{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:50:52Z","timestamp":1793163052658,"version":"4.5.0"},"reference-count":195,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000040","name":"Government of Canada Agriculture and Agri-Food Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008921","name":"Saskatchewan Ministry of Agriculture","doi-asserted-by":"publisher","award":["20220105"],"award-info":[{"award-number":["20220105"]}],"id":[{"id":"10.13039\/100008921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021824","name":"Government of Saskatchewan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["1092"],"award-info":[{"award-number":["1092"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RPN-2024-03752"],"award-info":[{"award-number":["RPN-2024-03752"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RPN-2018- 04138"],"award-info":[{"award-number":["RPN-2018- 04138"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.virol.2025.110412","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T19:43:36Z","timestamp":1737229416000},"page":"110412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Towards developing multistrain PEDV vaccines: Integrating basic concepts and SARS-CoV-2 pan-sarbecovirus strategies"],"prefix":"10.1016","volume":"604","author":[{"given":"Mario","family":"Fragoso-Saavedra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-7172","authenticated-orcid":false,"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2025.110412_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.654289","article-title":"Novel vaccine technologies in veterinary medicine: a herald to human medicine vaccines","volume":"8","author":"Aida","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.virol.2025.110412_bib2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13567-017-0469-7","article-title":"Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain","volume":"48","author":"Annamalai","year":"2017","journal-title":"Vet. Res."},{"key":"10.1016\/j.virol.2025.110412_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.vetimm.2015.09.006","article-title":"Age-dependent variation in innate immune responses to porcine epidemic diarrhea virus infection in suckling versus weaned pigs","volume":"168","author":"Annamalai","year":"2015","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virol.2025.110412_bib4","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1128\/JVI.01131-10","article-title":"A conserved domain in the coronavirus membrane protein tail is important for virus assembly","volume":"84","author":"Arndt","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nri2868","article-title":"Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns","volume":"10","author":"Bachmann","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.virol.2025.110412_bib6","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.dci.2013.11.005","article-title":"Colostral antibody-mediated and cell-mediated immunity contributes to innate and antigen-specific immunity in piglets","volume":"43","author":"Bandrick","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.virol.2025.110412_bib7","doi-asserted-by":"crossref","first-page":"10910","DOI":"10.1128\/JVI.01919-12","article-title":"Complete genome sequence of porcine epidemic diarrhea virus strain AJ1102 isolated from a suckling piglet with acute diarrhea in China","volume":"86","author":"Bi","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib8","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.immuni.2021.07.017","article-title":"Accelerated COVID-19 vaccine development: milestones, lessons, and prospects","volume":"54","author":"Bok","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.virol.2025.110412_bib9","author":"Bozic"},{"key":"10.1016\/j.virol.2025.110412_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2022.102209","article-title":"Principles and practical applications of structure-based vaccine design","volume":"77","author":"Byrne","year":"2022","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.virol.2025.110412_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41423-023-01116-8","article-title":"In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms","volume":"21","author":"Cankat","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.virol.2025.110412_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40813-015-0007-9","article-title":"Porcine epidemic diarrhoea: new insights into an old disease","volume":"1","author":"Carvajal","year":"2015","journal-title":"Porcine Health Manage."},{"key":"10.1016\/j.virol.2025.110412_bib13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3390\/v10070346","article-title":"Display of porcine epidemic diarrhea virus spike protein on baculovirus to improve immunogenicity and protective efficacy","volume":"10","author":"Chang","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib14","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1016-8478(23)15106-5","article-title":"Identification of the epitope region capable of inducing neutralizing antibodies against the porcine epidemic diarrhea virus","volume":"14","author":"Chang","year":"2002","journal-title":"Mol. Cell."},{"key":"10.1016\/j.virol.2025.110412_bib15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev-animal-022114-111038","article-title":"Strategies for design and application of enteric viral vaccines","volume":"3","author":"Chattha","year":"2015","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.1016\/j.virol.2025.110412_bib16","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41573-021-00283-5","article-title":"mRNA vaccines for infectious diseases: principles, delivery and clinical translation","volume":"20","author":"Chaudhary","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.virol.2025.110412_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.meegid.2019.01.022","article-title":"Genetic evolution analysis and pathogenicity assessment of porcine epidemic diarrhea virus strains circulating in part of China during 2011\u20132017","volume":"69","author":"Chen","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.virol.2025.110412_bib18","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1099\/jgv.0.000419","article-title":"Pathogenesis comparison between the United States porcine epidemic diarrhoea virus prototype and S-INDEL-variant strains in conventional neonatal piglets","volume":"97","author":"Chen","year":"2016","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib19","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1128\/JCM.02820-13","article-title":"Isolation and characterization of porcine epidemic diarrhea viruses associated with the 2013 disease outbreak among swine in the United States","volume":"52","author":"Chen","year":"2020","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib20","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jmv.25681","article-title":"Emerging coronaviruses: genome structure, replication, and pathogenesis","volume":"92","author":"Chen","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib21","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2314392120","article-title":"Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA)","volume":"120","author":"Cheng","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2025.110412_bib22","doi-asserted-by":"crossref","first-page":"eabj0299","DOI":"10.1126\/science.abj0299","article-title":"Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates","volume":"373","author":"Corbett","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.virol.2025.110412_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.virusres.2007.10.015","article-title":"The GPRLQPY motif located at the carboxy-terminal of the spike protein induces antibodies that neutralize porcine epidemic diarrhea virus","volume":"132","author":"Cruz","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110412_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-2427(01)00417-2","article-title":"Mucosal and systemic isotype-specific antibody responses and protection in conventional pigs exposed to virulent or attenuated porcine epidemic diarrhoea virus","volume":"85","author":"de Arriba","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virol.2025.110412_bib25","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1128\/JVI.74.11.4967-4978.2000","article-title":"Assembly of the coronavirus envelope: homotypic interactions between the M proteins","volume":"74","author":"de Haan","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0378-1135(81)90007-9","article-title":"The pathogenesis of an enteric infection in pigs, experimentally induced by the coronavirus-like agent, CV 777","volume":"6","author":"Debouck","year":"1981","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib27","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/rna.8.2.15013","article-title":"Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity","volume":"8","author":"Denison","year":"2011","journal-title":"RNA Biol."},{"key":"10.1016\/j.virol.2025.110412_bib28","first-page":"60","article-title":"Porcine epidemic diarrhea virus: an overview of current virological and serological diagnostic methods","volume":"226","author":"Diel","year":"2016","journal-title":"Virus Res., Emerging Porcine Coronaviruses"},{"key":"10.1016\/j.virol.2025.110412_bib29","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00705-019-04492-7","article-title":"Recombinant adenovirus carrying a core neutralizing epitope of porcine epidemic diarrhea virus and heat-labile enterotoxin B of escherichia coli as a mucosal vaccine","volume":"165","author":"Do","year":"2020","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1251001","article-title":"Virus-like particle vaccines with epitopes from porcine epidemic virus and transmissible gastroenteritis virus incorporated into self-assembling ADDomer platform provide clinical immune responses in piglets","volume":"14","author":"Du","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2025.110412_bib31","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00647-20","article-title":"The nucleocapsid protein of SARS\u2013CoV-2: a target for vaccine development","volume":"94","author":"Dutta","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib32","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1016\/j.vaccine.2020.05.007","article-title":"A veterinary vaccine development process map to assist in the development of new vaccines","volume":"38","author":"Francis","year":"2020","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2025.110412_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2024.05.028","article-title":"Efficacy of a stable broadly protective subunit vaccine platform against SARS-CoV-2 variants of concern","author":"Garg","year":"2024","journal-title":"Vaccine S0264410X24005863"},{"key":"10.1016\/j.virol.2025.110412_bib34","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.cell.2021.02.030","article-title":"Novel approaches for vaccine development","volume":"184","author":"Gebre","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.virol.2025.110412_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.vetmic.2016.11.029","article-title":"Vaccines for porcine epidemic diarrhea virus and other swine coronaviruses","volume":"206","author":"Gerdts","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib36","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1128\/JCM.02507-16","article-title":"Reactivity of porcine epidemic diarrhea virus structural proteins to antibodies against porcine enteric coronaviruses: diagnostic implications","volume":"55","author":"Gimenez-Lirola","year":"2017","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev-med-121217-094234","article-title":"Structure-based vaccine antigen design","volume":"70","author":"Graham","year":"2019","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.virol.2025.110412_bib38","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.crimmu.2022.08.005","article-title":"From alpha to omicron: the response of T cells","volume":"3","author":"Grifoni","year":"2022","journal-title":"Curr. Res. Immunol."},{"key":"10.1016\/j.virol.2025.110412_bib39","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.chom.2021.05.010","article-title":"SARS-CoV-2 human T cell epitopes: adaptive immune response against COVID-19","volume":"29","author":"Grifoni","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.virol.2025.110412_bib40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/tbed.12991","article-title":"Evolutionary and genotypic analyses of global porcine epidemic diarrhea virus strains","volume":"66","author":"Guo","year":"2019","journal-title":"Transboundary Emerging Dis"},{"key":"10.1016\/j.virol.2025.110412_bib41","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.vaccine.2024.01.020","article-title":"Immunogenicity and protective efficacy of a trimeric full-length S protein subunit vaccine for porcine epidemic diarrhea virus","volume":"42","author":"Guo","year":"2024","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2025.110412_bib42","first-page":"1","article-title":"Advanced technologies for the development of infectious disease vaccines","author":"Gupta","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.virol.2025.110412_bib43","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1099\/jgv.0.000586","article-title":"Immunogenicity of a recombinant parapoxvirus expressing the spike protein of porcine epidemic diarrhea virus","volume":"97","author":"Hain","year":"2016","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abq1945","article-title":"Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 omicron and delta variants in preclinical models","volume":"14","author":"Hajnik","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.virol.2025.110412_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41541-024-00957-2","article-title":"Broad protection and respiratory immunity of dual mRNA vaccination against SARS-CoV-2 variants","volume":"9","author":"Hajnik","year":"2024","journal-title":"npj Vaccines"},{"key":"10.1016\/j.virol.2025.110412_bib46","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/s41565-024-01655-9","article-title":"Proactive vaccination using multiviral quartet nanocages to elicit broad anti-coronavirus responses","volume":"19","author":"Hills","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.virol.2025.110412_bib47","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1128\/jcm.26.11.2235-2239.1988","article-title":"Propagation of the virus of porcine epidemic diarrhea in cell culture","volume":"26","author":"Hofmann","year":"1988","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib48","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/v10030106","article-title":"Oral immunization against PEDV with recombinant lactobacillus casei expressing dendritic cell-targeting peptide fusing COE protein of PEDV in piglets","volume":"10","author":"Hou","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib49","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.abd0826","article-title":"Structure-based design of prefusion-stabilized SARS-CoV-2 spikes","volume":"369","author":"Hsieh","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.virol.2025.110412_bib50","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1038\/s41467-024-45404-x","article-title":"Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge","volume":"15","author":"Hsieh","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virol.2025.110412_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2022.102385","article-title":"Protein engineering responses to the COVID-19 pandemic","volume":"74","author":"Hsieh","year":"2022","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.virol.2025.110412_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109929","article-title":"Stabilized coronavirus spike stem elicits a broadly protective antibody","volume":"37","author":"Hsieh","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.virol.2025.110412_bib53","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3390\/v12101122","article-title":"Parenterally administered porcine epidemic diarrhea virus-like particle-based vaccine formulated with CCL25\/28 chemokines induces systemic and mucosal immune protectivity in pigs","volume":"12","author":"Hsu","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib54","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.3390\/ani12233388","article-title":"Molecular and structural evolution of porcine epidemic diarrhea virus","volume":"12","author":"Huang","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.virol.2025.110412_bib55","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1038\/s41467-022-32588-3","article-title":"In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM","volume":"13","author":"Huang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virol.2025.110412_bib56","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00737-13","article-title":"Origin, evolution, and genotyping of emergent porcine epidemic diarrhea virus strains in the United States","volume":"4","author":"Huang","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.virol.2025.110412_bib57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","article-title":"Mechanisms of SARS-CoV-2 entry into cells","volume":"23","author":"Jackson","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.virol.2025.110412_bib58","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.4142\/jvs.23090","article-title":"Porcine epidemic diarrhea virus: an update overview of virus epidemiology, vaccines, and control strategies in South Korea","volume":"24","author":"Jang","year":"2023","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.virol.2025.110412_bib59","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.prevetmed.2015.10.020","article-title":"Genomic and evolutionary inferences between American and global strains of porcine epidemic diarrhea virus","volume":"123","author":"Jarvis","year":"2016","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.virol.2025.110412_bib60","first-page":"16","article-title":"Aminopeptidase-N-independent entry of porcine epidemic diarrhea virus into vero or porcine small intestine epithelial cells","volume":"517","author":"Ji","year":"2018","journal-title":"Virology, Nidovirus Research"},{"key":"10.1016\/j.virol.2025.110412_bib61","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.3390\/v16101580","article-title":"Construction and immunogenicity of a recombinant porcine pseudorabies virus (PRV) expressing the major neutralizing epitope regions of S1 protein of variant PEDV","volume":"16","author":"Jiao","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.str.2024.08.022","article-title":"Discovery and characterization of a pan-betacoronavirus S2-binding antibody","author":"Johnson","year":"2024","journal-title":"Structure S0969212624003691"},{"key":"10.1016\/j.virol.2025.110412_bib63","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.biori.2017.10.001","article-title":"The development of veterinary vaccines: a review of traditional methods and modern biotechnology approaches","volume":"1","author":"Jorge","year":"2017","journal-title":"Biotechnology Research and Innovation"},{"key":"10.1016\/j.virol.2025.110412_bib64","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1007\/s00705-018-3855-1","article-title":"Passive immunity to porcine epidemic diarrhea virus following immunization of pregnant gilts with a recombinant orf virus vector expressing the spike protein","volume":"163","author":"Joshi","year":"2018","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110143","article-title":"SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity","volume":"37","author":"Joyce","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.virol.2025.110412_bib66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.vetmic.2015.04.022","article-title":"Comparative pathogenesis of US porcine epidemic diarrhea virus (PEDV) strain PC21A in conventional 9-day-old nursing piglets vs. 26-day-old weaned pigs","volume":"178","author":"Jung","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib67","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tvjl.2015.02.017","article-title":"Porcine epidemic diarrhea virus infection: etiology, epidemiology, pathogenesis and immunoprophylaxis","volume":"204","author":"Jung","year":"2015","journal-title":"Vet. J."},{"key":"10.1016\/j.virol.2025.110412_bib68","doi-asserted-by":"crossref","DOI":"10.3201\/eid2004.131685","article-title":"Pathology of US porcine epidemic diarrhea virus strain PC21A in gnotobiotic pigs","volume":"20","author":"Jung","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virol.2025.110412_bib69","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41467-020-20321-x","article-title":"Stabilizing the closed SARS-CoV-2 spike trimer","volume":"12","author":"Juraszek","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virol.2025.110412_bib70","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3390\/v10080399","article-title":"The accessory protein ORF3 contributes to porcine epidemic diarrhea virus replication by direct binding to the spike protein","volume":"10","author":"Kaewborisuth","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib71","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1038\/s41467-022-30222-w","article-title":"Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants","volume":"13","author":"Kang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virol.2025.110412_bib72","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40813-020-00159-x","article-title":"Major swine viral diseases: an asian perspective after the african swine fever introduction","volume":"6","author":"Kedkovid","year":"2020","journal-title":"Porcine Health Manage."},{"key":"10.1016\/j.virol.2025.110412_bib73","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3390\/vaccines9040370","article-title":"Construction of porcine epidemic diarrhea virus-like particles and its immunogenicity in mice","volume":"9","author":"Kim","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.virol.2025.110412_bib74","doi-asserted-by":"crossref","DOI":"10.4110\/in.2018.18.e21","article-title":"N-terminal domain of the spike protein of porcine epidemic diarrhea virus as a new candidate molecule for a mucosal vaccine","volume":"18","author":"Kim","year":"2018","journal-title":"Immune Netw"},{"key":"10.1016\/j.virol.2025.110412_bib75","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.str.2020.12.003","article-title":"Structure and immune recognition of the porcine epidemic diarrhea virus spike protein","volume":"29","author":"Kirchdoerfer","year":"2021","journal-title":"Structure"},{"key":"10.1016\/j.virol.2025.110412_bib76","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00281-023-00996-2","article-title":"The role of vaccines in the COVID-19 pandemic: what have we learned?","volume":"45","author":"Krammer","year":"2024","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.virol.2025.110412_bib77","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41586-020-2798-3","article-title":"SARS-CoV-2 vaccines in development","volume":"586","author":"Krammer","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.virol.2025.110412_bib78","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3389\/fimmu.2019.00727","article-title":"Stage of gestation at porcine epidemic diarrhea virus infection of pregnant swine impacts maternal immunity and lactogenic immune protection of neonatal suckling piglets","volume":"10","author":"Langel","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2025.110412_bib79","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3390\/pathogens9020130","article-title":"Host factors affecting generation of immunity against porcine epidemic diarrhea virus in pregnant and lactating swine and passive protection of neonates","volume":"9","author":"Langel","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.virol.2025.110412_bib80","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00474-22","article-title":"SARS-CoV-2 spike furin cleavage site and S2\u2032 basic residues modulate the entry process in a host cell-dependent manner","volume":"96","author":"Lavie","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib81","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41586-020-2550-z","article-title":"SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls","volume":"584","author":"Le Bert","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.virol.2025.110412_bib82","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12985-015-0421-2","article-title":"Porcine epidemic diarrhea virus: an emerging and re-emerging epizootic swine virus","volume":"12","author":"Lee","year":"2015","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2025.110412_bib83","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1038\/s41467-024-49656-5","article-title":"A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines","volume":"15","author":"Lee","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virol.2025.110412_bib84","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1038\/s41467-024-50133-2","article-title":"Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters","volume":"15","author":"Leekha","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virol.2025.110412_bib85","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3390\/ani14020294","article-title":"Porcine epidemic diarrhea virus: etiology, epidemiology, antigenicity, and control strategies in China","volume":"14","author":"Lei","year":"2024","journal-title":"Animals"},{"key":"10.1016\/j.virol.2025.110412_bib86","first-page":"91","article-title":"Cell attachment domains of the porcine epidemic diarrhea virus spike protein are key targets of neutralizing antibodies","author":"Li","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib87","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev-virology-110615-042301","article-title":"Structure, function, and evolution of coronavirus spike proteins","volume":"3","author":"Li","year":"2016","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib88","article-title":"Spike 1 trimer, a nanoparticle vaccine against porcine epidemic diarrhea virus induces protective immunity challenge in piglets","volume":"15","author":"Li","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib89","article-title":"Accurate location of two conserved linear epitopes of PEDV utilizing monoclonal antibodies induced by S1 protein nanoparticles","volume":"253","author":"Li","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.virol.2025.110412_bib90","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.virusres.2016.05.031","article-title":"Cellular entry of the porcine epidemic diarrhea virus","volume":"226","author":"Li","year":"2016","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110412_bib91","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.virs.2022.08.002","article-title":"Isolation and oral immunogenicity assessment of porcine epidemic diarrhea virus NH-TA2020 strain: one of the predominant strains circulating in China from 2017 to 2021","volume":"37","author":"Li","year":"2022","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virol.2025.110412_bib92","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12917-021-02885-y","article-title":"The construction of recombinant lactobacillus casei vaccine of PEDV and its immune responses in mice","volume":"17","author":"Li","year":"2021","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.virol.2025.110412_bib93","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s00705-012-1592-4","article-title":"Sequence and phylogenetic analysis of nucleocapsid genes of porcine epidemic diarrhea virus (PEDV) strains in China","volume":"158","author":"Li","year":"2013","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib94","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.virusres.2016.05.023","article-title":"Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains","volume":"226","author":"Lin","year":"2016","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110412_bib95","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1128\/JVI.00430-15","article-title":"Receptor usage and cell entry of porcine epidemic diarrhea coronavirus","volume":"89","author":"Liu","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib96","article-title":"Evaluation of the efficacy of a recombinant adenovirus expressing the spike protein of porcine epidemic diarrhea virus in pigs","volume":"2019","author":"Liu","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.virol.2025.110412_bib97","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1016\/j.vaccine.2020.06.009","article-title":"Virus-like particle vaccine with B-cell epitope from porcine epidemic diarrhea virus (PEDV) incorporated into hepatitis B virus core capsid provides clinical alleviation against PEDV in neonatal piglets through lactogenic immunity","volume":"38","author":"Lu","year":"2020","journal-title":"Vaccine"},{"key":"10.1016\/j.virol.2025.110412_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1396894","article-title":"Research progress of porcine epidemic diarrhea virus S protein","volume":"15","author":"Luo","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib99","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00202-17","article-title":"Tight junction protein occludin is a porcine epidemic diarrhea virus entry factor","volume":"91","author":"Luo","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib100","first-page":"1","article-title":"Porcine epidemic diarrhea virus: current insights","volume":"8","author":"Lv","year":"2016","journal-title":"Virus Adapt. Treat."},{"key":"10.1016\/j.virol.2025.110412_bib101","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12985-016-0512-8","article-title":"S1 domain of the porcine epidemic diarrhea virus spike protein as a vaccine antigen","volume":"13","author":"Makadiya","year":"2016","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2025.110412_bib102","article-title":"Postepidemic epidemiology of porcine epidemic diarrhea virus in the United States","volume":"2024","author":"Makau","year":"2024","journal-title":"Transboundary Emerging Dis"},{"key":"10.1016\/j.virol.2025.110412_bib103","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41579-023-00878-2","article-title":"The evolution of SARS-CoV-2","volume":"21","author":"Markov","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib104","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13567-021-00971-5","article-title":"Stable trimer formation of spike protein from porcine epidemic diarrhea virus improves the efficiency of secretory production in silkworms and induces neutralizing antibodies in mice","volume":"52","author":"Masuda","year":"2021","journal-title":"Vet. Res."},{"key":"10.1016\/j.virol.2025.110412_bib105","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1073\/pnas.2002589117","article-title":"Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells","volume":"117","author":"Matsuyama","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2025.110412_bib106","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.3390\/v6082991","article-title":"The coronavirus nucleocapsid is a multifunctional protein","volume":"6","author":"McBride","year":"2014","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib107","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/9313267","article-title":"The key to increase immunogenicity of next-generation COVID-19 vaccines lies in the inclusion of the SARS-CoV-2 nucleocapsid protein","volume":"2024","author":"Mendoza-Ram\u00edrez","year":"2024","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.virol.2025.110412_bib108","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.virol.2023.05.001","article-title":"Recombinant human adenovirus type 5 based vaccine candidates against GIIa- and GIIb-genotype porcine epidemic diarrhea virus induce robust humoral and cellular response in mice","volume":"584","author":"Miao","year":"2023","journal-title":"Virology"},{"key":"10.1016\/j.virol.2025.110412_bib109","article-title":"Surface-modified measles vaccines encoding oligomeric, prefusion-stabilized SARS-CoV-2 spike glycoproteins boost neutralizing antibody responses to omicron and historical variants","author":"Mu\u00f1oz-Al\u00eda","year":"2024","journal-title":"independent of measles seropositivity. mBio"},{"key":"10.1016\/j.virol.2025.110412_bib110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41541-023-00792-x","article-title":"Bringing immunofocusing into focus","volume":"9","author":"Musunuri","year":"2024","journal-title":"npj Vaccines"},{"key":"10.1016\/j.virol.2025.110412_bib111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41541-021-00330-7","article-title":"Protein-based antigen presentation platforms for nanoparticle vaccines","volume":"6","author":"Nguyen","year":"2021","journal-title":"npj Vaccines"},{"key":"10.1016\/j.virol.2025.110412_bib112","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/tbed.12823","article-title":"Swine enteric coronavirus disease: a review of 4 years with porcine epidemic diarrhoea virus and porcine deltacoronavirus in the United States and Canada","volume":"65","author":"Niederwerder","year":"2018","journal-title":"Transboundary Emerging Dis"},{"key":"10.1016\/j.virol.2025.110412_bib113","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1038\/s41467-024-50976-9","article-title":"Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogens","volume":"15","author":"Nuqui","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virol.2025.110412_bib114","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.01813","article-title":"The curious case of the nidovirus exoribonuclease: its role in RNA synthesis and replication fidelity","volume":"10","author":"Ogando","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib115","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1007\/s00705-014-2163-7","article-title":"Immunogenicity and protective efficacy of recombinant S1 domain of the porcine epidemic diarrhea virus spike protein","volume":"159","author":"Oh","year":"2014","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib116","first-page":"149","article-title":"The first case of porcine epidemic diarrhea in Canada","volume":"56","author":"Ojkic","year":"2015","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.virol.2025.110412_bib117","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.virol.2017.06.013","article-title":"The S2 glycoprotein subunit of porcine epidemic diarrhea virus contains immunodominant neutralizing epitopes","volume":"509","author":"Okda","year":"2017","journal-title":"Virology"},{"key":"10.1016\/j.virol.2025.110412_bib118","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.anireprosci.2010.07.004","article-title":"Impact of porcine epidemic diarrhea virus infection at different periods of pregnancy on subsequent reproductive performance in gilts and sows","volume":"122","author":"Olanratmanee","year":"2010","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.virol.2025.110412_bib119","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13567-017-0472-z","article-title":"Evaluation of the efficacy of a commercial inactivated genogroup 2b-based porcine epidemic diarrhea virus (PEDV) vaccine and experimental live genogroup 1b exposure against 2b challenge","volume":"48","author":"Opriessnig","year":"2017","journal-title":"Vet. Res."},{"key":"10.1016\/j.virol.2025.110412_bib120","series-title":"Research in Agricultural & Applied Economics","article-title":"Updated estimated economic welfare impacts of porcine epidemic diarrhea virus (PEDV)","year":"2014"},{"key":"10.1016\/j.virol.2025.110412_bib121","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/s41422-022-00746-3","article-title":"A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein","volume":"32","author":"Pang","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.virol.2025.110412_bib122","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/vaccines12020212","article-title":"Porcine epidemic diarrhea: insights and progress on vaccines","volume":"12","author":"Park","year":"2024","journal-title":"Vaccines"},{"key":"10.1016\/j.virol.2025.110412_bib123","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/v11080682","article-title":"Recombinant chimeric transmissible gastroenteritis virus (TGEV)\u2014porcine epidemic diarrhea virus (PEDV) virus provides protection against virulent PEDV","volume":"11","author":"Pascual-Iglesias","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib124","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/01652176.2014.973999","article-title":"Evaluation of antibody response of killed and live vaccines against porcine epidemic diarrhea virus in a field study","volume":"34","author":"Paudel","year":"2014","journal-title":"Vet. Q."},{"key":"10.1016\/j.virol.2025.110412_bib125","article-title":"Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2","volume":"3","author":"Peng","year":"2022","journal-title":"Cell Rep. Med"},{"key":"10.1016\/j.virol.2025.110412_bib126","article-title":"Phylogenetic analysis of porcine epidemic diarrhea virus (PEDV) during 2020\u20132022 and isolation of a variant recombinant PEDV strain","volume":"25","author":"Peng","year":"2024","journal-title":"IJMS"},{"key":"10.1016\/j.virol.2025.110412_bib127","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12896-016-0268-7","article-title":"Trigger factor assisted soluble expression of recombinant spike protein of porcine epidemic diarrhea virus in escherichia coli","volume":"16","author":"Piao","year":"2016","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.virol.2025.110412_bib128","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.abj3321","article-title":"Broad betacoronavirus neutralization by a stem helix\u2013specific human antibody","volume":"373","author":"Pinto","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.virol.2025.110412_bib129","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153041","article-title":"Does circulating antibody play a role in the protection of piglets against porcine epidemic diarrhea virus?","volume":"11","author":"Poonsuk","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2025.110412_bib130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1017\/S1466252317000123","article-title":"Historical and contemporary aspects of maternal immunity in swine","volume":"19","author":"Poonsuk","year":"2018","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.virol.2025.110412_bib131","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.4049\/jimmunol.2001438","article-title":"Genome-wide B cell, CD4+, and CD8+ T cell epitopes that are highly conserved between human and animal coronaviruses, identified from SARS-CoV-2 as targets for preemptive pan-coronavirus vaccines","volume":"206","author":"Prakash","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.virol.2025.110412_bib132","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/tbed.13426","article-title":"Emerging strains of porcine epidemic diarrhoea virus (PEDv) in Mexico","volume":"67","author":"Reveles-F\u00e9lix","year":"2020","journal-title":"Transboundary Emerging Dis"},{"key":"10.1016\/j.virol.2025.110412_bib133","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.molcel.2020.07.027","article-title":"Coronavirus RNA proofreading: molecular basis and therapeutic targeting","volume":"79","author":"Robson","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.virol.2025.110412_bib134","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3390\/v16020238","article-title":"Comparative review of the state of the art in research on the porcine epidemic diarrhea virus and SARS-CoV-2, scope of knowledge between coronaviruses","volume":"16","author":"Rosas-Murrieta","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib135","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/tbed.13496","article-title":"The canadian 2014 porcine epidemic diarrhoea virus outbreak: important risk factors that were not considered in the epidemiological investigation could change the conclusions","volume":"67","author":"Russell","year":"2020","journal-title":"Transboundary Emerging Dis"},{"key":"10.1016\/j.virol.2025.110412_bib136","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12985-018-0940-8","article-title":"Efficacy of genogroup 1 based porcine epidemic diarrhea live vaccine against genogroup 2 field strain in Japan","volume":"15","author":"Sato","year":"2018","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2025.110412_bib137","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/s41591-021-01464-w","article-title":"Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19\/mRNA vaccination","volume":"27","author":"Schmidt","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.virol.2025.110412_bib138","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12985-019-1182-0","article-title":"Coronavirus envelope protein: current knowledge","volume":"16","author":"Schoeman","year":"2019","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2025.110412_bib139","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.2527\/jas.2015-9136","article-title":"Assessment of the economic impacts of porcine epidemic diarrhea virus in the United States","volume":"93","author":"Schulz","year":"2015","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.virol.2025.110412_bib140","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3390\/v14081801","article-title":"Evaluation of the efficacy of an S-INDEL PEDV strain administered to pregnant gilts against a virulent non-S-INDEL PEDV challenge in newborn piglets","volume":"14","author":"Schumacher","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2023.102572","article-title":"A concise guide to choosing suitable gene expression systems for recombinant protein production","volume":"4","author":"Sch\u00fctz","year":"2023","journal-title":"STAR Protoc"},{"key":"10.1016\/j.virol.2025.110412_bib142","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.immuni.2022.04.010","article-title":"Inducing broad-based immunity against viruses with pandemic potential","volume":"55","author":"Sette","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.virol.2025.110412_bib143","doi-asserted-by":"crossref","first-page":"7872","DOI":"10.1128\/JVI.00464-11","article-title":"Role of proteases in the release of porcine epidemic diarrhea virus from infected cells","volume":"85","author":"Shirato","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106280","article-title":"Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesis","volume":"26","author":"Si","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.virol.2025.110412_bib145","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3390\/vaccines12030330","article-title":"Towards a safer future: enhancing vaccine development to combat animal coronaviruses","volume":"12","author":"Si","year":"2024","journal-title":"Vaccines"},{"key":"10.1016\/j.virol.2025.110412_bib146","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.dci.2008.07.011","article-title":"The ontogeny of the porcine immune system","volume":"33","author":"\u0160inkora","year":"2009","journal-title":"Developmental & Comparative Immunology, The Porcine Immune System"},{"key":"10.1016\/j.virol.2025.110412_bib147","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11262-012-0713-1","article-title":"Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines","volume":"44","author":"Song","year":"2012","journal-title":"Virus Gene."},{"key":"10.1016\/j.virol.2025.110412_bib148","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01309-24","article-title":"Efficacy evaluation of a bivalent subunit vaccine against epidemic PEDV heterologous strains with low cross-protection","volume":"98","author":"Song","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib149","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.05233-22","article-title":"Correlation between the IgG\/IgA antibody response against PEDV structural protein and virus neutralization","volume":"11","author":"Song","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.virol.2025.110412_bib150","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1177\/1040638713501675","article-title":"Emergence of porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences","volume":"25","author":"Stevenson","year":"2013","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.virol.2025.110412_bib151","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/tbed.13439","article-title":"A molecular epidemiological investigation of PEDV in China: characterization of co-infection and genetic diversity of S1-based genes","volume":"67","author":"Su","year":"2020","journal-title":"Transboundary Emerging Dis"},{"key":"10.1016\/j.virol.2025.110412_bib152","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1007\/s00705-018-3874-y","article-title":"New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017","volume":"163","author":"Su","year":"2018","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib153","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.vetmic.2008.02.022","article-title":"Identification of two novel B cell epitopes on porcine epidemic diarrhea virus spike protein","volume":"131","author":"Sun","year":"2008","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib154","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.chom.2023.05.017","article-title":"Broad-spectrum pan-genus and pan-family virus vaccines","volume":"31","author":"Tan","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.virol.2025.110412_bib155","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02453-20","article-title":"Trypsin-enhanced infection with porcine epidemic diarrhea virus is determined by the S2 subunit of the spike glycoprotein","author":"Tan","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib156","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.virol.2017.11.024","article-title":"Differential gene modulation of pattern-recognition receptor TLR and RIG-I-like and downstream mediators on intestinal mucosa of pigs infected with PEDV non S-INDEL and PEDV S-INDEL strains","volume":"517","author":"Temeeyasen","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.virol.2025.110412_bib157","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1111\/tbed.13953","article-title":"Molecular characterization of porcine epidemic diarrhea virus associated with outbreaks in southwest China during 2014\u20132018","volume":"68","author":"Tian","year":"2021","journal-title":"Transboundary Emerging Dis"},{"key":"10.1016\/j.virol.2025.110412_bib158","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41563-020-0746-0","article-title":"Next-generation vaccine platforms for COVID-19","volume":"19","author":"van Riel","year":"2020","journal-title":"Nat. Mater."},{"key":"10.1016\/j.virol.2025.110412_bib159","doi-asserted-by":"crossref","DOI":"10.3201\/eid2010.140491","article-title":"Distinct characteristics and complex evolution of PEDV strains, north America, may 2013\u2013february 2014","volume":"20","author":"Vlasova","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virol.2025.110412_bib160","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.cell.2020.10.043","article-title":"Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2","volume":"183","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.virol.2025.110412_bib161","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cell.2020.02.058","article-title":"Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein","volume":"181","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.virol.2025.110412_bib162","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s11262-017-1450-2","article-title":"Porcine epidemic diarrhea virus virus-like particles produced in insect cells induce specific immune responses in mice","volume":"53","author":"Wang","year":"2017","journal-title":"Virus Gene."},{"key":"10.1016\/j.virol.2025.110412_bib163","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00376-24","article-title":"Pan-beta-coronavirus subunit vaccine prevents SARS-CoV-2 omicron, SARS-CoV, and MERS-CoV challenge","volume":"98","author":"Wang","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib164","doi-asserted-by":"crossref","first-page":"veaa049","DOI":"10.1093\/ve\/veaa049","article-title":"Emergence and evolution of highly pathogenic porcine epidemic diarrhea virus by natural recombination of a low pathogenic vaccine isolate and a highly pathogenic strain in the spike gene","volume":"6","author":"Wang","year":"2020","journal-title":"Virus Evol"},{"key":"10.1016\/j.virol.2025.110412_bib165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coviro.2018.12.001","article-title":"Emerging and re-emerging coronaviruses in pigs","volume":"34","author":"Wang","year":"2019","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108729","article-title":"Identification of host cell proteins that interact with the M protein of porcine epidemic diarrhea virus","volume":"246","author":"Wang","year":"2020","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib167","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00705-015-2694-6","article-title":"Immunogenicity and antigenic relationships among spike proteins of porcine epidemic diarrhea virus subtypes G1 and G2","volume":"161","author":"Wang","year":"2016","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib168","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/jam.13652","article-title":"Oral immunization with a Lactobacillus casei based anti-porcine epidemic diarrhoea virus (PEDV) vaccine expressing microfold cell-targeting peptide Co1 fused with the COE antigen of PEDV","volume":"124","author":"Wang","year":"2018","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.virol.2025.110412_bib169","article-title":"A novel CpG ODN compound adjuvant enhances immune response to spike subunit vaccines of porcine epidemic diarrhea virus","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2025.110412_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.tvjl.2024.106097","article-title":"Overview of the recent advances in porcine epidemic diarrhea vaccines","volume":"304","author":"Wei","year":"2024","journal-title":"Vet. J."},{"key":"10.1016\/j.virol.2025.110412_bib171","doi-asserted-by":"crossref","first-page":"7952","DOI":"10.1128\/JVI.00297-14","article-title":"Proteolytic activation of the porcine epidemic diarrhea coronavirus spike fusion protein by trypsin in cell culture","volume":"88","author":"Wicht","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib172","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3390\/vaccines8040642","article-title":"Efficacy of porcine epidemic diarrhea vaccines: a systematic review and meta-analysis","volume":"8","author":"Won","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.virol.2025.110412_bib173","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00923-19","article-title":"The 3.1-angstrom cryo-electron microscopy structure of the porcine epidemic diarrhea virus spike protein in the prefusion conformation","author":"Wrapp","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib174","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3390\/v14050890","article-title":"Evaluation of the immunogenicity in mice orally immunized with recombinant lactobacillus casei expressing porcine epidemic diarrhea virus S1 protein","volume":"14","author":"Xiao","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib175","doi-asserted-by":"crossref","first-page":"12235","DOI":"10.1021\/acsnano.4c00809","article-title":"Combination of S1\u2013N\u2013terminal and S1\u2013C\u2013terminal domain antigens targeting double receptor-binding domains bolsters protective immunity of a nanoparticle vaccine against porcine epidemic diarrhea virus","volume":"18","author":"Yang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.virol.2025.110412_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.virol.2024.110113","article-title":"Construction and immune effect evaluation of the S protein heptad repeat-based nanoparticle vaccine against porcine epidemic diarrhea virus","volume":"596","author":"Yang","year":"2024","journal-title":"Virology"},{"key":"10.1016\/j.virol.2025.110412_bib177","article-title":"SARS-CoV-2 epitope-specific T cells: immunity response feature, TCR repertoire characteristics and cross-reactivity","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2025.110412_bib178","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s00705-022-05513-8","article-title":"Mechanisms of host type I interferon response modulation by the nucleocapsid proteins of alpha- and betacoronaviruses","volume":"167","author":"Yelemali","year":"2022","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2025.110412_bib179","article-title":"Newly characterized porcine epidemic diarrhea virus GII subtype strain","volume":"2023","author":"Yu","year":"2023","journal-title":"Transboundary Emerging Dis"},{"key":"10.1016\/j.virol.2025.110412_bib180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41541-021-00283-x","article-title":"Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus","volume":"6","author":"Yu","year":"2021","journal-title":"npj Vaccines"},{"key":"10.1016\/j.virol.2025.110412_bib181","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1159\/000492424","article-title":"Three main inducers of alphacoronavirus infection of enterocytes: sialic acid, proteases, and low pH","volume":"61","author":"Yuan","year":"2018","journal-title":"Intervirology"},{"key":"10.1016\/j.virol.2025.110412_bib182","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12934-024-02409-x","article-title":"Display of porcine epidemic diarrhea virus spike protein B-cell linear epitope on lactobacillus mucosae G01 S-layer surface induce a robust immunogenicity in mice","volume":"23","author":"Zhang","year":"2024","journal-title":"Microb. Cell Factories"},{"key":"10.1016\/j.virol.2025.110412_bib183","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msad052","article-title":"Global dynamics of porcine enteric coronavirus PEDV epidemiology, evolution, and transmission","volume":"40","author":"Zhang","year":"2023","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.virol.2025.110412_bib184","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.78633","article-title":"A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against omicron and other SARS-CoV-2 variants","volume":"11","author":"Zhang","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.virol.2025.110412_bib185","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.virusres.2016.05.015","article-title":"Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signaling","volume":"226","author":"Zhang","year":"2016","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110412_bib186","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008682","article-title":"Transferrin receptor 1 levels at the cell surface influence the susceptibility of newborn piglets to PEDV infection","volume":"16","author":"Zhang","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virol.2025.110412_bib187","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.3390\/v14112434","article-title":"Porcine epidemic diarrhea virus: an updated overview of virus epidemiology, virulence variation patterns and virus\u2013host interactions","volume":"14","author":"Zhang","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib188","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s11262-016-1316-z","article-title":"Construction of a bivalent DNA vaccine co-expressing S genes of transmissible gastroenteritis virus and porcine epidemic diarrhea virus delivered by attenuated salmonella typhimurium","volume":"52","author":"Zhang","year":"2016","journal-title":"Virus Gene."},{"key":"10.1016\/j.virol.2025.110412_bib189","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41541-022-00597-4","article-title":"Challenges and developments in universal vaccine design against SARS-CoV-2 variants","volume":"7","author":"Zhao","year":"2022","journal-title":"npj Vaccines"},{"key":"10.1016\/j.virol.2025.110412_bib190","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.104956","article-title":"Expression of the human or porcine C-type lectins DC-SIGN\/L-SIGN confers susceptibility to porcine epidemic diarrhea virus entry and infection in otherwise refractory cell lines","volume":"157","author":"Zhao","year":"2021","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.virol.2025.110412_bib191","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02958-23","article-title":"PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge","volume":"15","author":"Zhao","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.virol.2025.110412_bib192","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/v14010007","article-title":"Immune responses in pregnant sows induced by recombinant lactobacillus johnsonii expressing the COE protein of porcine epidemic diarrhea virus provide protection for piglets against PEDV infection","volume":"14","author":"Zheng","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110412_bib195","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.immuni.2023.02.005","article-title":"Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease","volume":"56","author":"Zhou","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.virol.2025.110412_bib193","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abi9215","article-title":"A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection","volume":"14","author":"Zhou","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.virol.2025.110412_bib194","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.vetmic.2018.11.019","article-title":"Effect of route of inoculation on innate and adaptive immune responses to porcine epidemic diarrhea virus infection in suckling pigs","volume":"228","author":"Zhou","year":"2019","journal-title":"Vet. Microbiol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682225000248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682225000248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T05:20:09Z","timestamp":1772342409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682225000248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":195,"alternative-id":["S0042682225000248"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2025.110412","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Towards developing multistrain PEDV vaccines: Integrating basic concepts and SARS-CoV-2 pan-sarbecovirus strategies","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2025.110412","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110412"}}