemagglutinin of influenza A virus antagonizes type I interferon (IFN) responses by inducing degradation of type I IFN receptor 1","volume":"90","author":"Xia","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2024.110367_bib102","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.antiviral.2018.08.010","article-title":"Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice","volume":"158","author":"Xia","year":"2018","journal-title":"Antivir. Res."},{"issue":"9","key":"10.1016\/j.virol.2024.110367_bib103","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.3390\/ijms25094677","article-title":"Triggering degradation of host cellular proteins for robust propagation of influenza viruses","volume":"25","author":"Xia","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.virol.2024.110367_bib104","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010794","article-title":"Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection","volume":"18","author":"Xu","year":"2022","journal-title":"PLoS Pathog."},{"issue":"2","key":"10.1016\/j.virol.2024.110367_bib105","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/tra.12239","article-title":"Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins","volume":"16","author":"Yamaji","year":"2015","journal-title":"Traffic"},{"issue":"5","key":"10.1016\/j.virol.2024.110367_bib106","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1183\/09031936.02.00253302","article-title":"Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels","volume":"19","author":"Yang","year":"2002","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.virol.2024.110367_bib107","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1038\/s41467-022-33909-2","article-title":"The influenza virus PB2 protein evades antiviral innate immunity by inhibiting JAK1\/STAT signalling","volume":"13","author":"Yang","year":"2022","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.virol.2024.110367_bib108","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009300","article-title":"The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation","volume":"17","author":"Zeng","year":"2021","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.virol.2024.110367_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41421-020-00235-0","article-title":"Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension","volume":"6","author":"Zhang","year":"2020","journal-title":"Cell Discov."},{"issue":"12","key":"10.1016\/j.virol.2024.110367_bib110","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.260682","article-title":"Viral evasion of the interferon response at a glance","volume":"136","author":"Zhu","year":"2023","journal-title":"J. Cell Sci."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268222400391X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268222400391X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T13:01:47Z","timestamp":1769950907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004268222400391X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":107,"alternative-id":["S004268222400391X"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2024.110367","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiple sphingolipid-metabolizing enzymes modulate influenza virus replication","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2024.110367","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110367"}}