{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:31:25Z","timestamp":1787506285416,"version":"build-2736575974"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007014","name":"Cooperative State Research, Education, and Extension Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2018-67015-28287"],"award-info":[{"award-number":["2018-67015-28287"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2023-67015-39710"],"award-info":[{"award-number":["2023-67015-39710"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["ILLU-888-944"],"award-info":[{"award-number":["ILLU-888-944"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.virol.2025.110484","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T11:11:21Z","timestamp":1741345881000},"page":"110484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Coinfection with bacterial pathogens and genetic modification of PRRSV-2 for suppression of NF-\u03baB and attenuation of proinflammatory responses"],"prefix":"10.1016","volume":"606","author":[{"given":"Junyu","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ming","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jineui","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6730-9729","authenticated-orcid":false,"given":"Dongwan","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2025.110484_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-2427(97)00134-7","article-title":"Immune responses in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV)","volume":"61","author":"Albina","year":"1998","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virol.2025.110484_bib2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/v9030058","article-title":"Virus-bacteria interactions: an emerging topic in human infection","volume":"9","author":"Almand","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110484_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.197980","article-title":"Molecular and cellular mechanisms for PRRSV pathogenesis and host response to infection","volume":"286","author":"An","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110484_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156019","article-title":"Transcriptional analysis of PRRSV-infected porcine dendritic cell response to Streptococcus suis infection reveals up-regulation of inflammatory-related genes expression","volume":"11","author":"Auray","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2025.110484_bib5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1369\/jhc.2009.955435","article-title":"Structure and epigenetics of nucleoli in comparison with non-nucleolar compartments","volume":"58","author":"B\u00e1rtov\u00e1","year":"2010","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.virol.2025.110484_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1286-4579(01)01534-9","article-title":"Actinobacillus pleuropneumoniae: pathobiology and pathogenesis of infection","volume":"4","author":"Boss\u00e9","year":"2002","journal-title":"Microb. Infect."},{"key":"10.1016\/j.virol.2025.110484_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.vetmic.2017.02.003","article-title":"Comparison of Asian porcine high fever disease isolates of porcine reproductive and respiratory syndrome virus to United States isolates for their ability to cause disease and secondary bacterial infection in swine","volume":"203","author":"Brockmeier","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/978-1-4615-5331-1_59","article-title":"In vivo and in vitro interferon (IFN) studies with the porcine reproductive and respiratory syndrome virus (PRRSV)","volume":"440","author":"Buddaert","year":"1998","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.virol.2025.110484_bib9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/1040638712445764","article-title":"Pathogenesis of nonsuppurative encephalitis caused by highly pathogenic Porcine reproductive and respiratory syndrome virus","volume":"24","author":"Cao","year":"2012","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.virol.2025.110484_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tvjl.2015.10.030","article-title":"Porcine respiratory disease complex: interaction of vaccination and porcine circovirus type 2, porcine reproductive and respiratory syndrome virus, and Mycoplasma hyopneumoniae","volume":"212","author":"Chae","year":"2016","journal-title":"Vet. J."},{"key":"10.1016\/j.virol.2025.110484_bib11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrm1368","article-title":"Shaping the nuclear action of NF-kappaB","volume":"5","author":"Chen","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.virol.2025.110484_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.meegid.2018.12.011","article-title":"Co-infection status of classical swine fever virus (CSFV), porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circoviruses (PCV2 and PCV3) in eight regions of China from 2016 to 2018","volume":"68","author":"Chen","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.virol.2025.110484_bib13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetmic.2014.01.031","article-title":"Up-regulation of pro-inflammatory factors by HP-PRRSV infection in microglia: implications for HP-PRRSV neuropathogenesis","volume":"170","author":"Chen","year":"2014","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib14","first-page":"735","article-title":"Retrospective analysis of etiologic agents associated with respiratory diseases in pigs","volume":"44","author":"Choi","year":"2003","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.virol.2025.110484_bib15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00281-017-0639-8","article-title":"Cytokine storm and sepsis disease pathogenesis","volume":"39","author":"Chousterman","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.virol.2025.110484_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1192604","article-title":"Simultaneous co-infection with swine influenza A and porcine reproductive and respiratory syndrome viruses potentiates adaptive immune responses","volume":"14","author":"Chrun","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2025.110484_bib17","doi-asserted-by":"crossref","first-page":"489","DOI":"10.2478\/jvetres-2019-0063","article-title":"Proinflammatory cytokine changes in bronchoalveolar lavage fluid cells isolated from pigs infected solely with porcine reproductive and respiratory syndrome virus or Co-infected with swine influenza virus","volume":"63","author":"Czy\u017cewska-Dors","year":"2019","journal-title":"J. Vet Res."},{"key":"10.1016\/j.virol.2025.110484_bib18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3390\/v11030251","article-title":"Hepatitis E virus (HEV)-The future","volume":"11","author":"Denner","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110484_bib19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1378\/chest.118.2.503","article-title":"Proinflammatory cytokines","volume":"118","author":"Dinarello","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.virol.2025.110484_bib20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.vetmic.2013.11.037","article-title":"In vitro and ex vivo analyses of co-infections with swine influenza and porcine reproductive and respiratory syndrome viruses","volume":"169","author":"Dobrescu","year":"2014","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1354\/vp.40-2-143","article-title":"Detection rates of porcine reproductive and respiratory syndrome virus, porcine circovirus type 2, and swine influenza virus in porcine proliferative and necrotizing pneumonia","volume":"40","author":"Drolet","year":"2003","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.virol.2025.110484_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/1743-422X-10-265","article-title":"Synergistic effects of sequential infection with highly pathogenic porcine reproductive and respiratory syndrome virus and porcine circovirus type 2","volume":"10","author":"Fan","year":"2013","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2025.110484_bib23","doi-asserted-by":"crossref","first-page":"942","DOI":"10.3390\/vaccines12080942","article-title":"A comprehensive review on porcine reproductive and respiratory syndrome virus with emphasis on immunity","volume":"12","author":"Fiers","year":"2024","journal-title":"Vaccines"},{"key":"10.1016\/j.virol.2025.110484_bib24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/v9060110","article-title":"UK pigs at the time of slaughter: investigation into the correlation of infection with PRRSV and HEV","volume":"9","author":"Frossard","year":"2017","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110484_bib25","doi-asserted-by":"crossref","first-page":"7625","DOI":"10.1128\/JVI.00177-12","article-title":"Porcine reproductive and respiratory syndrome virus induces interleukin-15 through the NF-\u03baB signaling pathway","volume":"86","author":"Fu","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110484_bib26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/vr.134.3.60","article-title":"Interaction between Streptococcus suis serotype 2 and porcine reproductive and respiratory syndrome virus in specific pathogen-free piglets","volume":"134","author":"Galina","year":"1994","journal-title":"Vet. Rec."},{"key":"10.1016\/j.virol.2025.110484_bib27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2217\/fmb.10.2","article-title":"Streptococcus suis: a new emerging or an old neglected zoonotic pathogen?","volume":"5","author":"Gottschalk","year":"2010","journal-title":"Future Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib28","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.tvjl.2012.11.012","article-title":"Immunopathogenesis of porcine reproductive and respiratory syndrome in the respiratory tract of pigs","volume":"195","author":"G\u00f3mez-Laguna","year":"2013","journal-title":"Vet. J."},{"key":"10.1016\/j.virol.2025.110484_bib29","article-title":"Editorial: porcine reproductive and respiratory syndrome virus - animal virology, immunology, and pathogenesis","volume":"14","author":"Guo","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2025.110484_bib30","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1128\/JVI.78.5.2232-2241.2004","article-title":"IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection","volume":"78","author":"Haeberle","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110484_bib31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/cr.2011.13","article-title":"NF-\u03baB in immunobiology","volume":"21","author":"Hayden","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.virol.2025.110484_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1099\/jmm.0.000659","article-title":"Actinobacillus pleuropneumoniae culture supernatant antiviral effect against porcine reproductive and respiratory syndrome virus occurs prior to the viral genome replication and transcription through actin depolymerization","volume":"67","author":"Hernandez Reyes","year":"2018","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nrmicro1597","article-title":"RNA viruses: hijacking the dynamic nucleolus","volume":"5","author":"Hiscox","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib34","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3201\/eid1902.120470","article-title":"Streptococcus suis and porcine reproductive and respiratory syndrome, Vietnam","volume":"19","author":"Hoa","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virol.2025.110484_bib35","doi-asserted-by":"crossref","first-page":"10934","DOI":"10.1128\/JVI.01396-14","article-title":"Porcine reproductive and respiratory syndrome virus nonstructural protein 4 antagonizes beta interferon expression by targeting the NF-\u03baB essential modulator","volume":"88","author":"Huang","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110484_bib36","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1099\/vir.0.014001-0","article-title":"Porcine reproductive and respiratory syndrome virus modifies innate immunity and alters disease outcome in pigs subsequently infected with porcine respiratory coronavirus: implications for respiratory viral co-infections","volume":"90","author":"Jung","year":"2009","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2025.110484_bib37","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1097-2765(01)00349-5","article-title":"Involvement of PIAS1 in the sumoylation of tumor suppressor p53","volume":"8","author":"Kahyo","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.virol.2025.110484_bib38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.vetmic.2015.08.026","article-title":"Immune response of porcine alveolar macrophages to a concurrent infection with porcine reproductive and respiratory syndrome virus and Haemophilus parasuis in vitro","volume":"180","author":"Kavanov\u00e1","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47495-9","article-title":"Interaction of PIAS1 with PRRS virus nucleocapsid protein mediates NF-\u03baB activation and triggers proinflammatory mediators during viral infection","volume":"9","author":"Ke","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2025.110484_bib40","doi-asserted-by":"crossref","first-page":"6276","DOI":"10.1093\/emboj\/17.21.6276","article-title":"Requirement of the mouse I-mfa gene for placental development and skeletal patterning","volume":"17","author":"Kraut","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.virol.2025.110484_bib41","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00111-17","article-title":"Virological and immunological outcomes of coinfections","volume":"31","author":"Kumar","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.virol.2025.110484_bib42","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1111\/tbed.13846","article-title":"Co-infection status of novel parvovirus's (PPV2 to 4) with porcine circovirus 2 in porcine respiratory disease complex and porcine circovirus-associated disease from 1997 to 2012","volume":"68","author":"Lagan Tregaskis","year":"2021","journal-title":"Transbound Emerg. Dis."},{"key":"10.1016\/j.virol.2025.110484_bib43","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.virol.2005.11.005","article-title":"Mutations within the nuclear localization signal of the porcine reproductive and respiratory syndrome virus nucleocapsid protein attenuate virus replication","volume":"346","author":"Lee","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.virol.2025.110484_bib44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.virol.2005.07.034","article-title":"Porcine arterivirus activates the NF-kappaB pathway through IkappaB degradation","volume":"342","author":"Lee","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.virol.2025.110484_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098434","article-title":"Actinobacillus pleuropneumoniae possesses an antiviral activity against porcine reproductive and respiratory syndrome virus","volume":"9","author":"L\u00e9vesque","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2025.110484_bib46","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.virusres.2014.11.006","article-title":"Transcription analysis on response of porcine alveolar macrophages to co-infection of the highly pathogenic porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae","volume":"196","author":"Li","year":"2015","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110484_bib47","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/tbed.13072","article-title":"Porcine reproductive and respiratory syndrome virus NADC30-like strain accelerates Streptococcus suis serotype 2 infection in vivo and in vitro","volume":"66","author":"Li","year":"2019","journal-title":"Transbound Emerg. Dis."},{"key":"10.1016\/j.virol.2025.110484_bib48","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vetmic.2017.03.035","article-title":"Secondary Haemophilus parasuis infection enhances highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection-mediated inflammatory responses","volume":"204","author":"Li","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib49","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s11262-012-0763-4","article-title":"Sequence analysis of the NSP2, ORF5, and ORF7 genes of 11 PRRS virus isolates from China","volume":"45","author":"Li","year":"2012","journal-title":"Virus Genes"},{"key":"10.1016\/j.virol.2025.110484_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2019.108563","article-title":"Porcine reproductive and respiratory syndrome virus infection promotes C1QBP secretion to enhance inflammatory responses","volume":"241","author":"Li","year":"2020","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib51","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/ni1104","article-title":"PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity","volume":"5","author":"Liu","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.virol.2025.110484_bib52","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1128\/MCB.25.3.1113-1123.2005","article-title":"Negative regulation of NF-kappaB signaling by PIAS1","volume":"25","author":"Liu","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.virol.2025.110484_bib53","doi-asserted-by":"crossref","first-page":"L226","DOI":"10.1152\/ajplung.00037.2015","article-title":"ICAM-1-dependent and ICAM-1-independent neutrophil lung infiltration by porcine reproductive and respiratory syndrome virus infection","volume":"309","author":"Liu","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.virol.2025.110484_bib54","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jviromet.2010.12.023","article-title":"A multiplex RT-PCR for rapid and simultaneous detection of porcine teschovirus, classical swine fever virus, and porcine reproductive and respiratory syndrome virus in clinical specimens","volume":"172","author":"Liu","year":"2011","journal-title":"J. Virol Methods"},{"key":"10.1016\/j.virol.2025.110484_bib55","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1128\/CVI.00517-09","article-title":"Dynamic changes in inflammatory cytokines in pigs infected with highly pathogenic porcine reproductive and respiratory syndrome virus","volume":"17","author":"Liu","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.virol.2025.110484_bib56","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.vetimm.2004.09.005","article-title":"Role of neutralizing antibodies in PRRSV protective immunity","volume":"102","author":"Lopez","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virol.2025.110484_bib57","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11262-010-0548-6","article-title":"Activation of NF-\u03baB by nucleocapsid protein of the porcine reproductive and respiratory syndrome virus","volume":"42","author":"Luo","year":"2011","journal-title":"Virus Genes"},{"key":"10.1016\/j.virol.2025.110484_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198118","article-title":"Swine influenza virus: current status and challenge","volume":"288","author":"Ma","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110484_bib59","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12985-022-01814-1","article-title":"COVID-19 infection: an overview on cytokine storm and related interventions","volume":"19","author":"Montazersaheb","year":"2022","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2025.110484_bib60","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fvets.2019.00053","article-title":"Porcine hemagglutinating encephalomyelitis virus: a review","volume":"6","author":"Mora-D\u00edaz","year":"2019","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.virol.2025.110484_bib61","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/tbed.12272","article-title":"Pathology and virus distribution in the lung and lymphoid tissues of pigs experimentally inoculated with three distinct type 1 PRRS virus isolates of varying pathogenicity","volume":"63","author":"Morgan","year":"2016","journal-title":"Transbound Emerg. Dis."},{"key":"10.1016\/j.virol.2025.110484_bib62","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz8700","article-title":"Increased vaccine tolerability and protection via NF-\u03baB modulation","volume":"6","author":"Moser","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.virol.2025.110484_bib63","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13567-020-00789-7","article-title":"Evaluation of local and systemic immune responses in pigs experimentally challenged with porcine reproductive and respiratory syndrome virus","volume":"51","author":"Nazki","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.virol.2025.110484_bib64","doi-asserted-by":"crossref","first-page":"8519","DOI":"10.1128\/MCB.23.23.8519-8527.2003","article-title":"Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse","volume":"23","author":"Newton","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.virol.2025.110484_bib65","article-title":"Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern Vietnam","volume":"6","author":"Ngo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2025.110484_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2016.03.008","article-title":"Microbiome associations in pigs with the best and worst clinical outcomes following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2)","volume":"188","author":"Niederwerder","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib67","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.vetmic.2012.02.010","article-title":"Effect of porcine circovirus type 2a or 2b on infection kinetics and pathogenicity of two genetically divergent strains of porcine reproductive and respiratory syndrome virus in the conventional pig model","volume":"158","author":"Opriessnig","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib68","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.virusres.2011.09.014","article-title":"Concurrent infections are important for expression of porcine circovirus associated disease","volume":"164","author":"Opriessnig","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110484_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198044","article-title":"Porcine circoviruses: current status, knowledge gaps and challenges","volume":"286","author":"Opriessnig","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110484_bib70","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1042\/BST0351405","article-title":"PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription","volume":"35","author":"Palvimo","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.virol.2025.110484_bib71","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.virusres.2008.02.012","article-title":"Functional mapping of the porcine reproductive and respiratory syndrome virus capsid protein nuclear localization signal and its pathogenic association","volume":"135","author":"Pei","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110484_bib72","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0378-1135(96)01323-5","article-title":"Dual infections of PRRSV\/influenza or PRRSV\/Actinobacillus pleuropneumoniae in the respiratory tract","volume":"55","author":"Pol","year":"1997","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib73","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/104063870201400601","article-title":"Case-control study on the association of porcine circovirus type 2 and other swine viral pathogens with postweaning multisystemic wasting syndrome","volume":"14","author":"Pogranichniy","year":"2022","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.virol.2025.110484_bib74","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40813-023-00326-w","article-title":"Detection and genetic characterization of enteric viruses in diarrhoea outbreaks from swine farms in Spain","volume":"9","author":"Puente","year":"2023","journal-title":"Porcine Health Manag."},{"key":"10.1016\/j.virol.2025.110484_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31554-8","article-title":"Viral communities associated with porcine respiratory disease complex in intensive commercial farms in Sichuan province, China","volume":"8","author":"Qin","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2025.110484_bib76","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1089\/vim.2010.0051","article-title":"Porcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigs","volume":"23","author":"Renukaradhya","year":"2010","journal-title":"Viral Immunol."},{"key":"10.1016\/j.virol.2025.110484_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/030098589803500101","article-title":"Porcine reproductive and respiratory syndrome","volume":"35","author":"Rossow","year":"1998","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.virol.2025.110484_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1702(99)00048-9","article-title":"The localization of porcine reproductive and respiratory syndrome virus nucleocapsid protein to the nucleolus of infected cells and identification of a potential nucleolar localization signal sequence","volume":"64","author":"Rowland","year":"1999","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110484_bib79","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0042-6822(03)00482-3","article-title":"Peptide domains involved in the localization of the porcine reproductive and respiratory syndrome virus nucleocapsid protein to the nucleolus","volume":"316","author":"Rowland","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.virol.2025.110484_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2020.108652","article-title":"Influenza infection, SARS, MERS and COVID-19: cytokine storm - the common denominator and the lessons to be learned","volume":"223","author":"Ryabkova","year":"2021","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.virol.2025.110484_bib81","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13567-015-0207-y","article-title":"Hepatitis E virus chronic infection of swine co-infected with porcine reproductive and respiratory syndrome virus","volume":"46","author":"Salines","year":"2015","journal-title":"Vet. Res."},{"key":"10.1016\/j.virol.2025.110484_bib82","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijfoodmicro.2018.12.023","article-title":"Persistent viremia and presence of hepatitis E virus RNA in pig muscle meat after experimental co-infection with porcine reproductive and respiratory syndrome virus","volume":"292","author":"Salines","year":"2019","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib83","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.virol.2025.110484_bib84","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1101\/gad.1421006","article-title":"PIAS proteins and transcriptional regulation--more than just SUMO E3 ligases?","volume":"20","author":"Sharrocks","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.virol.2025.110484_bib85","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.vetmic.2009.07.021","article-title":"Cytokine mRNA expression profiles in peripheral blood mononuclear cells from piglets experimentally co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2","volume":"140","author":"Shi","year":"2010","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib86","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1038\/sj.onc.1203522","article-title":"Modulation of STAT signaling by STAT-interacting proteins","volume":"19","author":"Shuai","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.virol.2025.110484_bib87","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.cr.7310027","article-title":"Regulation of cytokine signaling pathways by PIAS proteins","volume":"16","author":"Shuai","year":"2006","journal-title":"Cell Res."},{"key":"10.1016\/j.virol.2025.110484_bib88","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.vetmic.2011.05.005","article-title":"Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding","volume":"152","author":"Sinha","year":"2011","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib89","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0378-1135(96)01325-9","article-title":"Porcine reproductive and respiratory syndrome virus (PRRSv) interaction with Haemophilus parasuis","volume":"55","author":"Solano","year":"1997","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib90","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.virol.2010.08.025","article-title":"Nonstructural protein 1\u03b1 subunit-based inhibition of NF-\u03baB activation and suppression of interferon-\u03b2 production by porcine reproductive and respiratory syndrome virus","volume":"407","author":"Song","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.virol.2025.110484_bib91","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1515\/BC.2009.028","article-title":"Interaction of the porcine reproductive and respiratory syndrome virus nucleocapsid protein with the inhibitor of MyoD family-a domain-containing protein","volume":"390","author":"Song","year":"2009","journal-title":"Biol. Chem."},{"key":"10.1016\/j.virol.2025.110484_bib92","article-title":"Modified live vaccine strains of porcine reproductive and respiratory syndrome virus cause immune system dysregulation similar to wild strains","volume":"14","author":"Stepanova","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2025.110484_bib93","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012128","article-title":"A clinically attenuated double-mutant of porcine reproductive and respiratory syndrome virus-2 that does not prompt overexpression of proinflammatory cytokines during co-infection with a secondary pathogen","volume":"20","author":"Su","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virol.2025.110484_bib94","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92941-2","article-title":"Activation of NF-\u03baB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2","volume":"11","author":"Su","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2025.110484_bib95","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.virol.2010.07.016","article-title":"Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-\u03baB and Sp1","volume":"406","author":"Subramaniam","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.virol.2025.110484_bib96","article-title":"Matrine displayed antiviral activity in porcine alveolar macrophages co-infected by porcine reproductive and respiratory syndrome virus and porcine circovirus type 2","volume":"6","author":"Sun","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virol.2025.110484_bib97","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.960033","article-title":"Investigation and analysis of etiology associated with porcine respiratory disease complex in China from 2017 to 2021","volume":"9","author":"Sun","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.virol.2025.110484_bib98","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1600-065X.2011.01088.x","article-title":"The noncanonical NF-\u03baB pathway","volume":"246","author":"Sun","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.virol.2025.110484_bib99","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3390\/v4040424","article-title":"Interplay between interferon-mediated innate immunity and porcine reproductive and respiratory syndrome virus","volume":"4","author":"Sun","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110484_bib100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168314","article-title":"Nonstructural protein 11 of porcine reproductive and respiratory syndrome virus suppresses both MAVS and RIG-I expression as one of the mechanisms to antagonize type I interferon production","volume":"11","author":"Sun","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.virol.2025.110484_bib101","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.rvsc.2020.02.010","article-title":"Early infection of Streptococcus suis serotype 2 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome MLV-like virus in pigs","volume":"130","author":"Sun","year":"2020","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.virol.2025.110484_bib102","first-page":"425","article-title":"Epidemiological survey of four reproductive disorder associated viruses of sows in hunan province during 2019-2021","volume":"9","author":"Tang","year":"2022","journal-title":"Vet Sci."},{"key":"10.1016\/j.virol.2025.110484_bib103","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1128\/JCM.37.3.620-627.1999","article-title":"Mycoplasma hyopneumoniae potentiation of porcine reproductive and respiratory syndrome virus-induced pneumonia","volume":"37","author":"Thacker","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib104","first-page":"901","article-title":"Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae","volume":"11","author":"Thanawongnuwech","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.virol.2025.110484_bib105","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0165-2427(01)00243-4","article-title":"Differential production of proinflammatory cytokines: in vitro PRRSV and Mycoplasma hyopneumoniae co-infection model","volume":"79","author":"Thanawongnuwech","year":"2001","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virol.2025.110484_bib106","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.1128\/JVI.76.13.6800-6814.2002","article-title":"Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells","volume":"76","author":"Tian","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110484_bib107","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0955-0674(97)80005-1","article-title":"Function and synthesis of small nucleolar RNAs","volume":"9","author":"Tollervey","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.virol.2025.110484_bib108","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.rvsc.2014.12.003","article-title":"Expression profile of Toll-like receptor mRNA in pigs co-infected with porcine reproductive and respiratory syndrome virus and porcine circovirus type 2","volume":"98","author":"Tu","year":"2015","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.virol.2025.110484_bib110","first-page":"78","article-title":"Viral co-infections of the porcine respiratory tract: insight into the local cytokine response","author":"Turlewicz-Podbielska","year":"2022","journal-title":"Med. Weter."},{"issue":"5","key":"10.1016\/j.virol.2025.110484_bib109","article-title":"Respiratory viral infections drive different lung cytokine profiles in pigs","volume":"17","author":"Turlewicz-Podbielska","year":"2021","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.virol.2025.110484_bib111","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1053\/rvsc.1998.0277","article-title":"Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity","volume":"67","author":"Van Reeth","year":"1999","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.virol.2025.110484_bib112","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0378-1135(95)00145-X","article-title":"Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: a clinical and virological study","volume":"48","author":"Van Reeth","year":"1996","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105810","article-title":"Synergistic pathogenicity by coinfection and sequential infection with JXA1-like HP-PRRSV and PCV2d in PCV2 antibody-positive post-weaned pigs","volume":"173","author":"Wang","year":"2022","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.virol.2025.110484_bib114","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/S2095-3119(15)61044-9","article-title":"Investigation on the co-infections of Toxoplasma gondii with PRRSV, CSFV or PCV-2 in swine in part of China","volume":"14","author":"Wang","year":"2015","journal-title":"J. Integr. Agric."},{"key":"10.1016\/j.virol.2025.110484_bib115","article-title":"Characterization of two porcine parainfluenza virus 1 isolates and human parainfluenza virus 1 infection in weaned nursery pigs","volume":"10","author":"Welch","year":"2022","journal-title":"Vet Sci."},{"key":"10.1016\/j.virol.2025.110484_bib116","doi-asserted-by":"crossref","first-page":"10569","DOI":"10.1128\/JVI.76.20.10569-10576.2002","article-title":"Phosphorylation of the porcine reproductive and respiratory syndrome virus nucleocapsid protein","volume":"76","author":"Wootton","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110484_bib117","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1128\/JVI.77.8.4546-4557.2003","article-title":"Homo-oligomerization of the porcine reproductive and respiratory syndrome virus nucleocapsid protein and the role of disulfide linkages","volume":"77","author":"Wootton","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110484_bib118","first-page":"63","article-title":"Analysis of the N protein sequence variability in 13 isolated PRRSV strains from China","volume":"9","author":"Xia","year":"2021","journal-title":"J. Biosci. Med."},{"key":"10.1016\/j.virol.2025.110484_bib119","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00705-014-2309-7","article-title":"The gene expression profile of porcine alveolar macrophages infected with a highly pathogenic porcine reproductive and respiratory syndrome virus indicates overstimulation of the innate immune system by the virus","volume":"160","author":"Xiao","year":"2015","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2025.110484_bib120","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/1743-422X-7-184","article-title":"Secondary infection with Streptococcus suis serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs","volume":"7","author":"Xu","year":"2010","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2025.110484_bib121","doi-asserted-by":"crossref","first-page":"12173","DOI":"10.1128\/JVI.77.22.12173-12183.2003","article-title":"Colocalization and interaction of the porcine arterivirus nucleocapsid protein with the small nucleolar RNA-associated protein fibrillarin","volume":"77","author":"Yoo","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110484_bib122","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00705-007-0027-0","article-title":"Genetic characterization of the Korean porcine reproductive and respiratory syndrome viruses based on the nucleocapsid protein gene (ORF7) sequences","volume":"153","author":"Yoon","year":"2008","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2025.110484_bib123","first-page":"143","article-title":"Concurrent respiratory infections in 221 cases of PRRS virus pneumonia : 1992 \u2013 1994","volume":"4","author":"Zeman","year":"1992","journal-title":"Swine Health Prod."},{"key":"10.1016\/j.virol.2025.110484_bib124","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/v14020193","article-title":"Synergistic pathogenicity by coinfection and sequential infection with NADC30-like PRRSV and PCV2 in post-weaned pigs","volume":"14","author":"Zhang","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2025.110484_bib125","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.699561","article-title":"Advanced Research in porcine reproductive and respiratory syndrome virus Co-infection with other pathogens in swine","volume":"8","author":"Zhao","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.virol.2025.110484_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104385","article-title":"Identification of enterobacteria in viscera of pigs afflicted with porcine reproductive and respiratory syndrome and other viral co-infections","volume":"147","author":"Zhao","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.virol.2025.110484_bib127","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.vetmic.2011.09.028","article-title":"Microbial ecology of swine farms and PRRS vaccine vaccination strategies","volume":"155","author":"Zhao","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110484_bib128","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1089\/vim.2020.0025","article-title":"Prevalence of porcine pseudorabies virus and its coinfection rate in heilongjiang province in China from 2013 to 2018","volume":"33","author":"Zhou","year":"2020","journal-title":"Viral Immunol."},{"key":"10.1016\/j.virol.2025.110484_bib129","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41440-023-01460-2","article-title":"The role of SARS-CoV-2-mediated NF-\u03baB activation in COVID-19 patients","volume":"47","author":"Zhou","year":"2024","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.virol.2025.110484_bib130","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/vms3.533","article-title":"Co-infection analysis of bacterial and viral respiratory pathogens from clinically healthy swine in Eastern China","volume":"7","author":"Zhu","year":"2021","journal-title":"Vet. Med. Sci."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682225000960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682225000960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:52:30Z","timestamp":1777459950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682225000960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":130,"alternative-id":["S0042682225000960"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2025.110484","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coinfection with bacterial pathogens and genetic modification of PRRSV-2 for suppression of NF-\u03baB and attenuation of proinflammatory responses","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2025.110484","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110484"}}