{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:56:22Z","timestamp":1777521382994,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFE0111700"],"award-info":[{"award-number":["2024YFE0111700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017698","name":"Henan Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["2024TD03"],"award-info":[{"award-number":["2024TD03"]}],"id":[{"id":"10.13039\/501100017698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017698","name":"Henan Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["2024JC16"],"award-info":[{"award-number":["2024JC16"]}],"id":[{"id":"10.13039\/501100017698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.virol.2025.110501","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:49:32Z","timestamp":1741913372000},"page":"110501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Fine mapping of conserved neutralizing epitopes within the VP2 protein of Senecavirus A using monoclonal antibodies"],"prefix":"10.1016","volume":"606","author":[{"given":"Wanying","family":"Zou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zekun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2025.110501_bib1","doi-asserted-by":"crossref","first-page":"13087","DOI":"10.1073\/pnas.1814309115","article-title":"Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1","volume":"115","author":"Cao","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.virol.2025.110501_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2024.110198","article-title":"A nanoparticle vaccine based on the VP121-26 and VP2 structural proteins of Senecavirus A induces robust protective immune responses","volume":"296","author":"Cao","year":"2024","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110501_bib3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.biotechadv.2018.01.008","article-title":"RNA interference technology to improve the baculovirus-insect cell expression system","volume":"36","author":"Chavez-Pena","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.virol.2025.110501_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02043-24","article-title":"Development and optimization of a double antigen sandwich ELISA detecting for Senecavirus A antibodies based on VP2 protein","volume":"12","author":"Chen","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.virol.2025.110501_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108753","article-title":"Identification of linear B cell epitopes on VP1 and VP2 proteins of Senecavirus A (SVA) using monoclonal antibodies","volume":"247","author":"Fan","year":"2020","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virol.2025.110501_bib6","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1099\/vir.0.83570-0","article-title":"Complete genome sequence analysis of Seneca Valley virus-001, a novel oncolytic picornavirus","volume":"89","author":"Hales","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2025.110501_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198038","article-title":"Comprehensive review on immunopathogenesis, diagnostic and epidemiology of Senecavirus A","volume":"286","author":"Houston","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2025.110501_bib8","doi-asserted-by":"crossref","first-page":"E10934","DOI":"10.1073\/pnas.1810664115","article-title":"Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus","volume":"115","author":"Jayawardena","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virol.2025.110501_bib9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/tbed.12430","article-title":"Senecavirus A: an emerging vesicular infection in Brazilian pig herds","volume":"62","author":"Leme","year":"2015","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.virol.2025.110501_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.meegid.2018.12.009","article-title":"Isolation and phylogenetic analysis of an emerging Senecavirus A in China, 2017","volume":"68","author":"Liu","year":"2019","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.virol.2025.110501_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2020.567792","article-title":"A 5-year review of senecavirus A in China since its emergence in 2015","volume":"7","author":"Liu","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.virol.2025.110501_bib12","article-title":"Senecavirus A as an oncolytic virus: prospects, challenges and development directions","volume":"12","author":"Luo","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.virol.2025.110501_bib13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12985-016-0508-4","article-title":"Development of an HSV-1 neutralization test with a glycoprotein D specific antibody for measurement of neutralizing antibody titer in human sera","volume":"13","author":"Luo","year":"2016","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2025.110501_bib14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12985-022-01934-8","article-title":"Development of an indirect ELISA using a novel linear epitope at the C-terminal region of the VP2 protein to specifically detect antibodies against Senecavirus A","volume":"19","author":"Ma","year":"2022","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2025.110501_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00736-22","article-title":"Structure of senecavirus A 3C protease revealed the cleavage pattern of 3C protease in picornaviruses","volume":"96","author":"Meng","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110501_bib16","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.3201\/eid2207.151863","article-title":"Vesicular disease in 9-week-old pigs experimentally infected with senecavirus A","volume":"22","author":"Montiel","year":"2016","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virol.2025.110501_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.virol.2017.06.013","article-title":"The S2 glycoprotein subunit of porcine epidemic diarrhea virus contains immunodominant neutralizing epitopes","volume":"509","author":"Okda","year":"2017","journal-title":"Virology"},{"key":"10.1016\/j.virol.2025.110501_bib18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10529-019-02755-6","article-title":"Expression, purification, and characterisation of recombinant ferritin in insect cells using the baculovirus expression system","volume":"42","author":"Qu","year":"2020","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.virol.2025.110501_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/tbed.12654","article-title":"The first detection of Senecavirus A in pigs in Thailand, 2016","volume":"65","author":"Saeng-chuto","year":"2018","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.virol.2025.110501_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/0300985816653990","article-title":"Senecavirus A","volume":"54","author":"Segal\u00e9s","year":"2017","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.virol.2025.110501_bib21","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.05229-22","article-title":"The construction and immunogenicity analyses of a recombinant pseudorabies virus with senecavirus A VP2 protein coexpression","volume":"11","author":"Tao","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.virol.2025.110501_bib22","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1080\/14760584.2022.2085565","article-title":"The baculovirus expression vector system: a modern technology for the future of influenza vaccine manufacturing","volume":"21","author":"Trombetta","year":"2022","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.virol.2025.110501_bib23","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/tbed.12410","article-title":"Identification and complete genome of Seneca Valley Virus in vesicular fluid and sera of pigs affected with idiopathic vesicular disease, Brazil","volume":"62","author":"Vannucci","year":"2015","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.virol.2025.110501_bib24","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.str.2008.07.013","article-title":"Structure of Seneca Valley Virus-001: an oncolytic picornavirus representing a new genus","volume":"16","author":"Venkataraman","year":"2008","journal-title":"Structure"},{"key":"10.1016\/j.virol.2025.110501_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.virol.2023.06.004","article-title":"Structural and nonstructural proteins of Senecavirus A: recent research advances, and lessons learned from those of other picornaviruses","volume":"585","author":"Wang","year":"2023","journal-title":"Virology"},{"key":"10.1016\/j.virol.2025.110501_bib26","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1111\/tbed.14435","article-title":"Development of a VP2-based real-time fluorescent reverse transcription recombinase-aided amplification assay to rapidly detect Senecavirus A","volume":"69","author":"Wang","year":"2022","journal-title":"Transbound. Emerg. Dis"},{"key":"10.1016\/j.virol.2025.110501_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12985-022-01791-5","article-title":"Identification of a conserved neutralizing epitope in Seneca Valley virus VP2 protein: new insight for epitope vaccine designment","volume":"19","author":"Wen","year":"2022","journal-title":"Virol. J."},{"key":"10.1016\/j.virol.2025.110501_bib28","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1128\/JVI.01107-10","article-title":"Structural features of the Seneca Valley virus internal ribosome entry site (IRES) element: a picornavirus with a pestivirus-like IRES","volume":"85","author":"Willcocks","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virol.2025.110501_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02090-22","article-title":"The evolution and global spatiotemporal dynamics of senecavirus A","volume":"10","author":"Wu","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.virol.2025.110501_bib30","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/tbed.12557","article-title":"The first identification and complete genome of senecavirus A affecting pig with idiopathic vesicular disease in China","volume":"64","author":"Wu","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.virol.2025.110501_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1107173","article-title":"The game between host antiviral innate immunity and immune evasion strategies of senecavirus A - A cell biological perspective","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virol.2025.110501_bib32","article-title":"Identification of a linear B-cell epitope on the \u201cpuff\u201d loop of the Senecavirus A VP2 protein involved in receptor binding","volume":"15","author":"Zhou","year":"2024","journal-title":"Front. Microbiol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268222500114X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004268222500114X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T19:25:34Z","timestamp":1743449134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004268222500114X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":32,"alternative-id":["S004268222500114X"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2025.110501","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fine mapping of conserved neutralizing epitopes within the VP2 protein of Senecavirus A using monoclonal antibodies","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2025.110501","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110501"}}