{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:06:00Z","timestamp":1777946760328,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100021260","name":"Legacy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023350","name":"Hans Merensky Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.virol.2026.110903","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:32:46Z","timestamp":1775665966000},"page":"110903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Leaf bleaching is associated with extensive transcriptional reprogramming in avocado trees with sunblotch disease"],"prefix":"10.1016","volume":"620","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1937-0274","authenticated-orcid":false,"given":"M.","family":"Joubert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Theron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Swart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virol.2026.110903_bib1","series-title":"Fundamentals of Viroid Biology","first-page":"275","article-title":"Viroid-induced RNA silencing and its secondary effect on the host transcriptome","author":"Adkar-Purushothama","year":"2024"},{"key":"10.1016\/j.virol.2026.110903_bib2","article-title":"Current overview on viroid\u2013host interactions","volume":"11","author":"Adkar\u2010Purushothama","year":"2019","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.virol.2026.110903_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1071\/APP9810031","article-title":"Purified avocado sunblotch viroid causes disease in avocado seedlings","volume":"10","author":"Allen","year":"1981","journal-title":"Australas. Plant Pathol."},{"key":"10.1016\/j.virol.2026.110903_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2022.928176","article-title":"Differing responses to Phytophthora cinnamomi infection in susceptible and partially resistant Persea americana (Mill.) rootstocks: a case for the role of receptor-like kinases and apoplastic proteases","volume":"13","author":"Backer","year":"2022","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.virol.2026.110903_bib5","first-page":"1","article-title":"RNA-seq profiling reveals the transcriptional response against potato spindle tuber viroid in different potato cultivars and developmental stages","author":"Chi","year":"2022","journal-title":"Potato Res."},{"key":"10.1016\/j.virol.2026.110903_bib6","series-title":"Receptor-Like Kinases in Plants: from Development to Defense","first-page":"227","article-title":"Phosphorylation and RLK signaling","author":"Clouse","year":"2011"},{"key":"10.1016\/j.virol.2026.110903_bib7","first-page":"65","article-title":"Avocado sunblotch","volume":"3","author":"Da Graca","year":"1979","journal-title":"South African Avocado Growers\u2019 Association Research Report"},{"key":"10.1016\/j.virol.2026.110903_bib8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1439-0434.1981.tb03379.x","article-title":"Ultrastructural changes in avocado leaf tissue infected with avocado sunblotch","volume":"102","author":"Da Graca","year":"1981","journal-title":"Phytopathol. Z."},{"key":"10.1016\/j.virol.2026.110903_bib9","first-page":"83","article-title":"Field indexing for avocado sunblotch disease","volume":"6","author":"Da Graca","year":"1983","journal-title":"S Afr Avocado Growers' Assoc Yearbook"},{"key":"10.1016\/j.virol.2026.110903_bib10","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1080\/15476286.2019.1600396","article-title":"How sequence variants of a plastid-replicating viroid with one single nucleotide change initiate disease in its natural host","volume":"16","author":"Delgado","year":"2019","journal-title":"RNA Biol."},{"key":"10.1016\/j.virol.2026.110903_bib11","series-title":"The Viroids","first-page":"299","article-title":"Avocado sunblotch","author":"Desjardins","year":"1987"},{"key":"10.1016\/j.virol.2026.110903_bib12","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1099\/jgv.0.001045","article-title":"ICTV virus taxonomy profile: avsunviroidae","volume":"99","author":"Di Serio","year":"2018","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2026.110903_bib13","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001543","article-title":"ICTV virus taxonomy profile: pospiviroidae","volume":"102","author":"Di Serio","year":"2021","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2026.110903_bib14","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/femsre\/fuaa011","article-title":"Viroid pathogenesis: a critical appraisal of the role of RNA silencing in triggering the initial molecular lesion","volume":"44","author":"Flores","year":"2020","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.virol.2026.110903_bib15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.tplants.2009.03.002","article-title":"Interplay between viroid-induced pathogenesis and RNA silencing pathways","volume":"14","author":"G\u00f3mez","year":"2009","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.virol.2026.110903_bib16","doi-asserted-by":"crossref","first-page":"992","DOI":"10.3390\/v11110992","article-title":"Root transcriptomic analysis reveals global changes induced by systemic infection of Solanum lycopersicum with mild and severe variants of potato spindle tuber viroid","volume":"11","author":"G\u00f3ra-Sochacka","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2026.110903_bib17","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.3390\/plants10122687","article-title":"Transcriptome analysis reveals dynamic cultivar-dependent patterns of gene expression in potato spindle tuber viroid-infected pepper","volume":"10","author":"Hadjieva","year":"2021","journal-title":"Plants"},{"key":"10.1016\/j.virol.2026.110903_bib18","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3389\/fpls.2018.01387","article-title":"Mitogen-activated protein kinase cascades in plant hormone signaling","volume":"9","author":"Jagodzik","year":"2018","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.virol.2026.110903_bib19","series-title":"Fundamentals of Viroid Biology","first-page":"255","article-title":"Transcriptomic analyses provide insights into plant-viroid interactions","author":"Jak\u0161e","year":"2024"},{"key":"10.1016\/j.virol.2026.110903_bib20","first-page":"66","article-title":"Avocado sunblotch viroid (ASBVd) symptom identification and detection in avocado orchards","volume":"44","author":"Jooste","year":"2021","journal-title":"S Afr Avocado Growers' Assoc Yearbook"},{"key":"10.1016\/j.virol.2026.110903_bib21","doi-asserted-by":"crossref","first-page":"7677","DOI":"10.3390\/ijms23147677","article-title":"Transcriptomics advancement in the complex response of plants to viroid infection","volume":"23","author":"Joubert","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.virol.2026.110903_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2023.199263","article-title":"Global transcriptomic analysis in avocado nursery trees reveals differential gene expression during asymptomatic infection by avocado sunblotch viroid (ASBVd)","volume":"339","author":"Joubert","year":"2024","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2026.110903_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00705-025-06360-z","article-title":"Small RNAs derived from avocado sunblotch viroid and their association with bleaching symptoms: implications for pathogenesis in avocado sunblotch disease","volume":"170","author":"Joubert","year":"2025","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2026.110903_bib24","series-title":"Viroids and Satellites","first-page":"297","article-title":"Avocado sunblotch viroid","author":"Kuhn","year":"2017"},{"key":"10.1016\/j.virol.2026.110903_bib25","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/pce.12231","article-title":"Mercator: a fast and simple web server for genome scale functional annotation of plant sequence data","volume":"5","author":"Lohse","year":"2014","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.virol.2026.110903_bib26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00705-003-0215-5","article-title":"RNA silencing as related to viroid induced symptom expression","volume":"149","author":"Markarian","year":"2004","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virol.2026.110903_bib28","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3390\/v10100570","article-title":"Genome-wide transcriptomic analysis reveals insights into the response to citrus bark cracking viroid (CBCVd) in hop (Humulus lupulus L.)","volume":"10","author":"Mishra","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2026.110903_bib27","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1111\/pce.14647","article-title":"Integrative time\u2010scale and multi\u2010omics analysis of host responses to viroid infection","volume":"46","author":"M\u00e1rquez\u2010Molins","year":"2023","journal-title":"Plant Cell Environ."},{"key":"10.1016\/j.virol.2026.110903_bib29","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1365-313X.2012.04940.x","article-title":"Small RNAs containing the pathogenic determinant of a chloroplast\u2010replicating viroid guide the degradation of a host mRNA as predicted by RNA silencing","volume":"70","author":"Navarro","year":"2012","journal-title":"Plant J."},{"key":"10.1016\/j.virol.2026.110903_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0042-6822(79)90045-X","article-title":"Characterization of a viroid associated with avocado sunblotch disease","volume":"99","author":"Palukaitis","year":"1979","journal-title":"Virology"},{"key":"10.1016\/j.virol.2026.110903_bib31","series-title":"Rstudio: Integrated Development Environment for R. Posit Software","year":"2024"},{"key":"10.1016\/j.virol.2026.110903_bib32","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1364-3703.2012.00794.x","article-title":"Microarray analysis of etrog citron (Citrus medica L.) reveals changes in chloroplast, cell wall, peroxidase and symporter activities in response to viroid infection","volume":"13","author":"Rizza","year":"2012","journal-title":"Mol. Plant Pathol."},{"key":"10.1016\/j.virol.2026.110903_bib33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.plaphy.2022.07.029","article-title":"Unveiling the functions of plastid ribosomal proteins in plant development and abiotic stress tolerance","volume":"189","author":"Robles","year":"2022","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.virol.2026.110903_bib34","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.molp.2019.01.003","article-title":"MapMan4: a refined protein classification and annotation framework applicable to multi-omics data analysis","volume":"12","author":"Schwacke","year":"2019","journal-title":"Mol. Plant"},{"key":"10.1016\/j.virol.2026.110903_bib35","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1099\/0022-1317-75-7-1543","article-title":"Avocado sunblotch disease: a persistent viroid infection in which variants are associated with differential symptoms","volume":"75","author":"Semancik","year":"1994","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virol.2026.110903_bib36","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/nph.18934","article-title":"Expression of symptoms elicited by a hammerhead viroid through RNA silencing is related to population bottlenecks in the infected host","volume":"239","author":"Serra","year":"2023","journal-title":"New Phytol."},{"key":"10.1016\/j.virol.2026.110903_bib37","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrg3207","article-title":"Transcription factors: from enhancer binding to developmental control","volume":"13","author":"Spitz","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.virol.2026.110903_bib38","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.3390\/ijms20133154","article-title":"Evaluation of disease severity and global transcriptome response induced by Citrus bark cracking viroid, Hop latent viroid, and their co-infection in hop (Humulus lupulus L.)","volume":"20","author":"\u0160tajner","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.virol.2026.110903_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.plgene.2019.100181","article-title":"Global transcriptome analyses reveal that infection with chrysanthemum stunt viroid (CSVd) affects gene expression profile of chrysanthemum plants, but the genes involved in plant hormone metabolism and signaling may not be silencing target of CSVd-siRNAs","volume":"18","author":"Takino","year":"2019","journal-title":"Plant Gene"},{"key":"10.1016\/j.virol.2026.110903_bib40","first-page":"158","article-title":"Histopathology of avocado fruit infected by Avocado sunblotch viroid","volume":"6","author":"Vallejo-P\u00e9rez","year":"2014","journal-title":"J. Agric. Sci."},{"key":"10.1016\/j.virol.2026.110903_bib41","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3390\/v11050453","article-title":"Global transcriptomic analysis reveals insights into the response of 'Etrog' citron (Citrus medica L.) to Citrus exocortis viroid infection","volume":"11","author":"Wang","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2026.110903_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.202000034","article-title":"Transcription factors: bridge between cell signaling and gene regulation","volume":"21","author":"Weidem\u00fcller","year":"2021","journal-title":"Proteomics"},{"key":"10.1016\/j.virol.2026.110903_bib43","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3390\/v10050257","article-title":"Time-course microarray analysis reveals differences between transcriptional changes in tomato leaves triggered by mild and severe variants of potato spindle tuber viroid","volume":"10","author":"Wi\u0119syk","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.virol.2026.110903_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198090","article-title":"Differences in gene expression profiles at the early stage of Solanum lycopersicum infection with mild and severe variants of potato spindle tuber viroid","volume":"286","author":"Wi\u0119syk","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.virol.2026.110903_bib45","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.3389\/fmicb.2017.02427","article-title":"Global transcriptomic changes induced by infection of cucumber (Cucumis sativus L.) with mild and severe variants of hop stunt viroid","volume":"8","author":"Xia","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virol.2026.110903_bib46","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.10005","article-title":"Transcriptomic analysis reveals insights into the response to hop stunt viroid (HSVd) in sweet cherry (Prunus avium L.) fruits","volume":"8","author":"Xu","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.virol.2026.110903_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.virol.2026.110903_bib48","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3390\/plants12030427","article-title":"Advances in receptor-like protein kinases in balancing plant growth and stress responses","volume":"12","author":"Zhu","year":"2023","journal-title":"Plants"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682226001182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682226001182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T20:20:50Z","timestamp":1777753250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682226001182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":48,"alternative-id":["S0042682226001182"],"URL":"https:\/\/doi.org\/10.1016\/j.virol.2026.110903","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leaf bleaching is associated with extensive transcriptional reprogramming in avocado trees with sunblotch disease","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virol.2026.110903","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110903"}}